Centre for Biological Signalling Studies

Prof. Dr. Annegret Wilde

Prof. Dr. Annegret Wilde

Institute of Biology III - Molecular Genetics of Prokaryotes

+49 761 203 97828


Cyanobacteria are photosynthetic bacteria that populate extremely diverse environments like soil crusts, open oceans, deserts, hot springs, permafrost and glacial regions, or have adopted a symbiotic lifestyle. They have produced the oxygenic atmosphere on Earth and are the ancestors of chloroplasts. We are investigating regulatory systems and adaptation strategies of cyanobacteria on a molecular level. We intend to focus our work on a model cyanobacterium with a well-annotated genome and simple genetic manipulation systems in order to characterize specific cyanobacterial functions that also might be relevant for future biotechnological applications. Main current projects include investigations on phototaxis using different photoreceptors, circadian clock and the role of regulatory RNA in cyanobacteria. In addition, we are working on several applied projects elucidating the potential of cyanobacteria as producers of amino acids, proteins as well as biofuels.


10 selected publications:

  • The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP.
    Wallner T, Pedroza L, Voigt K, Kaever V, Wilde A. (2020)
    Photochem. Photobiol. Sci. 19, 631-643.
  • Phototaxis in a wild isolate of the cyanobacterium Synechococcus elongatus.
    Yang Y, Lam V, Adomako M, Simkovsky R, Jakob A, Rockwell NC, Cohen SE, Taton A, Wang J, Lagarias JC, Wilde A, Nobles DR, Brand JJ, Golden SS. (2018)
    Proc. Natl. Acad. Sci U.S.A. 115(52):E12378-E12387.
  • The role of the Synechocystis sp. PCC 6803 homolog of the circadian clock output regulator RpaA in day-night transitions.
    Köbler C, Schultz SJ, Kopp D, Voigt K, Wilde A. (2018)
    Mol. Microbiol. 110, 847-861.
  • The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR-Cas subtype III-Bv system.
    Behler J, Sharma K, Reimann V, Wilde A, Urlaub H, Hess WR. (2018)
    Nat. Microbiol. 3, 367-377
  • The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2.
    Angerer V, Schwenk P, Wallner T, Kaever V, Hiltbrunner A, Wilde A. (2017)
    Microbiology 163, 920-930.
  • Cyanobacteria use micro-optics to sense light direction.
    Schuergers N, Lenn T, Kampmann R, Meissner MV, Esteves T, Temerinac-Ott M, Korvink JG, Lowe AR, Mullineaux CW, Wilde A. (2016)
    eLife 5, e12620.
  • The small regulatory RNA SyR1/PsrR1 controls photosynthetic functions in cyanobacteria.
    Georg J, Dienst D, Schuergers N, Wallner T, Kopp D, Stazic D, Kuchmina K, Klähn S, Lokstein H, Hess WR, Wilde A. (2014)
    Plant Cell 26, 3661-79.
  • Binding of the RNA chaperone Hfq to the type IV pilus base is crucial for its function in Synechocystis sp. PCC 6803.
    Schuergers N, Ruppert U, Watanabe S, Nürnberg DJ, Lochnit G, Dienst D, Mullineaux CW, Wilde A. (2014)
    Mol. Microbiol. 92, 840-852.
  • Light-induced alteration of c-di-GMP level controls motility of Synechocystis sp. PCC 6803.
    Savakis P, De Causmaecker S, Angerer V, Ruppert U, Anders K, Essen LO, Wilde A. (2012)
    Mol. Microbiol. 85, 239-251.
  • A naturally occurring antisense RNA affecting expression of isiA and assembly of IsiA supercomplexes.
    Dühring U, Axmann IM, Hess WR, Wilde A. (2006)
    Proc. Nat. Acad. Sci. U.S.A 103, 7054-7058.