2022

• An improved organotypic cell culture system to study tissue-resident macrophages ex vivo.
  Aktories P, Petry P, Glatz P, Andrieux G, Oschwald A, Botterer H, Gorka O, Erny D, Boerries M, Henneke P, Groß O, Prinz M, Kierdorf K.
  Cell Rep Methods. 2022 Jul 26;2(8):100260
• MARVEL-domain containing CMTM4 affects CXCR4 trafficking.
  Bona A, Seifert M, Thünauer R, Zodel K, Frew IJ, Römer W, Walz G, Yakulov TA.
  Mol Biol Cell. 2022 Aug 31. Online ahead of print.
• Phenotypic and functional analysis of ?? T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection.
  Ruggieri M, Ducasa N, Juraske C, Polo VG, Berini C, Quiroga MF, Christopoulos P, Minguet S, Biglione M, Schamel WW.
  Front Immunol. 2022 Aug 11;13:920888.
• Shedding light on current trends in molecular optogenetics.
  Fischer AAM, Kramer MM, Radziwill G, Weber W.
  Curr Opin Chem Biol. 2022 Aug 18;70:102196.
• Impact of older age in patients receiving atezolizumab and bevacizumab for hepatocellular carcinoma.
  Vithayathil M, D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ, Sharma R.
  Liver Int. 2022 Aug 20. Online ahead of print.
• Anaplastic ganglioglioma - a diagnosis comprising several distinct tumour types.
  Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A.
  Neuropathol Appl Neurobiol. 2022 Aug 17. Online ahead of print.
• Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction.
  Rizzo G, Gropper J, Piollet M, Vafadarnejad E, Rizakou A, Bandi SR, Arampatzi P, Krammer T, DiFabion N, Dietrich O, Arias-Loza AP, Prinz M, Mack M, Schlepckow K, Haass C, Silvestre JS, Zernecke A, Saliba AE, Cochain C.
  Cardiovasc Res. 2022 Aug 11. Online ahead of print.
• BlotIt-Optimal alignment of Western blot and qPCR experiments.
  Kemmer S, Bang S, Rosenblatt M, Timmer J, Kaschek D.
  PLoS One. 2022 Aug 10;17(8):e0264295.
• COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation.
  Reinscheid M, Luxenburger H, Karl V, Graeser A, Giese S, Ciminski K, Reeg DB, Oberhardt V, Roehlen N, Lang-Meli J, Heim K, Gross N, Baum C, Rieg S, Speer C, Emmerich F, Breisinger S, Steinmann D, Bengsch B, Boettler T, Kochs G, Schwemmle M, Thimme R, Neumann-Haefelin C, Hofmann M.
  Nat Commun. 2022 Aug 8;13(1):4631
• Complex electrostatic effects on the selectivity of membrane-permeabilizing cyclic lipopeptides.
  Steigenberger J, Verleysen Y, Geudens N, Madder A, Martins JC, Heerklotz H.
  Biophys J. 2022 Aug 3. Online ahead of print.
• A root phloem pole cell atlas reveals common transcriptional states in protophloem-adjacent cells.
  Otero S, Gildea I, Roszak P, Lu Y, Di Vittori V, Bourdon M, Kalmbach L, Blob B, Heo JO, Peruzzo F, Laux T, Fernie AR, Tavares H, Helariutta Y.
  Nat Plants. 2022 Aug;8(8):954-970.
• 3D Printed Solutions for Spheroid Engineering and Cancer Research.
  Butelmann T, Gu Y, Li A, Tribukait-Riemenschneider F, Hoffmann J, Molazem A, Jaeger E, Pellegrini D, Forget A, Shastri VP.
  Int J Mol Sci. 2022 Jul 25;23(15):8188.
• Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling.
  Gehttps://pubmed.ncbi.nlm.nih.gov/35859176/ssler S, Guthmann C, Schuler V, Lilienkamp M, Walz G, Yakulov TA.
  Int J Mol Sci. 2022 Jul 17;23(14):7870.
• Seed-induced A? deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer's disease.
  Ziegler-Waldkirch S, Friesen M, Loreth D, Sauer JF, Kemna S, Hilse A, Erny D, Helm C, D Errico P, Prinz M, Bartos M, Meyer-Luehmann M.
  Mol Psychiatry. 2022 Jul 22. Online ahead of print.
• Clock genes rescue nphp mutations in zebrafish.
  Kayser N, Zaiser F, Veenstra AC, Wang H, Göcmen B, Eckert P, Franz H, Köttgen A, Walz G, Yakulov TA.
  Hum Mol Genet. 2022 Jul 21. Online ahead of print.
• ADAR1 averts fatal type I interferon induction by ZBP1.
  Jiao H, Wachsmuth L, Wolf S, Lohmann J, Nagata M, Kaya GG, Oikonomou N, Kondylis V, Rogg M, Diebold M, Tröder SE, Zevnik B, Prinz M, Schell C, Young GR, Kassiotis G, Pasparakis M.
  Nature. 2022 Jul;607(7920):776-783.
• Comparative transcriptomics identifies candidate genes involved in the evolutionary transition from dehiscent to indehiscent fruits in Lepidium (Brassicaceae).
  Gramzow L, Klupsch K, Fernández-Pozo N, Hölzer M, Marz M, Rensing SA, Theißen G.
  BMC Plant Biol. 2022 Jul 14;22(1):340
• Designing electrochemical microfluidic multiplexed biosensors for on-site applications.
  Glatz RT, Ates HC, Mohsenin H, Weber W, Dincer C. >
  Anal Bioanal Chem. 2022 Sep;414(22):6531-6540.
• Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia.
  Grüninger PK, Uhl F, Herzog H, Gentile G, Andrade-Martinez M, Schmidt T, Han K, Morgens DW, Bassik MC, Cleary ML, Gorka O, Zeiser R, Groß O, Duque-Afonso J.
  Cancer Gene Ther. 2022 Jul 6. Online ahead of print.
• Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
  Baranasic D, Hörtenhuber M, Balwierz PJ, Zehnder T, Mukarram AK, Nepal C, Várnai C, Hadzhiev Y, Jimenez-Gonzalez A, Li N, Wragg J, D'Orazio FM, Relic D, Pachkov M, Díaz N, Hernández-Rodríguez B, Chen Z, Stoiber M, Dong M, Stevens I, Ross SE, Eagle A, Martin R, Obasaju O, Rastegar S, McGarvey AC, Kopp W, Chambers E, Wang D, Kim HR, Acemel RD, Naranjo S, Lapinski M, Chong V, Mathavan S, Peers B, Sauka-Spengler T, Vingron M, Carninci P, Ohler U, Lacadie SA, Burgess SM, Winata C, van Eeden F, Vaquerizas JM, Gómez-Skarmeta JL, Onichtchouk D, Brown BJ, Bogdanovic O, van Nimwegen E, Westerfield M, Wardle FC, Daub CO, Lenhard B, Müller F.
  Nat Genet. 2022 Jul;54(7):1037-1050.
• Therapy response of glucocorticoid-refractory acute GVHD of the lower intestinal tract.
  Biavasco F, Ihorst G, Wäsch R, Wehr C, Bertz H, Finke J, Zeiser R.
  Bone Marrow Transplant. 2022 Jun 29. Online ahead of print.
• B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates.
  Hossain MA, Anasti K, Watts B, Cronin K, Derking R, Groschel B, Kane AP, Edwards RJ, Easterhoff D, Zhang J, Rountree W, Ortiz Y, Saunders K, Schief WR, Sanders RW, Verkoczy L, Reth M, Alam SM.
  Cell Rep. 2022 Jun 28;39(13):111021.
• High-dimensional profiling reveals Tc17 cell enrichment in active Crohn's disease and identifies a potentially targetable signature.
  Globig AM, Hipp AV, Otto-Mora P, Heeg M, Mayer LS, Ehl S, Schwacha H, Bewtra M, Tomov V, Thimme R, Hasselblatt P, Bengsch B.
  Nat Commun. 2022 Jun 27;13(1):3688.
• Editorial on Translational Research in Graft-Versus-Host Disease (GVHD) and Graft-Versus-Tumor (GVT) Effect After Allogeneic Hematopoietic Cell Transplantation.
  Czech M, Zeiser R, Toubai T.
  Front Immunol. 2022 Jun 8;13:948720.
• Therapeutic significance of ARID1A mutation in bladder cancer.
  Conde M, Frew IJ.
  Neoplasia. 2022 Sep;31:100814.
• The greening ashore.
  Schreiber M, Rensing SA, Gould SB.
  Trends Plant Sci. 2022 Sep;27(9):847-857.
• Exhaustion of CD39-Expressing CD8+ T Cells in Crohn's Disease Is Linked to Clinical Outcome.
  Globig AM, Mayer LS, Heeg M, Andrieux G, Ku M, Otto-Mora P, Hipp AV, Zoldan K, Pattekar A, Rana N, Schell C, Boerries M, Hofmann M, Neumann-Haefelin C, Kuellmer A, Schmidt A, Boettler T, Tomov V, Thimme R, Hasselblatt P, Bengsch B.
  Gastroenterology. 2022 Jun 20:S0016-5085(22)00663-1.
• In-Depth Characterization of a Re-Engineered Cholera Toxin Manufacturing Process Using Growth-Decoupled Production in Escherichia coli.
  Danielewicz N, Dai W, Rosato F, Webb ME, Striedner G, Römer W, Turnbull WB, Mairhofer J.
  Toxins (Basel). 2022 Jun 8;14(6):396.
• Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.
  Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K, Woessner NM, Lalioti ME, Velasco-Hernandez T, Sikora K, Wäsch R, Lehnertz B, Sauvageau G, Manke T, Menendez P, Walter SG, Minguet S, Laurenti E, Günther S, Grün D, Cabezas-Wallscheid N.
  Nat Cell Biol. 2022 Jul;24(7):1038-1048.
• Experimental Characterization of In Silico Red-Shift-Predicted iLOVL470T/Q489K and iLOVV392K/F410V/A426S Mutants.
  Wehler P, Armbruster D, Günter A, Schleicher E, Di Ventura B, Öztürk MA.
  ACS Omega. 2022 Jun 1;7(23):19555-19560.
• Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders.
  Hook G, Reinheckel T, Ni J, Wu Z, Kindy M, Peters C, Hook V.
  Pharmacol Rev. 2022 Jul;74(3):600-629.
• Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma.
  Ravi VM, Will P, Kueckelhaus J, Sun N, Joseph K, Salié H, Vollmer L, Kuliesiute U, von Ehr J, Benotmane JK, Neidert N, Follo M, Scherer F, Goeldner JM, Behringer SP, Franco P, Khiat M, Zhang J, Hofmann UG, Fung C, Ricklefs FL, Lamszus K, Boerries M, Ku M, Beck J, Sankowski R, Schwabenland M, Prinz M, Schüller U, Killmer S, Bengsch B, Walch AK, Delev D, Schnell O, Heiland DH.
  Cancer Cell. 2022 Jun 13;40(6):639-655.e13.
• Histone Deacetylase 6 Inhibitor JS28 Prevents Pathological Gene Expression in Cardiac Myocytes.
  Ngo V, Fleischmann BK, Jung M, Hein L, Lother A.
  J Am Heart Assoc. 2022 Jun 21;11(12):e025857.
• PLDMS: Phosphopeptide Library Dephosphorylation Followed by Mass Spectrometry Analysis to Determine the Specificity of Phosphatases for Dephosphorylation Site Sequences.
  Kokot T, Hoermann B, Helm D, Chojnacki JE, Savitski MM, Köhn M.
  Methods Mol Biol. 2022;2499:43-64.
• GM-CSF suppresses antioxidant signaling and drives IL-1? secretion through NRF2 downregulation.
  Di Carlo S, Häcker G, Gentle IE.
  EMBO Rep. 2022 Aug 3;23(8):e54226.
• RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells.
  Hölzen L, Mitschke J, Schönichen C, Hess ME, Ehrenfeld S, Boerries M, Miething C, Brummer T, Reinheckel T.
  Theranostics. 2022 May 16;12(9):4348-4373.
• Spatially Defined Gene Delivery into Native Cells with the Red Light-Controlled OptoAAV Technology.
  Hörner M, Weber W.
  Curr Protoc. 2022 Jun;2(6):e440.
• Synthetic microbiology applications powered by light.
  Mazraeh D, Di Ventura B.
  Curr Opin Microbiol. 2022 Aug;68:102158.
• Anti-CRISPR prediction using deep learning reveals an inhibitor of Cas13b nucleases.
  Wandera KG, Alkhnbashi OS, Bassett HVI, Mitrofanov A, Hauns S, Migur A, Backofen R, Beisel CL.
  Mol Cell. 2022 Jul 21;82(14):2714-2726.e4
• Disentangling ERBB Signaling in Breast Cancer Subtypes-A Model-Based Analysis.
  Kemmer S, Berdiel-Acer M, Reinz E, Sonntag J, Tarade N, Bernhardt S, Fehling-Kaschek M, Hasmann M, Korf U, Wiemann S, Timmer J. Cancers (Basel). 2022 May 12;14(10):2379.
• A set point in the selection of the ??TCR T cell repertoire imposed by pre-TCR signaling strength.
  Bovolenta ER, García-Cuesta EM, Horndler L, Ponomarenko J, Schamel WW, Mellado M, Castro M, Abia D, van Santen HM.
  Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2201907119.
• Distinct CD8 T Cell Populations with Differential Exhaustion Profiles Associate with Secondary Complications in Common Variable Immunodeficiency.
  Klocperk A, Friedmann D, Schlaak AE, Unger S, Parackova Z, Goldacker S, Sediva A, Bengsch B, Warnatz K.
  J Clin Immunol. 2022 May 19. Online ahead of print.
• Determination of protoplast growth properties using quantitative single-cell tracking analysis.
  Dawson J, Pandey S, Yu Q, Schaub P, Wüst F, Moradi AB, Dovzhenko O, Palme K, Welsch R.
  Plant Methods. 2022 May 18;18(1):64.
• Single-Cell Protein and Transcriptional Characterization of Epiretinal Membranes From Patients With Proliferative Vitreoretinopathy.
  Laich Y, Wolf J, Hajdu RI, Schlecht A, Bucher F, Pauleikhoff L, Busch M, Martin G, Faatz H, Killmer S, Bengsch B, Stahl A, Lommatzsch A, Schlunck G, Agostini H, Boneva S, Lange C.
  Invest Ophthalmol Vis Sci. 2022 May 2;63(5):17.
• Paradoxical immunodeficiencies-When failures of innate immunity cause immunopathology.
  Kolter J, Henneke P, Groß O, Kierdorf K, Prinz M, Graf L, Schwemmle M.
  Eur J Immunol. 2022 May 12. Online ahead of print.
• Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity.
  Fröhlich K, Brombacher E, Fahrner M, Vogele D, Kook L, Pinter N, Bronsert P, Timme-Bronsert S, Schmidt A, Bärenfaller K, Kreutz C, Schilling O.
  Nat Commun. 2022 May 12;13(1):2622.
• Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs).
  Fontanillo M, Trebacz M, Reinkemeier CD, Avilés Huerta D, Uhrig U, Sehr P, Köhn M.
  Bioorg Med Chem. 2022 Jul 1;65:116785.
• Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas.
  Lopez C, Schleussner N, Bernhart SH, Kleinheinz K, Sungalee S, Sczakiel HL, Kretzmer H, Toprak UH, Glaser S, Wagener R, Ammerpohl O, Bens S, Giefing M, Sanchez JCG, Apic G, Hubschmann D, Janz M, Kreuz M, Mottok A, Muller JM, Seufert J, Hoffmann S, Korbel JO, Russell RB, Schule R, Trumper L, Klapper W, Radlwimmer B, Lichter P, Kuppers R, Schlesner M, Mathas S, Siebert R.
  Haematologica. 2022 Apr 28. Online ahead of print.
• Reversible, β-sheet-dependent self-assembly of the phosphoprotein phosvitin is controlled by the concentration and valency of cations.
  Betschart MU, Sarem M, Shastri VP, Lüdeke S.
  Phys Chem Chem Phys. 2022 May 18;24(19):11791-11800.
• Mitochondria supply sub-lethal signals for cytokine secretion and DNA-damage in H. pylori infection.
  Dörflinger B, Badr MT, Haimovici A, Fischer L, Vier J, Metz A, Eisele B, Bronsert P, Aumann K, Höppner J, Waguia Kontchou C, Parui I, Weber A, Kirschnek S, Häcker G.
  Cell Death Differ. 2022 May 3. Online ahead of print.
• The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei.
  Iyer A, Niemann M, Serricchio M, Dewar CE, Oeljeklaus S, Farine L, Warscheid B, Schneider A, Bütikofer P.
  PLoS Pathog. 2022 May 2;18(5):e1009717.
• The Lectin LecB Induces Patches with Basolateral Characteristics at the Apical Membrane to Promote Pseudomonas aeruginosa Host Cell Invasion.
  Thuenauer R, Kühn K, Guo Y, Kotsis F, Xu M, Trefzer A, Altmann S, Wehrum S, Heshmatpour N, Faust B, Landi A, Diedrich B, Dengjel J, Kuehn EW, Imberty A, Römer W.
  mBio. 2022 Jun 28;13(3):e0081922.
• Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer.
  Taromi S, Firat E, Simonis A, Braun LM, Apostolova P, Elze M, Passlick B, Schumacher A, Lagies S, Frey A, Schmitt-Graeff A, Burger M, Schmittlutz K, Follo M, von Elverfeldt D, Zhu X, Kammerer B, Diederichs S, Duyster J, Manz MG, Niedermann G, Zeiser R.
  Cancer Lett. 2022 Jul 10;538:215697.
• SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals.
  Lang-Meli J, Luxenburger H, Wild K, Karl V, Oberhardt V, Salimi Alizei E, Graeser A, Reinscheid M, Roehlen N, Reeg DB, Giese S, Ciminski K, Götz V, August D, Rieg S, Waller CF, Wengenmayer T, Staudacher D, Huzly D, Bengsch B, Kochs G, Schwemmle M, Emmerich F, Boettler T, Thimme R, Hofmann M, Neumann-Haefelin C.
  Nat Microbiol. 2022 May;7(5):675-679.
• Benchmarking of Cph1 Mutants and DrBphP for Light-Responsive Phytochrome-Based Hydrogels with Reversibly Adjustable Mechanical Properties.
  Emig R, Hoess P, Cai H, Kohl P, Peyronnet R, Weber W, Hörner M.
  Adv Biol (Weinh). 2022 Jul;6(7):e2000337.
• SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis.
  Boettler T, Csernalabics B, Salié H, Luxenburger H, Wischer L, Salimi Alizei E, Zoldan K, Krimmel L, Bronsert P, Schwabenland M, Prinz M, Mogler C, Neumann-Haefelin C, Thimme R, Hofmann M, Bengsch B.
  J Hepatol. 2022 Sep;77(3):653-659.
• TAT-MeCP2 protein variants rescue disease phenotypes in human and mouse models of Rett syndrome.
  Steinkellner H, Kempaiah P, Beribisky AV, Pferschy S, Etzler J, Huber A, Sarne V, Neuhaus W, Kuttke M, Bauer J, Arunachalam JP, Christodoulou J, Dressel R, Mildner A, Prinz M, Laccone F.
  Int J Biol Macromol. 2022 Jun 1;209(Pt A):972-983.
• Specification of CNS macrophage subsets occurs postnatally in defined niches.
  Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M.
  Nature. 2022 Apr;604(7907):740-748.
• Inborn errors of immunity and immunodeficiencies: Antibody-mediated pathology and autoimmunity as a consequence of impaired immune reactions.
  Minguet S, Nyström A, Kiritsi D, Rizzi M.
  Eur J Immunol. 2022 Apr 20. Online ahead of print.
• Microridge-like structures anchor motile cilia.
  Yasunaga T, Wiegel J, Bergen MD, Helmstädter M, Epting D, Paolini A, Çiçek Ö, Radziwill G, Engel C, Brox T, Ronneberger O, Walentek P, Ulbrich MH, Walz G.
  Nat Commun. 2022 Apr 19;13(1):2056.
• patcHwork: a user-friendly pH sensitivity analysis web server for protein sequences and structures.
  Schmitz M, Schultze A, Vanags R, Voigt K, Di Ventura B, Öztürk MA.
  Nucleic Acids Res. 2022 Apr 19;50(W1):W560-7.
• Galaxy workflows for fragment-based virtual screening: a case study on the SARS-CoV-2 main protease.
  Bray S, Dudgeon T, Skyner R, Backofen R, Grüning B, von Delft F.
  J Cheminform. 2022 Apr 12;14(1):22.
• Life and death of microglia: Mechanisms governing microglial states and fates.
  Matsudaira T, Prinz M.
  Immunol Lett. 2022 May;245:51-60.
• BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk.
  Bork T, Liang W, Kretz O, Lagies S, Yamahara K, Hernando-Erhard C, Helmstädter M, Schell C, Kammerer B, Huber TB.
  Int J Mol Sci. 2022 Mar 30;23(7):3825.
• Microbial carbohydrate-binding toxins - From etiology to biotechnological application.
  Danielewicz N, Rosato F, Dai W, Römer W, Turnbull WB, Mairhofer J.
  Biotechnol Adv. 2022 Oct;59:107951.
• Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak.
  Waguia Kontchou C, Gentle IE, Weber A, Schoeniger A, Edlich F, Häcker G.
  Cell Death Differ. 2022 Apr 9. Online ahead of print.
• Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse.
  Haimovici A, Höfer C, Badr MT, Bavafaye Haghighi E, Amer T, Boerries M, Bronsert P, Glavynskyi I, Fanfone D, Ichim G, Thilmany N, Weber A, Brummer T, Spohr C, Öllinger R, Janssen KP, Rad R, Häcker G.
  Cell Death Dis. 2022 Apr 7;13(4):315.
• T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma.
  Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D'Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B.
  J Hepatol. 2022 Aug;77(2):397-409.
• 100 Hz ROCS microscopy correlated with fluorescence reveals cellular dynamics on different spatiotemporal scales.
  Jünger F, Ruh D, Strobel D, Michiels R, Huber D, Brandel A, Madl J, Gavrilov A, Mihlan M, Daller CC, Rog-Zielinska EA, Römer W, Lämmermann T, Rohrbach A.
  Nat Commun. 2022 Apr 1;13(1):1758.
• The living interface between synthetic biology and biomaterial design.
  Liu AP, Appel EA, Ashby PD, Baker BM, Franco E, Gu L, Haynes K, Joshi NS, Kloxin AM, Kouwer PHJ, Mittal J, Morsut L, Noireaux V, Parekh S, Schulman R, Tang SKY, Valentine MT, Vega SL, Weber W, Stephanopoulos N, Chaudhuri O.
  Nat Mater. 2022 Apr;21(4):390-397.
• Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy.
  Kao WC, Hunte C.
  Biochem Soc Trans. 2022 Apr 29;50(2):877-893.
• CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival.
  Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford AL, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy KJ, Gagliani N, Flavell RA, Waisman A, Huber S.
  Cell Rep. 2022 Mar 29;38(13):110565.
• Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.
  Smulski CR, Zhang L, Burek M, Teixidó Rubio A, Briem JS, Sica MP, Sevdali E, Vigolo M, Willen L, Odermatt P, Istanbullu D, Herr S, Cavallari M, Hess H, Rizzi M, Eibel H, Schneider P.
  Cell Rep. 2022 Mar 29;38(13):110583.
• The phytochrome interacting proteins ERF55 and ERF58 repress light-induced seed germination in Arabidopsis thaliana.
  Li Z, Sheerin DJ, von Roepenack-Lahaye E, Stahl M, Hiltbrunner A.
  Nat Commun. 2022 Mar 29;13(1):1656.
• GVHD, IBD, and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity.
  Zeiser R, Warnatz K, Rosshart S, Sagar, Tanriver Y.
  Eur J Immunol. 2022 Sep;52(9):1406-1418.
• Deterministic Lateral Displacement Microfluidic Chip for Minicell Purification.
  Sherbaz A, Konak BMK, Pezeshkpour P, Di Ventura B, Rapp BE.
  Micromachines (Basel). 2022 Feb 25;13(3):365.
• Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA.
  Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, Beisel CL.
  Nat Microbiol. 2022 Apr;7(4):530-541.
• Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child-Pugh A and B cirrhosis: A real-world study.
  D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Gaillard VE, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Sharma R, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ.
  Hepatology. 2022 Mar 21. Online ahead of print.
• A simple pipeline for cell cycle kinetic studies in the root apical meristem.
  Pasternak T, Kircher S, Pérez-Pérez JM, Palme K.
  J Exp Bot. 2022 Aug 11;73(14):4683-4695.
• Phytochrome A Mediates the Disassembly of Processing Bodies in Far-Red Light.
  Schwenk P, Hiltbrunner A.
  Front Plant Sci. 2022 Feb 23;13:828529.
• Unexpected Arabinosylation after Humanization of Plant Protein N-Glycosylation.
  Bohlender LL, Parsons J, Hoernstein SNW, Bangert N, Rodríguez-Jahnke F, Reski R, Decker EL. Front Bioeng Biotechnol.
  2022 Feb 18;10:838365.
• Process Engineering of Biopharmaceutical Production in Moss Bioreactors via Model-Based Description and Evaluation of Phytohormone Impact.
  Ruiz-Molina N, Parsons J, Schroeder S, Posten C, Reski R, Decker EL.
  Front Bioeng Biotechnol. 2022 Feb 17;10:837965.
• Flow-cytometry-based protocol to analyze respiratory chain function in mouse microglia.
  Erny D, Dokalis N, Mezö C, Mossad O, Blank T, Prinz M.
  STAR Protoc. 2022 Feb 18;3(1):101186.
• Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine.
  Mossad O, Batut B, Yilmaz B, Dokalis N, Mezö C, Nent E, Nabavi LS, Mayer M, Maron FJM, Buescher JM, de Agüero MG, Szalay A, Lämmermann T, Macpherson AJ, Ganal-Vonarburg SC, Backofen R, Erny D, Prinz M, Blank T.
  Nat Neurosci. 2022 Mar;25(3):295-305.
• A common evolutionary origin reveals fundamental principles of protein insertases.
  Vögtle FN, Koch HG, Meisinger C.
  PLoS Biol. 2022 Mar 2;20(3):e3001558.
• Low-level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus.
  Reinheckel T, Tholen M.
  FEBS Open Bio. 2022 Apr;12(4):694-707.
• Challenges and pitfalls between lichen planus pemphigoides and bullous lichen planus.
  Papara C, Danescu S, Sitaru C, Baican A.
  Australas J Dermatol. 2022 May;63(2):165-171
• A synthetic protein as efficient multitarget regulator against complement over-activation.
  Ruiz-Molina N, Parsons J, Müller M, Hoernstein SNW, Bohlender LL, Pumple S, Zipfel PF, Häffner K, Reski R, Decker EL.
  Commun Biol. 2022 Feb 22;5(1):152.
• Stimulated Raman histology in the neurosurgical workflow of a major European neurosurgical center - part A.
  Neidert N, Straehle J, Erny D, Sacalean V, El Rahal A, Steybe D, Schmelzeisen R, Vlachos A, Reinacher PC, Coenen VA, Mizaikoff B, Heiland DH, Prinz M, Beck J, Schnell O.
  Neurosurg Rev. 2022 Apr;45(2):1731-1739
• T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.
  Ravi VM, Neidert N, Will P, Joseph K, Maier JP, Kückelhaus J, Vollmer L, Goeldner JM, Behringer SP, Scherer F, Boerries M, Follo M, Weiss T, Delev D, Kernbach J, Franco P, Schallner N, Dierks C, Carro MS, Hofmann UG, Fung C, Sankowski R, Prinz M, Beck J, Salié H, Bengsch B, Schnell O, Heiland DH.
  Nat Commun. 2022 Feb 17;13(1):925.
• IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
  Dudek M, Lohr K, Donakonda S, Baumann T, Lüdemann M, Hegenbarth S, Dübbel L, Eberhagen C, Michailidou S, Yassin A, Prinz M, Popper B, Rose-John S, Zischka H, Knolle PA.
  Cell Rep. 2022 Feb 15;38(7):110389.
• Democratizing data-independent acquisition proteomics analysis on public cloud infrastructures via the Galaxy framework.
  Fahrner M, Föll MC, Grüning BA, Bernt M, Röst H, Schilling O.
  Gigascience. 2022 Feb 15;11:giac005.
• An overview of bioinformatics, genomics, and transcriptomics resources for bryophytes.
  Fernandez-Pozo N, Haas FB, Gould SB, Rensing SA.
  J Exp Bot. 2022 Jul 16;73(13):4291-4305.
• Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.
  Spohr C, Poggio T, Andrieux G, Schönberger K, Cabezas-Wallscheid N, Boerries M, Halbach S, Illert AL, Brummer T.
  Leukemia. 2022 Apr;36(4):970-982
• Pluripotency factors determine gene expression repertoire at zygotic genome activation.
  Gao M, Veil M, Rosenblatt M, Riesle AJ, Gebhard A, Hass H, Buryanova L, Yampolsky LY, Grüning B, Ulianov SV, Timmer J, Onichtchouk D.
  Nat Commun. 2022 Feb 10;13(1):788.
• Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas.
  Friedrich M, Sankowski R, Bunse L, Kilian M, Green E, Ramallo Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Gegner HM, Sonner JK, von Landenberg A, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland DH, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana FJ, von Deimling A, Wick W, Prinz M, Platten M.
  Nat Cancer. 2021 Jul;2(7):723-740.
• Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila.
  Gerstner L, Chen M, Kampf LL, Milosavljevic J, Lang K, Schneider R, Hildebrandt F, Helmstädter M, Walz G, Hermle T.
  Kidney Int. 2022 Jun;101(6):1216-1231.
• Differential regulation of progranulin derived granulin peptides.
  Zhang T, Du H, Santos MN, Wu X, Pagan MD, Trigiani LJ, Nishimura N, Reinheckel T, Hu F.
  Mol Neurodegener. 2022 Feb 4;17(1):15.
• Neuropathological interpretation of stimulated Raman histology images of brain and spine tumors: part B.
  Straehle J, Erny D, Neidert N, Heiland DH, El Rahal A, Sacalean V, Steybe D, Schmelzeisen R, Vlachos A, Mizaikoff B, Reinacher PC, Coenen VA, Prinz M, Beck J, Schnell O.
  Neurosurg Rev. 2022 Apr;45(2):1721-1729
• Molecular Control of Sporophyte-Gametophyte Ontogeny and Transition in Plants.
  Pandey S, Moradi AB, Dovzhenko O, Touraev A, Palme K, Welsch R.
  Front Plant Sci. 2022 Jan 13;12:789789.
• Structural basis for safe and efficient energy conversion in a respiratory supercomplex.
  Kao WC, Ortmann de Percin Northumberland C, Cheng TC, Ortiz J, Durand A, von Loeffelholz O, Schilling O, Biniossek ML, Klaholz BP, Hunte C.
  Nat Commun. 2022 Jan 27;13(1):545.
• Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis.
  Nührenberg TG, Stöckle J, Marini F, Zurek M, Grüning BA, Benes V, Hein L, Neumann FJ, Stratz C, Cederqvist M, Hochholzer W.
  PLoS One. 2022 Jan 27;17(1):e0260222.
• Dual role of Mic10 in mitochondrial cristae organization and ATP synthase-linked metabolic adaptation and respiratory growth.
  Rampelt H, Wollweber F, Licheva M, de Boer R, Perschil I, Steidle L, Becker T, Bohnert M, van der Klei I, Kraft C, van der Laan M, Pfanner N.
  Cell Rep. 2022 Jan 25;38(4):110290.
• From shape to contents: heterogeneity of CNS glial cells.
  Chhatbar C, Prinz M.
  Acta Neuropathol. 2022 Feb;143(2):123-124.
• Canonical TGFß signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT.
  Flum M, Dicks S, Teng YH, Schrempp M, Nyström A, Boerries M, Hecht A.
  Oncogene. 2022 Mar;41(10):1492-1506.
• Wnt/ß-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish.
  Westphal M, Panza P, Kastenhuber E, Wehrle J, Driever W.
  Sci Rep. 2022 Jan 19;12(1):1030.
• The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis.
  Dold MN, Ng X, Alber C, Gentle IE, Häcker G, Weber A.
  Apoptosis. 2022 Feb;27(1-2):112-132.
• Evaluating microglial phenotypes using single-cell technologies.
  Sankowski R, Monaco G, Prinz M.
  Trends Neurosci.

  2022 Feb;45(2):133-144.

• The renal inflammatory network of nephronophthisis.
  Quatredeniers M, Bienaimé F, Ferri G, Isnard P, Porée E, Billot K, Birgy E, Mazloum M, Ceccarelli S, Silbermann F, Braeg S, Nguyen-Khoa T, Salomon R, Gubler MC, Kuehn EW, Saunier S, Viau A.
  Hum Mol Genet. 2022 Jul 7;31(13):2121-2136.
• RiboReport - benchmarking tools for ribosome profiling-based identification of open reading frames in bacteria.
  Gelhausen R, Müller T, Svensson SL, Alkhnbashi OS, Sharma CM, Eggenhofer F, Backofen R.
  Brief Bioinform. 2022 Mar 10;23(2):bbab549.
• CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling.
  Zhang Z, Zhang F, Davis AK, Xin M, Walz G, Tian W, Zheng Y. Cell Rep. 2022 Jan 11;38(2):110009.
• 46 The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML.
  Charlet A, Kappenstein M, Keye P, Kläsener K, Endres C, Poggio T, Gorantla SP, Kreutmair S, Sänger J, Illert AL, Miething C, Reth M, Duyster J, Rummelt C, von Bubnoff N.
  Leukemia. 2022 Mar;36(3):701-711
• Viral suppressor of RNA silencing in vascular plants also interferes with the development of the bryophyte Physcomitrella patens.
  Marttinen EM, Lehtonen MT, van Gessel N, Reski R, Valkonen JPT.
  Plant Cell Environ. 2022 Jan;45(1):220-235.
• A small and highly sensitive red/far-red optogenetic switch for applications in mammals.
  Zhou Y, Kong D, Wang X, Yu G, Wu X, Guan N, Weber W, Ye H.
  Nat Biotechnol. 2022 Feb;40(2):262-272
• Oligosarcomas, IDH-mutant are distinct and aggressive.
  Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE.
  Acta Neuropathol. 2022 Feb;143(2):263-281
• Bacterial flavoprotein monooxygenase YxeK salvages toxic S-(2-succino)-adducts via oxygenolytic C-S bond cleavage.
  Matthews A, Schönfelder J, Lagies S, Schleicher E, Kammerer B, Ellis HR, Stull F, Teufel R.
  FEBS J. 2022 Feb;289(3):787-807
• The role of AUX1 during lateral root development in the domestication of the model C4 grass Setaria italica.
  Tang S, Shahriari M, Xiang J, Pasternak T, Igolkina A, Aminizade S, Zhi H, Gao Y, Roodbarkelari F, Sui Y, Jia G, Wu C, Zhang L, Zhao L, Li X, Meshcheryakov G, Samsonova M, Diao X, Palme K, Teale W.
  J Exp Bot. 2022 Apr 5;73(7):2021-2034
• Monitoring checkpoints of metabolism and protein biogenesis in mitochondria by Phos-tag technology.
  Walter C, Marada A, Meisinger C.
  J Proteomics. 2022 Feb 10;252:104430.
• Microglia contribute to the propagation of Aβ into unaffected brain tissue.
  d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M.
  Nat Neurosci. 2022 Jan;25(1):20-25.

2021

• Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.
  Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P.
  Elife. 2021 Dec 31;10:e68213.
• The EpiDiverse Plant Epigenome-Wide Association Studies (EWAS) Pipeline.
  Can SN, Nunn A, Galanti D, Langenberger D, Becker C, Volmer K, Heer K, Opgenoorth L, Fernandez-Pozo N, Rensing SA.
  Epigenomes. 2021 May 4;5(2):12.
• Screening for Optimal Liposome Preparation Conditions by Using Dual Centrifugation and Time-Resolved Fluorescence Measurements.
  Koehler JK, Schnur J, Heerklotz H, Massing U.
  Pharmaceutics. 2021 Nov 30;13(12):2046.
• Editorial: Plant Phytochromes: From Structure to Signaling and Beyond.
  Viczián A, Klose C, Hiltbrunner A, Nagy F.
  Front Plant Sci. 2021 Dec 9;12:811379.
• Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts.
  Corrales E, Levit-Zerdoun E, Metzger P, Kowar S, Ku M, Brummer T, Boerries M.
  Cell Commun Signal. 2021 Dec 20;19(1):123.
• finDr: A web server for in silico D-peptide ligand identification.
  Engel H, Guischard F, Krause F, Nandy J, Kaas P, Höfflin N, Köhn M, Kilb N, Voigt K, Wolf S, Aslan T, Baezner F, Hahne S, Ruckes C, Weygant J, Zinina A, Akmeriç EB, Antwi EB, Dombrovskij D, Franke P, Lesch KL, Vesper N, Weis D, Gensch N, Di Ventura B, Öztürk MA.
  Synth Syst Biotechnol. 2021 Nov 23;6(4):402-413.
• Designed membrane protein heterodimers and control of their affinity by binding domain and membrane linker properties.
  Lan C, Stulz A, Barthes NPF, Lauw S, Salavei P, Jung M, Heerklotz H, Ulbrich MH.
  Nanoscale. 2021 Dec 16;13(48):20692-20702.
• Transcriptome-wide in vivo mapping of cleavage sites for the compact cyanobacterial ribonuclease E reveals insights into its function and substrate recognition.
  Hoffmann UA, Heyl F, Rogh SN, Wallner T, Backofen R, Hess WR, Steglich C, Wilde A.
  Nucleic Acids Res. 2021 Dec 16;49(22):13075-13091.
• Kinase Inhibition as Treatment for Acute and Chronic Graft-Versus-Host Disease.
  Braun LM, Zeiser R.
  Front Immunol. 2021 Nov 17;12:760199.
• Small molecules mediate cellular reprogramming across two kingdoms.
  Welsch R, Touraev A, Palme K.
  J Exp Bot. 2021 Dec 4;72(22):7645-7647.
• Biobridge: An Outlook on Translational Bioinks for 3D Bioprinting.
  Gu Y, Forget A, Shastri VP.
  Adv Sci (Weinh). 2021 Dec 3:e2103469.
• Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications.
  Rigano A, Ehmsen S, Öztürk SU, Ryan J, Balashov A, Hammer M, Kirli K, Boehm U, Brown CM, Bellve K, Chambers JJ, Cosolo A, Coleman RA, Faklaris O, Fogarty KE, Guilbert T, Hamacher AB, Itano MS, Keeley DP, Kunis S, Lacoste J, Laude A, Ma WY, Marcello M, Montero-Llopis P, Nelson G, Nitschke R, Pimentel JA, Weidtkamp-Peters S, Park PJ, Alver BH, Grunwald D, Strambio-De-Castillia C.
  Nat Methods. 2021 Dec;18(12):1489-1495.
• Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model.
  Hammer M, Huisman M, Rigano A, Boehm U, Chambers JJ, Gaudreault N, North AJ, Pimentel JA, Sudar D, Bajcsy P, Brown CM, Corbett AD, Faklaris O, Lacoste J, Laude A, Nelson G, Nitschke R, Farzam F, Smith CS, Grunwald D, Strambio-De-Castillia C.
  Nat Methods. 2021 Dec;18(12):1427-1440.
• Reversible Shielding and Immobilization of Liposomes and Viral Vectors by Tailored Antibody-Ligand Interactions.
  Thomas OS, Rebmann B, Tonn M, Schirmeister IC, Wehrle S, Becker J, Zea Jimenez GJ, Hook S, Jäger S, Klenzendorf M, Laskowski M, Kaier A, Pütz G, Zurbriggen MD, Weber W, Hörner M, Wagner HJ.
  Small. 2021 Dec 3:e2105157.
• Towards non-blind optical tweezing by finding 3D refractive index changes through off-focus interferometric tracking.
  Landenberger B, Yatish, Rohrbach A.
  Nat Commun. 2021 Nov 26;12(1):6922.
• Methods of In Situ Quantitative Root Biology.
  Pasternak T, Pérez-Pérez JM.
  Plants (Basel). 2021 Nov 6;10(11):2399.
• Next- and Third-Generation Sequencing Outperforms Culture-Based Methods in the Diagnosis of Ascitic Fluid Bacterial Infections of ICU Patients.
  Goelz H, Wetzel S, Mehrbarzin N, Utzolino S, Häcker G, Badr MT.
  Cells. 2021 Nov 18;10(11):3226.
• The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake.
  Siukstaite L, Rosato F, Mitrovic A, Müller PF, Kraus K, Notova S, Imberty A, Römer W.
  Toxins (Basel). 2021 Nov 9;13(11):792.
• Editorial: Cytoskeletal Regulation of Immune Response.
  Kumari S, Schamel WW, Alarcon B.
  Front Cell Dev Biol. 2021 Nov 4;9:791327.
• Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
  Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B.
  Cell Metab. 2021 Dec 7;33(12):2464-2483.e18.
• Pharmacokinetic study of the novel phosphocholine derivative 3-dibutylaminopropylphosphonic acid by LC-MS coupling.
  Kather MG, Zeller J, Plattner D, Breit B, Kreuzaler S, Krippner G, Peter K, Eisenhardt SU, Kammerer B.
  J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Dec 1;1186:122998.
• Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination.
  Wild K, Smits M, Killmer S, Strohmeier S, Neumann-Haefelin C, Bengsch B, Krammer F, Schwemmle M, Hofmann M, Thimme R, Zoldan K, Boettler T.
  Nat Commun. 2021 Nov 18;12(1):6720.
• Proteome biology of primary colorectal carcinoma and corresponding liver metastases.
  Fahrner M, Bronsert P, Fichtner-Feigl S, Jud A, Schilling O.
  Neoplasia. 2021 Dec;23(12):1240-1251.
• Morpholinos meet mitochondria: Targeting organellar gene expression.
  Rampelt H, Pfanner N.
  Cell. 2021 Nov 11;184(23):5693-5695.
• The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics.
  Kollewe A, Chubanov V, Tseung FT, Correia L, Schmidt E, Rössig A, Zierler S, Haupt A, Müller CS, Bildl W, Schulte U, Nicke A, Fakler B, Gudermann T.
  Elife. 2021 Nov 12;10:e68544.
• Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy.
  Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer A, Stadelmann C, Nessler S, Gärtner J.
  Nat Commun. 2021 Nov 11;12(1):6530.
• Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment.
  Kotsis F, Janusch H, Li Y, Viau A, Epting D, Kramer-Zucker A, Walz G, Nitschke R, Lorentzen E, Ganner A, Neumann-Haefelin E, Kuehn EW, Boehlke C.
  Biochem Biophys Res Commun. 2021 Dec 20;584:19-25.
• Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia.
  El Khawanky N, Hughes A, Yu W, Myburgh R, Matschulla T, Taromi S, Aumann K, Clarson J, Vinnakota JM, Shoumariyeh K, Miething C, Lopez AF, Brown MP, Duyster J, Hein L, Manz MG, Hughes TP, White DL, Yong ASM, Zeiser R.
  Nat Commun. 2021 Nov 8;12(1):6436.
• Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria.
  Omar M, Marchionni L, Häcker G, Badr MT.
  Front Cell Infect Microbiol. 2021 Oct 22;11:743616.
• 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels.
  Govindasamy N, Long H, Jeong HW, Raman R, Özcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH, Trappmann B, Bedzhov I.
  Dev Cell. 2021 Dec 6;56(23):3276-3287.e8.
• Cardiomyocyte-specific miR-100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS production by direct suppression of Nox4 and CD36.
  Smolka C, Schlösser D, Koentges C, Tarkhnishvili A, Gorka O, Pfeifer D, Bemtgen X, Asmussen A, Groß O, Diehl P, Moser M, Bode C, Bugger H, Grundmann S, Pankratz F.
  FASEB J. 2021 Nov;35(11):e21956.
• The Optimal Lipid Chain Length of a Membrane-Permeabilizing Lipopeptide Results From the Balance of Membrane Partitioning and Local Damage.
  Steigenberger J, Verleysen Y, Geudens N, Martins JC, Heerklotz H.
  Front Microbiol. 2021 Sep 14;12:669709.
• Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages.
  Lagies S, Pichler R, Vladimirov G, Gawron J, Bäzner F, Schreiner A, Kadena D, Plattner DA, Lienkamp SS, Kammerer B.
  Int J Mol Sci. 2021 Sep 18;22(18):10111.
• Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.
  Dannenmaier S, Desroches Altamirano C, Schüler L, Zhang Y, Hummel J, Milanov M, Oeljeklaus S, Koch HG, Rospert S, Alberti S, Warscheid B.
  J Biol Chem. 2021 Sep 24:101050.
• Subcellular proteomics.
  Christopher JA, Stadler C, Martin CE, Morgenstern M, Pan Y, Betsinger CN, Rattray DG, Mahdessian D, Gingras AC, Warscheid B, Lehtiö J, Cristea IM, Foster LJ, Emili A, Lilley KS.
  Nat Rev Methods Primers. 2021;1:32.
• Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics.
  Ates HC, Mohsenin H, Wenzel C, Glatz RT, Wagner HJ, Bruch R, Höfflin N, Spassov S, Streicher L, Lozano-Zahonero S, Flamm B, Trittler R, Hug MJ, Köhn M, Schmidt J, Schumann S, Urban GA, Weber W, Dincer C.
  Adv Mater. 2021 Sep 21:e2104555.
• The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation.
  Zhang P, Schlecht A, Wolf J, Boneva S, Laich Y, Koch J, Ludwig F, Boeck M, Thien A, Härdtner C, Kierdorf K, Agostini H, Schlunck G, Prinz M, Hilgendorf I, Wieghofer P, Lange C.
  J Neuroinflammation. 2021 Sep 20;18(1):215.
• Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling.
  Schwarz JJ, Grundmann L, Kokot T, Kläsener K, Fotteler S, Medgyesi D, Köhn M, Reth M, Warscheid B.
  Life Sci Alliance. 2021 Sep 15;4(11):e202101084.
• Magnitude of Ubiquitination Determines the Fate of Epidermal Growth Factor Receptor Upon Ligand Stimulation.
  Akimov V, Fehling-Kaschek M, Barrio-Hernandez I, Puglia M, Bunkenborg J, Nielsen MM, Timmer J, Dengjel J, Blagoev B.
  J Mol Biol. 2021 Sep 8;433(21):167240.
• Neuronal TNFα, Not α-Syn, Underlies PDD-Like Disease Progression in IFNβ-KO Mice. Villanueva EB, Tresse E, Liu Y, Duarte JN, Jimenez-Duran G, Ejlerskov P, Kretz O, Loreth D, Goldmann T, Prinz M, Issazadeh-Navikas S.
  Ann Neurol. 2021 Nov;90(5):789-807
• Essential role of γ-clade RNA-dependent RNA polymerases in rice development and yield-related traits is linked to their atypical polymerase activities regulating specific genomic regions.
  Jha V, Narjala A, Basu D, T N S, Pachamuthu K, Chenna S, Nair A, Shivaprasad PV.
  New Phytol. 2021 Nov; 90(5):789-807
• The reaction of innate lymphoid cells in the mouse female genital tract to chlamydial infection.
  Barth S, Kirschnek S, Ortmann N, Tanriver Y, Häcker G.
  Infect Immun. 2021 Oct 15;89(11):e0080020.
• Mitochondria as emergency landing for abandoned peroxins.
  Vögtle FN, Meisinger C.
  EMBO Rep. 2021 Oct 5;22(10):e53790.
• Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer.
  Taromi S, Firat E, Simonis A, Braun LM, Apostolova P, Elze M, Passlick B, Schumacher A, Lagies S, Frey A, Schmitt-Graeff A, Burger M, Schmittlutz K, Follo M, von Elverfeldt D, Zhu X, Kammerer B, Diederichs S, Duyster J, Manz MG, Niedermann G, Zeiser R.
  Cancer Lett. 2021 Nov 1;520:385-399.
• RNAProt: an efficient and feature-rich RNA binding protein binding site predictor.
  Uhl M, Tran VD, Heyl F, Backofen R.
  Gigascience. 2021 Aug 18;10(8):giab054.
• Current tools to interrogate microglial biology.
  Dumas AA, Borst K, Prinz M.
  Neuron 2021 Sep 15;109(18):2805-2819.
• Glycans in autophagy, endocytosis and lysosomal functions.
  Reggiori F, Gabius HJ, Aureli M, Römer W, Sonnino S, Eskelinen EL.
  Glycoconj J. 2021 Oct;38(5):625-647
• Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3.
  Siukstaite L, Imberty A, Römer W.
  Front Mol Biosci. 2021 Jul 26;8:704685.
• Importance of Bcl-2-family proteins in murine hematopoietic progenitor and early B cells.
  Kurschat C, Metz A, Kirschnek S, Häcker G.
  Cell Death Dis. 2021 Aug 11;12(8):784.
• Signatures of Transcription Factor Evolution and the Secondary Gain of Red Algae Complexity.
  Petroll R, Schreiber M, Finke H, Cock JM, Gould SB, Rensing SA.
  Genes (Basel). 2021 Jul 9;12(7):1055.
• Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine.
  Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MS, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R, Neumann-Haefelin C, Hofmann M.
  Nature. 2021 Sep;597(7875):268-273.
• Flowering plant embryos: How did we end up here?
  Rensing SA, Weijers D.
  Plant Reprod. 2021 Dec;34(4):365-371
• Maintaining proteostasis under mechanical stress.
  Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B.
  EMBO Rep. 2021 Aug 4;22(8):e52507.
• Editorial: How Cells Build Plants: Regulatory Mechanisms for Integrated Functioning of Plant Cells and the Whole Plant Body.
  Máthé C, Nick P, Pasternak TP.
  Front Plant Sci. 2021 Jul 6;12:706892.
• Sulfatides are endogenous ligands for the TLR4-MD-2 complex.
  Su L, Athamna M, Wang Y, Wang J, Freudenberg M, Yue T, Wang J, Moresco EMY, He H, Zor T, Beutler B.
  Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2105316118.
• A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress.
  Moeglin E, Desplancq D, Stoessel A, Massute C, Ranniger J, McEwen AG, Zeder-Lutz G, Oulad-Abdelghani M, Chiper M, Lafaye P, Di Ventura B, Didier P, Poterszman A, Weiss E.
  Cancers (Basel). 2021 Jul 1;13(13):3317.
• Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile.
  Merz J, Nettesheim A, von Garlen S, Albrecht P, Saller BS, Engelmann J, Hertle L, Schäfer I, Dimanski D, König S, Karnbrock L, Bulatova K, Peikert A, Hoppe N, Hilgendorf I, von Zur Mühlen C, Wolf D, Groß O, Bode C, Zirlik A, Stachon P.
• Membrane-water partitioning - Tackling the challenges of poorly soluble drugs using chaotropic co-solvents.
  Naßwetter LC, Fischer M, Scheidt HA, Heerklotz H.
  Biophys Chem. 2021 Oct;277:106654.
• Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation.
  Györfi AH, Matei AE, Fuchs M, Liang C, Rigau AR, Hong X, Zhu H, Luber M, Bergmann C, Dees C, Ludolph I, Horch RE, Distler O, Wang J, Bengsch B, Schett G, Kunz M, Distler JHW.
  J Exp Med. 2021 Sep 6;218(9):e20201916.
• Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery.
  Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C.
  Nat Commun. 2021 Jul 13;12(1):4284.
• Functional assessment of two variants of unknown significance in TEK by endothelium-specific expression in zebrafish embryos.
  Bell LM, Holm A, Matysiak U, Driever W, Rößler J, Schanze D, Wieland I, Niemeyer CM, Zenker M, Kapp FG.
  Hum Mol Genet. 2021 Dec 17;31(1):10-17
• CdrS Is a Global Transcriptional Regulator Influencing Cell Division in Haloferax volcanii.
  Liao Y, Vogel V, Hauber S, Bartel J, Alkhnbashi OS, Maaß S, Schwarz TS, Backofen R, Becher D, Duggin IG, Marchfelder A.
  mBio. 2021 Aug 31;12(4):e0141621.
• Complex Micellization Behavior of the Polysorbates Tween 20 and Tween 80.
  Knoch H, Ulbrich MH, Mittag JJ, Buske J, Garidel P, Heerklotz H.
  Mol Pharm. 2021 Aug 2;18(8):3147-3157.
• DTL-DephosSite: Deep Transfer Learning Based Approach to Predict Dephosphorylation Sites.
  Chaudhari M, Thapa N, Ismail H, Chopade S, Caragea D, Köhn M, Newman RH, Kc DB.
  Front Cell Dev Biol. 2021 Jun 24;9:662983.
• PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.
  Magalhaes J, Tresse E, Ejlerskov P, Hu E, Liu Y, Marin A, Montalant A, Satriano L, Rundsten CF, Carlsen EMM, Rydbirk R, Sharifi-Zarchi A, Andersen JB, Aznar S, Brudek T, Khodosevich K, Prinz M, Perrier JM, Sharma M, Gasser T, Issazadeh-Navikas S.
  Mol Psychiatry. 2021 Oct;26(10):6083-6099
• Green Light-Controlled Gene Switch for Mammalian and Plant Cells.
  Schneider N, Chatelle CV, Ochoa-Fernandez R, Zurbriggen MD, Weber W.
  Methods Mol Biol. 2021;2312:89-107.
• The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression.
  Gentle IE, Moelter I, Badr MT, Döhner K, Lübbert M, Häcker G.
  Cell Death Dis. 2021 Jul 5;12(7):675. Purinergic Signal. 2021 Sep;17(3):481-492.
• DNA Repair Protein APE1 Degrades Dysfunctional Abasic mRNA in Mitochondria Affecting Oxidative Phosphorylation.
  Barchiesi A, Bazzani V, Jabczynska A, Borowski LS, Oeljeklaus S, Warscheid B, Chacinska A, Szczesny RJ, Vascotto C.
  J Mol Biol. 2021 Sep 3;433(18):167125.
• Autophosphorylation of the KaiC-like protein ArlH inhibits oligomerization and interaction with ArlI, the motor ATPase of the archaellum.
  de Sousa Machado JN, Vollmar L, Schimpf J, Chaudhury P, Kumariya R, van der Does C, Hugel T, Albers SV.
  Mol Microbiol. 2021 Sep;116(3):943-956.
• QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy.
  Nelson G, Boehm U, Bagley S, Bajcsy P, Bischof J, Brown CM, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North AJ, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow JR, Alexopoulos I, Aumayr K, Avilov S, Bakker GJ, Bammann RR, Bassi A, Beckert H, Beer S, Belyaev Y, Bierwagen J, Birngruber KA, Bosch M, Breitlow J, Cameron LA, Chalfoun J, Chambers JJ, Chen CL, Conde-Sousa E, Corbett AD, Cordelieres FP, Nery ED, Dietzel R, Eismann F, Fazeli E, Felscher A, Fried H, Gaudreault N, Goh WI, Guilbert T, Hadleigh R, Hemmerich P, Holst GA, Itano MS, Jaffe CB, Jambor HK, Jarvis SC, Keppler A, Kirchenbuechler D, Kirchner M, Kobayashi N, Krens G, Kunis S, Lacoste J, Marcello M, Martins GG, Metcalf DJ, Mitchell CA, Moore J, Mueller T, Nelson MS, Ogg S, Onami S, Palmer AL, Paul-Gilloteaux P, Pimentel JA, Plantard L, Podder S, Rexhepaj E, Royon A, Saari MA, Schapman D, Schoonderwoert V, Schroth-Diez B, Schwartz S, Shaw M, Spitaler M, Stoeckl MT, Sudar D, Teillon J, Terjung S, Thuenauer R, Wilms CD, Wright GD, Nitschke R.
  J Microsc. 2021 Oct;284(1):56-73.
• Deciphering the role of Minor histocompatibility antigens for acute graft-versus-host disease.
  Giesler S, Zeiser R.
  Transplant Cell Ther. 2021 Jul;27(7):523-524.
• Synthetic biology as driver for the biologization of materials sciences.
  Burgos-Morales O, Gueye M, Lacombe L, Nowak C, Schmachtenberg R, Hörner M, Jerez-Longres C, Mohsenin H, Wagner HJ, Weber W.
  Mater Today Bio. 2021 May 26;11:100115.
• Gene-rich UV sex chromosomes harbor conserved regulators of sexual development.
  Carey SB, Jenkins J, Lovell JT, Maumus F, Sreedasyam A, Payton AC, Shu S, Tiley GP, Fernandez-Pozo N, Healey A, Barry K, Chen C, Wang M, Lipzen A, Daum C, Saski CA, McBreen JC, Conrad RE, Kollar LM, Olsson S, Huttunen S, Landis JB, Burleigh JG, Wickett NJ, Johnson MG, Rensing SA, Grimwood J, Schmutz J, McDaniel SF.
  Sci Adv. 2021 Jun 30;7(27):eabh2488.
• The Polycomb group protein MEDEA controls cell proliferation and embryonic patterning in Arabidopsis.
  Simonini S, Bemer M, Bencivenga S, Gagliardini V, Pires ND, Desvoyes B, van der Graaff E, Gutierrez C, Grossniklaus U.
  Dev Cell. 2021 Jul 12;56(13):1945-1960.e7.
• Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
  Schwabenland M, Salié H, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B.
  Immunity. 2021 Jul 13;54(7):1594-1610.e11.
• Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells.
  Ngoenkam J, Paensuwan P, Wipa P, Schamel WWA, Pongcharoen S.
  Cell Dev Biol. 2021 Jun 8;9:674572.
• 3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis.
  Shen JX, Couchet M, Dufau J, de Castro Barbosa T, Ulbrich MH, Helmstädter M, Kemas AM, Zandi Shafagh R, Marques MA, Hansen JB, Mejhert N, Langin D, Rydén M, Lauschke VM.
  Adv Sci (Weinh). 2021 Aug;8(16):e2100106.
• Hierarchical dynamics in allostery following ATP hydrolysis monitored by single molecule FRET measurements and MD simulations.
  Wolf S, Sohmen B, Hellenkamp B, Thurn J, Stock G, Hugel T.
  Chem Sci. 2021 Jan 15;12(9):3350-3359.
• StoatyDive: Evaluation and classification of peak profiles for sequencing data.
  Heyl F, Backofen R.
  Gigascience. 2021 Jun 18;10(6):giab045.
• Neutrophils self-limit swarming to contain bacterial growth in vivo.
  Kienle K, Glaser KM, Eickhoff S, Mihlan M, Knöpper K, Reátegui E, Epple MW, Gunzer M, Baumeister R, Tarrant TK, Germain RN, Irimia D, Kastenmüller W, Lämmermann T.
  Science. 2021 Jun 18;372(6548):eabe7729. d
• Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors.
  Hörner M, Jerez-Longres C, Hudek A, Hook S, Yousefi OS, Schamel WWA, Hörner C, Zurbriggen MD, Ye H, Wagner HJ, Weber W.
  Sci Adv. 2021 Jun 16;7(25):eabf0797.
• CRISPRloci: comprehensive and accurate annotation of CRISPR-Cas systems.
  Alkhnbashi OS, Mitrofanov A, Bonidia R, Raden M, Tran VD, Eggenhofer F, Shah SA, Öztürk E, Padilha VA, Sanches DS, de Carvalho ACPLF, Backofen R.
  Nucleic Acids Res. 2021 Jul 2;49(W1):W125-W130.
• The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.
  Rubio T, Weyershaeuser J, Montero MG, Hoffmann A, Lujan P, Jechlinger M, Sotillo R, Köhn M.
  J Mol Med (Berl). 2021 Oct;99(10):1413-1426.
• Expanding the SiMPl Plasmid Toolbox for Use with Spectinomycin/Streptomycin.
  Palanisamy N, Ballestin JB, Di Ventura B.
  ACS Omega. 2021 May 21;6(22):14148-14153.
• Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions.
  Hoermann B, Köhn M. Biochem Soc Trans. 2021 Jun 30;49(3):1065-1074.
• Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.
  Herati RS, Silva LV, Vella LA, Muselman A, Alanio C, Bengsch B, Kurupati RK, Kannan S, Manne S, Kossenkov AV, Canaday DH, Doyle SA, Ertl HCJ, Schmader KE, Wherry EJ.
  Cell Rep Med. 2021 May 7;2(5):100262.
• Immunomodulatory Therapies for the Treatment of Graft-versus-host Disease.
  Braun LM, Zeiser R.
  Hemasphere. 2021 Jun 1;5(6):e581.
• A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Lines.
  Fahrner M, Kook L, Fröhlich K, Biniossek ML, Schilling O.
  Proteomes. 2021 May 25;9(2):26.
• Optogenetic Approaches for the Spatiotemporal Control of Signal Transduction Pathways. Kramer MM, Lataster L, Weber W, Radziwill G.
  Int J Mol Sci. 2021 May 18;22(10):5300.
• Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation.
  Friedrich SK, Schmitz R, Bergerhausen M, Lang J, Duhan V, Hardt C, Tenbusch M, Prinz M, Asano K, Bhat H, Hamdan TA, Lang PA, Lang KS.
  Pathogens. 2021 May 19;10(5):622.
• Mapping of Metabolic Heterogeneity of Glioma Using MR-Spectroscopy.
  Franco P, Huebschle I, Simon-Gabriel CP, Dacca K, Schnell O, Beck J, Mast H, Urbach H, Wuertemberger U, Prinz M, Hosp JA, Delev D, Mader I, Heiland DH.
  Cancers (Basel). 2021 May 17;13(10):2417.
• Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding.
  Yousefi OS, Ruggieri M, Idstein V, von Prillwitz KU, Herr LA, Chalupsky J, Köhn M, Weber W, Timmer J, Schamel WWA.
  Int J Mol Sci. 2021 May 6;22(9):4920.
• DIMA: Data-Driven Selection of an Imputation Algorithm.
  Egert J, Brombacher E, Warscheid B, Kreutz C.
  J Proteome Res. 2021 Jul 2;20(7):3489-3496.
• GPCRomics of Homeostatic and Disease-Associated Human Microglia.
  Hsiao CC, Sankowski R, Prinz M, Smolders J, Huitinga I, Hamann J.
  Front Immunol. 2021 May 14;12:674189.
• Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin.
  Sponga A, Arolas JL, Schwarz TC, Jeffries CM, Rodriguez Chamorro A, Kostan J, Ghisleni A, Drepper F, Polyansky A, De Almeida Ribeiro E, Pedron M, Zawadzka-Kazimierczuk A, Mlynek G, Peterbauer T, Doto P, Schreiner C, Hollerl E, Mateos B, Geist L, Faulkner G, Kozminski W, Svergun DI, Warscheid B, Zagrovic B, Gautel M, Konrat R, Djinović-Carugo K.
  Sci Adv. 2021 May 28;7(22):eabg7653.
• Metabolic reprogramming of inner ear cell line HEI-OC1 after dexamethasone application.
  Kather M, Koitzsch S, Breit B, Plontke S, Kammerer B, Liebau A.
  Metabolomics. 2021 May 24;17(6):52.
• The Rise of Molecular Optogenetics.
  Di Ventura B, Weber W.
  Adv Biol (Weinh). 2021 May;5(5):e2100776.
• The Universally Conserved ATPase YchF Regulates Translation of Leaderless mRNA in Response to Stress Conditions.
  Landwehr V, Milanov M, Angebauer L, Hong J, Jüngert G, Hiersemenzel A, Siebler A, Schmit F, Öztürk Y, Dannenmaier S, Drepper F, Warscheid B, Koch HG.
  Front Mol Biosci. 2021 May 7;8:643696.
• QUAREP-LiMi: a community endeavor to advance quality assessment and reproducibility in light microscopy.
  Boehm U, Nelson G, Brown CM, Bagley S, Bajcsy P, Bischof J, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North AJ, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow JR, Nitschke R.
  Nat Methods. 2021 Dec;18(12):1423-1426
• Coregulation of gene expression by White collar 1 and phytochrome in Ustilago maydis.
  Brych A, Haas FB, Parzefall K, Panzer S, Schermuly J, Altmüller J, Engelsdorf T, Terpitz U, Rensing SA, Kiontke S, Batschauer A.
  Fungal Genet Biol. 2021 Jul;152:103570.
• S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV).
  Görög A, Antiga E, Caproni M, Cianchini G, De D, Dmochowski M, Dolinsek J, Drenovska K, Feliciani C, Hervonen K, Lakos Jukic I, Kinyó Á, Koltai T, Korponay-Szabó I, Marzano AV, Patsatsi A, Rose C, Salmi T, Schmidt E, Setterfield J, Shahid M, Sitaru C, Uzun S, Valitutti F, Vassileva S, Yayli S, Sárdy M.
  J Eur Acad Dermatol Venereol. 2021 Jun;35(6):1251-1277.
• Automated and semi-automated enhancement, segmentation and tracing of cytoskeletal networks in microscopic images: A review.
  Özdemir B, Reski R.
  Comput Struct Biotechnol J. 2021 Apr 15;19:2106-2120.
• Synthetic Biology: Emerging Concepts to Design and Advance Adeno-Associated Viral Vectors for Gene Therapy.
  Wagner HJ, Weber W, Fussenegger M.
  Adv Sci (Weinh). 2021 Feb 26;8(9):2004018.
• Extrusion-Based 3D Bioprinting of Gradients of Stiffness, Cell Density, and Immobilized Peptide Using Thermogelling Hydrogels.
  Kuzucu M, Vera G, Beaumont M, Fischer S, Wei P, Shastri VP, Forget A.
  ACS Biomater Sci Eng. 2021 Jun 14;7(6):2192-2197.
• Eplerenone Improves Pulmonary Vascular Remodeling and Hypertension by Inhibition of the Mineralocorticoid Receptor in Endothelial Cells.
  Kowalski J, Deng L, Suennen C, Koca D, Meral D, Bode C, Hein L, Lother A.
  Hypertension. 2021 Aug;78(2):456-465.
• Architecture of the membrane-bound cytochrome c heme lyase CcmF.
  Brausemann A, Zhang L, Ilcu L, Einsle O.
  Nat Chem Biol. 2021 Jul;17(7):800-805.
• 2nSILAC for Quantitative Proteomics of Prototrophic Baker's Yeast.
  Dannenmaier S, Oeljeklaus S, Warscheid B.
  Methods Mol Biol. 2021;2228:253-270.
• Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation.
  Emmerich F, Zschiedrich S, Reichenbach-Braun C, Süsal C, Minguet S, Pauly MC, Seidl M.
  Molecules. 2021 Apr 30;26(9):2648.
• Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition.
  Catalano A, Adlesic M, Kaltenbacher T, Klar RFU, Albers J, Seidel P, Brandt LP, Hejhal T, Busenhart P, Röhner N, Zodel K, Fritsch K, Wild PJ, Duyster J, Fritsch R, Brummer T, Frew IJ.
  Cancers (Basel). 2021 Apr 13;13(8):1852.
• Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups.
  Rammensee HG, Gouttefangeas C, Heidu S, Klein R, Preuß B, Walz JS, Nelde A, Haen SP, Reth M, Yang J, Tabatabai G, Bösmüller H, Hoffmann H, Schindler M, Planz O, Wiesmüller KH, Löffler MW.
  Vaccines (Basel). 2021 Apr 24;9(5):428.
• Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.
  Hartl FA, Ngoenkam J, Beck-Garcia E, Cerqueira L, Wipa P, Paensuwan P, Suriyaphol P, Mishra P, Schraven B, Günther S, Pongcharoen S, Schamel WWA, Minguet S.
  Cells. 2021 Apr 7;10(4):834.
• GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
  Bhandari P, Vandael D, Fernández-Fernández D, Fritzius T, Kleindienst D, Önal C, Montanaro J, Gassmann M, Jonas P, Kulik A, Bettler B, Shigemoto R, Koppensteiner P.
  Elife. 2021 Apr 29;10:e68274.
• Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells.
  Hatscher L, Lehmann CHK, Purbojo A, Onderka C, Liang C, Hartmann A, Cesnjevar R, Bruns H, Gross O, Nimmerjahn F, Ivanović-Burmazović I, Kunz M, Heger L, Dudziak D.
  Sci Signal. 2021 Apr 27;14(680):eabe1757.
• Engineering AraC to make it responsive to light instead of arabinose.
  Romano E, Baumschlager A, Akmeriç EB, Palanisamy N, Houmani M, Schmidt G, Öztürk MA, Ernst L, Khammash M, Di Ventura B.
  Nat Chem Biol. 2021 Jul;17(7):817-827.
• CD4+ T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate.
  Bernardi C, Maurer G, Ye T, Marchal P, Jost B, Wissler M, Maurer U, Kastner P, Chan S, Charvet C.
  Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2023172118.
• Barcoded viral tracing of single-cell interactions in central nervous system inflammation.
  Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ.
  Science. 2021 Apr 23;372(6540):eabf1230.
• Molecular basis of F-actin regulation and sarcomere assembly via myotilin.
  Kostan J, Pavšič M, Puž V, Schwarz TC, Drepper F, Molt S, Graewert MA, Schreiner C, Sajko S, van der Ven PFM, Onipe A, Svergun DI, Warscheid B, Konrat R, Fürst DO, Lenarčič B, Djinović-Carugo K.
  PLoS Biol. 2021 Apr 12;19(4):e3001148.
• The Leishmania donovani LDBPK_220120.1 Gene Encodes for an Atypical Dual Specificity Lipid-Like Phosphatase Expressed in Promastigotes and Amastigotes; Substrate Specificity, Intracellular Localizations, and Putative Role(s).
  Papadaki A, Tziouvara O, Kotopouli A, Koumarianou P, Doukas A, Rios P, Tardieux I, Köhn M, Boleti H.
  Front Cell Infect Microbiol. 2021 Mar 25;11:591868.
• HAG1 and SWI3A/B control of male germ line development in P. patens suggests conservation of epigenetic reproductive control across land plants.
  Genau AC, Li Z, Renzaglia KS, Fernandez Pozo N, Nogué F, Haas FB, Wilhelmsson PKI, Ullrich KK, Schreiber M, Meyberg R, Grosche C, Rensing SA.
  Plant Reprod. 2021 Jun;34(2):149-173.
• Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19.
  Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT.
  Brain. 2021 May 7;144(4):1263-1276.
• Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing.
  Emig R, Knodt W, Krussig MJ, Zgierski-Johnston CM, Gorka O, Groß O, Kohl P, Ravens U, Peyronnet R.
  Cells. 2021 Mar 16;10(3):663.
• Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis.
  Hoefflin R, Lazarou A, Hess ME, Reiser M, Wehrle J, Metzger P, Frey AV, Becker H, Aumann K, Berner K, Boeker M, Buettner N, Dierks C, Duque-Afonso J, Eisenblaetter M, Erbes T, Fritsch R, Ge IX, Geißler AL, Grabbert M, Heeg S, Heiland DH, Hettmer S, Kayser G, Keller A, Kleiber A, Kutilina A, Mehmed L, Meiss F, Poxleitner P, Rawluk J, Ruf J, Schäfer H, Scherer F, Shoumariyeh K, Tzschach A, Peters C, Brummer T, Werner M, Duyster J, Lassmann S, Miething C, Boerries M, Illert AL, von Bubnoff N.
  Cancers (Basel). 2021 Mar 8;13(5):1151.
• Multiscale Molecular Dynamics Studies Reveal Different Modes of Receptor Clustering by Gb3-Binding Lectins.
  Kociurzynski R, Makshakova ON, Knecht V, Römer W.
  J Chem Theory Comput. 2021 Apr 13;17(4):2488-2501.
• Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants.
  Schwenk P, Sheerin DJ, Ponnu J, Staudt AM, Lesch KL, Lichtenberg E, Medzihradszky KF, Hoecker U, Klement E, Viczián A, Hiltbrunner A. Elife. 2021 Mar 30;10:e63697.
• FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices.
  Lerner E, Barth A, Hendrix J, Ambrose B, Birkedal V, Blanchard SC, Börner R, Sung Chung H, Cordes T, Craggs TD, Deniz AA, Diao J, Fei J, Gonzalez RL, Gopich IV, Ha T, Hanke CA, Haran G, Hatzakis NS, Hohng S, Hong SC, Hugel T, Ingargiola A, Joo C, Kapanidis AN, Kim HD, Laurence T, Lee NK, Lee TH, Lemke EA, Margeat E, Michaelis J, Michalet X, Myong S, Nettels D, Peulen TO, Ploetz E, Razvag Y, Robb NC, Schuler B, Soleimaninejad H, Tang C, Vafabakhsh R, Lamb DC, Seidel CA, Weiss S.
  Elife. 2021 Mar 29;10:e60416.
• Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development.
  Schoels M, Zhuang M, Fahrner A, Küchlin S, Sagar, Franz H, Schmitt A, Walz G, Yakulov TA.
  Am J Physiol Renal Physiol. 2021 May 1;320(5):F826-F837.
• Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice.
  Vasiljeva O, Sevenich L, Reinheckel T.
  Methods Mol Biol. 2021;2294:275-293.
• CEDAR, an online resource for the reporting and exploration of complexome profiling data.
  van Strien J, Haupt A, Schulte U, Braun HP, Cabrera-Orefice A, Choudhary JS, Evers F, Fernandez-Vizarra E, Guerrero-Castillo S, Kooij TWA, Páleníková P, Pardo M, Ugalde C, Wittig I, Wöhlbrand L, Brandt U, Arnold S, Huynen MA.
  Biochim Biophys Acta Bioenerg. 2021 Jul 1;1862(7):148411.
• Comprehensive Integration of Genome-Wide Association and Gene Expression Studies Reveals Novel Gene Signatures and Potential Therapeutic Targets for Helicobacter pylori-Induced Gastric Disease.
  Badr MT, Omar M, Häcker G.
  Front Immunol. 2021 Feb 24;12:624117.
• A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction.
  Siegel PM, Bojti I, Bassler N, Holien J, Flierl U, Wang X, Waggershauser P, Tonnar X, Vedecnik C, Lamprecht C, Stankova I, Li T, Helbing T, Wolf D, Anto-Michel N, Mitre LS, Ehrlich J, Orlean L, Bender I, Przewosnik A, Mauler M, Hollederer L, Moser M, Bode C, Parker MW, Peter K, Diehl P.
  Basic Res Cardiol. 2021 Mar 15;116(1):17.
• Involvement of N-glycans in binding of Photorhabdus luminescens Tc toxin.
  Ng'ang'a PN, Siukstaite L, Lang AE, Bakker H, Römer W, Aktories K, Schmidt G.
  Cell Microbiol. 2021 Aug;23(8):e13326.
• Is the Pr form of phytochrome biologically active in the nucleus?
  Li J, Hiltbrunner A.
  Mol Plant. 2021 Apr 5;14(4):535-537.
• Optimizing Protocols for Arabidopsis Shoot and Root Protoplast Cultivation.
  Pasternak T, Paponov IA, Kondratenko S.
  Plants (Basel). 2021 Feb 15;10(2):375.
• Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells.
  Kern U, Fröhlich K, Bedacht J, Schmidt N, Biniossek ML, Gensch N, Baerenfaller K, Schilling O.
  Cells. 2021 Feb 16;10(2):404.
• Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
  Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A.
  Immunity. 2021 Apr 13;54(4):648-659.e8.
• The active repertoire of Escherichia coli peptidoglycan amidases varies with physiochemical environment.
  Mueller EA, Iken AG, Ali Öztürk M, Winkle M, Schmitz M, Vollmer W, Di Ventura B, Levin PA.
  Mol Microbiol. 2021 Jul;116(1):311-328.
• Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides.
  Frensch B, Lechtenberg T, Kather M, Yunt Z, Betschart M, Kammerer B, Lüdeke S, Müller M, Piel J, Teufel R.
  Nat Commun. 2021 Mar 4;12(1):1431.
• Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.
  Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S.
  Nat Commun. 2021 Feb 4;12(1):782.