Centre for Biological Signalling Studies

Prof. Dr. Asifa Akhtar

Prof. Dr. Asifa Akhtar

Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg

+49 761 5108 565


10 selected publications:

  • DHX9 suppresses RNA processing defects originating from Alu invasion of the human genome.
    Aktas T, Ilik IA, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G., Manke T, Backofen R, Akhtar A. (2017).
    Nature 544, 115-119.
  • MOF acetyl transferase regulates transcription and respiration in mitochondria.
    Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A (2016).
    Cell 67, 722-738.e23.
  • Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.
    Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, Dündar F, Dasmeh P, Mittler G, Cadete FT, Ramírez F, Conrad T, Wei W, Raja S, Manke T, Luscombe NM, Steinmetz LM, Akhtar A (2016).
    Nat Struct Mol Biol. 23, 580-9
  • High-affinity sites form an interaction network to facilitate spreading of the MSL complex across the X chromosome in Drosophila.
    Ramírez F, Lingg T, Toscano S, Lam KC, Georgiev P, Chung HR, Lajoie BR, de Wit E, Zhan Y, de Laat W, Dekker J, Manke T, Akhtar A (2015).
    Mol Cell 60, 146-62.
  • Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.
    Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J, Akhtar A (2014).
    Genes Dev. 28, 929-42.
  • MOF-associated complexes ensure stem cell identity and Xist repression.
    Chelmicki T, Dündar F, Turley MJ, Khanam T, Aktas T, Ramírez F, Gendrel AV, Wright PR, Videm P, Backofen R, Heard E, Manke T, Akhtar A (2014).
    Elife. 20;3:e02024.
  • Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.
    Ilik IA, Quinn JJ, Georgiev P, Tavares-Cadete F, Maticzka D, Toscano S, Wan Y, Spitale RC, Luscombe N, Backofen R, Chang HY, Akhtar A (2013).
    Mol. Cell 51, 156-73.
  • Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters.
    Conrad T, Cavalli FM, Vaquerizas JM, Luscombe NM, Akhtar A (2012).
    Science 337, 742-6.
  • Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.
    Kadlec J, Hallacli E, Lipp M, Holz H, Sanchez-Weatherby J, Cusack S, Akhtar A (2011).
    Nat. Struct. Mol. Biol. 18, 142-9.
  • Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila.
    Kind J, Vaquerizas JM, Gebhardt P, Gentzel M, Luscombe NM, Bertone P, Akhtar A (2008).
    Cell 133, 813-28.