Cluster of Excellence –
University of Freiburg


  • Lipid self-assembly and lectin-induced reorganization of the plasma membrane.
    Sych T, Mély Y, Römer W (2018).
    Philos Trans R Soc Lond B Biol Sci. 373(1747).
  • A microfluidic biochip for locally confined stimulation of cells within an epithelial monolayer.
    Thuenauer R, Nicklaus S, Frensch M, Troendle K, Madl J, Römer W (2018).
    RSC Adv. 8(14):7839-7846.
  • Molecular AFM imaging of Hsp70-1A association with dipalmitoyl phosphatidylserine reveals membrane blebbing in the presence of cholesterol.
    Lamprecht C, Gehrmann M, Madl J, Römer W, Multhoff G, Ebner A.
    Cell Stress Chaperones. 2018 Feb 5. [Epub ahead of print]
  • Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion.
    Villringer S, Madl J, Sych T, Manner C, Imberty A, Römer W (2018).
    Sci Rep. 8(1):1932
  • Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis.
    Singh PK, Roukounakis A, Frank DO, Kirschnek S, Das KK, Neumann S, Madl J, Römer W, Zorzin C, Borner C, Haimovici A, Garcia-Saez A, Weber A, Häcker G (2017).
    Genes Dev. 31(17):1754-1769.
  • Dynamic cooperative glycan assembly blocks the binding of bacterial lectins to epithelial cells.
    Machida T, Novoa A, Gillon É, Zheng S, Claudinon J, Eierhoff T, Imberty A, Römer W, Winssinger N (2017).
    Angew Chem Int Ed Engl. 6;56(24):6762-6766.
  • Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression.
    Andrlová H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Mittapalli VR, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R (2017).
    Oncotarget. ;8(26):42901-42916
  • The Pseudomonas aeruginosa lectin LecA triggers host cell signalling by glycosphingolipid-dependent phosphorylation of the adaptor protein CrkII.
    Zheng S, Eierhoff T, Aigal S, Brandel A, Thuenauer R, de Bentzmann S, Imberty A, Römer W (2017).
    Biochim Biophys Acta. 1864(7):1236-1245.
  • Gb3-binding lectins as potential carriers for transcellular drug delivery.
    Müller SK, Wilhelm I, Schubert T, Zittlau K, Imberty A, Madl J, Eierhoff T, Thuenauer R, Römer W (2017).
    Expert Opin Drug Deliv. 14(2):141-153.
  • Pathways of protein and lipid receptor-mediated transcytosis in drug delivery.
    Thuenauer R, Müller S, Römer W (2017).
    Expert Opin Drug Deliv. 14(3):341-351
  • Synthesis of cholesterol-substituted glycopeptides for tailor-made glycocalyxification of artificial membrane systems.
    Stuhr-Hansen N, Madl J, Villringer S, Aili U, Römer W, Blixt O. (2016)
    Chembiochem. 17(15):1403-6.
  • Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation.
    Cott C, Thuenauer R, Landi A, Kühn K, Juillot S, Imberty A, Madl J, Eierhoff T, Römer W. (2016)
    Biochim Biophys Acta. 1863(6 Pt A):1106-18
  • Injury-driven stiffening of the dermis expedites skin carcinoma progression.
    Mittapalli VR, Madl J, Löffek S, Kiritsi D, Kern JS, Römer W, Nyström A, Bruckner-Tuderman L (2016).
    Cancer Res. 76(4):940-51
  • Signalling to the nucleus under the control of light and small molecules.
    Juillot S, Beyer HM, Madl J, Weber W, Zurbriggen MD, Römer W. (2016).
    Mol Biosyst. 12(2):345-9.
  • Differential induction of innate defense antimicrobial peptides in primary nasal epithelial cells upon stimulation with inflammatory cytokines, Th17 cytokines or bacterial conditioned medium from Staphylococcus aureus isolates.
    Burgey C, Kern WV, Römer W, Rieg S. (2016).
    Microb Pathog. 90:69-77.
  • Uptake of Marasmius oreades agglutinin disrupts integrin-dependent cell adhesion.
    Juillot S, Cott C, Madl J, Claudinon J, van der Velden NS, Künzler M, Thuenauer R, Römer W.
    Biochim Biophys Acta. 2016 Feb;1860(2):392-401.
  • Considering autophagy, beta-Catenin and E-Cadherin as innovative therapy aspects in AML.
    Kühn K, Römer W. (2015).
    Cell Death Dis. 6:e1950
  • The interplay of autophagy and ?-Catenin signaling regulates differentiation in acute myeloid leukemia.
    Kühn K, Cott C, Bohler S, Aigal S, Zheng S, Villringer S, Imberty A, Claudinon J, Römer W. (2015).
    Cell Death Discov. 1: 15031
  • How synthetic membrane systems contribute to the understanding of lipid-driven endocytosis.
    Schubert T, Römer W. (2015).
    Biochim Biophys Acta. 1853(11 Pt B):2992-3005.
  • 2-Hydroxy Fatty Acid Enantiomers of Gb3 Impact Shiga Toxin Binding and Membrane Organization.
    Schütte OM, Patalag LJ, Weber LM, Ries A, Römer W, Werz DB, Steinem C. (2015).
    Biophys J. 108(12):2775-8.
  • A first step toward liposome-mediated intracellular bacteriophage therapy.
    Nieth A, Verseux, C, Barnert S, S&uumlss R, Römer W. (2015).
    Expert Opin. Drug Deliv. 2015;12(9):1411-24
  • Red light-regulated reversible nuclear localization of proteins in mammalian cells and zebrafish
    Beyer HM, Juillot S, Herbst K, Samodelov SL, M&uumlller K, Schamel WW, Römer W, Sch&aumlfer E, Nagy F, Straehle U, Weber W, Zurbriggen MD. (2015).
    ACS Synth Biol 2015 Sep 18;4(9):951-8.
  • Lectins from opportunistic bacteria interact with acquired variable region glycans of surface immunoglobulin in follicular lymphoma.
    Schneider D, D&uumlhren- von Minden M, Alkhatib A, Setz C, van Bergen CA, Benkisser-Peterson M, Wilhelm I, Villringer S, Krysov S, Packham G, Zirlik K, Römer W, Buske C, Stevenson FK, Veelken H, Jumaa H. (2015).
    Blood. 125(21): 3287-96
  • A question of attire - Dressing up bacteriophage therapy for the battle against antibiotic-resistant intracellular bacteria.
    Nieth A, Verseux C, Römer W. (2015).
    Springer Science Reviews. 3(1): 1-11
  • The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines.
    Burgey C, Kern WV, Römer W, Sakinc T, Rieg S. (2015).
    Microbes and Infection. 17(5): 353-9
  • Aquaporin 5 expression in mouse mammary gland cells is not driven by promoter methylation.
    Arbeithuber B, Thuenauer R, Gravogl Y, Balogi Z, Römer W, Sonnleitner A, Tiemann-Boege I. 2015.
    Biomed Res Int. 2015: 460598
  • Plasma membrane reorganization: A glycolipid gateway for microbes.
    Aigal S, Claudinon J, Römer W. (2015).
    Biochimica et Biophysica Acta - Molecular Cell Research. 1853(4): 858-71
  • Influence of Gb3 glycosphingolipids differing in their fatty acid chain on the phase behaviour of solid supported membranes: chemical syntheses and impact of Shiga toxin binding.
    Schütte OM, Ries A, Orth A, Patalag LJ, Römer W, Steinem C, Werz DB (2014).
    Chem. Sci. 5, 3104-3114 
  • A lipid zipper triggers bacterial invasion.
    Eierhoff T, Bastian B, Thuenauer R, Madl J, Audfray A, Aigal S, Juillot S, Rydell GE, Müller S, de Bentzmann S, Imberty A, Fleck C, Römer W (2014).
    Proc Natl Acad Sci U S A. 111(35):12895-900
  • A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa.
    Novoa A, Eierhoff T, Topin J, Varrot A, Barluenga S, Imberty A, Römer W, Winssinger N (2014).
    Angew Chem Int Ed Engl. 53(34):8885-9
  • Membrane deformation by neolectins with engineered glycolipid binding sites.
    Arnaud J, Tröndle K, Claudinon J, Audfray A, Varrot A, Römer W, Imberty A (2014).
    Angew Chem Int Ed Engl. 53(35):9267-70.
  • Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tü6071 by liquid chromatography/mass spectrometry coupling.
    Kiske C, Erxleben A, Lucas X, Willmann L, Klementz D, Günther S, Römer W, Kammerer B  (2014).
    Rapid Commun Mass Spectrom. 28(13):1459-67
  • Rab12 localizes to Shiga toxin-induced plasma membrane invaginations and controls toxin transport.
    Rydell GE, Renard HF, Garcia-Castillo MD, Dingli F, Loew D, Lamaze C, Römer W, Johannes L (2014).
    Traffic. 15(7):772-87.
  • Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis.
    Sic H, Kraus H, Madl J, Flittner KA, von Münchow AL, Pieper K, Rizzi M, Kienzler AK, Ayata K, Rauer S, Kleuser B, Salzer U, Burger M, Zirlik K, Lougaris V, Plebani A, Römer W, Loeffler C, Scaramuzza S, Villa A, Noguchi E, Grimbacher B, Eibel H (2014).
    J Allergy Clin Immunol. 134(2):420-8
  • Induced phagocytic particle uptake into a giant unilamellar vesicle.
    Meinel A, Tränkle B, Römer W, Rohrbach A (2014).
    Soft Matter. 10(20):3667-78
  • Microfluidic approaches for epithelial cell layer culture and characterisation.
    Thuenauer R, Rodriguez-Boulan E, Römer W (2014).
    Analyst 139(13):3206-18.
  • Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates.
    Thuenauer R, Hsu YC, Carvajal-Gonzalez JM, Deborde S, Chuang JZ, Römer W, Sonnleitner A, Rodriguez-Boulan E, Sung CH (2014).
    Proc Natl Acad Sci U S A. 111(11):4127-32
  • Reduction of lectin valency drastically changes glycolipid dynamics in membranes but not surface avidity.
    Arnaud J, Claudinon J, Tröndle K, Trovaslet M, Larson G, Thomas A, Varrot A, Römer W, Imberty A, Audfray A (2013).
    ACS Chem Biol. 8(9):1918-24
  • Human GII.4 norovirus VLP induces membrane invaginations on giant unilamellar vesicles containing secretor gene dependent ?1,2-fucosylated glycosphingolipids.
    Rydell GE, Svensson L, Larson G, Johannes L, Römer W (2013).
    Biochim Biophys Acta. 1828(8):1840-1845.  
  • Photoreductive uncaging of fluorophore in response to protein oligomers by templated reaction in vitro and in cellulo.
    Sadhu KK, Eierhoff T, Römer W, Winssinger N (2012).
    J Am Chem Soc. 134(49): 20013-6.
  • The fucose-binding lectin from opportunistic pathogen Burkholderia ambifaria binds to both plant and human oligosaccharidic epitopes.
    Audfray A, Claudinon J, Abounit S, Ruvoën-Clouet N, Larson G, Smith DF, Wimmerová M, Le Pendu J, Römer W, Varrot A, Imberty A (2012).
    JBC 287(6) : 4335-47
  • Creating and modulating microdomains in pore-spanning membranes.
    Orth A, Johannes L, Römer W, Steinem C (2012).
    ChemPhysChem. 13: 108-14
  • Lipid cosorting mediated by Shiga toxin tubulation.
    Safouane M, Berland L, Callan-Jones A, Sorre B, Römer W, Johannes L, Toombes G, Bassereau P (2010).
    Traffic. 11: 1519-29
  • AGAP2 regulates retrograde transport between early endosomes and the TGN.
    Shiba Y, Römer W, Mardones G, Burgos PV, Lamaze C, Johannes L (2010).
    J Cell Sci. 123(14): 2381-90.
  • Actin dynamics drive membrane reorganization and scission in clathrin-independent endocytosis.
    Römer W*, Pontani L, Sorre B, Rentero C, Berland L, Chambon V, Lamaze C, Bassereau P, Sykes C, Gaus K, Johannes L* (2010).
    Cell 140(4): 540-53. * corresponding author
  • Shiga toxins - from cell biology to biomedical applications.
    Johannes L, Römer W (2010).
    Nat Rev Microbiol. 8(2): 105-16.
  • GM1 structure determines SV40-induced membrane invagination and infection.
    Ewers H*, Römer W*, Smith AE, Bacia K, Dmitrieff S, Chai W, Mancini R, Kartenbeck J, Chambon V, Berland L, Oppenheim A, Schwarzmann G, Feizi T, Schwille P, Sens P, Helenius A, Johannes  ( 2010).
    Nat Cell Biol. 12(1): 11-8.  *contributed equally
  • Lipid reorganization induced by Shiga toxin clustering on planar membranes.
    Windschiegl B, Orth A, Römer W, Berland L, Stechmann B, Bassereau P, Johannes L, Steinem C (2009).
    PLoS One. 4(7): e6238
  • Shiga toxin induces tubular membrane invaginations for its uptake into cells.
    Römer W, Berland L, Chambon V, Gaus K, Windschiegl B, Tenza D, Aly MR, Fraisier V, Florent J-C, Perrais D, Lamaze C, Raposo G, Steinem C, Sens P, Bassereau P, Johannes L (2007).
    Nature 450: 670-675.
  • Trafficking of Shiga toxin/Shiga-like toxin-1 in human glomerular microvascular endothelial cells and human mesangial cells.
    Warnier M., Römer W, Geelen J, Lesieur J, Amessou M, van den Heuvel L, Monnens L, Johannes L (2006).
    Kidney Intern. 70: 2085-2091.
  • Functionally different pools of Shiga toxin receptor, globotriaosyl ceramide, in HeLa cells.
    Falguières T, Römer W, Amessou M, Afonso C, Wolf C, Tabet JC, Lamaze C, Johannes L. 2006.
    FEBS J. 273(22): 5205-18
  • Subcellular localization of a 15N labelled peptidic vector using NanoSIMS imaging.
    Römer W*, Wu T-D*, Duchambon P, Amessou M, Carrez D, Johannes L, Guerquin-Kern J-L (2006).
    Appl Surf Science 252: 6925-6930.  * contributed equally
  • Lipidmembranen in Biosensoren und Arrays.
    Römer W and Steinem C (2006)
    HighChem hautnah– Aktuelles aus der Analytischen Chemie. 43-44
  • Channel activity of a viral transmembrane peptide in micro-BLMs: Vpu1-32 from HIV-1.
    Römer W, Lam Y-H, Fischer D, Watts A, Fischer WB, Göring P, Wehrspohn RB,Gösele U, Steinem C (2004).
    J Am Chem Soc. 126: 16267-16274.
  • Impedance analysis and single channel recordings on nano-BLMs based on porous alumina.
    Römer W, Steinem C (2004).
    Biophys J. 86 (2): 955-965.