Centre for Biological Signalling Studies

Prof. Dr. Heiko Heerklotz

Prof. Dr. Heiko Heerklotz

BIOSS and Institute of Pharmaceutical Sciences,
University of Freiburg

+49 761 203 6338


10 selected publications:

  • Complex electrostatic effects on the selectivity of membrane-permeabilizing cyclic lipopeptides.
    Steigenberger J, Verleysen Y, Geudens N, Madder A, Martins JC, Heerklotz H (2023).
    Biophys J. 122(6):950-963.
  • Complex Micellization Behavior of the Polysorbates Tween 20 and Tween 80.
    Knoch H, Ulbrich MH, Mittag JJ, Buske J, Garidel P, Heerklotz H (2021).
    Mol Pharm. 18(8):3147-3157.
  • Stairway to Asymmetry: Five Steps to Lipid-Asymmetric Proteoliposomes.
    Markones M, Fippel A, Kaiser M, Drechsler C, Hunte C, Heerklotz H (2020).
    Biophys J. 118(2):294-302.
  • Characterizing vesicle leakage by fluorescence lifetime measurements.
    Patel H, Tscheka C, Heerklotz H (2009).
    Soft Matter 5:2849-2851
  • Monitoring detergent-mediated solubilization and reconstitution of lipid membranes by isothermal titration calorimetry.
    Heerklotz H, Tsamaloukas A, Keller S (2009).
    Nat Protocols 4:686-697
  • Interactions of surfactants with lipid membranes.
    Heerklotz H (2008).
    Quarterly Reviews of Biophysics 41:205-264
  • Uptake and release protocol for assessing membrane binding and permeation by way of isothermal titration calorimetry.
    Tsamaloukas A, Keller S, Heerklotz H (2007).
    Nat Protocols 2:695-704
  • A quantitative model describing the selective solubilization of membrane domains.
    Keller S, Tsamaloukas , Heerklotz H (2005).
    J Am Chem Soc. 127:11469-11476
  • Structural, volumetric and thermodynamic characterization of a micellar sphere-to-rod transition.
    Heerklotz H, Tsamaloukas A, Kita-Tokarczyk K, Strunz P, Gutberlet T (2004).
    J Am Chem Soc. 126:16544
  • Triton promotes domain formation in ´lipid raft´ mixtures.
    Heerklotz H (2002).
    Biophys. J. 83:2693-2701