See als on https://pubmed.ncbi.nlm.nih.gov/?term=((MINGUET%20and%20marcos))%20OR%20SUSANA%20MINGUET
2026
- Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota
Obwegs D, Oschwald A, Koetter L, Crisand C, Doerr S, Bruder K, Runge S, Ghanem N, Fuchs V, Eckert M, Koengeter C, Schaffer A, Amann L, Papaioannou S, Rollenske T, Kolter J, Erny D, Prinz M, Minguet S, Schamel W, Henneke P, Rosshart S, Kierdorf K, Sagar.
Science Advances Immunology. 2026 Aug. eaec9180 - Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective
Knapp LR, Fischer KS, Sosat J, Villena-Ossa JF, Kluge P, Schmiedel D, Kuball J, Dolstra H, Minguet S, Cornu T, Cathomen T, Alici E, O´Dwyer M, Wels W, Malmberg KJ, Romee R, Vivier E, Köhl U, Cerwenka A, Ullrich E.
Hum Gene Ther. 2026 Aug. 691-701
- The TCR and LCK: foundations for T-cell activation and therapeutic innovation.Front Immunol. 2026 Jan 12;16:1737013.
- LCK at the crossroad of immunodeficiency and autoimmunity: Mechanisms and therapeutic opportunities. Immunol Lett. 2026 Jun;279:107126.
- Cis- and trans-binding chimeric costimulatory receptors enhance T-cell fitness and tumor control. Cell Mol Immunol. 2026 Jan;23(1):79-93.
- Menin inhibition enhances graft-versus-leukemia effects by T-cell activation and endogenous retrovirus induction in AML
Fetsch V, Schwöbel LF, Ozyerli-Goknar E PhD, Stell AV, Punta M, Plenge T, Klaus T, Gupta MK, Andrieux G, Shoumariyeh K, Pfeiffer S, Corrales E, Schlenke L, Baniadam H, Brandl SM, Andreis M, Remen M, Hartmann A, Grueter K, Zwick M, Köhler N, Kuban M, Metzger E, Rummelt C, Duyster J, Börries M, Hofmann M, Färber J, Braun LM, Zähringer A, Lübbert M, Toffalori C, Vago L, Heidel FH, Minguet S, Apostolova P, Feuchtinger T, Maas-Bauer K, Blaeschke F, Kühn MWM, Timmers M, Wertheimer T, Perner F, Zeiser R.
Blood. 2026 Jan 29;147(5):584-601.
2025
- Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy.
Beringer DX, Straetemans T, Minguet S, Riillo C, Lynch L, Sebestyen Z, Kuball J.
Nat Rev Cancer. 2025 Aug;25(8):590-612. - Development of a Peptide Inhibitor Targeting the C-SH2 Domain of the SHP2 Phosphatase.
Kiani A, Pierotti CL, Schedel F, Kokot T, Weyershaeuser J, Brehm M, Rios P, Fehrenbach K, Warscheid B, Minguet S, Schamel WW, Köhn M.
Chembiochem. 2025 May 27;26(10):e202400938 - Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity
Braun LM, Giesler S, Andrieux G, Riemer R, Talvard-Balland N, Duquesne S, Rückert T, Unger S, Kreutmair S, Zwick M, Follo M, Hartmann A, Osswald N, Melchinger W, Chapman S, Hutchinson JA, Haferkamp S, Torster L, Kött J, Gebhardt C, Hellwig D, Karantzelis N, Wallrabenstein T, Lowinus T, Yücel M, Brehm N, Rawluk J, Pfeifer D, Bronsert P, Rogg M, Mattern S, Heikenwälder M, Fusco S, Malek NP, Singer S, Schmitt-Graeff A, Ceteci F, Greten FR, Blazar BR, Boerries M, Köhler N, Duyster J, Ihorst G, Lassmann S, Keye P, Minguet S, Schadendorf D, Ugurel S, Rafei-Shamsabadi D, Thimme R, Hasselblatt P, Bengsch B, Schell C, Pearce EL, Meiss F, Becher B, Funke-Lorenz C, Placke JM, Apostolova P, Zeiser R.
Cancer Cell. 2025 Feb 10;43(2):269-291.e19
2024
- The potential of γδ CAR and TRuC T cells: An unearthed treasure.
Schamel WW, Zintchenko M, Nguyen T, Fehse B, Briquez PS, Minguet S.
Eur J Immunol. 2024 Nov;54(11):e2451074. - From TCR fundamental research to innovative chimeric antigen receptor design
Minguet S, Maus MV, Schamel WW.
Nat Rev Immunol. 2024 Oct 21. doi: 10.1038/s41577-024-01093-7. Online ahead of print. - TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation.
Mühlgrabner V, Peters T, Velasco Cárdenas RM, Salzer B, Göhring J, Plach A, Höhrhan M, Perez ID, Goncalves VDR, Farfán JS, Lehner M, Stockinger H, Schamel WW, Schober K, Busch DH, Hudecek M, Dushek O, Minguet S, Platzer R, Huppa JB.
Sci Adv. 2024 Sep 6;10(36):eadj4632. - Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms
Sumaria N*, Fiala GJ*, Inácio D, Curado-Avelar M, Cachucho A, Pinheiro R, Wiesheu R, Kimura S, Courtois L, Blankenhaus B, Darrigues J, Suske T, Almeida ARM, Minguet S, Asnafi V, Lhermitte L, Mullighan CG, Coffelt SB, Moriggl R, Barata JT*, Pennington DJ* & Silva-Santos B*
Nat Immunol. 2024 Jul;25(7):1207-1217. - Pro- and antitumorigenic functions of γδ T cells
Fiala GJ*, Lücke J*, Huber S.
Eur J Immunol. 2024 May 27;0:2451070 - Phospho-mimetic CD3ε variants prevent TCR and CAR signaling
Woessner NM, Brandl SM, Hartmann S, Schamel WW, Hartl FA*, Minguet S*.
Front Immunol 2024 May 08; 15:1392933. - Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
Herr LA, Fiala GJ, Schaffer AM, Hummel JF, Zintchenko M, Raute K, Velasco Cárdenas RMH, Heizmann B, Ebert K, Fehrenbach K, Janowska I, Chan S, Tanriver Y, Minguet S, Schamel WW.
Sci Adv 2024 Mar 15;10(11):eadj2802. - Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia.
Märkl F, Schultheiß C, Ali M, Chen SS, Zintchenko M, Egli L, Mietz J, Chijioke O, Paschold L, Spajic S, Holtermann A, Dörr J, Stock S, Zingg A, Läubli H, Piseddu I, Anz D, Minden MD, Zhang T, Nerreter T, Hudecek M, Minguet S, Chiorazzi N, Kobold S, Binder M.
Nat Commun. 2024 Feb 2;15(1):993. - Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.
Hernández-López P, van Diest E, Brazda P, Heijhuurs S, Meringa A, Hoorens van Heyningen L, Riillo C, Schwenzel C, Zintchenko M, Johanna I, Nicolasen MJT, Cleven A, Kluiver TA, Millen R, Zheng J, Karaiskaki F, Straetemans T, Clevers H, de Bree R, Stunnenberg HG, Peng WC, Roodhart J, Minguet S, Sebestyén Z, Beringer DX, Kuball J.
Nat Immunol. 2024 Jan;25(1):88-101 - Kidins220 regulates the development of B cells bearing the λ light chain.
Schaffer AM, Fiala GJ, Hils M, Natali E, Babrak L, Herr LA, Romero-Mulero MC, Cabezas-Wallscheid N, Rizzi M, Miho E, Schamel WWA, Minguet S.
Elife. 2024 Jan 25;13:e83943. - Reprogramming of human γδ T cells by expression of an anti-CD19 TCR fusion construct (εTRuC) to enhance tumor killing
Juraske C, Krissmer SM, Teuber ES, Parigiani MA, Strietz J, Wesch D, Kabelitz D, Minguet S, Schamel WW
J Leukoc Biol. 2024 Jan 19;115(2):293-305 - A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation.
Lui VG, Hoenig M, Cabrera-Martinez B, Baxter RM, Garcia-Perez JE, Bailey O, Acharya A, Lundquist K, Capera J, Matusewicz P, Hartl FA, D’Abramo M, Alba J, Jacobsen EM, Niewolik D, Lorenz M, Pannicke U, Schulz AS, Debatin KM, Schamel WW, Minguet S, Gumbart JC, Dustin ML, Cambier JC, Schwarz K, Hsieh EWY.
J Exp Med. 2024 Jan 1;221(1):e20230927.
2023
- Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK.
Keller B, Kfir-Erenfeld S, Matusewicz P, Hartl F, Lev A, Lee YN, Simon AJ, Stauber T, Elpeleg O, Somech R, Stepensky P, Minguet S, Schraven B, Warnatz K.
J Clin Immunol. 2023 Dec 19;44(1):4. - Harnessing CD3 diversity to optimize CAR T cells
Velasco Cárdenas RMH, Brandl SM, Meléndez AV*, Schlaak AE*, Buschky A, Peters T, Beier F, Serrels B, Taromi S, Raute K, Hauri S, Gstaiger M, Lassmann S, Huppa JB, Boerries M, Andrieux G, Bengsch B, Schamel WW, Minguet S
Nat Immunol. 2023 Dec;24(12):2135-2149 - Breast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands.
Raute K, Strietz J*, Parigiani MA*, Andrieux G, Thomas OS, Kistner KM, Zintchenko M, Aichele P, Hofmann M, Zhou H, Weber W, Boerries M, Swamy M, Maurer J, Minguet S.
Cancer Immunol Res. 2023 Jun 2;11(6):810-829. - MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production.
Langenbach M, Giesler S, Richtsfeld S, da Costa-Pereira S, Rindlisbacher L, Wertheimer T, Braun LM, Andrieux G, Duquesne S, Pfeifer D, Woessner NM, Menssen HD, Taromi S, Duyster J, Boerries M, Brummer T, Blazar BR, Minguet S, Turko P, Levesque MP, Becher B, Zeiser R.
Mol Cancer Res. 2023 Aug 1;21(8):849-864. - Opto-APC: Engineering of cells that display phytochrome B on their surface for optogenetic studies of cell-cell interactions.
Russ M*, Ehret AK*, Hörner M, Peschkov D, Bohnert R, Idstein V, Minguet S, Weber W, Lillemeier BF, Yousefi OS, Schamel WW.
Front Mol Biosci. 2023 Feb 20;10:1143274.
2022
- Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling.
Rückert T, Andrieux G, Boerries M, Hanke-Müller K, Woessner NM, Doetsch S, Schell C, Aumann K, Kolter J, Schmitt-Graeff A, Schiff M, Braun LM, Haring E, Kissel S, Siranosian BA, Bhatt AS, Nordkild P, Wehkamp J, Jensen BAH, Minguet S, Duyster J, Zeiser R, Köhler N.
Sci Transl Med. 2022 Dec 21;14(676):eabp9675. - Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells.
Meléndez AV, Velasco Cárdenas RM, Lagies S, Strietz J, Siukstaite L, Thomas OS, Tomisch J, Weber W, Kammerer B, Römer W, Minguet S.
Cell Mol Life Sci. 2022 Sep 12;79(10):513 - A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling.
Schultz A, Schnurra M, El-Bizri A, Woessner NM, Hartmann S, Hartig R, Minguet S, Schraven B, Simeoni L.
Cells. 2022 Sep 1;11(17):2723. - Phenotypic and functional analysis of γδ T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection.
Ruggieri M, Ducasa N, Juraske C, Polo VG, Berini C, Quiroga MF, Christopoulos P, Minguet S, Biglione M, Schamel WW.
Front Immunol. 2022 Aug 11;13:920888. - Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.
Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K, Woessner NM, Lalioti ME, Velasco-Hernandez T, Sikora K, Wäsch R, Lehnertz B, Sauvageau G, Manke T, Menendez P, Walter SG, Minguet S, Laurenti E, Günther S, Grün D, Cabezas-Wallscheid N.
Nat Cell Biol. 2022 Jul;24(7):1038-1048. - Inborn errors of immunity and immunodeficiencies: Antibody-mediated pathology and autoimmunity as a consequence of impaired immune reactions.
Minguet S, Nyström A, Kiritsi D, Rizzi M.
Eur J Immunol. 2022 Apr 20.Online ahead of print.
2021
- Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport
Spieth L, Berghoff SA, Stumpf SK, Winchenbach J, Michaelis T, Watanabe T, Gerndt N, Düking T, Hofer S, Ruhwedel T, Shaib AH, Willig K, Kronenberg K, Karst U, Frahm J, Rhee JS, Minguet S, Möbius W, Kruse N, von der Brelie C, Michels P, Stadelmann C, Hülper P, Saher G
Neurooncol Adv. 2021 Sep 20;3(1) - Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation
Emmerich F, Zschiedrich S, Reichenbach-Braun C, Süsal C, Minguet S, Pauly MC, Seidl M
Molecules. 2021 Apr 30;26(9):2648 - Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling
Hartl FA, Ngoenkam J, Beck-Garcia E, Cerqueira L, Wipa P, Paensuwan P, Suriyaphol P, Mishra P, Schraven B, Günther S, Pongcharoen S, Schamel WWA, Minguet S
Cells 2021 Apr 07;10(4):834. - NLRC5 promotes transcription of BTN3A1-3 genes and Vγ9Vδ2 T cell-mediated killing
Dang AT, Strietz J, Zenobi A, Khameneh HJ, Brandl SM, Lozza L, Conradt G, Kaufmann SHE, Reith W, Kwee I, Minguet S, Chelbi ST, Guarda G
iScience 2021 Jan 22;24(1):101900
2020
- Caveolin-1, tetraspanin CD81 and flotillins in lymphocyte cell membrane organization, signaling and immunopathology
Schaffer A, Minguet S
Biochem Soc Trans. 2020 Nov 26;48(6):2387–2397. - Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions
Kästle M, Merten C, Hartig R, Kaehne T, Liaunardy-Jopeace A, Woessner NM, Schamel WW, James J, Minguet S, Simeoni L, Schraven B
Cell Com and Sig. 2020 Nov 23;18(183). - Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
Hartl FA, Beck-Garcìa E, Woessner NM, Flachsmann LJ, Velasco Cárdenas RMH, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WW, Minguet S
Nat Immunol. 2020 Jul 20;21:902–913. - Actin polymerization regulates recruitment of Nck to CD3ε upon T-cell receptor triggering.
Wipa P, Paensuwan P, Ngoenkam J, Woessner NM, Minguet S, Schamel WW, Pongcharoen S.
Immunology. 2020 Mar;159(3):298-308.
2019
- The TCR is an allosterically regulated macromolecular machinery changing its conformation while working.
Schamel WW, Alarcon B, Minguet S.
Immunol Rev. 2019 Sep;291(1):8-25. - Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult γδ T Cell Development.
Fiala GJ, Schaffer AM, Merches K, Morath A, Swann J, Herr LA, Hils M, Esser C, Minguet S, Schamel WWA.
J Immunol. 2019 Jul 15;203(2):569-579. - Phytochrome-based extracellular matrix with reversibly tunable mechanical properties.
Hörner M, Raute K, Hummel B, Madl J, Creusen G, Thomas OS, Christen EH, Hotz N, Gübeli RJ, Engesser R, Rebmann B, Lauer J, Rolauffs B, Timmer J, Schamel WWA, Pruszak J, Römer W, Zurbriggen MD, Friedrich C, Walther A, Minguet S, Sawarkar R, Weber W.
Adv Mater. 2019 Mar;31(12):e1806727.
2018
- Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells.
Baaske J, Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W, Zurbriggen MD.
Sci Rep. 2018 Oct 9;8(1):15024. - Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor.
Juraske C, Wipa P, Morath A, Hidalgo JV, Hartl FA, Raute K, Oberg HH, Wesch D, Fisch P, Minguet S, Pongcharoen S, Schamel WW.
Front Immunol. 2018 Jul 9;9:1579. - Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.
Prestipino A, Emhardt AJ, Aumann K, O’Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R.
Sci Transl Med. 2018 Feb 21;10(429). - Caveolin-1: The unnoticed player in TCR and BCR signaling.
Fiala GJ, Minguet S.
Adv Immunol. 2018;137:83-133.
2017
- Regulatory T cells characterized by low Id3 expression are highly suppressive and accumulate during chronic infection.
Rauch KS, Hils M, Menner AJ, Sigvardsson M, Minguet S, Aichele P, Schachtrup C, Schachtrup K.
Oncotarget. 2017 Oct 27;8(61):102835-102851. - Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.
Minguet S, Kläsener K, Schaffer AM, Fiala GJ, Osteso-Ibánez T, Raute K, Navarro-Lérida I, Hartl FA, Seidl M, Reth M, Del Pozo MA.
Nat Immunol. 2017 Oct;18(10):1150-1159. - The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.
Dolezal E, Infantino S, Drepper F, Börsig T, Singh A, Wossning T, Fiala GJ, Minguet S, Warscheid B, Tarlinton DM, Jumaa H, Medgyesi D, Reth M.
Nat Immunol. 2017 Aug;18(8):911-920. - Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression.
Andrlová H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Rao Mittapalli V, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R.
Oncotarget. 2017 Jun 27;8(26):42901-42916 - The Allostery Model of TCR Regulation.
Schamel WW, Alarcon B, Höfer T, Minguet S.
J Immunol. 2017 Jan 1;198(1):47-52. Review.
2016
- Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3.
Rauch KS, Hils M, Lupar E, Minguet S, Sigvardsson M, Rottenberg ME, Izcue A, Schachtrup C, Schachtrup K.
Cell Rep. 2016 Dec 13;17(11):2827-2836. - Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells.
Schönle A, Hartl FA, Mentzel J, Nöltner T, Rauch KS, Prestipino A, Wohlfeil SA, Apostolova P, Hechinger AK, Melchinger W, Fehrenbach K, Guadamillas MC, Follo M, Prinz G, Ruess AK, Pfeifer D, Angel Del Pozo M, Schmitt-Graeff A, Duyster J, Hippen KI, Blazar BR, Schachtrup K, Minguet S, Zeiser R.
Blood. 2016 Apr 14;127(15):1930-9 - A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation.
Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnár E, Schulze AK, Blanco R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S, Schamel WW.
Immunity. 2016 May 17;44(5):1091-101. - Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning.
Paensuwan P, Hartl FA, Yousefi OS, Ngoenkam J, Wipa P, Beck-Garcia E, Dopfer EP, Khamsri B, Sanguansermsri D, Minguet S, Schamel WW, Pongcharoen S.
J Immunol. 2016 Jan 1;196(1):448-58.
2015
- Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis.
Strippoli R, Loureiro J, Moreno V, Benedicto I, Lozano ML, Barreiro O, Pellinen T, Minguet S, Foronda M, Osteso MT, Calvo E, Vázquez J, Cabrera ML, Del Pozo MA.
EMBO Mol Med. 2015 Mar 4;7(3):357 - Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW.
J Exp Med. 2015 Sep 21;212(10):1693-708.
2014
- Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis.
Strippoli R, Loureiro J, Moreno V, Benedicto I, Pérez Lozano ML, Barreiro O, Pellinen T, Minguet S, Foronda M, Osteso MT, Calvo E, Vázquez J, López Cabrera M, del Pozo MA.
EMBO Mol Med. 2014 Dec 30;7(1):102-23 - Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.
Ngoenkam J, Paensuwan P, Preechanukul K, Khamsri B, Yiemwattana I, Beck-García E, Minguet S, Schamel WW, Pongcharoen S.
Cell Commun Signal. 2014 Mar 26;12:21
- The CD3 Conformational Change in the ?? T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing.
Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WW.
Cell Rep. 2014 Jun 12;7(5):1704-15. - Activation of the TCR complex by peptide-MHC and superantigens.
Louis-Dit-Sully C, Blumenthal B, Duchniewicz M, Beck-Garcia K, Fiala GJ, Beck-García E, Mukenhirn M, Minguet S, Schamel WW.
EXS. 2014;104:9-23.
2011
- A new vampire saga: the molecular mechanism of T cell trogocytosis.
Dopfer EP, Minguet S, Schamel WW.
Immunity. 2011 Aug 26;35(2):151-3. - Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis.
Goetz JG, Minguet S, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibáñez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, Sánchez-Mateos P, Cukierman E, Del Pozo MA.
Cell. 2011 Jul 8;146(1):148-63.
2010
- Low-valency, but not monovalent, antigens trigger the B-cell antigen receptor (BCR).
Minguet S, Dopfer EP, Schamel WW.
Int Immunol. 2010 Mar;22(3):205-12.
2008
- Enhanced B-cell activation mediated by TLR4 and BCR crosstalk.
Minguet S, Dopfer EP, Pollmer C, Freudenberg MA, Galanos C, Reth M, Huber M, Schamel WW.
Eur J Immunol. 2008 Sep;38(9):2475-87 - The extracellular part of zeta is buried in the T cell antigen receptor complex.
Minguet S, Swamy M, Dopfer EP, Dengler E, Alarcón B, Schamel WW.
Immunol Lett. 2008 Mar 15;116(2):203-10 - The short length of the extracellular domain of zeta is crucial for T cell antigen receptor function.
Minguet S, Swamy M, Schamel WW.
Immunol Lett. 2008 Mar 15;116(2):195-202.
- A permissive geometry model for TCR-CD3 activation.
Minguet S, Schamel WW.
Trends Biochem Sci. 2008 Feb;33(2):51-7.
2007
- Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.
Siegers GM, Swamy M, Fernández-Malavé E, Minguet S, Rathmann S, Guardo AC, Pérez-Flores V, Regueiro JR, Alarcón B, Fisch P, Schamel WW.
J Exp Med. 2007 Oct 29;204(11):2537-44. - A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multiprotein complexes.
Swamy M, Minguet S, Siegers GM, Alarcón B, Schamel WW.
J Immunol Methods. 2007 Jul 31;324(1-2):74-83. - Association of protein kinase C-delta with the B cell antigen receptor complex.
Pracht C, Minguet S, Leitges M, Reth M, Huber M.
Cell Signal. 2007 Apr;19(4):715-22.
- Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation.
Lessmann E, Ngo M, Leitges M, Minguet S, Ridgway ND, Huber M.
Cell Signal. 2007 Feb;19(2):384-92. - Full activation of the T cell receptor requires both clustering and conformational changes at CD3.
Minguet S, Swamy M, Alarcón B, Luescher IF, Schamel WW.
Immunity. 2007 Jan;26(1):43-54.
2006
- Blue native polyacrylamide gel electrophoresis (BN-PAGE) for the identification and analysis of multiprotein complexes.
Swamy M, Siegers GM, Minguet S, Wollscheid B, Schamel WW.
Sci STKE. 2006 Jul 25;2006(345):pl4.
- A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex.
Schamel WW, Risueño RM, Minguet S, Ortíz AR, Alarcón B.
Trends Immunol. 2006 Apr;27(4):176-82
2005
- Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors.
Minguet S, Huber M, Rosenkranz L, Schamel WW, Reth M, Brummer T.
Eur J Immunol. 2005 Jan;35(1):31-41.
2003
- A population of c-Kit(low)(CD45/TER119)- hepatic cell progenitors of 11-day postcoitus mouse embryo liver reconstitutes cell-depleted liver organoids.
Minguet S, Cortegano I, Gonzalo P, Martínez-Marin JA, de Andrés B, Salas C, Melero D, Gaspar ML, Marcos MA.
J Clin Invest. 2003 Oct;112(8):1152-63
2002
- The first 3 days of B-cell development in the mouse embryo.
de Andrés B, Gonzalo P, Minguet S, Martínez-Marin JA, Soro PG, Marcos MA, Gaspar ML.+
Blood. 2002 Dec 1;100(12):4074-81. - Role of zeta PKC in B-cell signaling and function.
Martin P, Duran A, Minguet S, Gaspar ML, Diaz-Meco MT, Rennert P, Leitges M, Moscat J.
EMBO J. 2002 Aug 1;21(15):4049-57.
2001
- Both B and gammadelta TCR(+) lymphocytes regulate alphabeta TCR(+) lymphocytes involved in superantigen specific responses.
Izcue A, Morales G, Minguet S, Sánchez-Movilla A, Morales P, Martínez-M JA, Gaspar ML, Marcos MA.
Eur J Immunol. 2001 Sep;31(9):2811-7. - Long-lived polyclonal B-cell lines derived from midgestation mouse embryo lymphohematopoietic progenitors reconstitute adult immunodeficient mice.
Martínez-M JA, Minguet S, Gonzalo P, Soro PG, de Andrés B, Izcue A, Marcos MA, Gaspar ML.
Blood. 2001 Sep 15;98(6):1862-71.
1998
- Developmental hematopoiesis.
Morales-Alcelay S, Copín SG, Martínez JA, Morales P, Minguet S, Gaspar ML, Marcos MA.
Crit Rev Immunol. 1998;18(6):485-501
