Cluster of Excellence –
University of Freiburg

Prof. Dr. Michael Reth

Prof. Dr. Michael Reth

Institute of Biology III (Molecular Immunology), University of Freiburg
and Max-Planck-Institute of Immunobiology and Epigenetics Freiburg

+49 761 203 97663


10 Selected publications:  

  • Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
    Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman, CL, Melnick A, Mignon LL, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Clifford AL, Müschen M (2015).
    Nature. 521(7552):357-61.
  • CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.
    Hobeika E, Levit-Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, Dobenecker MW, Pelanda R, Reth M. (2015).
    EMBO J. 34(7):925-39.
  • B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.
    Kläsener K, Maity PC, Hobeika E, Yang J, Reth M. (2014).
    Elife 3: e02069.
  • The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling.
    Alsadeq A, Hobeika E, Medgyesi D, Kläsener K, Reth M. (2014).
    J Immunol 193(1):268-276.
  • The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 signaling and of B cell autoimmunity.
    Medgyesi D, Hobeika E, Biesen R, Kollert F, Taddeo A, Voll R, Hiepe F and Reth M. (2014).
    J Exp Med 211(3): 427-440.
  • Matching cellular dimensions with molecular sizes.
    Reth M.
    Nat Immunol. 2013 Aug;14(8):765-7.
  • Pillars of Immunology article.
    Reth M. (2014).
    J Immunol 192(9):415-416.
    Reprint of “Antigen receptor tail clue”. Nature (1989).338:383-384.
  • Oligomeric organization of the B-cell antigen receptor on resting cells.
    Yang J, Reth M (2010).
    Nature 467(7314): 465-469.
  • Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia.
    Jumaa H, Bossaller L, Portugal K, Storch B, Lotz M, Flemming A, Schrappe M, Postila V, Riikonen P, Pelkonen J, Niemeyer CM, Reth M (2003).
    Nature 423, 452-456.
  • Molecular components of the B-cell antigen receptor complex of the IgM class.
    Hombach J, Tsubata T, Leclercq L, Stappert H, Reth M (1990).
    Nature 343: 760-762.
    Reprinted as Pillars of Immunology in J Immunol (2009) 183: 1505-1507