Our group is interested in how B and T cells get activated — especially how signals from the outside (like antigens) are picked up by receptors on the cell surface and passed into the cell to trigger a response. A big part of our work focuses on how the T cell receptor (TCR) works on a molecular level and what happens in the very first moments after it gets activated.

We’re also excited about using this knowledge in real-world applications, especially when it comes to improving cancer immunotherapies like CAR T cells or working with γδ T cells. On top of that, we study how signaling goes wrong in autoimmune diseases or immunodeficiencies, and how proteins like Kidins220 and Caveolin-1 play a role in keeping immune cells in balance.

Our main topics: Lymphocytes Signaling, Cancer Immunotherapy, γδ T cells, Autoimmunity & Immunodeficiency