BIOSS

Centre for Biological Signalling Studies

News

Exploring Cutting-Edge Biological Signalling Research in Freiburg

The Lord Mayor of Freiburg, Martin Horn, recently embarked on a visit to the renowned Signalhaus Freiburg, a symbol of research excellence housing the Clusters

March 22, 2024

2 new DFG research units at the University of Freiburg

The research unit “UcarE – Urothelial Carcinoma Epigenetics” aims to investigate the biological mechanisms that underlie bladder cancer. The unit’s spokesman is Prof Dr Ian

September 22, 2023

First joint Open Day of CIBSS and BIOSS

In June, the two Freiburg signalling research centres CIBSS and BIOSS gave visitors insights into current research topics.

Glowing molecules and the memories of plants:

July 28, 2023

Home » Publications

Publications

Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity.
Soll D, Chu CF, Sun S, Lutz V, Arunkumar M, Gachechiladze M, Schäuble S, Alissa-Alkhalaf M, Nguyen T, Khalil MA, Garcia-Ribelles I, Mueller M, Buder K, Michalke B, Panagiotou G, Ziegler-Martin K, Benz P, Schatzlmaier P, Hiller K, Stockinger H, Luu M, Schober K, Moosmann C, Schamel WW, Huber M, Zielinski CE.
Nat Immunol. 2024 Oct;25(10):1830-1844.
The potential of γδ CAR and TRuC T cells: An unearthed treasure.
Schamel WW, Zintchenko M, Nguyen T, Fehse B, Briquez PS, Minguet S.
Eur J Immunol. 2024 Nov;54(11):e2451074.
Photo-Claisen Rearrangement in a Coumarin-Caged Peptide Leads to a Surprising Enzyme Hyperactivation.
Maller C, Marouda E, Köhn M.
Chembiochem. 2024 Nov 18;25(22):e202400561.
Aqueous extracts from Dioscorea sansibarensis Pax show cytotoxic and radiosensitizing potential in 3D growing HPV-negative and HPV-positive human head and neck squamous cell carcinoma models.
Schott M, Vehlow A, Benka M, Lagies S, Kammerer B, Rieckmann T, Cordes N.
Biomed Pharmacother. 2024 Oct;179:117305.
Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes.
Wogram E, Sümpelmann F, Dong W, Rawat E, Fernández Maestre I, Fu D, Braswell B, Khalil A, Buescher JM, Mittler G, Borner GHH, Vlachos A, Tholen S, Schilling O, Bell GW, Rambold AS, Akhtar A, Schnell O, Beck J, Abu-Remaileh M, Prinz M, Jaenisch R.
Immunity. 2024 Sep 10;57(9):2216-2231.e11.
Novel pathomechanistic insights into lysosomal storage disorders: how neuron-intrinsic cGAS-STING signaling drives disease progression.
Frosch M, Prinz M.
Signal Transduct Target Ther. 2024 Aug 16;9(1):203.
Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors.
Kuehn JC, Metzger P, Neidert N, Matysiak U, Gräßel L, Philipp U, Bleul S, Pauli T, Falkenstein J, Bertemes H, Cysar S, Hess ME, Frey AV, Duque-Afonso J, Schorb E, Machein M, Beck J, Schnell O, von Bubnoff N, Illert AL, Peters C, Brummer T, Prinz M, Miething C, Becker H, Lassmann S, Werner M, Börries M, Duyster J, Heiland DH, Sankowski R, Scherer F.
NPJ Precis Oncol. 2024 Aug 14;8(1):180.
Inhibition of B cell receptor signaling induced by the human adenovirus species D E3/49K protein.
Hildenbrand A, Cramer P, Bertolotti M, Kaiser NS, Kläsener K, Nickel CM, Reth M, Heim A, Hengel H, Burgert HG, Ruzsics Z.
Front Immunol. 2024 Jul 30;15:1432226.
MinD2 modulates cell shape and motility in the archaeon Haloferax volcanii.
Patro M, Sivabalasarma S, Gfrerer S, Rodriguez-Franco M, Nußbaum P, Ithurbide S, Albers SV.
bioRxiv [Preprint]. 2024 Aug 1:2024.08.01.606218.
Enzyme Is the Name-Adapter Is the Game.
Huber M, Brummer T.
Cells. 2024 Jul 25;13(15):1249.
An ancient role for CYP73 monooxygenases in phenylpropanoid biosynthesis and embryophyte development.
Knosp S, Kriegshauser L, Tatsumi K, Malherbe L, Erhardt M, Wiedemann G, Bakan B, Kohchi T, Reski R, Renault H.
EMBO J. 2024 Sep;43(18):4092-4109.
The membrane transporter SLC25A48 enables transport of choline into human mitochondria.
Patil S, Borisov O, Scherer N, Wirth C, Schlosser P, Wuttke M, Ehret S, Hannibal L, Eckardt KU, Hunte C, Neubauer B, Köttgen A, Köttgen M.
Kidney Int. 2024 Jul 29:S0085-2538(24)00526-X.
High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains.
Schwabenland M, Hasavci D, Frase S, Wolf K, Deigendesch N, Buescher JM, Mertz KD, Ondruschka B, Altmeppen H, Matschke J, Glatzel M, Frank S, Thimme R, Beck J, Hosp JA, Blank T, Bengsch B, Prinz M.
Acta Neuropathol. 2024 Jul 25;148(1):11.
Distinct sequential death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling.
Wertman RS, Yost W, Herrmann BI, Bourne CM, Sorobetea D, Go CK, Saller BS, Groß O, Scott P, Rongvaux A, Taabazuing CY, Brodsky IE.
Sci Adv. 2024 Jul 26;10(30):eadl3629.
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system.
Tiwari V, Prajapati B, Asare Y, Damkou A, Ji H, Liu L, Naser N, Gouna G, Leszczyńska KB, Mieczkowski J, Dichgans M, Wang Q, Kawaguchi R, Shi Z, Swarup V, Geschwind DH, Prinz M, Gokce O, Simons M.
Immunity. 2024 Sep 10;57(9):2173-2190.e8.
Gene expression networks in endothelial cells from failing human hearts.
Wirth L, Erny E, Krane M, Lahm H, Hein L, Gilsbach R, Lother A.
Am J Physiol Heart Circ Physiol. 2024 Sep 1;327(3):H573-H581.
Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases.
Rempfer C, Hoernstein SNW, van Gessel N, Graf AW, Spiegelhalder RP, Bertolini A, Bohlender LL, Parsons J, Decker EL, Reski R.
Comput Struct Biotechnol J. 2024 Jun 13;23:2580-2594.
Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis.
Ruiz-Blázquez P, Fernández-Fernández M, Pistorio V, Martinez-Sanchez C, Costanzo M, Iruzubieta P, Zhuravleva E, Cacho-Pujol J, Ariño S, Del Castillo-Cruz A, Núñez S, Andersen JB, Ruoppolo M, Crespo J, García-Ruiz C, Pavone LM, Reinheckel T, Sancho-Bru P, Coll M, Fernández-Checa JC, Moles A.
Mol Metab. 2024 Sep;87:101989.
The caspase-activated DNase promotes cellular senescence.
Haimovici A, Rupp V, Amer T, Moeed A, Weber A, Häcker G.
EMBO J. 2024 Aug;43(16):3523-3544.
Comparison of the diversity of anaerobic-cultured gut bacterial communities on different culture media using 16S rDNA sequencing.
Lichtenegger AS, Posadas-Cantera S, Badr MT, Häcker G.
J Microbiol Methods. 2024 Sep;224:106988.
Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body.
Rosmus DD, Koch J, Hausmann A, Chiot A, Arnhold F, Masuda T, Kierdorf K, Hansen SM, Kuhrt H, Fröba J, Wolf J, Boneva S, Gericke M, Ajami B, Prinz M, Lange C, Wieghofer P.
J Neuroinflammation. 2024 Jul 3;21(1):168.
Central nervous system-associated macrophages modulate the immune response following stroke in aged mice.
Levard D, Seillier C, Bellemain-Sagnard M, Fournier AP, Lemarchand E, Dembech C, Riou G, McDade K, Smith C, McQuaid C, Montagne A, Amann L, Prinz M, Vivien D, Rubio M.
Nat Neurosci. 2024 Sep;27(9):1721-1733
Photoimmunotherapy of HER2-expressing Breast Cancer Cells.
Klemenz L, Wolf I, Storz J, Schultze-Seemann S, Gratzke C, Lauw S, Brückner R, Wolf P.
Cancer Genomics Proteomics. 2024 Jul-Aug;21(4):361-367.
Time-resolved fluorescence of tryptophan characterizes membrane perturbation by cyclic lipopeptides.
Carabadjac I, Steigenberger J, Geudens N, De Roo V, Muangkaew P, Madder A, Martins JC, Heerklotz H.
Biophys J. 2024 Jun 21:S0006-3495(24)00419-3.
After the Gold Rush – Getting Far from the Shallow in Studying Asymmetric Membranes.
Pabst G, Heerklotz H.
Biophys J. 2024 Jun 19:S0006-3495(24)00416-8.
DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring.
Marada A, Walter C, Suhm T, Shankar S, Nandy A, Brummer T, Dhaouadi I, Vögtle FN, Meisinger C.
Nat Commun. 2024 Jun 20;15(1):5265.
Effects of tumor treating fields (TTFields) on human mesenchymal stromal cells.
Strack M, Kückelhaus J, Diebold M, Wuchter P, Huber PE, Schnell O, Sankowski R, Prinz M, Grosu AL, Heiland DH, Nicolay NH, Rühle A.
J Neurooncol. 2024 Jun 20. doi: 10.1007/s11060-024-04740-0. Online ahead of print.
CDC48A, an interactor of WOX2, is required for embryonic patterning in Arabidopsis thaliana.
Gong W, Bak DT, Wendrich JR, Weijers D, Laux T.
Plant Cell Rep. 2024 Jun 15;43(7):174.
CryoEM reveals the structure of an archaeal pilus involved in twitching motility.
Gaines MC, Sivabalasarma S, Isupov MN, Haque RU, McLaren M, Hanus C, Gold VAM, Albers SV, Daum B.
Nat Commun. 2024 Jun 14;15(1):5050.
Adhesion pilus retraction powers twitching motility in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius.
Charles-Orszag A, van Wolferen M, Lord SJ, Albers SV, Mullins RD.
Nat Commun. 2024 Jun 14;15(1):5051.
Long days induce adaptive secondary dormancy in the seeds of the Mediterranean plant Aethionema arabicum.
Mérai Z, Graeber K, Xu F, Donà M, Lalatović K, Wilhelmsson PKI, Fernandez-Pozo N, Rensing SA, Leubner-Metzger G, Mittelsten Scheid O, Dolan L.
Curr Biol. 2024 Jun 9:S0960-9822(24)00686-9. doi: 10.1016/j.cub.2024.05.043. Online ahead of print.
The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection.
Moeed A, Thilmany N, Beck F, Puthussery BK, Ortmann N, Haimovici A, Badr MT, Haghighi EB, Boerries M, Öllinger R, Rad R, Kirschnek S, Gentle IE, Donakonda S, Petric PP, Hummel JF, Pfaffendorf E, Zanetta P, Schell C, Schwemmle M, Weber A, Häcker G.
Cell Death Differ. 2024 Jun 7. doi: 10.1038/s41418-024-01320-7. Online ahead of print.
Take your sunscreen: plant photoreceptor systems in Serritaenia testaceovaginata.
Hess WR, Hiltbrunner A.
J Exp Bot. 2024 Jun 7;75(11):3206-3208.
New dimensions for fluorescence-based barcoding in complex mixtures.
Hugel T.
Nat Nanotechnol. 2024 Jun 6. doi: 10.1038/s41565-024-01686-2. Online ahead of print.
How sensor Amt-like proteins integrate ammonium signals.
Pflüger T, Gschell M, Zhang L, Shnitsar V, Zabadné AJ, Zierep P, Günther S, Einsle O, Andrade SLA.
Sci Adv. 2024 Jun 7;10(23):eadm9441.
Photoimmunotherapy of Prostate Cancer With Antibody and Fab Fragments Targeting the Prostate Specific Membrane Antigen.
Waibel S, Graf N, Storz J, Schultze-Seemann S, Lauw S, Gratzke C, Brückner R, Wolf P, Wolf I.
Anticancer Res. 2024 Jun;44(6):2343-2348.
FIP200 Phosphorylation Regulates Late Steps in Mitophagy.
Eickhorst C, Babic R, Rush-Kittle J, Lucya L, Imam FL, Sánchez-Martín P, Hollenstein DM, Michaelis J, Münch C, Meisinger C, Slade D, Gámez-Díaz L, Kraft C.
J Mol Biol. 2024 May 29:168631. doi: 10.1016/j.jmb.2024.168631. Online ahead of print.
Pro- and antitumorigenic functions of γδ T cells.
Fiala GJ, Lücke J, Huber S.
Eur J Immunol. 2024 May 27:e2451070. doi: 10.1002/eji.202451070. Online ahead of print.
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms.
Sumaria N, Fiala GJ, Inácio D, Curado-Avelar M, Cachucho A, Pinheiro R, Wiesheu R, Kimura S, Courtois L, Blankenhaus B, Darrigues J, Suske T, Almeida ARM, Minguet S, Asnafi V, Lhermitte L, Mullighan CG, Coffelt SB, Moriggl R, Barata JT, Pennington DJ, Silva-Santos B.
Nat Immunol. 2024 May 27. doi: 10.1038/s41590-024-01855-4. Online ahead of print.
MOST wanted: navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models.
Sigaud R, Brummer T, Kocher D, Milde T, Selt F.
Childs Nerv Syst. 2024 May 25. doi: 10.1007/s00381-024-06463-z. Online ahead of print.
Phospho-mimetic CD3ε variants prevent TCR and CAR signaling.
Woessner NM, Brandl SM, Hartmann S, Schamel WW, Hartl FA, Minguet S.
Front Immunol. 2024 May 8;15:1392933.
Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes.
Leroy C, Lang K, Spitz D, Milosavljevic J, Heinkele H, Kayser S, Helmstädter M, Walz G, Ulbrich MH, Hermle T.
J Am Soc Nephrol. 2024 May 22;(0). doi: 10.1681/ASN.0000000000000400. Online ahead of print.
A practical guide to bioimaging research data management in core facilities.
Schmidt C, Boissonnet T, Dohle J, Bernhardt K, Ferrando-May E, Wernet T, Nitschke R, Kunis S, Weidtkamp-Peters S.
J Microsc. 2024 Jun;294(3):350-371.
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome.
Vinnakota JM, Biavasco F, Schwabenland M, Chhatbar C, Adams RC, Erny D, Duquesne S, El Khawanky N, Schmidt D, Fetsch V, Zähringer A, Salié H, Athanassopoulos D, Braun LM, Javorniczky NR, Ho JNHG, Kierdorf K, Marks R, Wäsch R, Simonetta F, Andrieux G, Pfeifer D, Monaco G, Capitini C, Fry TJ, Blank T, Blazar BR, Wagner E, Theobald M, Sommer C, Stelljes M, Reicherts C, Jeibmann A, Schittenhelm J, Monoranu CM, Rosenwald A, Kortüm M, Rasche L, Einsele H, Meyer PT, Brumberg J, Völkl S, Mackensen A, Coras R, von Bergwelt-Baildon M, Albert NL, Bartos LM, Brendel M, Holzgreve A, Mack M, Boerries M, Mackall CL, Duyster J, Henneke P, Priller J, Köhler N, Strübing F, Bengsch B, Ruella M, Subklewe M, von Baumgarten L, Gill S, Prinz M, Zeiser R.
Nat Cancer. 2024 May 13. doi: 10.1038/s43018-024-00764-7. Online ahead of print.
Catecholamine treatment induces reversible heart injury and cardiomyocyte gene expression.
Bode C, Preissl S, Hein L, Lother A.
Intensive Care Med Exp. 2024 May 11;12(1):48.
Int&in: A machine learning-based web server for active split site identification in inteins.
Schmitz M, Ballestin JB, Liang J, Tomas F, Freist L, Voigt K, Di Ventura B, Öztürk MA.
Protein Sci. 2024 Jun;33(6):e4985.
Tyrosine-modifying glycosylation by Yersinia effectors.
Schneider S, Wirth C, Jank T, Hunte C, Aktories K.
J Biol Chem. 2024 May 2:107331.
Genomes of multicellular algal sisters to land plants illuminate signaling network evolution.
Feng X, Zheng J, Irisarri I, Yu H, Zheng B, Ali Z, de Vries S, Keller J, Fürst-Jansen JMR, Dadras A, Zegers JMS, Rieseberg TP, Dhabalia Ashok A, Darienko T, Bierenbroodspot MJ, Gramzow L, Petroll R, Haas FB, Fernandez-Pozo N, Nousias O, Li T, Fitzek E, Grayburn WS, Rittmeier N, Permann C, Rümpler F, Archibald JM, Theißen G, Mower JP, Lorenz M, Buschmann H, von Schwartzenberg K, Boston L, Hayes RD, Daum C, Barry K, Grigoriev IV, Wang X, Li FW, Rensing SA, Ben Ari J, Keren N, Mosquna A, Holzinger A, Delaux PM, Zhang C, Huang J, Mutwil M, de Vries J, Yin Y.
Nat Genet. 2024 May;56(5):1018-1031.
Antibody-dye Conjugates Targeting EGFR and HER2 for the Photoimmunotherapy of Bladder Cancer.
Huber F, Wolf I, Storz J, Schultze-Seemann S, Lauw S, Klemenz L, Miernik A, Gratzke C, Brückner R, Wolf P.
Anticancer Res. 2024 May;44(5):1837-1844.
Proteomic Analysis of Spatial Heterogeneity Identifies HMGB2 as Putative Biomarker of Tumor Progression in Adult-Type Diffuse Astrocytomas.
Becker AP, Becker V, McElroy J, Webb A, Han C, Guo Y, Bell EH, Fleming J, Popp I, Staszewski O, Prinz M, Otero JJ, Haque SJ, Grosu AL, Chakravarti A.
Cancers (Basel). 2024 Apr 16;16(8):1516.
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.
Kocher D, Cao L, Guiho R, Langhammer M, Lai YL, Becker P, Hamdi H, Friedel D, Selt F, Vonhören D, Zaman J, Valinciute G, Herter S, Picard D, Rettenmeier J, Maass KK, Pajtler KW, Remke M, von Deimling A, Pusch S, Pfister SM, Oehme I, Jones DTW, Halbach S, Brummer T, Martinez-Barbera JP, Witt O, Milde T, Sigaud R.
J Neurooncol. 2024 Jun;168(2):317-332
Transfer of ANS-Like Drugs from Micellar Drug Delivery Systems to Albumin Is Highly Favorable and Protected from Competition with Surfactant by “Reserved” Binding Sites.
Carabadjac I, Vormittag LC, Muszer T, Wuth J, Ulbrich MH, Heerklotz H.
Mol Pharm. 2024 May 6;21(5):2198-2211.
Empowering γδ T-cell functionality with vitamin C.
Kabelitz D, Cierna L, Juraske C, Zarobkiewicz M, Schamel WW, Peters C.
Eur J Immunol. 2024 Apr 15:e2451028. doi: 10.1002/eji.202451028.
Measurement of Phytochrome B Thermal Reversion Rates In Vivo.
Klose C, Hiltbrunner A.
Methods Mol Biol. 2024;2795:85-93
Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice.
Fischer AAM, Robertson HB, Kong D, Grimm MM, Grether J, Groth J, Baltes C, Fliegauf M, Lautenschläger F, Grimbacher B, Ye H, Helms V, Weber W.
Small. 2024 Apr 4:e2311834.
Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover.
Schneider J, Mitschke J, Bhat M, Vogele D, Schilling O, Reinheckel T, Heß L.
Biochimie. 2024 Mar 28:S0300-9084(24)00071-3. doi: 10.1016/j.biochi.2024.03.013. Online ahead of print.
Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer.
Heß L, Aliar K, Grünwald BT, Griffin R, Lozan A, Knöller M, Khokha R, Brummer T, Reinheckel T. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167133.
Type I Interferon, Induced by Adenovirus or Adenoviral Vector Infection, Regulates the Cytokine Response to Lipopolysaccharide in a Macrophage Type-Specific Manner.
Maler MD, Zwick S, Kallfass C, Engelhard P, Shi H, Hellig L, Zhengyang P, Hardt A, Zissel G, Ruzsics Z, Jahnen-Dechent W, Martin SF, Nielsen PJ, Stolz D, Lopatecka J, Bastyans S, Beutler B, Schamel WW, Fejer G, Freudenberg MA.
J Innate Immun. 2024;16(1):226-247.
Ratiometric gibberellin biosensors for the analysis of signaling dynamics and metabolism in plant protoplasts.
Andres J, Schmunk LJ, Grau-Enguix F, Braguy J, Samodelov SL, Blomeier T, Ochoa-Fernandez R, Weber W, Al-Babili S, Alabadí D, Blázquez MA, Zurbriggen MD.
Plant J. 2024 May;118(4):927-939.
Aethionema arabicum dimorphic seed trait resetting during transition to seedlings.
Arshad W, Steinbrecher T, Wilhelmsson PKI, Fernandez-Pozo N, Pérez M, Mérai Z, Rensing SA, Chandler JO, Leubner-Metzger G.
Front Plant Sci. 2024 Mar 8;15:1358312.
The dimorphic diaspore model Aethionema arabicum (Brassicaceae): Distinct molecular and morphological control of responses to parental and germination temperatures.
Chandler JO, Wilhelmsson PKI, Fernandez-Pozo N, Graeber K, Arshad W, Pérez M, Steinbrecher T, Ullrich KK, Nguyen TP, Mérai Z, Mummenhoff K, Theißen G, Strnad M, Mittelsten Scheid O, Schranz ME, Petřík I, Tarkowská D, Novák O, Rensing SA, Leubner-Metzger G.
Plant Cell. 2024 Mar 21:koae085. doi: 10.1093/plcell/koae085. Online ahead of print.
Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast.
Moretti-Horten DN, Peselj C, Taskin AA, Myketin L, Schulte U, Einsle O, Drepper F, Luzarowski M, Vögtle FN.
Dev Cell. 2024 Apr 22;59(8):1043-1057.e8.
Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
Herr LA, Fiala GJ, Sagar, Schaffer AM, Hummel JF, Zintchenko M, Raute K, Velasco Cárdenas RM, Heizmann B, Ebert K, Fehrenbach K, Janowska I, Chan S, Tanriver Y, Minguet S, Schamel WW.
Sci Adv. 2024 Mar 15;10(11):eadj2802.
The role of the 5′ sensing function of ribonuclease E in cyanobacteria.
Hoffmann UA, Lichtenberg E, Rogh SN, Bilger R, Reimann V, Heyl F, Backofen R, Steglich C, Hess WR, Wilde A.
RNA Biol. 2024 Jan;21(1):1-18.
Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression.
Deng L, Pollmeier L, Bednarz R, Cao C, Laurette P, Wirth L, Mamazhakypov A, Bode C, Hein L, Gilsbach R, Lother A.
Sci Adv. 2024 Mar 8;10(10):eadj5101.
Proteins containing photosynthetic reaction centre domains modulate FtsZ-based archaeal cell division.
Nußbaum P, Kureisaite-Ciziene D, Bellini D, van der Does C, Kojic M, Taib N, Yeates A, Tourte M, Gribaldo S, Loose M, Löwe J, Albers SV.
Nat Microbiol. 2024 Mar;9(3):698-711.
Hilde Mangold: Original microscope slides and records of the gastrula organizer experiments
Driever W, Holzschuh J, Sommer L, Nitschke R, Naumann A, Elmer J, Giere P.
Cells Dev. 2024 Feb 28:203909. doi: 10.1016/j.cdev.2024.203909. Online ahead of print.
A Modular Approach for the Synthesis of Diverse Heterobifunctional Cyanine Dyes.
Maller C, Schedel F, Köhn M.
J Org Chem. 2024 Mar 15;89(6):3844-3856.
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
Linnerbauer M, Lößlein L, Vandrey O, Peter A, Han Y, Tsaktanis T, Wogram E, Needhamsen M, Kular L, Nagel L, Zissler J, Andert M, Meszaros L, Hanspach J, Zuber F, Naumann UJ, Diebold M, Wheeler MA, Beyer T, Nirschl L, Cirac A, Laun FB, Günther C, Winkler J, Bäuerle T, Jagodic M, Hemmer B, Prinz M, Quintana FJ, Rothhammer V.
Nat Immunol. 2024 Mar;25(3):432-447.
A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts.
Hoermann B, Dürr EM, Ludwig C, Ercan M, Köhn M.
Chem Sci. 2024 Jan 12;15(8):2792-2804.
Association of RNF43 Genetic Alterations With BRAFV600E and MSIhigh in Colorectal Cancer.
Vogel A, Murugesan K, Kendre G, Quintanilha JCF, Ross JS, Brummer T, Saborowski A.
JCO Precis Oncol. 2024 Feb;8:e2300411.
Identification of MIMAS, a multifunctional mega-assembly integrating metabolic and respiratory biogenesis factors of mitochondria.
Horten P, Song K, Garlich J, Hardt R, Colina-Tenorio L, Horvath SE, Schulte U, Fakler B, van der Laan M, Becker T, Stuart RA, Pfanner N, Rampelt H.
Cell Rep. 2024 Mar 26;43(3):113772.
Eutectic Resolves Lysolipid Paradox in Thermoresponsive Liposomes.
Eckhardt D, Semeraro EF, Steigenberger J, Schnur J, Kalie L, Massing U, Pabst G, Heerklotz H.
Mol Pharm. 2024 Apr 1;21(4):1768-1776.
Spine plasticity of dentate gyrus parvalbumin-positive interneurons is regulated by experience.
Kaufhold D, Maristany de Las Casas E, Ocaña-Fernández MDÁ, Cazala A, Yuan M, Kulik A, Cholvin T, Steup S, Sauer JF, Eyre MD, Elgueta C, Strüber M, Bartos M.
Cell Rep. 2024 Mar 26;43(3):113806.
Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery.
Busto JV, Ganesan I, Mathar H, Steiert C, Schneider EF, Straub SP, Ellenrieder L, Song J, Stiller SB, Lübbert P, Chatterjee R, Elsaesser J, Melchionda L, Schug C, den Brave F, Schulte U, Klecker T, Kraft C, Fakler B, Becker T, Wiedemann N.
Cell Rep. 2024 Mar 26;43(3):113805.
Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer’s disease.
Srinivasan S, Kancheva D, De Ren S, Saito T, Jans M, Boone F, Vandendriessche C, Paesmans I, Maurin H, Vandenbroucke RE, Hoste E, Voet S, Scheyltjens I, Pavie B, Lippens S, Schwabenland M, Prinz M, Saido T, Bottelbergs A, Movahedi K, Lamkanfi M, van Loo G.
Front Immunol. 2024 Jan 29;15:1323409.
A mismatch in the expression of cell surface molecules induces tissue-intrinsic defense against aberrant cells.
Fischer F, Ernst L, Frey A, Holstein K, Prasad D, Weichselberger V, Balaji R, Classen AK.
Curr Biol. 2024 Mar 11;34(5):980-996.e6.
The niche matters: origin, function and fate of CNS-associated macrophages during health and disease.
Dalmau Gasull A, Glavan M, Samawar SKR, Kapupara K, Kelk J, Rubio M, Fumagalli S, Sorokin L, Vivien D, Prinz M.
Acta Neuropathol. 2024 Feb 12;147(1):37.
OptoREACT: Optogenetic Receptor Activation on Nonengineered Human T Cells.
Armbruster A, Ehret AK, Russ M, Idstein V, Klenzendorf M, Gaspar D, Juraske C, Yousefi OS, Schamel WW, Weber W, Hörner M.
ACS Synth Biol. 2024 Mar 15;13(3):752-762.
Inhibition of cysteine protease cathepsin L increases the level and activity of lysosomal glucocerebrosidase.
Kim MJ, Kim S, Reinheckel T, Krainc D.
JCI Insight. 2024 Feb 8;9(3):e169594.
Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia.
Märkl F, Schultheiß C, Ali M, Chen SS, Zintchenko M, Egli L, Mietz J, Chijioke O, Paschold L, Spajic S, Holtermann A, Dörr J, Stock S, Zingg A, Läubli H, Piseddu I, Anz D, Minden MD, Zhang T, Nerreter T, Hudecek M, Minguet S, Chiorazzi N, Kobold S, Binder M.
Nat Commun. 2024 Feb 2;15(1):993.
Longitudinal dynamics of gut bacteriome and mycobiome interactions pre- and post-visceral surgery in Crohn’s disease.
Wetzel S, Müller A, Kohnert E, Mehrbarzin N, Huber R, Häcker G, Kreutz C, Lederer AK, Badr MT.
Front Cell Infect Microbiol. 2024 Jan 15;13:1275405
Kidins220 regulates the development of B cells bearing the λ light chain.
Schaffer AM, Fiala GJ, Hils M, Natali E, Babrak L, Herr LA, Romero-Mulero MC, Cabezas-Wallscheid N, Rizzi M, Miho E, Schamel WWA, Minguet S.
Elife. 2024 Jan 25;13:e83943.
Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization.
Simon N, Safyan A, Pyrowolakis G, Matsuda S.
Elife. 2024 Jan 24;12:RP86663.
Vdelta1 T cells are more resistant than Vdelta2 T cells to the immunosuppressive properties of galectin-3.
Schadeck J, Oberg HH, Peipp M, Hedemann N, Schamel WW, Bauerschlag D, Wesch D.
Front Immunol. 2024 Jan 8;14:1286097.
Multifactorial analysis of terminator performance on heterologous gene expression in Physcomitrella.
Niederau PA, Eglé P, Willig S, Parsons J, Hoernstein SNW, Decker EL, Reski R.
Plant Cell Rep. 2024 Jan 22;43(2):43.
Cochaperones convey the energy of ATP hydrolysis for directional action of Hsp90.
Vollmar L, Schimpf J, Hermann B, Hugel T.
Nat Commun. 2024 Jan 17;15(1):569.
GM-CSF in Allogenic Hematopoietic Stem Cell Transplantation: from Graft-versus-Host Disease to Graft-versus-Tumor effect.
Bernardi C, Charvet C, Zeiser R, Simonetta F.
Transplant Cell Ther. 2024 Jan 13:S2666-6367(24)00141-6.
Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease.
Burbano de Lara S, Kemmer S, Biermayer I, Feiler S, Vlasov A, D’Alessandro LA, Helm B, Mölders C, Dieter Y, Ghallab A, Hengstler JG, Körner C, Matz-Soja M, Götz C, Damm G, Hoffmann K, Seehofer D, Berg T, Schilling M, Timmer J, Klingmüller U.
Mol Syst Biol. 2024 Jan 12. doi: 10.1038/s44320-023-00007-4. Online ahead of print.
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.
Maas-Bauer K, Stell AV, Yan KL, de Vega E, Vinnakota JM, Unger S, Núñez N, Norona J, Talvard-Balland N, Koßmann S, Schwan C, Miething C, Martens US, Shoumariyeh K, Nestor RP, Duquesne S, Hanke K, Rackiewicz M, Hu Z, El Khawanky N, Taromi S, Andrlova H, Faraidun H, Walter S, Pfeifer D, Follo M, Waldschmidt J, Melchinger W, Rassner M, Wehr C, Schmitt-Graeff A, Halbach S, Liao J, Häcker G, Brummer T, Dengjel J, Andrieux G, Grosse R, Tugues S, Blazar BR, Becher B, Boerries M, Zeiser R.
Nat Commun. 2024 Jan 10;15(1):446.
DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress.
Hersperger F, Meyring T, Weber P, Chhatbar C, Monaco G, Dionne MS, Paeschke K, Prinz M, Groß O, Classen AK, Kierdorf K.
Elife. 2024 Jan 8;12:RP86700.
Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection.
Torcellan T, Friedrich C, Doucet-Ladevèze R, Ossner T, Solé VV, Riedmann S, Ugur M, Imdahl F, Rosshart SP, Arnold SJ, Gomez de Agüero M, Gagliani N, Flavell RA, Backes S, Kastenmüller W, Gasteiger G.
Immunity. 2024 Jan 9;57(1):124-140.e7.
EID1 promotes the response to canopy shade in Arabidopsis thaliana by repressing the action of phytochrome A.
Staudt AM, Kretsch T, Hiltbrunner A.
MicroPubl Biol. 2023 Dec 12;2023:10.17912/micropub.biology.001015.
Reprogramming of human γδ T cells by expression of an anti-CD19 TCR fusion construct (εTRuC) to enhance tumor killing.
Juraske C, Krissmer SM, Teuber ES, Parigiani MA, Strietz J, Wesch D, Kabelitz D, Minguet S, Schamel WW.
J Leukoc Biol. 2024 Jan 19;115(2):293-305.
Multiomic spatial landscape of innate immune cells at human central nervous system borders.
Sankowski R, Süß P, Benkendorff A, Böttcher C, Fernandez-Zapata C, Chhatbar C, Cahueau J, Monaco G, Gasull AD, Khavaran A, Grauvogel J, Scheiwe C, Shah MJ, Heiland DH, Schnell O, Markfeld-Erol F, Kunze M, Zeiser R, Priller J, Prinz M.
Nat Med. 2024 Jan;30(1):186-198.
Genomic imprints of unparalleled growth.
Murik O, Geffen O, Shotland Y, Fernandez-Pozo N, Ullrich KK, Walther D, Rensing SA, Treves H.
New Phytol. 2024 Feb;241(3):1144-1160.
Interrogating two extensively self-targeting Type I CRISPR-Cas systems in Xanthomonas albilineans reveals distinct anti-CRISPR proteins that block DNA degradation.
Wimmer F, Englert F, Wandera KG, Alkhnbashi OS, Collins SP, Backofen R, Beisel CL.
Nucleic Acids Res. 2024 Jan 25;52(2):769-783.
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.
Hernández-López P, van Diest E, Brazda P, Heijhuurs S, Meringa A, Hoorens van Heyningen L, Riillo C, Schwenzel C, Zintchenko M, Johanna I, Nicolasen MJT, Cleven A, Kluiver TA, Millen R, Zheng J, Karaiskaki F, Straetemans T, Clevers H, de Bree R, Stunnenberg HG, Peng WC, Roodhart J, Minguet S, Sebestyén Z, Beringer DX, Kuball J.
Nat Immunol. 2024 Jan;25(1):88-101.
iNClusive: a database collecting useful information on non-canonical amino acids and their incorporation into proteins for easier genetic code expansion implementation.
Icking LS, Riedlberger AM, Krause F, Widder J, Frederiksen AS, Stockert F, Spädt M, Edel N, Armbruster D, Forlani G, Franchini S, Kaas P, Kırpat Konak BM, Krier F, Lefebvre M, Mazraeh D, Ranniger J, Gerstenecker J, Gescher P, Voigt K, Salavei P, Gensch N, Di Ventura B, Öztürk MA.
Nucleic Acids Res. 2024 Jan 5;52(D1):D476-D482.
A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation.
Lui VG, Hoenig M, Cabrera-Martinez B, Baxter RM, Garcia-Perez JE, Bailey O, Acharya A, Lundquist K, Capera J, Matusewicz P, Hartl FA, D’Abramo M, Alba J, Jacobsen EM, Niewolik D, Lorenz M, Pannicke U, Schulz AS, Debatin KM, Schamel WW, Minguet S, Gumbart JC, Dustin ML, Cambier JC, Schwarz K, Hsieh EWY.
J Exp Med. 2024 Jan 1;221(1):e20230927.
Mitochondrial entry gate as regulatory hub.
den Brave F, Pfanner N, Becker T.
Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119529.

Efficient formation and maintenance of humoral and CD4 T-cell immunity targeting the viral capsid in acute-resolving hepatitis E infection.
Csernalabics B, Marinescu MS, Maurer L, Kelsch L, Werner J, Baumann K, Zoldan K, Panning M, Reuken P, Bruns T, Bengsch B, Neumann-Haefelin C, Hofmann M, Thimme R, Dao Thi VL, Boettler T.
J Hepatol. 2023 Dec 26:S0168-8278(23)05370-9. doi: 10.1016/j.jhep.2023.12.016. Online ahead of print.
Design of a Biohybrid Materials Circuit with Binary Decoder Functionality.
Mohsenin H, Wagner HJ, Rosenblatt M, Kemmer S, Drepper F, Huesgen P, Timmer J, Weber W.
Adv Mater. 2023 Dec 20:e2308092. doi: 10.1002/adma.202308092. Online ahead of print.
Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK.
Keller B, Kfir-Erenfeld S, Matusewicz P, Hartl F, Lev A, Lee YN, Simon AJ, Stauber T, Elpeleg O, Somech R, Stepensky P, Minguet S, Schraven B, Warnatz K.
J Clin Immunol. 2023 Dec 19;44(1):4.
Characterization of the zinc finger μ-protein HVO_0758 from Haloferax volcanii: biological roles, zinc binding, and NMR solution structure.
Üresin D, Pyper DJ, Borst A, Hadjeras L, Gelhausen R, Backofen R, Sharma C, Schwalbe H, Soppa J.
Front Microbiol. 2023 Nov 29;14:1280972.
Proteome plasticity during Physcomitrium patens spore germination – from the desiccated phase to heterotrophic growth and reconstitution of photoautotrophy.
Hembach L, Niemeyer PW, Schmitt K, Zegers JMS, Scholz P, Brandt D, Dabisch JJ, Valerius O, Braus GH, Schwarzländer M, de Vries J, Rensing SA, Ischebeck T.
Plant J. 2023 Dec 7. doi: 10.1111/tpj.16574. Online ahead of print.
Microglia out of place-mapping macrophages across the developing human body.
Sankowski R, Prinz M.
Cell Mol Immunol. 2023 Nov 28. doi: 10.1038/s41423-023-01100-2. Online ahead of print.
Transformer-based tool recommendation system in Galaxy.
Kumar A, Grüning B, Backofen R.
BMC Bioinformatics. 2023 Nov 27;24(1):446.
A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing.
Karunakaran MM, Subramanian H, Jin Y, Mohammed F, Kimmel B, Juraske C, Starick L, Nöhren A, Länder N, Willcox CR, Singh R, Schamel WW, Nikolaev VO, Kunzmann V, Wiemer AJ, Willcox BE, Herrmann T.
Nat Commun. 2023 Nov 22;14(1):7617.
Mosses.
Lueth VM, Reski R.
Curr Biol. 2023 Nov 20;33(22):R1175-R1181.
The Onset of Molecule-Spanning Dynamics in Heat Shock Protein Hsp90.
Sohmen B, Beck C, Frank V, Seydel T, Hoffmann I, Hermann B, Nüesch M, Grimaldo M, Schreiber F, Wolf S, Roosen-Runge F, Hugel T.
Adv Sci (Weinh). 2023 Dec;10(36):e2304262.
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Aguado J, Amarilla AA, Taherian Fard A, Albornoz EA, Tyshkovskiy A, Schwabenland M, Chaggar HK, Modhiran N, Gómez-Inclán C, Javed I, Baradar AA, Liang B, Peng L, Dharmaratne M, Pietrogrande G, Padmanabhan P, Freney ME, Parry R, Sng JDJ, Isaacs A, Khromykh AA, Valenzuela Nieto G, Rojas-Fernandez A, Davis TP, Prinz M, Bengsch B, Gladyshev VN, Woodruff TM, Mar JC, Watterson D, Wolvetang EJ.
Nat Aging. 2023 Dec;3(12):1561-1575.
A DELAY OF GERMINATION 1 (DOG1)-like protein regulates spore germination in the moss Physcomitrium patens.
Vollmeister E, Phokas A, Meyberg R, Böhm CV, Peter M, Kohnert E, Yuan J, Grosche C, Göttig M, Ullrich KK, Perroud PF, Hiltbrunner A, Kreutz C, Coates JC, Rensing SA.
Plant J. 2023 Nov 13. doi: 10.1111/tpj.16537. Online ahead of print.
Neurog1 and Olig2 integrate patterning and neurogenesis signals in development of zebrafish dopaminergic and glutamatergic dual transmitter neurons.
Altbürger C, Rath M, Armbruster D, Driever W.
Dev Biol. 2023 Nov 7;505:85-98.
Phytochromes transmit photoperiod information via the evening complex in Brachypodium.
Gao M, Lu Y, Geng F, Klose C, Staudt AM, Huang H, Nguyen D, Lan H, Lu H, Mockler TC, Nusinow DA, Hiltbrunner A, Schäfer E, Wigge PA, Jaeger KE.
Genome Biol. 2023 Nov 7;24(1):256
Harnessing CD3 diversity to optimize CAR T cells.
Velasco Cárdenas RM, Brandl SM, Meléndez AV, Schlaak AE, Buschky A, Peters T, Beier F, Serrels B, Taromi S, Raute K, Hauri S, Gstaiger M, Lassmann S, Huppa JB, Boerries M, Andrieux G, Bengsch B, Schamel WW, Minguet S.
Nat Immunol. 2023 Dec;24(12):2135-2149
The proneural factors Ascl1a and Ascl1b contribute to the terminal differentiation of dopaminergic GABAergic dual transmitter neurons in zebrafish.
Altbürger C, Rath M, Wehrle J, Driever W.
Dev Biol. 2023 Nov 4;505:58-74.
LAZing Around: The Intricate Dance of Amyloplast Sedimentation and Gravity Sensing in Plants.
Zhang N, Gui S, Wang Y.
Mol Plant. 2023 Nov 2:S1674-2052(23)00356-8.
Mitochondrial complexome and import network.
den Brave F, Schulte U, Fakler B, Pfanner N, Becker T.
Trends Cell Biol. 2023 Oct 30:S0962-8924(23)00208-8.
Ribosome profiling reveals the fine-tuned response of Escherichia coli to mild and severe acid stress.
Schumacher K, Gelhausen R, Kion-Crosby W, Barquist L, Backofen R, Jung K.
mSystems. 2023 Dec 21;8(6):e0103723.
GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites.
Perozzo AM, Schwenk J, Kamalova A, Nakagawa T, Fakler B, Bowie D.
Nat Commun. 2023 Oct 26;14(1):6799.
ReverseDock: a web server for blind docking of a single ligand to multiple protein targets using AutoDock Vina.
Krause F, Voigt K, Di Ventura B, Öztürk MA. Front Mol Biosci. 2023 Oct 10;10:1243970.
APOE set the microglia free.
Wogram E, Prinz M.
Nat Immunol. 2023 Nov;24(11):1790-1791.
A novel role for the chloride intracellular channel protein Clic5 in ciliary function.
Ott E, Hoff S, Indorf L, Ditengou FA, Müller J, Renschler G, Lienkamp SS, Kramer-Zucker A, Bergmann C, Epting D.
Sci Rep. 2023 Oct 17;13(1):17647.
COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function.
Guhathakurta S, Erdogdu NU, Hoffmann JJ, Grzadzielewska I, Schendzielorz A, Seyfferth J, Mårtensson CU, Corrado M, Karoutas A, Warscheid B, Pfanner N, Becker T, Akhtar A.
Nat Metab. 2023 Nov;5(11):1931-1952
SGK-1 mediated inhibition of iron import is a determinant of lifespan in C. elegans.
Wu G, Baumeister R, Heimbucher
MicroPubl Biol. 2023 Sep 17;2023.
Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes.
Jamwal A, Constantin CF, Hirschi S, Henrich S, Bildl W, Fakler B, Draper SJ, Schulte U, Higgins MK.
Elife. 2023 Oct 5;12:e83681.
The RPT2a-MET1 axis regulates TERMINAL FLOWER1 to control inflorescence meristem indeterminacy in Arabidopsis.
Yao WJ, Wang YP, Peng J, Yin PP, Gao H, Xu L, Laux T, Zhang XS, Su YH. Plant Cell.
2023 Oct 5:koad249.
Engineering of an Optogenetic T Cell Receptor Compatible with Fluorescence-Based Readouts.
Idstein V, Ehret AK, Yousefi OS, Schamel WW. ACS Synth Biol. 2023Oct 20;12(10):2857-2864.
Cell Cycle Control by Optogenetically Regulated Cell Cycle Inhibitor Protein p21.
Lataster L, Huber HM, Böttcher C, Föller S, Takors R, Radziwill G. Biology
(Basel). 2023 Aug 31;12(9):1194.
Discovering immunoreceptor coupling and organization motifs.
Reth M.
Front Immunol. 2023 Sep 4;14:1253412.
Disease severity, arrhythmogenesis, and fibrosis are related to longer action potentials in tetralogy of Fallot.
Fürniss HE, Wülfers EM, Iaconianni P, Ravens U, Kroll J, Stiller B, Kohl P, Rog-Zielinska EA, Peyronnet R.
Clin Res Cardiol. 2023 Sep 19. Online ahead of print.
Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas.
Lauer EM, Riegler E, Mutter JA, Alig SK, Bleul S, Kuehn J, Ranganathan L, Klingler C, Demerath T, Würtemberger U, Rau A, Weiß J, Eisenblaetter M, Bamberg F, Prinz M, Finke J, Duyster J, Illerhaus G, Diehn M, Alizadeh AA, Schorb E, Reinacher PC, Scherer F.
Neuro Oncol. 2023 Sep 15. Online ahead of print.
Community-developed checklists for publishing images and image analyses.
Schmied C, Nelson MS, Avilov S, Bakker GJ, Bertocchi C, Bischof J, Boehm U, Brocher J, Carvalho MT, Chiritescu C, Christopher J, Cimini BA, Conde-Sousa E, Ebner M, Ecker R, Eliceiri K, Fernandez-Rodriguez J, Gaudreault N, Gelman L, Grunwald D, Gu T, Halidi N, Hammer M, Hartley M, Held M, Jug F, Kapoor V, Koksoy AA, Lacoste J, Le Dévédec S, Le Guyader S, Liu P, Martins GG, Mathur A, Miura K, Montero Llopis P, Nitschke R, North A, Parslow AC, Payne-Dwyer A, Plantard L, Ali R, Schroth-Diez B, Schütz L, Scott RT, Seitz A, Selchow O, Sharma VP, Spitaler M, Srinivasan S, Strambio-De-Castillia C, Taatjes D, Tischer C, Jambor HK.
Nat Methods. 2023 Sep 14. Online ahead of print.
Activator-blocker model of transcriptional regulation by pioneer-like factors.
Riesle AJ, Gao M, Rosenblatt M, Hermes J, Hass H, Gebhard A, Veil M, Grüning B, Timmer J, Onichtchouk D.
Nat Commun. 2023 Sep 14;14(1):5677.
Who wants yesterday’s papers?
Heerklotz H.
Biophys J. 2023 Oct 3;122(19):E1-E2.
Regulation of early seedling establishment and root development in Arabidopsis thaliana by light and carbohydrates.
Pasternak T, Kircher S, Palme K, Pérez-Pérez JM.
Planta. 2023 Sep 6;258(4):76
Peptides as Baits for the Coprecipitation of SH2 Domain-Containing Proteins.
Kiani A, Rios P, Köhn M.
Methods Mol Biol. 2023;2705:359-369.
Measuring Protein Tyrosine Phosphatase Activity Dependent on SH2 Domain-Mediated Regulation.
Rios P, Kiani A, Köhn M.
Methods Mol Biol. 2023;2705:351-358.
BRAFΔβ3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability.
Lauinger M, Christen D, Klar RFU, Roubaty C, Heilig CE, Stumpe M, Knox JJ, Radulovich N, Tamblyn L, Xie IY, Horak P, Forschner A, Bitzer M, Wittel UA, Boerries M, Ball CR, Heining C, Glimm H, Fröhlich M, Hübschmann D, Gallinger S, Fritsch R, Fröhling S, O’Kane GM, Dengjel J, Brummer T.
Sci Adv. 2023 Sep;9(35):eade7486.
Vesicle budding caused by lysolipid-induced asymmetry stress.
Hua L, Kaiser M, Carabadjac I, Meister A, Hause G, Heerklotz H.
Biophys J. 2023 Oct 17;122(20):4011-4022 t.
A comparative analysis of microglial inducible Cre lines.
Faust TE, Feinberg PA, O’Connor C, Kawaguchi R, Chan A, Strasburger H, Frosch M, Boyle MA, Masuda T, Amann L, Knobeloch KP, Prinz M, Schaefer A, Schafer DP.
Cell Rep. 2023 Sep 26;42(9):113031.
Eomes restricts Brachyury functions at the onset of mouse gastrulation.
Schüle KM, Weckerle J, Probst S, Wehmeyer AE, Zissel L, Schröder CM, Tekman M, Kim GJ, Schlägl IM, Sagar, Arnold SJ.
Dev Cell. 2023 Sep 25;58(18):1627-1642.e7.
Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus naudinianus.
Benka M, Görlitz K, Schöttgen MC, Lagies S, Mohl DA, Kather M, Du Preez-Bruwer I, Mumbengegwi D, Teufel R, Kowarschik S, Huber R, Plattner DA, Kammerer B.
Biomolecules. 2023 Jul 26;13(8):1168.
Dipeptidyl-Aminopeptidases 8 and 9 Regulate Autophagy and Tamoxifen Response in Breast Cancer Cells.
Bettecken A, Heß L, Hölzen L, Reinheckel T.
Cells. 2023 Aug 10;12(16):2031.
Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: research protocol of the DynaM-INT study.
Bögemann SA, Riepenhausen A, Puhlmann LMC, Bar S, Hermsen EJC, Mituniewicz J, Reppmann ZC, Uściƚko A, van Leeuwen JMC, Wackerhagen C, Yuen KSL, Zerban M, Weermeijer J, Marciniak MA, Mor N, van Kraaij A, Köber G, Pooseh S, Koval P, Arias-Vásquez A, Binder H, De Raedt W, Kleim B, Myin-Germeys I, Roelofs K, Timmer J, Tüscher O, Hendler T, Kobylińska D, Veer IM, Kalisch R, Hermans EJ, Walter H.
BMC Psychol. 2023 Aug 25;11(1):245.
Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells.
Tsang TH, Wiese M, Helmstädter M, Stehle T, Seyfferth J, Shvedunova M, Holz H, Walz G, Akhtar A.
Sci Adv. 2023 Aug 25;9(34):eadh5598.
CRISPR/Cas9-based QF2 knock-in at the tyrosine hydroxylase (th) locus reveals novel th-expressing neuron populations in the zebrafish mid- and hindbrain.
Altbürger C, Holzhauser J, Driever W.
Front Neuroanat. 2023 Aug 2;17:1196868.
A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors.
Boudkkazi S, Schwenk J, Nakaya N, Brechet A, Kollewe A, Harada H, Bildl W, Kulik A, Dong L, Sultana A, Zolles G, Schulte U, Tomarev S, Fakler B.
Neuron. 2023 Aug 16;111(16):2544-2556.e9.
A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of T. brucei.
Gerber M, Suppanz I, Oeljeklaus S, Niemann M, Käser S, Warscheid B, Schneider A, Dewar CE.
Life Sci Alliance. 2023 Aug 16;6(11):e202302004.
Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation.
Lan C, Kim J, Ulferts S, Aprile-Garcia F, Weyrauch S, Anandamurugan A, Grosse R, Sawarkar R, Reinhardt A, Hugel T.
Nat Commun. 2023 Aug 15;14(1):4831.
Methods to Activate the NLRP3 Inflammasome.
Saller BS, Neuwirt E, Groß O.
Methods Mol Biol. 2023;2696:169-197.
Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection.
Forde AJ, Kolter J, Zwicky P, Baasch S, Lohrmann F, Eckert M, Gres V, Lagies S, Gorka O, Rambold AS, Buescher JM, Kammerer B, Lachmann N, Prinz M, Groß O, Pearce EJ, Becher B, Henneke P.
Sci Immunol. 2023 Aug 18;8(86):eadg3517.
Adaptive evolution of the enigmatic Takakia now facing climate change in Tibet.
Hu R, Li X, Hu Y, Zhang R, Lv Q, Zhang M, Sheng X, Zhao F, Chen Z, Ding Y, Yuan H, Wu X, Xing S, Yan X, Bao F, Wan P, Xiao L, Wang X, Xiao W, Decker EL, van Gessel N, Renault H, Wiedemann G, Horst NA, Haas FB, Wilhelmsson PKI, Ullrich KK, Neumann E, Lv B, Liang C, Du H, Lu H, Gao Q, Cheng Z, You H, Xin P, Chu J, Huang CH, Liu Y, Dong S, Zhang L, Chen F, Deng L, Duan F, Zhao W, Li K, Li Z, Li X, Cui H, Zhang YE, Ma C, Zhu R, Jia Y, Wang M, Hasebe M, Fu J, Goffinet B, Ma H, Rensing SA, Reski R, He Y.
Cell. 2023 Aug 17;186(17):3558-3576.e17.
Boundaries and integration between microbiota, the nervous system, and immunity.
Macpherson AJ, Pachnis V, Prinz M.
Immunity. 2023 Aug 8;56(8):1712-1726
TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.
Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR.
Neuron. 2023 Jul 28:S0896-6273(23)00512-3.
Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells.
Winkler F, Hipp AV, Ramirez C, Martin B, Villa M, Neuwirt E, Gorka O, Aerssens J, Johansson SE, Rana N, Llewellyn-Lacey S, Price DA, Panning M, Groß O, Pearce EL, Hermann CM, Schumann K, Hannibal L, Neumann-Haefelin C, Boettler T, Knolle P, Hofmann M, Wohlleber D, Thimme R, Bengsch B.
Gut . 2023 Oct;72(10):1971-1984.
Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation-Immune signature correlates with response.
Apostolova P, Kreutmair S, Toffalori C, Punta M, Unger S, Burk AC, Wehr C, Maas-Bauer K, Melchinger W, Haring E, Hoefflin R, Shoumariyeh K, Hupfer V, Lauer EM, Duquesne S, Lowinus T, Gonzalo Núñez N, Alberti C, da Costa Pereira S, Merten CH, Power L, Weiss M, Böke C, Pfeifer D, Marks R, Bertz H, Wäsch R, Ihorst G, Gentner B, Duyster J, Boerries M, Andrieux G, Finke J, Becher B, Vago L, Zeiser R.
Br J Haematol. 2023 Oct;203(2):264-281.
cGAS-STING drives ageing-related inflammation and neurodegeneration.
Gulen MF, Samson N, Keller A, Schwabenland M, Liu C, Glück S, Thacker VV, Favre L, Mangeat B, Kroese LJ, Krimpenfort P, Prinz M, Ablasser A.
Nature. 2023 Aug;620(7973):374-380.
Central role of Tim17 in mitochondrial presequence protein translocation.
Fielden LF, Busch JD, Merkt SG, Ganesan I, Steiert C, Hasselblatt HB, Busto JV, Wirth C, Zufall N, Jungbluth S, Noll K, Dung JM, Butenko L, von der Malsburg K, Koch HG, Hunte C, van der Laan M, Wiedemann N.
Nature. 2023 Sep;621(7979):627-634.
Aha1 regulates Hsp90’s conformation and function in a stoichiometry-dependent way.
Mondol T, Silbermann LM, Schimpf J, Vollmar L, Hermann B, Tych KK, Hugel T.
Biophys J. 2023 Sep 5;122(17):3458-3468.
Assigning the Absolute Configuration of Inositol Poly- and Pyrophosphates by NMR Using a Single Chiral Solvating Agent.
Ritter K, Jork N, Unmüßig AS, Köhn M, Jessen HJ.
Biomolecules. 2023 Jul 19;13(7):1150.
A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells.
Tomisch J, Busse V, Rosato F, Makshakova ON, Salavei P, Kittel AS, Gillon E, Lataster L, Imberty A, Meléndez AV, Römer W.
Cells. 2023 Jul 20;12(14):1896.
How myeloid cells shape experimental autoimmune encephalomyelitis: At the crossroads of outside-in immunity.
Diebold M, Fehrenbacher L, Frosch M, Prinz M.
Eur J Immunol. 2023 Jul 28:e2250234.
MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas.
Sigaud R, Albert TK, Hess C, Hielscher T, Winkler N, Kocher D, Walter C, Münter D, Selt F, Usta D, Ecker J, Brentrup A, Hasselblatt M, Thomas C, Varghese J, Capper D, Thomale UW, Hernáiz Driever P, Simon M, Horn S, Herz NA, Koch A, Sahm F, Hamelmann S, Faria-Andrade A, Jabado N, Schuhmann MU, Schouten-van Meeteren AYN, Hoving E, Brummer T, van Tilburg CM, Pfister SM, Witt O, Jones DTW, Kerl K, Milde T.
Nat Commun. 2023 Jul 27;14(1):4533.
Dynamic fine-tuning of CAR-T cell therapy.
Trehin PVM, Muñoz-Guamuro G, Weber W.
Mol Ther Oncolytics. 2023 Jun 29;30:14-15.
Chimeric antigen receptor T cells for acute myeloid leukemia.
Fetsch V, Zeiser R.
Eur J Haematol. 2023 Jul 16. doi: 10.1111/ejh.14047. Online ahead of print.
Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans.
Xu F, Li R, von Gromoff ED, Drepper F, Knapp B, Warscheid B, Baumeister R, Qi W.
Nat Commun. 2023 Jul 13;14(1):4176.
Of tenants and nomads: The faces of memory T cells.
Schlaak AE, Bengsch B.
Immunity. 2023 Jul 11;56(7):1439-1442.
Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3.
Becker F, Fuchs S, Refisch L, Drepper F, Bildl W, Schulte U, Liang S, Heinicke JI, Hansen SC, Kreutz C, Warscheid B, Fakler B, Mymrikov EV, Hunte C.
Elife. 2023 Jul 12;12:e83868.
γ-2 and GSG1L bind with comparable affinities to the tetrameric GluA1 core.
Yu C, Runge HFP, Mukhopadhyay A, Zolles G, Ulbrich MH.
Cell Mol Biol Lett. 2023 Jul 10;28(1):54.
Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to Cold.
Wu G, Baumeister R, Heimbucher T.
Cells. 2023 May 10;12(10):1353
Real-time monitoring of cell surface protein arrival with split luciferases.
Fischer AAM, Schatz L, Baaske J, Römer W, Weber W, Thuenauer R.
Traffic. 2023 Oct;24(10):453-462.
Isolation and profiling of viable tumor cells from human ex vivo glioblastoma cultures through single-cell transcriptomics.
Zhang J, Straehle J, Joseph K, Neidert N, Behringer S, Göldner J, Vlachos A, Prinz M, Fung C, Beck J, Schnell O, Heiland DH, Ravi VM.
STAR Protoc. 2023 Jul 1;4(3):102383
Immune checkpoint inhibitor induced neurocognitive deficits in patients.
Zeiser R, Prinz M.
Brain Commun. 2023 Jun 20;5(3):fcad186.
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.
Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich R, Nave KA, Stassart RM.
Nat Neurosci. 2023 Jul;26(7):1218-1228.
Editorial: Current concepts of cellular and biological drugs to modulate regulatory T cell activity in the clinic, volume II.
Wenger V, Zeiser R.
Front Immunol. 2023 Jun 13;14:1221904.
CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease.
Frosch M, Amann L, Prinz M.
Nat Commun. 2023 Jun 26;14(1):3753
Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation.
Wang H, Zaiser F, Eckert P, Ruf J, Kayser N, Veenstra AC, Müller M, Haas R, Walz G, Yakulov TA.
Biochem Biophys Res Commun. 2023 Jun 19;673:9-15.
Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase.
Rohrer L, Spohr C, Beha C, Griffin R, Braun S, Halbach S, Brummer T.
Cell Commun Signal. 2023 Jun 14;21(1):136.
Dedicated macrophages organize and maintain the enteric nervous system.
Viola MF, Chavero-Pieres M, Modave E, Delfini M, Stakenborg N, Estévez MC, Fabre N, Appeltans I, Martens T, Vandereyken K, Theobald H, Van Herck J, Petry P, Verheijden S, De Schepper S, Sifrim A, Liu Z, Ginhoux F, Azhar M, Schlitzer A, Matteoli G, Kierdorf K, Prinz M, Berghe PV, Voet T, Boeckxstaens G.
Nature. 2023 Jun;618(7966):818-826.
Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics.
Uzun S, Zinner C, Beenen AC, Alborelli I, Bartoszek EM, Yeung J, Calgua B, Reinscheid M, Bonsert P, Stalder AK, Haslbauer J, Vosbeck J, Mazzucchelli L, Hoffmann T, Terracciano LM, Hutter G, Manz M, Panne I, Böttler T, Hofmann M, Bengsch B, Heim MH, Bernsmeier C, Jiang S, Tzankov A, Beretta-Piccoli BT, Matter MS.
J Hepatol. 2023 Jun 6:S0168-8278(23)00348-3.
NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems.
Molinari PE, Krapp AR, Weiner A, Beyer HM, Kondadi AK, Blomeier T, López M, Bustos-Sanmamed P, Tevere E, Weber W, Reichert AS, Calcaterra NB, Beller M, Carrillo N, Zurbriggen MD.
Nat Commun. 2023 Jun 6;14(1):3277.
Genetic code expansion in E. coli enables production of a functional ‘ready-to-click’ T cell receptor-specific scFv.
Pasupuleti R, Rosato F, Kolanovic D, Makshakova ON, Römer W, Wiltschi B.
N Biotechnol. 2023 Sep 25;76:127-137
Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration.
Jaiswal J, Egert J, Engesser R, Peyrotón AA, Nogay L, Weichselberger V, Crucianelli C, Grass I, Kreutz C, Timmer J, Classen AK.
PLoS Biol. 2023 May 30;21(5):e3001665
The enteric nervous system relays psychological stress to intestinal inflammation.
Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA.
Cell. 2023 Jun 22;186(13):2823-2838.e20.
Long-Distance Electrical and Calcium Signals Evoked by Hydrogen Peroxide in Physcomitrella.
Koselski M, Hoernstein SNW, Wasko P, Reski R, Trebacz K.
Plant Cell Physiol. 2023 May 26:pcad051.
Revealing the small proteome of Haloferax volcanii by combining ribosome profiling and small-protein optimized mass spectrometry.
Hadjeras L, Bartel J, Maier LK, Maaß S, Vogel V, Svensson SL, Eggenhofer F, Gelhausen R, Müller T, Alkhnbashi OS, Backofen R, Becher D, Sharma CM, Marchfelder A.
Microlife. 2023 Jan 16;4:uqad001.
Phytochrome higher order mutants reveal a complex set of light responses in the moss Physcomitrium patens.
Yuan J, Xu T, Hiltbrunner A.
New Phytol. 2023 Aug;239(3):1035-1050.
Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma.
Mohl DA, Lagies S, Zodel K, Zumkeller M, Peighambari A, Ganner A, Plattner DA, Neumann-Haefelin E, Adlesic M, Frew IJ, Kammerer B.
Cells. 2023 Apr 7;12(8):1102.
Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment.
Schwabenland M, Mossad O, Sievert A, Peres AG, Ringel E, Baasch S, Kolter J, Cascone G, Dokalis N, Vlachos A, Ruzsics Z, Henneke P, Prinz M, Blank T.
Nat Commun. 2023 May 11;14(1):2721.
Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model.
Langhammer M, Schöpf J, Jaquet T, Horn K, Angel M, Spohr C, Christen D, Uhl FM, Maié T, Jacobi H, Feyerabend TB, Huber J, Panning M, Sitaru C, Costa I, Zeiser R, Aumann K, Becker H, Braunschweig T, Koschmieder S, Shoumariyeh K, Huber M, Schemionek-Reinders M, Brummer T, Halbach S.
Leukemia. 2023 Jul;37(7):1474-1484.
Clickable Shiga Toxin B Subunit for Drug Delivery in Cancer Therapy.
Danielewicz N, Rosato F, Tomisch J, Gräber J, Wiltschi B, Striedner G, Römer W, Mairhofer J.
ACS Omega. 2023 Apr 18;8(17):15406-15421
Breast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands.
Raute K, Strietz J, Parigiani MA, Andrieux G, Thomas OS, Kistner KM, Zintchenko M, Aichele P, Hofmann M, Zhou H, Weber W, Boerries M, Swamy M, Maurer J, Minguet S.
Cancer Immunol Res. 2023 Jun 2;11(6):810-829.
Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression.
Irie T, Matsuda-Ito K, Matsuda T, Masuda T, Prinz M, Isobe N, Nakashima K.
Genes Cells. 2023 Jul;28(7):526-534.
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, et al.
Cell Death Differ. 2023 May;30(5):1097-1154.
An accessible infrastructure for artificial intelligence using a Docker-based JupyterLab in Galaxy.
Kumar A, Cuccuru G, Grüning B, Backofen R.
Gigascience. 2022 Dec 28;12:giad028.
Engineering a material-genetic interface as safety switch for embedded therapeutic cells.
Jerez-Longres C, Gómez-Matos M, Becker J, Hörner M, Wieland FG, Timmer J, Weber W.
Biomater Adv. 2023 Jul;150:213422.
MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production.
Langenbach M, Giesler S, Richtsfeld S, da Costa-Pereira S, Rindlisbacher L, Wertheimer T, Braun LM, Andrieux G, Duquesne S, Pfeifer D, Woessner NM, Menssen HD, Taromi S, Duyster J, Boerries M, Brummer T, Blazar BR, Minguet S, Turko P, Levesque MP, Becher B, Zeiser R.
Mol Cancer Res. 2023 Apr 18:MCR-22-0898.
Requirements for mammalian promoters to decode transcription factor dynamics.
Antwi EB, Marrakchi Y, Çiçek Ö, Brox T, Di Ventura B.
Nucleic Acids Res. 2023 May 22;51(9):4674-4690.
Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin.
Lewis AM, Willard DJ, H Manesh MJ, Sivabalasarma S, Albers SV, Kelly RM.
mBio. 2023 Apr 25;14(2):e0005323.
COLD REGULATED GENE 27 and 28 Antagonize the Transcriptional Activity of the RVE8/LNK1/LNK2 Circadian Complex.
Sorkin ML, Tzeng SC, King S, Romanowski A, Kahle N, Bindbeutel R, Hiltbrunner A, Yanovsky MJ, Evans BS, Nusinow DA.
Plant Physiol. 2023 Jul 3;192(3):2436-2456.
Membrane permeabilization can be crucially biased by a fusogenic lipid composition – leaky fusion caused by antimicrobial peptides in model membranes.
Beck K, Nandy J, Hoernke M.
Soft Matter. 2023 Apr 26;19(16):2919-2931.
A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone.
Sigloch C, Spitz D, Driever W.
Development. 2023 Apr 1;150(7):dev201301.
Impact of body mass index in patients receiving atezolizumab plus bevacizumab for hepatocellular carcinoma.
Vithayathil M, D’Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Zanuso V, Pressiani T, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ, Sharma R.
Hepatol Int. 2023 Aug;17(4):904-914.
A Guide to Your Desired Lipid-Asymmetric Vesicles.
Krompers M, Heerklotz H.
Membranes (Basel). 2023 Feb 23;13(3):267.
SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC.
Ganner A, Philipp A, Lagies S, Wingendorf L, Wang L, Pilz F, Welte T, Grand K, Lienkamp SS, Klein M, Kammerer B, Frew IJ, Walz G, Neumann-Haefelin E.
Cells. 2023 Mar 8;12(6):835.
Microglial Cytokines Mediate Plasticity Induced by 10 Hz Repetitive Magnetic Stimulation.
Eichler A, Kleidonas D, Turi Z, Fliegauf M, Kirsch M, Pfeifer D, Masuda T, Prinz M, Lenz M, Vlachos A.
J Neurosci. 2023 Mar 27:JN-RM-2226-22.
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins.
Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T.
Nat Methods. 2023 Apr;20(4):523-535. .
Pathophysiology of gastrointestinal acute graft-versus-host disease and the potential role of glucagon-like peptide 2.
Zeiser R, Chen YB, Youssef NN, Ayuk F.
Br J Haematol. 2023 May;201(4):620-627.
Opto-APC: Engineering of cells that display phytochrome B on their surface for optogenetic studies of cell-cell interactions.
Russ M, Ehret AK, Hörner M, Peschkov D, Bohnert R, Idstein V, Minguet S, Weber W, Lillemeier BF, Yousefi OS, Schamel WW.
Front Mol Biosci. 2023 Feb 20;10:1143274.
Mitochondrial protein transport: Versatility of translocases and mechanisms.
Busch JD, Fielden LF, Pfanner N, Wiedemann N.
Mol Cell. 2023 Mar 16;83(6):890-910.
AZG1 is a cytokinin transporter that interacts with auxin transporter PIN1 and regulates the root stress response.
Tessi TM, Maurino VG, Shahriari M, Meissner E, Novak O, Pasternak T, Schumacher BS, Ditengou F, Li Z, Duerr J, Flubacher NS, Nautscher M, Williams A, Kazimierczak Z, Strnad M, Thumfart JO, Palme K, Desimone M, Teale WD.
New Phytol. 2023 Jun;238(5):1924-1941
Mitochondrial Metabolomics of Sym1-Depleted Yeast Cells Revealed Them to Be Lysine Auxotroph.
Lagies S, Pan D, Mohl DA, Plattner DA, Gentle IE, Kammerer B. Cells 2023 Feb 22;12(5):692.
Droplet-based forward genetic screening of astrocyte-microglia cross-talk.
Wheeler MA, Clark IC, Lee HG, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, Rothhammer V, Yano H, Illouz T, Zandee SEJ, Daniel C, Artis D, Prinz M, Abate AR, Kuchroo VK, Antel JP, Prat A, Quintana FJ.
Science. 2023 Mar 10;379(6636):1023-1030.
Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation.
Ivan DC, Berve KC, Walthert S, Monaco G, Borst K, Bouillet E, Ferreira F, Lee H, Steudler J, Buch T, Prinz M, Engelhardt B, Locatelli G.
Acta Neuropathol Commun. 2023 Mar 8;11(1):35.
TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis.
Khan D, Bedner P, Müller J, Lülsberg F, Henning L, Prinz M, Steinhäuser C, Muhammad S.
Mol Neurobiol. 2023 Jun;60(6):3413-3422.
Role of mitochondrial outer membrane permeabilization during bacterial infection.
Waguia Kontchou C, Häcker G.
Int Rev Cell Mol Biol. 2023;374:83-127.
Pseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration.
Sponsel J, Guo Y, Hamzam L, Lavanant AC, Pérez-Riverón A, Partiot E, Muller Q, Rottura J, Gaudin R, Hauck D, Titz A, Flacher V, Römer W, Mueller CG.
EMBO Rep. 2023 Mar 1:e55971.
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
Pavic K, Gupta N, Omella JD, Derua R, Aakula A, Huhtaniemi R, Määttä JA, Höfflin N, Okkeri J, Wang Z, Kauko O, Varjus R, Honkanen H, Abankwa D, Köhn M, Hytönen VP, Xu W, Nilsson J, Page R, Janssens V, Leitner A, Westermarck J.
Nat Commun. 2023 Feb 28;14(1):1143.
Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions.
Ruiz-Molina N, Parsons J, Decker EL, Reski R.
Comput Struct Biotechnol J. 2023 Feb 3;21:1473-1486.
mRNA targeting eliminates the need for the signal recognition particle during membrane protein insertion in bacteria.
Sarmah P, Shang W, Origi A, Licheva M, Kraft C, Ulbrich M, Lichtenberg E, Wilde A, Koch HG.
Cell Rep. 2023 Mar 28;42(3):112140.
Tailoring the Lamellarity of Liposomes Prepared by Dual Centrifugation.
Koehler JK, Gedda L, Wurster L, Schnur J, Edwards K, Heerklotz H, Massing U.
Pharmaceutics. 2023 Feb 20;15(2):706.
Enzymatic Glyco-Modification of Synthetic Membrane Systems.
Jabeguero D, Siukstaite L, Wang C, Mitrovic A, Pérez S, Makshakova O, Richter RP, Römer W, Breton C. Biomolecules. 2023 Feb 9;13(2):335.
Isolation and Quality Control of Yeast Mitochondria.
Taskin AA, Moretti DN, Vögtle FN, Meisinger C.
Methods Mol Biol. 2023;2615:41-55
Boosting compromised SARS-CoV-2-specific immunity with mRNA vaccination in liver transplant recipients.
Luxenburger H, Reeg DB, Lang-Meli J, Reinscheid M, Eisner M, Bettinger D, Oberhardt V, Salimi Alizei E, Wild K, Graeser A, Karl V, Sagar, Emmerich F, Klein F, Panning M, Huzly D, Bengsch B, Boettler T, Elling R, Thimme R, Hofmann M, Neumann-Haefelin C.
J Hepatol. 2023 Feb 18:S0168-8278(23)00095-8.
Complex electrostatic effects on the selectivity of membrane-permeabilizing cyclic lipopeptides.
Steigenberger J, Verleysen Y, Geudens N, Madder A, Martins JC, Heerklotz H.
Biophys J. 2023 Mar 21;122(6):950-963.
Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas.
Lopez C, Schleussner N, Bernhart SH, Kleinheinz K, Sungalee S, Sczakiel HL, Kretzmer H, Toprak UH, Glaser S, Wagener R, Ammerpohl O, Bens S, Giefing M, Sanchez JCG, Apic G, Hubschmann D, Janz M, Kreuz M, Mottok A, Muller JM, Seufert J, Hoffmann S, Korbel JO, Russell RB, Schule R, Trumper L, Klapper W, Radlwimmer B, Lichter P, Kuppers R, Schlesner M, Mathas S, Siebert R.
Haematologica. 2023 Feb 1;108(2):543-554.
Phytochromes and flowering: legumes do it another way.
Yuan J, Ott T, Hiltbrunner A.
Trends Plant Sci. 2023 Apr;28(4):379-381.
Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes.
Fricke AL, Mühlhäuser WWD, Reimann L, Zimmermann JP, Reichenbach C, Knapp B, Peikert CD, Heberle AM, Faessler E, Schäuble S, Hahn U, Thedieck K, Radziwill G, Warscheid B.
J Proteome Res. 2023 Mar 3;22(3):768-789.
Mechanisms of myeloid cell entry to the healthy and diseased central nervous system.
Amann L, Masuda T, Prinz M.
Nat Immunol. 2023 Mar;24(3):393-407.
CD206+ macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia.
Hattori Y, Kato D, Murayama F, Koike S, Asai H, Yamasaki A, Naito Y, Kawaguchi A, Konishi H, Prinz M, Masuda T, Wake H, Miyata T.
Cell Rep. 2023 Feb 7;42(2):112092.
miR394 enhances WUSCHEL-induced somatic embryogenesis in Arabidopsis thaliana.
Lu L, Holt A, Chen X, Liu Y, Knauer S, Tucker EJ, Sarkar AK, Hao Z, Roodbarkelari F, Shi J, Chen J, Laux T.
New Phytol. 2023 May;238(3):1059-1072.
Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation.
Caligaris M, Nicastro R, Hu Z, Tripodi F, Hummel JE, Pillet B, Deprez MA, Winderickx J, Rospert S, Coccetti P, Dengjel J, De Virgilio C.
Elife. 2023 Feb 7;12:e84319.
Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells.
Prasad D, Illek K, Fischer F, Holstein K, Classen AK.
Elife. 2023 Feb 6;12:e80809.
Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function.
Edwards-Hicks J, Apostolova P, Buescher JM, Maib H, Stanczak MA, Corrado M, Klein Geltink RI, Maccari ME, Villa M, Carrizo GE, Sanin DE, Baixauli F, Kelly B, Curtis JD, Haessler F, Patterson A, Field CS, Caputa G, Kyle RL, Soballa M, Cha M, Paul H, Martin J, Grzes KM, Flachsmann L, Mitterer M, Zhao L, Winkler F, Rafei-Shamsabadi DA, Meiss F, Bengsch B, Zeiser R, Puleston DJ, O’Sullivan D, Pearce EJ, Pearce EL.
Nat Immunol. 2023 Mar;24(3):516-530.
Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia.
Wallach T, Raden M, Hinkelmann L, Brehm M, Rabsch D, Weidling H, Krüger C, Kettenmann H, Backofen R, Lehnardt S.
Front Immunol. 2023 Jan 13;13:1066456
Role of reactive oxygen species in the modulation of auxin flux and root development in Arabidopsis thaliana.
Pasternak T, Palme K, Pérez-Pérez JM.
Plant J. 2023 Apr;114(1):83-95.
Mitochondrial complexome reveals quality-control pathways of protein import.
Schulte U, den Brave F, Haupt A, Gupta A, Song J, Müller CS, Engelke J, Mishra S, Mårtensson C, Ellenrieder L, Priesnitz C, Straub SP, Doan KN, Kulawiak B, Bildl W, Rampelt H, Wiedemann N, Pfanner N, Fakler B, Becker T.
Nature. 2023 Feb;614(7946):153-159.
Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS.
Pallett LJ, Swadling L, Diniz M, Maini AA, Schwabenland M, Gasull AD, Davies J, Kucykowicz S, Skelton JK, Thomas N, Schmidt NM, Amin OE, Gill US, Stegmann KA, Burton AR, Stephenson E, Reynolds G, Whelan M, Sanchez J, de Maeyer R, Thakker C, Suveizdyte K, Uddin I, Ortega-Prieto AM, Grant C, Froghi F, Fusai G, Lens S, Pérez-Del-Pulgar S, Al-Akkad W, Mazza G, Noursadeghi M, Akbar A, Kennedy PTF, Davidson BR, Prinz M, Chain BM, Haniffa M, Gilroy DW, Dorner M, Bengsch B, Schurich A, Maini MK.
Nature. 2023 Feb;614(7947):334-342.
Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers.
Xu M, Antonova M, Salavei P, Illek K, Meléndez AV, Omidvar R, Thuenauer R, Makshakova O, Römer W.
Pharmaceutics. 2023 Jan 9;15(1):225.
TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional Regulation.
Antón-García P, Haghighi EB, Rose K, Vladimirov G, Boerries M, Hecht A.
Cancers (Basel). 2023 Jan 16;15(2):558.
Stabilization of membrane topologies by proteinaceous remorin scaffolds.
Su C, Rodriguez-Franco M, Lace B, Nebel N, Hernandez-Reyes C, Liang P, Schulze E, Mymrikov EV, Gross NM, Knerr J, Wang H, Siukstaite L, Keller J, Libourel C, Fischer AAM, Gabor KE, Mark E, Popp C, Hunte C, Weber W, Wendler P, Stanislas T, Delaux PM, Einsle O, Grosse R, Römer W, Ott T.
Nat Commun. 2023 Jan 19;14(1):323.
A deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in ageing in Physcomitrella and Arabidopsis.
Hoernstein SNW, Özdemir B, van Gessel N, Miniera AA, Rogalla von Bieberstein B, Nilges L, Schweikert Farinha J, Komoll R, Glauz S, Weckerle T, Scherzinger F, Rodriguez-Franco M, Müller-Schüssele SJ, Reski R.
Commun Biol. 2023 Jan 17;6(1):61.
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis.
Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O
Sci Signal. 2023 Jan 17;16(768):eabh1083.
SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.
Griewahn L, Müller-Foxworth M, Peintner L, Wissler M, Weiss M, Brauns-Schubert P, Massoumi R, Borner C, Groß O, Yabal M, Charvet C, Maurer U.
Cell Rep. 2023 Jan 31;42(1):111961.
Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development.
Chung C, Yang X, Bae T, Vong KI, Mittal S, Donkels C, Westley Phillips H, Li Z, Marsh APL, Breuss MW, Ball LL, Garcia CAB, George RD, Gu J, Xu M, Barrows C, James KN, Stanley V, Nidhiry AS, Khoury S, Howe G, Riley E, Xu X, Copeland B, Wang Y, Kim SH, Kang HC, Schulze-Bonhage A, Haas CA, Urbach H, Prinz M, Limbrick DD Jr, Gurnett CA, Smyth MD, Sattar S, Nespeca M, Gonda DD, Imai K, Takahashi Y, Chen HH, Tsai JW, Conti V, Guerrini R, Devinsky O, Silva WA Jr, Machado HR, Mathern GW, Abyzov A, Baldassari S, Baulac S; Focal Cortical Dysplasia Neurogenetics Consortium; Brain Somatic Mosaicism Network; Gleeson JG.
Nat Genet. 2023 Feb;55(2):209-220.
The Ramifications of synthetic biology.
Weber W, Fussenegger M.
Curr Opin Chem Biol. 2023 Apr;73:102258.
Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines.
Fröhlich J, Rose K, Hecht A.
Sci Rep. 2023 Jan 6;13(1):287.
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.
Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE.
Nat Immunol. 2023 Feb;24(2):295-308.
A multipoint guidance mechanism for β-barrel folding on the SAM complex.
Takeda H, Busto JV, Lindau C, Tsutsumi A, Tomii K, Imai K, Yamamori Y, Hirokawa T, Motono C, Ganesan I, Wenz LS, Becker T, Kikkawa M, Pfanner N, Wiedemann N, Endo T.
Nat Struct Mol Biol. 2023 Feb;30(2):176-187.
Thermal fluctuations of the lipid membrane determine particle uptake into Giant Unilamellar Vesicles.
Ayala YA, Omidvar R, Römer W, Rohrbach A.
Nat Commun. 2023 Jan 4;14(1):65.
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters.
Saltukoglu D, Özdemir B, Holtmannspötter M, Reski R, Piehler J, Kurre R, Reth M.
EMBO J. 2023 Feb 15;42(4):e112030.
Circulating Tumor DNA Profiling for Detection, Risk Stratification, and Classification of Brain Lymphomas.
Mutter JA, Alig SK, Esfahani MS, Lauer EM, Mitschke J, Kurtz DM, Kühn J, Bleul S, Olsen M, Liu CL, Jin MC, Macaulay CW, Neidert N, Volk T, Eisenblaetter M, Rauer S, Heiland DH, Finke J, Duyster J, Wehrle J, Prinz M, Illerhaus G, Reinacher PC, Schorb E, Diehn M, Alizadeh AA, Scherer F.
J Clin Oncol. 2023 Mar 20;41(9):1684-1694.
Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma.
Kendre G, Murugesan K, Brummer T, Segatto O, Saborowski A, Vogel A.
J Hepatol. 2023 Mar;78(3):614-626.
Microglia regulate central nervous system myelin growth and integrity.
McNamara NB, Munro DAD, Bestard-Cuche N, Uyeda A, Bogie JFJ, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJA, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE.
Nature. 2023 Jan;613(7942):120-129.
STAT3 signaling induced by the IL-6 family of cytokines modulates angiogenesis.
Rapp J, Jung M, Klar RFU, Wolf J, Arnold J, Gorka O, Groß O, Lange C, Agostini H, Schlunck G, Bucher F.
J Cell Sci. 2023 Jan 1;136(1):jcs260182.
Objection non-responsive! How maternal immune activation in pregnancy weakens subsequent microglial immune response.
Blank T, Prinz M.
Cell Res. 2023 Mar;33(3):193-194.
Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors.
Zahorska E, Rosato F, Stober K, Kuhaudomlarp S, Meiers J, Hauck D, Reith D, Gillon E, Rox K, Imberty A, Römer W, Titz A.
Angew Chem Int Ed Engl. 2023 Feb 6;62(7):e202215535.
IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation. Locatelli G, Marques-Ferreira F, Katsoulas A, Kalaitzaki V, Krueger M, Ingold-Heppner B, Walthert S, Sankowski R, Prazeres da Costa O, Dolga A, Huber M, Gold M, Culmsee C, Waisman A, Bechmann I, Milchevskaya V, Prinz M, Tresch A, Becher B, Buch T. Glia. 2023 Mar;71(3):616-632. doi: 10.1002/glia.24299.
Sub-lethal signals in the mitochondrial apoptosis apparatus: pernicious by-product or physiological event?
Häcker G, Haimovici A.
Cell Death Differ. 2023 Feb;30(2):250-257.

Electron cryo-microscopy reveals the structure of the archaeal thread filament.
Gaines MC, Isupov MN, Sivabalasarma S, Haque RU, McLaren M, Mollat CL, Tripp P, Neuhaus A, Gold VAM, Albers SV, Daum B.
Nat Commun. 2022 Dec 1;13(1):7411.
Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein 1 (LRP1) as crucial cellular receptor.
Schoellkopf J, Mueller T, Hippchen L, Mueller T, Reuten R, Backofen R, Orth J, Schmidt G.
PLoS Pathog. 2022 Dec 14;18(12):e1010781.
Leaky membrane fusion: an ambivalent effect induced by antimicrobial polycations.
Shi S, Fan H, Hoernke M.
Nanoscale Adv. 2022 Oct 27;4(23):5109-5122
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
Bussi C, Heunis T, Pellegrino E, Bernard EM, Bah N, Dos Santos MS, Santucci P, Aylan B, Rodgers A, Fearns A, Mitschke J, Moore C, MacRae JI, Greco M, Reinheckel T, Trost M, Gutierrez MG.
Nat Commun. 2022 Nov 28;13(1):7338.
Establishment and optimization of a new model organism to study early land plant evolution: Germination, cultivation and oospore variation of Chara braunii Gmelin, 1826.
Holzhausen A, Stingl N, Rieth S, Kühn C, Schubert H, Rensing SA.
Front Plant Sci. 2022 Nov 10;13:987741.
Mesenchymal-endothelial nexus in breast cancer spheroids induces vasculogenesis and local invasion in a CAM model.
Li A, Muenst S, Hoffman J, Starck L, Sarem M, Fischer A, Hutter G, Shastri VP.
Commun Biol. 2022 Nov 27;5(1):1303.
Extending Janus lectins architecture: Characterization and application to protocells.
Notova S, Siukstaite L, Rosato F, Vena F, Audfray A, Bovin N, Landemarre L, Römer W, Imberty A.
Comput Struct Biotechnol J. 2022 Nov 7;20:6108-6119.
Membrane Fusion Mediated by Non-covalent Binding of Re-engineered Cholera Toxin Assemblies to Glycolipids.
Wehrum S, Siukstaite L, Williamson DJ, Branson TR, Sych T, Madl J, Wildsmith GC, Dai W, Kempmann E, Ross JF, Thomsen M, Webb ME, Römer W, Turnbull WB.
ACS Synth Biol. 2022 Dec 16;11(12):3929-3938.
Novel insights into the origin and development of CNS macrophage subsets.
Masuda T, Amann L, Prinz M.
Clin Transl Med. 2022 Nov;12(11):e1096.
Microglia states and nomenclature: A field at its crossroads.
Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T.
Neuron. 2022 Nov 2;110(21):3458-3483.
Chimeric 3D gastruloids – a versatile tool for studies of mammalian peri-gastrulation development.
Wehmeyer AE, Schüle KM, Conrad A, Schröder CM, Probst S, Arnold SJ.
Development. 2022 Nov 15;149(22):dev200812.
Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth.
Hölzen L, Syré K, Mitschke J, Brummer T, Miething C, Reinheckel T.
Front Oncol. 2022 Oct 12;12:960109.
A slit-diaphragm-associated protein network for dynamic control of renal filtration.
Kocylowski MK, Aypek H, Bildl W, Helmstädter M, Trachte P, Dumoulin B, Wittösch S, Kühne L, Aukschun U, Teetzen C, Kretz O, Gaal B, Kulik A, Antignac C, Mollet G, Köttgen A, Göcmen B, Schwenk J, Schulte U, Huber TB, Fakler B, Grahammer F.
Nat Commun. 2022 Oct 28;13(1):6446.
Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.
Kollewe A, Schwarz Y, Oleinikov K, Raza A, Haupt A, Wartenberg P, Wyatt A, Boehm U, Ectors F, Bildl W, Zolles G, Schulte U, Bruns D, Flockerzi V, Fakler B.
Neuron. 2022 Dec 21;110(24):4162-4175.e7.
Structural principles of B cell antigen receptor assembly.
Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H.
Nature. 2022 Dec;612(7938):156-161.
Emerging insights into serine/threonine-specific phosphoprotein phosphatase function and selectivity.
Kokot T, Köhn M.
J Cell Sci. 2022 Oct 1;135(19):jcs259618.
Induction of embryogenic development in haploid microspore stem cells in droplet-based microfluidics.
Richter F, Chen M, Schaub P, Wüst F, Zhang D, Schneider S, Groß GA, Mäder P, Dovzhenko O, Palme K, Köhler JM, Cao J.
Lab Chip. 2022 Nov 8;22(22):4292-4305.
Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer.
Lüchtenborg AM, Metzger P, Cosenza Contreras M, Oria V, Biniossek ML, Lindner F, Fröhlich K, Malyi A, Erbes T, Gensch N, Maurer J, Thomsen A, Boerries M, Schilling O, Werner M, Bronsert P.
Breast Cancer Res. 2022 Oct 3;24(1):65.
Analysis of Slow-Cycling Variants of the Light-Inducible Nuclear Protein Export System LEXY in Mammalian Cells.
Forlani G, Antwi EB, Weis D, Öztürk MA, Queck BAW, Brecht D, Di Ventura B.
ACS Synth Biol. 2022 Oct 21;11(10):3529-3533.
Quality assessment in light microscopy for routine use through simple tools and robust metrics.
Faklaris O, Bancel-Vallée L, Dauphin A, Monterroso B, Frère P, Geny D, Manoliu T, de Rossi S, Cordelières FP, Schapman D, Nitschke R, Cau J, Guilbert T.
J Cell Biol. 2022 Nov 7;221(11):e202107093
The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity.
Grzejda D, Mach J, Schweizer JA, Hummel B, Rezansoff AM, Eggenhofer F, Panhale A, Lalioti ME, Cabezas Wallscheid N, Backofen R, Felsenberg J, Hilgers V.
Sci Adv. 2022 Sep 30;8(39):eabo5578.
Regulation of microglial physiology by the microbiota.
Cook J, Prinz M.
Gut Microbes. 2022 Jan-Dec;14(1):2125739.
Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis.
Weichselberger V, Dondl P, Classen AK.
Nat Commun. 2022 Oct 26;13(1):6377.
Septin barriers protect mammalian host cells against Pseudomonas aeruginosa invasion.
Aigal S, Omidvar R, Stober K, Ziegelbauer J, Eierhoff T, Schampera JN, Römer W, Schwan C.
Cell Rep. 2022 Oct 18;41(3):111510.
CRISPRtracrRNA: robust approach for CRISPR tracrRNA detection.
Mitrofanov A, Ziemann M, Alkhnbashi OS, Hess WR, Backofen R.
Bioinformatics. 2022 Sep 16;38(Suppl_2):ii42-ii48.
Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes.
Fischer S, Bürgi J, Gabay-Maskit S, Maier R, Mastalski T, Yifrach E, Obarska-Kosinska A, Rudowitz M, Erdmann R, Platta HW, Wilmanns M, Schuldiner M, Zalckvar E, Oeljeklaus S, Drepper F, Warscheid B.
Biol Chem. 2022 Sep 21;404(2-3):135-155.
ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma.
Ferrarese R, Izzo A, Andrieux G, Lagies S, Bartmuss JP, Masilamani AP, Wasilenko A, Osti D, Faletti S, Schulzki R, Yuan S, Kling E, Ribecco V, Heiland DH, Tholen S, Prinz M, Pelicci G, Kammerer B, Boerries M, Carro MS.
Life Sci Alliance. 2022 Nov 22;6(1):e202201400.
Multiplexed biosensor for point-of-care COVID-19 monitoring: CRISPR-powered unamplified RNA diagnostics and protein-based therapeutic drug management.
Johnston M, Ceren Ates H, Glatz RT, Mohsenin H, Schmachtenberg R, Göppert N, Huzly D, Urban GA, Weber W, Dincer C.
Mater Today (Kidlington). 2022 Dec;61:129-138.
Incidence and severity of immune-related hepatitis after dual checkpoint therapy is linked to younger age independent of herpes virus immunity.
Zhang Z, Rafei-Shamsabadi D, Lehr S, Buettner N, Diehl R, Huzly D, Pinato DJ, Thimme R, Meiss F, Bengsch B.
J Transl Med. 2022 Dec 12;20(1):582.
A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death.
Rosato F, Pasupuleti R, Tomisch J, Meléndez AV, Kolanovic D, Makshakova ON, Wiltschi B, Römer W.
J Transl Med. 2022 Dec 9;20(1):578.
Extending the Pseudo-Phase Model of Detergent-Lipid Dispersions by a Detergent-Binding Protein.
Vormittag LC, Heerklotz H.
Langmuir. 2022 Dec 20;38(50):15592-15603.
Toward 3D Bioprinting of Osseous Tissue of Predefined Shape Using Single-Matrix Cell-Bioink Constructs.
Gu Y, Pigeot S, Ahrens L, Tribukait-Riemenschneider F, Sarem M, Wolf F, García-García A, Barbero A, Martin I, Shastri VP.
Adv Healthc Mater. 2022 Dec 16:e2202550. Online ahead of print.
Membrane targeting with palmitoylated lysine added to PP1-disrupting peptide induces PP1-independent signaling.
Chojnacki JE, Scheinost L, Wang Y, Köhn M.
J Pept Sci. 2022 Dec 16:e3469. Online ahead of print.
Distinct signaling signatures drive compensatory proliferation via S-phase acceleration.
Crucianelli C, Jaiswal J, Vijayakumar Maya A, Nogay L, Cosolo A, Grass I, Classen AK.
PLoS Genet. 2022 Dec 15;18(12):e1010516.
Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling.
Rückert T, Andrieux G, Boerries M, Hanke-Müller K, Woessner NM, Doetsch S, Schell C, Aumann K, Kolter J, Schmitt-Graeff A, Schiff M, Braun LM, Haring E, Kissel S, Siranosian BA, Bhatt AS, Nordkild P, Wehkamp J, Jensen BAH, Minguet S, Duyster J, Zeiser R, Köhler N.
Sci Transl Med. 2022 Dec 21;14(676):eabp9675.
Exploring Uncharted Territory: Toward Metabolite Network Maps.
Dürr EM, Köhn M.
ACS Cent Sci. 2022 Dec 28;8(12):1576-1578.
Proteome-Wide Identification of RNA-Dependent Proteins in Lung Cancer Cells.
Rajagopal V, Loubal AS, Engel N, Wassmer E, Seiler J, Schilling O, Caudron-Herger M, Diederichs S.
Cancers (Basel). 2022 Dec 12;14(24):6109.
The effect of membrane thickness on the membrane permeabilizing activity of the cyclic lipopeptide tolaasin II.
Steigenberger J, Mergen C, De Roo V, Geudens N, Martins JC, Heerklotz H.
Front Mol Biosci. 2022 Dec 23;9:1064742.
The role of the different CD3γ domains in TCR expression and signaling.
Garcillán B, Megino RF, Herrero-Alonso M, Guardo AC, Perez-Flores V, Juraske C, Idstein V, Martin-Fernandez JM, Geisler C, Schamel WWA, Marin AV, Regueiro JR.
Front Immunol. 2022 Sep 2;13:978658.
A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories.
Götz M, Barth A, Bohr SS, Börner R, Chen J, Cordes T, Erie DA, Gebhardt C, Hadzic MCAS, Hamilton GL, Hatzakis NS, Hugel T, Kisley L, Lamb DC, de Lannoy C, Mahn C, Dunukara D, de Ridder D, Sanabria H, Schimpf J, Seidel CAM, Sigel RKO, Sletfjerding MB, Thomsen J, Vollmar L, Wanninger S, Weninger KR, Xu P, Schmid S.
Nat Commun. 2022 Sep 14;13(1):5402.
Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells.
Meléndez AV, Velasco Cárdenas RM, Lagies S, Strietz J, Siukstaite L, Thomas OS, Tomisch J, Weber W, Kammerer B, Römer W, Minguet S.
Cell Mol Life Sci. 2022 Sep 12;79(10):513.
The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3.
Notova S, Bonnardel F, Rosato F, Siukstaite L, Schwaiger J, Lim JH, Bovin N, Varrot A, Ogawa Y, Römer W, Lisacek F, Imberty A.
Commun Biol. 2022 Sep 12;5(1):954.
Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.
Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R, Félix R, Rodrigues T, Lucas SD, Groß O, Geiss-Friedlander R, Cravatt BF, Huber R, Kaiser M, Moreira R.
Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202210498.
A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling.
Schultz A, Schnurra M, El-Bizri A, Woessner NM, Hartmann S, Hartig R, Minguet S, Schraven B, Simeoni L.
Cells. 2022 Sep 1;11(17):2723.
Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
Zhuang M, Scholz A, Walz G, Yakulov TA.
Int J Mol Sci. 2022 Aug 24;23(17):9582.
Pattern Recognition Receptors of Nucleic Acids Can Cause Sublethal Activation of the Mitochondrial Apoptosis Pathway during Viral Infection.
Gradzka-Boberda S, Gentle IE, Häcker G.
J Virol. 2022 Sep 28;96(18):e0121222.
An improved organotypic cell culture system to study tissue-resident macrophages ex vivo.
Aktories P, Petry P, Glatz P, Andrieux G, Oschwald A, Botterer H, Gorka O, Erny D, Boerries M, Henneke P, Groß O, Prinz M, Kierdorf K.
Cell Rep Methods. 2022 Jul 26;2(8):100260
MARVEL-domain containing CMTM4 affects CXCR4 trafficking.
Bona A, Seifert M, Thünauer R, Zodel K, Frew IJ, Römer W, Walz G, Yakulov TA.
Mol Biol Cell. 2022 Nov 1;33(13):ar116
Phenotypic and functional analysis of ?? T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection.
Ruggieri M, Ducasa N, Juraske C, Polo VG, Berini C, Quiroga MF, Christopoulos P, Minguet S, Biglione M, Schamel WW.
Front Immunol. 2022 Aug 11;13:920888.
Shedding light on current trends in molecular optogenetics.
Fischer AAM, Kramer MM, Radziwill G, Weber W.
Curr Opin Chem Biol. 2022 Aug 18;70:102196.
Impact of older age in patients receiving atezolizumab and bevacizumab for hepatocellular carcinoma.
Vithayathil M, D’Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ, Sharma R.
Liver Int. 2022 Nov;42(11):2538-2547.
Anaplastic ganglioglioma – a diagnosis comprising several distinct tumour types.
Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A.
Neuropathol Appl Neurobiol. 2022 Dec;48(7):e12847
Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction.
Rizzo G, Gropper J, Piollet M, Vafadarnejad E, Rizakou A, Bandi SR, Arampatzi P, Krammer T, DiFabion N, Dietrich O, Arias-Loza AP, Prinz M, Mack M, Schlepckow K, Haass C, Silvestre JS, Zernecke A, Saliba AE, Cochain C.
Cardiovasc Res. 2022 Aug 11. Online ahead of print.
BlotIt-Optimal alignment of Western blot and qPCR experiments.
Kemmer S, Bang S, Rosenblatt M, Timmer J, Kaschek D.
PLoS One. 2022 Aug 10;17(8):e0264295.
COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation.
Reinscheid M, Luxenburger H, Karl V, Graeser A, Giese S, Ciminski K, Reeg DB, Oberhardt V, Roehlen N, Lang-Meli J, Heim K, Gross N, Baum C, Rieg S, Speer C, Emmerich F, Breisinger S, Steinmann D, Bengsch B, Boettler T, Kochs G, Schwemmle M, Thimme R, Neumann-Haefelin C, Hofmann M.
Nat Commun. 2022 Aug 8;13(1):4631
A root phloem pole cell atlas reveals common transcriptional states in protophloem-adjacent cells.
Otero S, Gildea I, Roszak P, Lu Y, Di Vittori V, Bourdon M, Kalmbach L, Blob B, Heo JO, Peruzzo F, Laux T, Fernie AR, Tavares H, Helariutta Y.
Nat Plants. 2022 Aug;8(8):954-970.
3D Printed Solutions for Spheroid Engineering and Cancer Research.
Butelmann T, Gu Y, Li A, Tribukait-Riemenschneider F, Hoffmann J, Molazem A, Jaeger E, Pellegrini D, Forget A, Shastri VP.
Int J Mol Sci. 2022 Jul 25;23(15):8188.
Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling.
Gehttps://pubmed.ncbi.nlm.nih.gov/35859176/ssler S, Guthmann C, Schuler V, Lilienkamp M, Walz G, Yakulov TA.
Int J Mol Sci. 2022 Jul 17;23(14):7870.
Seed-induced A beta deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer’s disease.
Ziegler-Waldkirch S, Friesen M, Loreth D, Sauer JF, Kemna S, Hilse A, Erny D, Helm C, D Errico P, Prinz M, Bartos M, Meyer-Luehmann M.
Mol Psychiatry. 2022 Oct;27(10):4274-4284.
Clock genes rescue nphp mutations in zebrafish.
Kayser N, Zaiser F, Veenstra AC, Wang H, Göcmen B, Eckert P, Franz H, Köttgen A, Walz G, Yakulov TA.
Hum Mol Genet. 2022 Dec 16;31(24):4143-4158.
ADAR1 averts fatal type I interferon induction by ZBP1.
Jiao H, Wachsmuth L, Wolf S, Lohmann J, Nagata M, Kaya GG, Oikonomou N, Kondylis V, Rogg M, Diebold M, Tröder SE, Zevnik B, Prinz M, Schell C, Young GR, Kassiotis G, Pasparakis M.
Nature. 2022 Jul;607(7920):776-783.
Comparative transcriptomics identifies candidate genes involved in the evolutionary transition from dehiscent to indehiscent fruits in Lepidium (Brassicaceae).
Gramzow L, Klupsch K, Fernández-Pozo N, Hölzer M, Marz M, Rensing SA, Theißen G.
BMC Plant Biol. 2022 Jul 14;22(1):340
Designing electrochemical microfluidic multiplexed biosensors for on-site applications.
Glatz RT, Ates HC, Mohsenin H, Weber W, Dincer C. >
Anal Bioanal Chem. 2022 Sep;414(22):6531-6540.
Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia.
Grüninger PK, Uhl F, Herzog H, Gentile G, Andrade-Martinez M, Schmidt T, Han K, Morgens DW, Bassik MC, Cleary ML, Gorka O, Zeiser R, Groß O, Duque-Afonso J.
Cancer Gene Ther. 2022 Nov;29(11):1751-1760. .
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic D, Hörtenhuber M, Balwierz PJ, Zehnder T, Mukarram AK, Nepal C, Várnai C, Hadzhiev Y, Jimenez-Gonzalez A, Li N, Wragg J, D’Orazio FM, Relic D, Pachkov M, Díaz N, Hernández-Rodríguez B, Chen Z, Stoiber M, Dong M, Stevens I, Ross SE, Eagle A, Martin R, Obasaju O, Rastegar S, McGarvey AC, Kopp W, Chambers E, Wang D, Kim HR, Acemel RD, Naranjo S, Lapinski M, Chong V, Mathavan S, Peers B, Sauka-Spengler T, Vingron M, Carninci P, Ohler U, Lacadie SA, Burgess SM, Winata C, van Eeden F, Vaquerizas JM, Gómez-Skarmeta JL, Onichtchouk D, Brown BJ, Bogdanovic O, van Nimwegen E, Westerfield M, Wardle FC, Daub CO, Lenhard B, Müller F.
Nat Genet. 2022 Jul;54(7):1037-1050.
Therapy response of glucocorticoid-refractory acute GVHD of the lower intestinal tract.
Biavasco F, Ihorst G, Wäsch R, Wehr C, Bertz H, Finke J, Zeiser R.
Bone Marrow Transplant. 2022 Oct;57(10):1500-1506.
B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates.
Hossain MA, Anasti K, Watts B, Cronin K, Derking R, Groschel B, Kane AP, Edwards RJ, Easterhoff D, Zhang J, Rountree W, Ortiz Y, Saunders K, Schief WR, Sanders RW, Verkoczy L, Reth M, Alam SM.
Cell Rep. 2022 Jun 28;39(13):111021.
High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature.
Globig AM, Hipp AV, Otto-Mora P, Heeg M, Mayer LS, Ehl S, Schwacha H, Bewtra M, Tomov V, Thimme R, Hasselblatt P, Bengsch B.
Nat Commun. 2022 Jun 27;13(1):3688.
Editorial on Translational Research in Graft-Versus-Host Disease (GVHD) and Graft-Versus-Tumor (GVT) Effect After Allogeneic Hematopoietic Cell Transplantation.
Czech M, Zeiser R, Toubai T.
Front Immunol. 2022 Jun 8;13:948720.
Therapeutic significance of ARID1A mutation in bladder cancer.
Conde M, Frew IJ.
Neoplasia. 2022 Sep;31:100814.
The greening ashore.
Schreiber M, Rensing SA, Gould SB.
Trends Plant Sci. 2022 Sep;27(9):847-857.
Exhaustion of CD39-Expressing CD8+ T Cells in Crohn’s Disease Is Linked to Clinical Outcome.
Globig AM, Mayer LS, Heeg M, Andrieux G, Ku M, Otto-Mora P, Hipp AV, Zoldan K, Pattekar A, Rana N, Schell C, Boerries M, Hofmann M, Neumann-Haefelin C, Kuellmer A, Schmidt A, Boettler T, Tomov V, Thimme R, Hasselblatt P, Bengsch B.
Gastroenterology. 2022 Jun 20:S0016-5085(22)00663-1.
In-Depth Characterization of a Re-Engineered Cholera Toxin Manufacturing Process Using Growth-Decoupled Production in Escherichia coli.
Danielewicz N, Dai W, Rosato F, Webb ME, Striedner G, Römer W, Turnbull WB, Mairhofer J.
Toxins (Basel). 2022 Jun 8;14(6):396.
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.
Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K, Woessner NM, Lalioti ME, Velasco-Hernandez T, Sikora K, Wäsch R, Lehnertz B, Sauvageau G, Manke T, Menendez P, Walter SG, Minguet S, Laurenti E, Günther S, Grün D, Cabezas-Wallscheid N.
Nat Cell Biol. 2022 Jul;24(7):1038-1048.
Experimental Characterization of In Silico Red-Shift-Predicted iLOVL470T/Q489K and iLOVV392K/F410V/A426S Mutants.
Wehler P, Armbruster D, Günter A, Schleicher E, Di Ventura B, Öztürk MA.
ACS Omega. 2022 Jun 1;7(23):19555-19560.
Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders.
Hook G, Reinheckel T, Ni J, Wu Z, Kindy M, Peters C, Hook V.
Pharmacol Rev. 2022 Jul;74(3):600-629.
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma.
Ravi VM, Will P, Kueckelhaus J, Sun N, Joseph K, Salié H, Vollmer L, Kuliesiute U, von Ehr J, Benotmane JK, Neidert N, Follo M, Scherer F, Goeldner JM, Behringer SP, Franco P, Khiat M, Zhang J, Hofmann UG, Fung C, Ricklefs FL, Lamszus K, Boerries M, Ku M, Beck J, Sankowski R, Schwabenland M, Prinz M, Schüller U, Killmer S, Bengsch B, Walch AK, Delev D, Schnell O, Heiland DH.
Cancer Cell. 2022 Jun 13;40(6):639-655.e13.
Histone Deacetylase 6 Inhibitor JS28 Prevents Pathological Gene Expression in Cardiac Myocytes.
Ngo V, Fleischmann BK, Jung M, Hein L, Lother A.
J Am Heart Assoc. 2022 Jun 21;11(12):e025857.
PLDMS: Phosphopeptide Library Dephosphorylation Followed by Mass Spectrometry Analysis to Determine the Specificity of Phosphatases for Dephosphorylation Site Sequences.
Kokot T, Hoermann B, Helm D, Chojnacki JE, Savitski MM, Köhn M.
Methods Mol Biol. 2022;2499:43-64.
GM-CSF suppresses antioxidant signaling and drives IL-1? secretion through NRF2 downregulation.
Di Carlo S, Häcker G, Gentle IE.
EMBO Rep. 2022 Aug 3;23(8):e54226.
RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells.
Hölzen L, Mitschke J, Schönichen C, Hess ME, Ehrenfeld S, Boerries M, Miething C, Brummer T, Reinheckel T.
Theranostics. 2022 May 16;12(9):4348-4373.
Spatially Defined Gene Delivery into Native Cells with the Red Light-Controlled OptoAAV Technology.
Hörner M, Weber W.
Curr Protoc. 2022 Jun;2(6):e440.
Synthetic microbiology applications powered by light.
Mazraeh D, Di Ventura B.
Curr Opin Microbiol. 2022 Aug;68:102158.
Anti-CRISPR prediction using deep learning reveals an inhibitor of Cas13b nucleases.
Wandera KG, Alkhnbashi OS, Bassett HVI, Mitrofanov A, Hauns S, Migur A, Backofen R, Beisel CL.
Mol Cell. 2022 Jul 21;82(14):2714-2726.e4
Disentangling ERBB Signaling in Breast Cancer Subtypes-A Model-Based Analysis.
Kemmer S, Berdiel-Acer M, Reinz E, Sonntag J, Tarade N, Bernhardt S, Fehling-Kaschek M, Hasmann M, Korf U, Wiemann S, Timmer J. Cancers (Basel). 2022 May 12;14(10):2379.
A set point in the selection of the ??TCR T cell repertoire imposed by pre-TCR signaling strength.
Bovolenta ER, García-Cuesta EM, Horndler L, Ponomarenko J, Schamel WW, Mellado M, Castro M, Abia D, van Santen HM.
Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2201907119.
Distinct CD8 T Cell Populations with Differential Exhaustion Profiles Associate with Secondary Complications in Common Variable Immunodeficiency.
Klocperk A, Friedmann D, Schlaak AE, Unger S, Parackova Z, Goldacker S, Sediva A, Bengsch B, Warnatz K.
J Clin Immunol. 2022 Aug;42(6):1254-1269.
Determination of protoplast growth properties using quantitative single-cell tracking analysis.
Dawson J, Pandey S, Yu Q, Schaub P, Wüst F, Moradi AB, Dovzhenko O, Palme K, Welsch R.
Plant Methods. 2022 May 18;18(1):64.
Single-Cell Protein and Transcriptional Characterization of Epiretinal Membranes From Patients With Proliferative Vitreoretinopathy.
Laich Y, Wolf J, Hajdu RI, Schlecht A, Bucher F, Pauleikhoff L, Busch M, Martin G, Faatz H, Killmer S, Bengsch B, Stahl A, Lommatzsch A, Schlunck G, Agostini H, Boneva S, Lange C.
Invest Ophthalmol Vis Sci. 2022 May 2;63(5):17.
Paradoxical immunodeficiencies-When failures of innate immunity cause immunopathology.
Kolter J, Henneke P, Groß O, Kierdorf K, Prinz M, Graf L, Schwemmle M.
Eur J Immunol. 2022 Sep;52(9):1419-1430.
Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity.
Fröhlich K, Brombacher E, Fahrner M, Vogele D, Kook L, Pinter N, Bronsert P, Timme-Bronsert S, Schmidt A, Bärenfaller K, Kreutz C, Schilling O.
Nat Commun. 2022 May 12;13(1):2622.
Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs).
Fontanillo M, Trebacz M, Reinkemeier CD, Avilés Huerta D, Uhrig U, Sehr P, Köhn M.
Bioorg Med Chem. 2022 Jul 1;65:116785.
Reversible, β-sheet-dependent self-assembly of the phosphoprotein phosvitin is controlled by the concentration and valency of cations.
Betschart MU, Sarem M, Shastri VP, Lüdeke S.
Phys Chem Chem Phys. 2022 May 18;24(19):11791-11800.
Mitochondria supply sub-lethal signals for cytokine secretion and DNA-damage in H. pylori infection.
Dörflinger B, Badr MT, Haimovici A, Fischer L, Vier J, Metz A, Eisele B, Bronsert P, Aumann K, Höppner J, Waguia Kontchou C, Parui I, Weber A, Kirschnek S, Häcker G.
Cell Death Differ. 2022 Nov;29(11):2218-2232.
The endoplasmic reticulum membrane protein complex localizes to the mitochondrial – endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei.
Iyer A, Niemann M, Serricchio M, Dewar CE, Oeljeklaus S, Farine L, Warscheid B, Schneider A, Bütikofer P.
PLoS Pathog. 2022 May 2;18(5):e1009717.
The Lectin LecB Induces Patches with Basolateral Characteristics at the Apical Membrane to Promote Pseudomonas aeruginosa Host Cell Invasion.
Thuenauer R, Kühn K, Guo Y, Kotsis F, Xu M, Trefzer A, Altmann S, Wehrum S, Heshmatpour N, Faust B, Landi A, Diedrich B, Dengjel J, Kuehn EW, Imberty A, Römer W.
mBio. 2022 Jun 28;13(3):e0081922.
Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer.
Taromi S, Firat E, Simonis A, Braun LM, Apostolova P, Elze M, Passlick B, Schumacher A, Lagies S, Frey A, Schmitt-Graeff A, Burger M, Schmittlutz K, Follo M, von Elverfeldt D, Zhu X, Kammerer B, Diederichs S, Duyster J, Manz MG, Niedermann G, Zeiser R.
Cancer Lett. 2022 Jul 10;538:215697.
SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals.
Lang-Meli J, Luxenburger H, Wild K, Karl V, Oberhardt V, Salimi Alizei E, Graeser A, Reinscheid M, Roehlen N, Reeg DB, Giese S, Ciminski K, Götz V, August D, Rieg S, Waller CF, Wengenmayer T, Staudacher D, Huzly D, Bengsch B, Kochs G, Schwemmle M, Emmerich F, Boettler T, Thimme R, Hofmann M, Neumann-Haefelin C.
Nat Microbiol. 2022 May;7(5):675-679.
Benchmarking of Cph1 Mutants and DrBphP for Light-Responsive Phytochrome-Based Hydrogels with Reversibly Adjustable Mechanical Properties.
Emig R, Hoess P, Cai H, Kohl P, Peyronnet R, Weber W, Hörner M.
Adv Biol (Weinh). 2022 Jul;6(7):e2000337.
SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis.
Boettler T, Csernalabics B, Salié H, Luxenburger H, Wischer L, Salimi Alizei E, Zoldan K, Krimmel L, Bronsert P, Schwabenland M, Prinz M, Mogler C, Neumann-Haefelin C, Thimme R, Hofmann M, Bengsch B.
J Hepatol. 2022 Sep;77(3):653-659.
TAT-MeCP2 protein variants rescue disease phenotypes in human and mouse models of Rett syndrome.
Steinkellner H, Kempaiah P, Beribisky AV, Pferschy S, Etzler J, Huber A, Sarne V, Neuhaus W, Kuttke M, Bauer J, Arunachalam JP, Christodoulou J, Dressel R, Mildner A, Prinz M, Laccone F.
Int J Biol Macromol. 2022 Jun 1;209(Pt A):972-983.
Specification of CNS macrophage subsets occurs postnatally in defined niches.
Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M.
Nature. 2022 Apr;604(7907):740-748.
Inborn errors of immunity and immunodeficiencies: Antibody-mediated pathology and autoimmunity as a consequence of impaired immune reactions.
Minguet S, Nyström A, Kiritsi D, Rizzi M.
Eur J Immunol. 2022 Sep;52(9):1396-1405
Microridge-like structures anchor motile cilia.
Yasunaga T, Wiegel J, Bergen MD, Helmstädter M, Epting D, Paolini A, Çiçek Ö, Radziwill G, Engel C, Brox T, Ronneberger O, Walentek P, Ulbrich MH, Walz G.
Nat Commun. 2022 Apr 19;13(1):2056.
patcHwork: a user-friendly pH sensitivity analysis web server for protein sequences and structures.
Schmitz M, Schultze A, Vanags R, Voigt K, Di Ventura B, Öztürk MA.
Nucleic Acids Res. 2022 Apr 19;50(W1):W560-7.
Galaxy workflows for fragment-based virtual screening: a case study on the SARS-CoV-2 main protease.
Bray S, Dudgeon T, Skyner R, Backofen R, Grüning B, von Delft F.
J Cheminform. 2022 Apr 12;14(1):22.
Life and death of microglia: Mechanisms governing microglial states and fates.
Matsudaira T, Prinz M.
Immunol Lett. 2022 May;245:51-60.
BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk.
Bork T, Liang W, Kretz O, Lagies S, Yamahara K, Hernando-Erhard C, Helmstädter M, Schell C, Kammerer B, Huber TB.
Int J Mol Sci. 2022 Mar 30;23(7):3825.
Microbial carbohydrate-binding toxins – From etiology to biotechnological application.
Danielewicz N, Rosato F, Dai W, Römer W, Turnbull WB, Mairhofer J.
Biotechnol Adv. 2022 Oct;59:107951.
Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak.
Waguia Kontchou C, Gentle IE, Weber A, Schoeniger A, Edlich F, Häcker G.
Cell Death Differ. 2022 Oct;29(10):2046-2059.
Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse.
Haimovici A, Höfer C, Badr MT, Bavafaye Haghighi E, Amer T, Boerries M, Bronsert P, Glavynskyi I, Fanfone D, Ichim G, Thilmany N, Weber A, Brummer T, Spohr C, Öllinger R, Janssen KP, Rad R, Häcker G.
Cell Death Dis. 2022 Apr 7;13(4):315.
T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma.
Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D’Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B.
J Hepatol. 2022 Aug;77(2):397-409.
100 Hz ROCS microscopy correlated with fluorescence reveals cellular dynamics on different spatiotemporal scales.
Jünger F, Ruh D, Strobel D, Michiels R, Huber D, Brandel A, Madl J, Gavrilov A, Mihlan M, Daller CC, Rog-Zielinska EA, Römer W, Lämmermann T, Rohrbach A.
Nat Commun. 2022 Apr 1;13(1):1758.
The living interface between synthetic biology and biomaterial design.
Liu AP, Appel EA, Ashby PD, Baker BM, Franco E, Gu L, Haynes K, Joshi NS, Kloxin AM, Kouwer PHJ, Mittal J, Morsut L, Noireaux V, Parekh S, Schulman R, Tang SKY, Valentine MT, Vega SL, Weber W, Stephanopoulos N, Chaudhuri O.
Nat Mater. 2022 Apr;21(4):390-397.
Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy.
Kao WC, Hunte C.
Biochem Soc Trans. 2022 Apr 29;50(2):877-893.
CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival.
Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford AL, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy KJ, Gagliani N, Flavell RA, Waisman A, Huber S.
Cell Rep. 2022 Mar 29;38(13):110565.
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.
Smulski CR, Zhang L, Burek M, Teixidó Rubio A, Briem JS, Sica MP, Sevdali E, Vigolo M, Willen L, Odermatt P, Istanbullu D, Herr S, Cavallari M, Hess H, Rizzi M, Eibel H, Schneider P.
Cell Rep. 2022 Mar 29;38(13):110583.
The phytochrome interacting proteins ERF55 and ERF58 repress light-induced seed germination in Arabidopsis thaliana.
Li Z, Sheerin DJ, von Roepenack-Lahaye E, Stahl M, Hiltbrunner A.
Nat Commun. 2022 Mar 29;13(1):1656.
GVHD, IBD, and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity.
Zeiser R, Warnatz K, Rosshart S, Sagar, Tanriver Y.
Eur J Immunol. 2022 Sep;52(9):1406-1418.
Deterministic Lateral Displacement Microfluidic Chip for Minicell Purification.
Sherbaz A, Konak BMK, Pezeshkpour P, Di Ventura B, Rapp BE.
Micromachines (Basel). 2022 Feb 25;13(3):365.
Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA.
Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, Beisel CL.
Nat Microbiol. 2022 Apr;7(4):530-541.
Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child-Pugh A and B cirrhosis: A real-world study.
D’Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, Schulze K, Wege H, Gaillard VE, Saeed A, Wietharn B, Hildebrand H, Wu L, Ang C, Marron TU, Weinmann A, Galle PR, Bettinger D, Bengsch B, Vogel A, Balcar L, Scheiner B, Lee PC, Huang YH, Amara S, Muzaffar M, Naqash AR, Cammarota A, Personeni N, Pressiani T, Sharma R, Pinter M, Cortellini A, Kudo M, Rimassa L, Pinato DJ.
Hepatology. 2022 Oct;76(4):1000-1012.
A simple pipeline for cell cycle kinetic studies in the root apical meristem.
Pasternak T, Kircher S, Pérez-Pérez JM, Palme K.
J Exp Bot. 2022 Aug 11;73(14):4683-4695.
Phytochrome A Mediates the Disassembly of Processing Bodies in Far-Red Light.
Schwenk P, Hiltbrunner A.
Front Plant Sci. 2022 Feb 23;13:828529.
Unexpected Arabinosylation after Humanization of Plant Protein N-Glycosylation.
Bohlender LL, Parsons J, Hoernstein SNW, Bangert N, Rodríguez-Jahnke F, Reski R, Decker EL. Front Bioeng Biotechnol.
2022 Feb 18;10:838365.
Process Engineering of Biopharmaceutical Production in Moss Bioreactors via Model-Based Description and Evaluation of Phytohormone Impact.
Ruiz-Molina N, Parsons J, Schroeder S, Posten C, Reski R, Decker EL.
Front Bioeng Biotechnol. 2022 Feb 17;10:837965.
Flow-cytometry-based protocol to analyze respiratory chain function in mouse microglia.
Erny D, Dokalis N, Mezö C, Mossad O, Blank T, Prinz M.
STAR Protoc. 2022 Feb 18;3(1):101186.
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine.
Mossad O, Batut B, Yilmaz B, Dokalis N, Mezö C, Nent E, Nabavi LS, Mayer M, Maron FJM, Buescher JM, de Agüero MG, Szalay A, Lämmermann T, Macpherson AJ, Ganal-Vonarburg SC, Backofen R, Erny D, Prinz M, Blank T.
Nat Neurosci. 2022 Mar;25(3):295-305.
A common evolutionary origin reveals fundamental principles of protein insertases.
Vögtle FN, Koch HG, Meisinger C.
PLoS Biol. 2022 Mar 2;20(3):e3001558.
Low-level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus.
Reinheckel T, Tholen M.
FEBS Open Bio. 2022 Apr;12(4):694-707.
Challenges and pitfalls between lichen planus pemphigoides and bullous lichen planus.
Papara C, Danescu S, Sitaru C, Baican A.
Australas J Dermatol. 2022 May;63(2):165-171
A synthetic protein as efficient multitarget regulator against complement over-activation.
Ruiz-Molina N, Parsons J, Müller M, Hoernstein SNW, Bohlender LL, Pumple S, Zipfel PF, Häffner K, Reski R, Decker EL.
Commun Biol. 2022 Feb 22;5(1):152.
Stimulated Raman histology in the neurosurgical workflow of a major European neurosurgical center – part A.
Neidert N, Straehle J, Erny D, Sacalean V, El Rahal A, Steybe D, Schmelzeisen R, Vlachos A, Reinacher PC, Coenen VA, Mizaikoff B, Heiland DH, Prinz M, Beck J, Schnell O.
Neurosurg Rev. 2022 Apr;45(2):1731-1739
T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.
Ravi VM, Neidert N, Will P, Joseph K, Maier JP, Kückelhaus J, Vollmer L, Goeldner JM, Behringer SP, Scherer F, Boerries M, Follo M, Weiss T, Delev D, Kernbach J, Franco P, Schallner N, Dierks C, Carro MS, Hofmann UG, Fung C, Sankowski R, Prinz M, Beck J, Salié H, Bengsch B, Schnell O, Heiland DH.
Nat Commun. 2022 Feb 17;13(1):925.
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
Dudek M, Lohr K, Donakonda S, Baumann T, Lüdemann M, Hegenbarth S, Dübbel L, Eberhagen C, Michailidou S, Yassin A, Prinz M, Popper B, Rose-John S, Zischka H, Knolle PA.
Cell Rep. 2022 Feb 15;38(7):110389.
Democratizing data-independent acquisition proteomics analysis on public cloud infrastructures via the Galaxy framework.
Fahrner M, Föll MC, Grüning BA, Bernt M, Röst H, Schilling O.
Gigascience. 2022 Feb 15;11:giac005.
An overview of bioinformatics, genomics, and transcriptomics resources for bryophytes.
Fernandez-Pozo N, Haas FB, Gould SB, Rensing SA.
J Exp Bot. 2022 Jul 16;73(13):4291-4305.
Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.
Spohr C, Poggio T, Andrieux G, Schönberger K, Cabezas-Wallscheid N, Boerries M, Halbach S, Illert AL, Brummer T.
Leukemia. 2022 Apr;36(4):970-982
Pluripotency factors determine gene expression repertoire at zygotic genome activation.
Gao M, Veil M, Rosenblatt M, Riesle AJ, Gebhard A, Hass H, Buryanova L, Yampolsky LY, Grüning B, Ulianov SV, Timmer J, Onichtchouk D.
Nat Commun. 2022 Feb 10;13(1):788.
Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas.
Friedrich M, Sankowski R, Bunse L, Kilian M, Green E, Ramallo Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Gegner HM, Sonner JK, von Landenberg A, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland DH, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana FJ, von Deimling A, Wick W, Prinz M, Platten M.
Nat Cancer. 2021 Jul;2(7):723-740.
Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila.
Gerstner L, Chen M, Kampf LL, Milosavljevic J, Lang K, Schneider R, Hildebrandt F, Helmstädter M, Walz G, Hermle T.
Kidney Int. 2022 Jun;101(6):1216-1231.
Differential regulation of progranulin derived granulin peptides.
Zhang T, Du H, Santos MN, Wu X, Pagan MD, Trigiani LJ, Nishimura N, Reinheckel T, Hu F.
Mol Neurodegener. 2022 Feb 4;17(1):15.
Neuropathological interpretation of stimulated Raman histology images of brain and spine tumors: part B.
Straehle J, Erny D, Neidert N, Heiland DH, El Rahal A, Sacalean V, Steybe D, Schmelzeisen R, Vlachos A, Mizaikoff B, Reinacher PC, Coenen VA, Prinz M, Beck J, Schnell O.
Neurosurg Rev. 2022 Apr;45(2):1721-1729
Molecular Control of Sporophyte-Gametophyte Ontogeny and Transition in Plants.
Pandey S, Moradi AB, Dovzhenko O, Touraev A, Palme K, Welsch R.
Front Plant Sci. 2022 Jan 13;12:789789.
Structural basis for safe and efficient energy conversion in a respiratory supercomplex.
Kao WC, Ortmann de Percin Northumberland C, Cheng TC, Ortiz J, Durand A, von Loeffelholz O, Schilling O, Biniossek ML, Klaholz BP, Hunte C.
Nat Commun. 2022 Jan 27;13(1):545.
Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis.
Nührenberg TG, Stöckle J, Marini F, Zurek M, Grüning BA, Benes V, Hein L, Neumann FJ, Stratz C, Cederqvist M, Hochholzer W.
PLoS One. 2022 Jan 27;17(1):e0260222.
Dual role of Mic10 in mitochondrial cristae organization and ATP synthase-linked metabolic adaptation and respiratory growth.
Rampelt H, Wollweber F, Licheva M, de Boer R, Perschil I, Steidle L, Becker T, Bohnert M, van der Klei I, Kraft C, van der Laan M, Pfanner N.
Cell Rep. 2022 Jan 25;38(4):110290.
From shape to contents: heterogeneity of CNS glial cells.
Chhatbar C, Prinz M.
Acta Neuropathol. 2022 Feb;143(2):123-124.
Canonical TGFß signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT.
Flum M, Dicks S, Teng YH, Schrempp M, Nyström A, Boerries M, Hecht A.
Oncogene. 2022 Mar;41(10):1492-1506.
Wnt/ß-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish.
Westphal M, Panza P, Kastenhuber E, Wehrle J, Driever W.
Sci Rep. 2022 Jan 19;12(1):1030.
The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis.
Dold MN, Ng X, Alber C, Gentle IE, Häcker G, Weber A.
Apoptosis. 2022 Feb;27(1-2):112-132.
Evaluating microglial phenotypes using single-cell technologies.
Sankowski R, Monaco G, Prinz M.
Trends Neurosci.2022 Feb;45(2):133-144.
The renal inflammatory network of nephronophthisis.
Quatredeniers M, Bienaimé F, Ferri G, Isnard P, Porée E, Billot K, Birgy E, Mazloum M, Ceccarelli S, Silbermann F, Braeg S, Nguyen-Khoa T, Salomon R, Gubler MC, Kuehn EW, Saunier S, Viau A.
Hum Mol Genet. 2022 Jul 7;31(13):2121-2136.
RiboReport – benchmarking tools for ribosome profiling-based identification of open reading frames in bacteria.
Gelhausen R, Müller T, Svensson SL, Alkhnbashi OS, Sharma CM, Eggenhofer F, Backofen R.
Brief Bioinform. 2022 Mar 10;23(2):bbab549.
CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling.
Zhang Z, Zhang F, Davis AK, Xin M, Walz G, Tian W, Zheng Y. Cell Rep. 2022 Jan 11;38(2):110009.
46 The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML.
Charlet A, Kappenstein M, Keye P, Kläsener K, Endres C, Poggio T, Gorantla SP, Kreutmair S, Sänger J, Illert AL, Miething C, Reth M, Duyster J, Rummelt C, von Bubnoff N.
Leukemia. 2022 Mar;36(3):701-711
Viral suppressor of RNA silencing in vascular plants also interferes with the development of the bryophyte Physcomitrella patens.
Marttinen EM, Lehtonen MT, van Gessel N, Reski R, Valkonen JPT.
Plant Cell Environ. 2022 Jan;45(1):220-235.
A small and highly sensitive red/far-red optogenetic switch for applications in mammals.
Zhou Y, Kong D, Wang X, Yu G, Wu X, Guan N, Weber W, Ye H.
Nat Biotechnol. 2022 Feb;40(2):262-272
Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE.
Acta Neuropathol. 2022 Feb;143(2):263-281
Bacterial flavoprotein monooxygenase YxeK salvages toxic S-(2-succino)-adducts via oxygenolytic C-S bond cleavage.
Matthews A, Schönfelder J, Lagies S, Schleicher E, Kammerer B, Ellis HR, Stull F, Teufel R.
FEBS J. 2022 Feb;289(3):787-807
The role of AUX1 during lateral root development in the domestication of the model C4 grass Setaria italica.
Tang S, Shahriari M, Xiang J, Pasternak T, Igolkina A, Aminizade S, Zhi H, Gao Y, Roodbarkelari F, Sui Y, Jia G, Wu C, Zhang L, Zhao L, Li X, Meshcheryakov G, Samsonova M, Diao X, Palme K, Teale W.
J Exp Bot. 2022 Apr 5;73(7):2021-2034
Monitoring checkpoints of metabolism and protein biogenesis in mitochondria by Phos-tag technology.
Walter C, Marada A, Meisinger C.
J Proteomics. 2022 Feb 10;252:104430.
Microglia contribute to the propagation of Aβ into unaffected brain tissue.
d’Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M.
Nat Neurosci. 2022 Jan;25(1):20-25.

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.
Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P.
Elife. 2021 Dec 31;10:e68213.
The EpiDiverse Plant Epigenome-Wide Association Studies (EWAS) Pipeline.
Can SN, Nunn A, Galanti D, Langenberger D, Becker C, Volmer K, Heer K, Opgenoorth L, Fernandez-Pozo N, Rensing SA.
Epigenomes. 2021 May 4;5(2):12.
Screening for Optimal Liposome Preparation Conditions by Using Dual Centrifugation and Time-Resolved Fluorescence Measurements.
Koehler JK, Schnur J, Heerklotz H, Massing U.
Pharmaceutics. 2021 Nov 30;13(12):2046.
Editorial: Plant Phytochromes: From Structure to Signaling and Beyond.
Viczián A, Klose C, Hiltbrunner A, Nagy F.
Front Plant Sci. 2021 Dec 9;12:811379.
Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts.
Corrales E, Levit-Zerdoun E, Metzger P, Kowar S, Ku M, Brummer T, Boerries M.
Cell Commun Signal. 2021 Dec 20;19(1):123.
finDr: A web server for in silico D-peptide ligand identification.
Engel H, Guischard F, Krause F, Nandy J, Kaas P, Höfflin N, Köhn M, Kilb N, Voigt K, Wolf S, Aslan T, Baezner F, Hahne S, Ruckes C, Weygant J, Zinina A, Akmeriç EB, Antwi EB, Dombrovskij D, Franke P, Lesch KL, Vesper N, Weis D, Gensch N, Di Ventura B, Öztürk MA.
Synth Syst Biotechnol. 2021 Nov 23;6(4):402-413.
Designed membrane protein heterodimers and control of their affinity by binding domain and membrane linker properties.
Lan C, Stulz A, Barthes NPF, Lauw S, Salavei P, Jung M, Heerklotz H, Ulbrich MH.
Nanoscale. 2021 Dec 16;13(48):20692-20702.
Transcriptome-wide in vivo mapping of cleavage sites for the compact cyanobacterial ribonuclease E reveals insights into its function and substrate recognition.
Hoffmann UA, Heyl F, Rogh SN, Wallner T, Backofen R, Hess WR, Steglich C, Wilde A.
Nucleic Acids Res. 2021 Dec 16;49(22):13075-13091.
Kinase Inhibition as Treatment for Acute and Chronic Graft-Versus-Host Disease.
Braun LM, Zeiser R.
Front Immunol. 2021 Nov 17;12:760199.
Small molecules mediate cellular reprogramming across two kingdoms.
Welsch R, Touraev A, Palme K.
J Exp Bot. 2021 Dec 4;72(22):7645-7647.
Biobridge: An Outlook on Translational Bioinks for 3D Bioprinting.
Gu Y, Forget A, Shastri VP.
Adv Sci (Weinh). 2021 Dec 3:e2103469.
Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications.
Rigano A, Ehmsen S, Öztürk SU, Ryan J, Balashov A, Hammer M, Kirli K, Boehm U, Brown CM, Bellve K, Chambers JJ, Cosolo A, Coleman RA, Faklaris O, Fogarty KE, Guilbert T, Hamacher AB, Itano MS, Keeley DP, Kunis S, Lacoste J, Laude A, Ma WY, Marcello M, Montero-Llopis P, Nelson G, Nitschke R, Pimentel JA, Weidtkamp-Peters S, Park PJ, Alver BH, Grunwald D, Strambio-De-Castillia C.
Nat Methods. 2021 Dec;18(12):1489-1495.
Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model.
Hammer M, Huisman M, Rigano A, Boehm U, Chambers JJ, Gaudreault N, North AJ, Pimentel JA, Sudar D, Bajcsy P, Brown CM, Corbett AD, Faklaris O, Lacoste J, Laude A, Nelson G, Nitschke R, Farzam F, Smith CS, Grunwald D, Strambio-De-Castillia C.
Nat Methods. 2021 Dec;18(12):1427-1440.
Reversible Shielding and Immobilization of Liposomes and Viral Vectors by Tailored Antibody-Ligand Interactions.
Thomas OS, Rebmann B, Tonn M, Schirmeister IC, Wehrle S, Becker J, Zea Jimenez GJ, Hook S, Jäger S, Klenzendorf M, Laskowski M, Kaier A, Pütz G, Zurbriggen MD, Weber W, Hörner M, Wagner HJ.
Small. 2021 Dec 3:e2105157.
Towards non-blind optical tweezing by finding 3D refractive index changes through off-focus interferometric tracking.
Landenberger B, Yatish, Rohrbach A.
Nat Commun. 2021 Nov 26;12(1):6922.
Methods of In Situ Quantitative Root Biology.
Pasternak T, Pérez-Pérez JM.
Plants (Basel). 2021 Nov 6;10(11):2399.
Next- and Third-Generation Sequencing Outperforms Culture-Based Methods in the Diagnosis of Ascitic Fluid Bacterial Infections of ICU Patients.
Goelz H, Wetzel S, Mehrbarzin N, Utzolino S, Häcker G, Badr MT.
Cells. 2021 Nov 18;10(11):3226.
The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake.
Siukstaite L, Rosato F, Mitrovic A, Müller PF, Kraus K, Notova S, Imberty A, Römer W.
Toxins (Basel). 2021 Nov 9;13(11):792.
Editorial: Cytoskeletal Regulation of Immune Response.
Kumari S, Schamel WW, Alarcon B.
Front Cell Dev Biol. 2021 Nov 4;9:791327.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B.
Cell Metab. 2021 Dec 7;33(12):2464-2483.e18.
Pharmacokinetic study of the novel phosphocholine derivative 3-dibutylaminopropylphosphonic acid by LC-MS coupling.
Kather MG, Zeller J, Plattner D, Breit B, Kreuzaler S, Krippner G, Peter K, Eisenhardt SU, Kammerer B.
J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Dec 1;1186:122998.
Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination.
Wild K, Smits M, Killmer S, Strohmeier S, Neumann-Haefelin C, Bengsch B, Krammer F, Schwemmle M, Hofmann M, Thimme R, Zoldan K, Boettler T.
Nat Commun. 2021 Nov 18;12(1):6720.
Proteome biology of primary colorectal carcinoma and corresponding liver metastases.
Fahrner M, Bronsert P, Fichtner-Feigl S, Jud A, Schilling O.
Neoplasia. 2021 Dec;23(12):1240-1251.
Morpholinos meet mitochondria: Targeting organellar gene expression.
Rampelt H, Pfanner N.
Cell. 2021 Nov 11;184(23):5693-5695.
The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics.
Kollewe A, Chubanov V, Tseung FT, Correia L, Schmidt E, Rössig A, Zierler S, Haupt A, Müller CS, Bildl W, Schulte U, Nicke A, Fakler B, Gudermann T.
Elife. 2021 Nov 12;10:e68544.
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy.
Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer A, Stadelmann C, Nessler S, Gärtner J.
Nat Commun. 2021 Nov 11;12(1):6530.
Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment.
Kotsis F, Janusch H, Li Y, Viau A, Epting D, Kramer-Zucker A, Walz G, Nitschke R, Lorentzen E, Ganner A, Neumann-Haefelin E, Kuehn EW, Boehlke C.
Biochem Biophys Res Commun. 2021 Dec 20;584:19-25.
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia.
El Khawanky N, Hughes A, Yu W, Myburgh R, Matschulla T, Taromi S, Aumann K, Clarson J, Vinnakota JM, Shoumariyeh K, Miething C, Lopez AF, Brown MP, Duyster J, Hein L, Manz MG, Hughes TP, White DL, Yong ASM, Zeiser R.
Nat Commun. 2021 Nov 8;12(1):6436.
Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria.
Omar M, Marchionni L, Häcker G, Badr MT.
Front Cell Infect Microbiol. 2021 Oct 22;11:743616.
3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels.
Govindasamy N, Long H, Jeong HW, Raman R, Özcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH, Trappmann B, Bedzhov I.
Dev Cell. 2021 Dec 6;56(23):3276-3287.e8.
Cardiomyocyte-specific miR-100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS production by direct suppression of Nox4 and CD36.
Smolka C, Schlösser D, Koentges C, Tarkhnishvili A, Gorka O, Pfeifer D, Bemtgen X, Asmussen A, Groß O, Diehl P, Moser M, Bode C, Bugger H, Grundmann S, Pankratz F.
FASEB J. 2021 Nov;35(11):e21956.
The Optimal Lipid Chain Length of a Membrane-Permeabilizing Lipopeptide Results From the Balance of Membrane Partitioning and Local Damage.
Steigenberger J, Verleysen Y, Geudens N, Martins JC, Heerklotz H.
Front Microbiol. 2021 Sep 14;12:669709.
Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages.
Lagies S, Pichler R, Vladimirov G, Gawron J, Bäzner F, Schreiner A, Kadena D, Plattner DA, Lienkamp SS, Kammerer B.
Int J Mol Sci. 2021 Sep 18;22(18):10111.
Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.
Dannenmaier S, Desroches Altamirano C, Schüler L, Zhang Y, Hummel J, Milanov M, Oeljeklaus S, Koch HG, Rospert S, Alberti S, Warscheid B.
J Biol Chem. 2021 Sep 24:101050.
Subcellular proteomics.
Christopher JA, Stadler C, Martin CE, Morgenstern M, Pan Y, Betsinger CN, Rattray DG, Mahdessian D, Gingras AC, Warscheid B, Lehtiö J, Cristea IM, Foster LJ, Emili A, Lilley KS.
Nat Rev Methods Primers. 2021;1:32.
Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics.
Ates HC, Mohsenin H, Wenzel C, Glatz RT, Wagner HJ, Bruch R, Höfflin N, Spassov S, Streicher L, Lozano-Zahonero S, Flamm B, Trittler R, Hug MJ, Köhn M, Schmidt J, Schumann S, Urban GA, Weber W, Dincer C.
Adv Mater. 2021 Sep 21:e2104555.
The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation.
Zhang P, Schlecht A, Wolf J, Boneva S, Laich Y, Koch J, Ludwig F, Boeck M, Thien A, Härdtner C, Kierdorf K, Agostini H, Schlunck G, Prinz M, Hilgendorf I, Wieghofer P, Lange C.
J Neuroinflammation. 2021 Sep 20;18(1):215.
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling.
Schwarz JJ, Grundmann L, Kokot T, Kläsener K, Fotteler S, Medgyesi D, Köhn M, Reth M, Warscheid B.
Life Sci Alliance. 2021 Sep 15;4(11):e202101084.
Magnitude of Ubiquitination Determines the Fate of Epidermal Growth Factor Receptor Upon Ligand Stimulation.
Akimov V, Fehling-Kaschek M, Barrio-Hernandez I, Puglia M, Bunkenborg J, Nielsen MM, Timmer J, Dengjel J, Blagoev B.
J Mol Biol. 2021 Sep 8;433(21):167240.
Neuronal TNFα, Not α-Syn, Underlies PDD-Like Disease Progression in IFNβ-KO Mice. Villanueva EB, Tresse E, Liu Y, Duarte JN, Jimenez-Duran G, Ejlerskov P, Kretz O, Loreth D, Goldmann T, Prinz M, Issazadeh-Navikas S.
Ann Neurol. 2021 Nov;90(5):789-807
Essential role of γ-clade RNA-dependent RNA polymerases in rice development and yield-related traits is linked to their atypical polymerase activities regulating specific genomic regions.
Jha V, Narjala A, Basu D, T N S, Pachamuthu K, Chenna S, Nair A, Shivaprasad PV.
New Phytol. 2021 Nov; 90(5):789-807
The reaction of innate lymphoid cells in the mouse female genital tract to chlamydial infection.
Barth S, Kirschnek S, Ortmann N, Tanriver Y, Häcker G.
Infect Immun. 2021 Oct 15;89(11):e0080020.
Mitochondria as emergency landing for abandoned peroxins.
Vögtle FN, Meisinger C.
EMBO Rep. 2021 Oct 5;22(10):e53790.
Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer.
Taromi S, Firat E, Simonis A, Braun LM, Apostolova P, Elze M, Passlick B, Schumacher A, Lagies S, Frey A, Schmitt-Graeff A, Burger M, Schmittlutz K, Follo M, von Elverfeldt D, Zhu X, Kammerer B, Diederichs S, Duyster J, Manz MG, Niedermann G, Zeiser R.
Cancer Lett. 2021 Nov 1;520:385-399.
RNAProt: an efficient and feature-rich RNA binding protein binding site predictor.
Uhl M, Tran VD, Heyl F, Backofen R.
Gigascience. 2021 Aug 18;10(8):giab054.
Current tools to interrogate microglial biology.
Dumas AA, Borst K, Prinz M.
Neuron 2021 Sep 15;109(18):2805-2819.
Glycans in autophagy, endocytosis and lysosomal functions.
Reggiori F, Gabius HJ, Aureli M, Römer W, Sonnino S, Eskelinen EL.
Glycoconj J. 2021 Oct;38(5):625-647
Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3.
Siukstaite L, Imberty A, Römer W.
Front Mol Biosci. 2021 Jul 26;8:704685.
Importance of Bcl-2-family proteins in murine hematopoietic progenitor and early B cells.
Kurschat C, Metz A, Kirschnek S, Häcker G.
Cell Death Dis. 2021 Aug 11;12(8):784.
Signatures of Transcription Factor Evolution and the Secondary Gain of Red Algae Complexity.
Petroll R, Schreiber M, Finke H, Cock JM, Gould SB, Rensing SA.
Genes (Basel). 2021 Jul 9;12(7):1055.
Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine.
Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MS, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R, Neumann-Haefelin C, Hofmann M.
Nature. 2021 Sep;597(7875):268-273.
Flowering plant embryos: How did we end up here?
Rensing SA, Weijers D.
Plant Reprod. 2021 Dec;34(4):365-371
Maintaining proteostasis under mechanical stress.
Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B.
EMBO Rep. 2021 Aug 4;22(8):e52507.
Editorial: How Cells Build Plants: Regulatory Mechanisms for Integrated Functioning of Plant Cells and the Whole Plant Body.
Máthé C, Nick P, Pasternak TP.
Front Plant Sci. 2021 Jul 6;12:706892.
Sulfatides are endogenous ligands for the TLR4-MD-2 complex.
Su L, Athamna M, Wang Y, Wang J, Freudenberg M, Yue T, Wang J, Moresco EMY, He H, Zor T, Beutler B.
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2105316118.
A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress.
Moeglin E, Desplancq D, Stoessel A, Massute C, Ranniger J, McEwen AG, Zeder-Lutz G, Oulad-Abdelghani M, Chiper M, Lafaye P, Di Ventura B, Didier P, Poterszman A, Weiss E.
Cancers (Basel). 2021 Jul 1;13(13):3317.
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile.
Merz J, Nettesheim A, von Garlen S, Albrecht P, Saller BS, Engelmann J, Hertle L, Schäfer I, Dimanski D, König S, Karnbrock L, Bulatova K, Peikert A, Hoppe N, Hilgendorf I, von Zur Mühlen C, Wolf D, Groß O, Bode C, Zirlik A, Stachon P.
Membrane-water partitioning – Tackling the challenges of poorly soluble drugs using chaotropic co-solvents.
Naßwetter LC, Fischer M, Scheidt HA, Heerklotz H.
Biophys Chem. 2021 Oct;277:106654.
Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation.
Györfi AH, Matei AE, Fuchs M, Liang C, Rigau AR, Hong X, Zhu H, Luber M, Bergmann C, Dees C, Ludolph I, Horch RE, Distler O, Wang J, Bengsch B, Schett G, Kunz M, Distler JHW.
J Exp Med. 2021 Sep 6;218(9):e20201916.
Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery.
Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C.
Nat Commun. 2021 Jul 13;12(1):4284.
Functional assessment of two variants of unknown significance in TEK by endothelium-specific expression in zebrafish embryos.
Bell LM, Holm A, Matysiak U, Driever W, Rößler J, Schanze D, Wieland I, Niemeyer CM, Zenker M, Kapp FG.
Hum Mol Genet. 2021 Dec 17;31(1):10-17
CdrS Is a Global Transcriptional Regulator Influencing Cell Division in Haloferax volcanii.
Liao Y, Vogel V, Hauber S, Bartel J, Alkhnbashi OS, Maaß S, Schwarz TS, Backofen R, Becher D, Duggin IG, Marchfelder A.
mBio. 2021 Aug 31;12(4):e0141621.
Complex Micellization Behavior of the Polysorbates Tween 20 and Tween 80.
Knoch H, Ulbrich MH, Mittag JJ, Buske J, Garidel P, Heerklotz H.
Mol Pharm. 2021 Aug 2;18(8):3147-3157.
DTL-DephosSite: Deep Transfer Learning Based Approach to Predict Dephosphorylation Sites.
Chaudhari M, Thapa N, Ismail H, Chopade S, Caragea D, Köhn M, Newman RH, Kc DB.
Front Cell Dev Biol. 2021 Jun 24;9:662983.
PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.
Magalhaes J, Tresse E, Ejlerskov P, Hu E, Liu Y, Marin A, Montalant A, Satriano L, Rundsten CF, Carlsen EMM, Rydbirk R, Sharifi-Zarchi A, Andersen JB, Aznar S, Brudek T, Khodosevich K, Prinz M, Perrier JM, Sharma M, Gasser T, Issazadeh-Navikas S.
Mol Psychiatry. 2021 Oct;26(10):6083-6099
Green Light-Controlled Gene Switch for Mammalian and Plant Cells.
Schneider N, Chatelle CV, Ochoa-Fernandez R, Zurbriggen MD, Weber W.
Methods Mol Biol. 2021;2312:89-107.
The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression.
Gentle IE, Moelter I, Badr MT, Döhner K, Lübbert M, Häcker G.
Cell Death Dis. 2021 Jul 5;12(7):675. Purinergic Signal. 2021 Sep;17(3):481-492.
DNA Repair Protein APE1 Degrades Dysfunctional Abasic mRNA in Mitochondria Affecting Oxidative Phosphorylation.
Barchiesi A, Bazzani V, Jabczynska A, Borowski LS, Oeljeklaus S, Warscheid B, Chacinska A, Szczesny RJ, Vascotto C.
J Mol Biol. 2021 Sep 3;433(18):167125.
Autophosphorylation of the KaiC-like protein ArlH inhibits oligomerization and interaction with ArlI, the motor ATPase of the archaellum.
de Sousa Machado JN, Vollmar L, Schimpf J, Chaudhury P, Kumariya R, van der Does C, Hugel T, Albers SV.
Mol Microbiol. 2021 Sep;116(3):943-956.
QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy.
Nelson G, Boehm U, Bagley S, Bajcsy P, Bischof J, Brown CM, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North AJ, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow JR, Alexopoulos I, Aumayr K, Avilov S, Bakker GJ, Bammann RR, Bassi A, Beckert H, Beer S, Belyaev Y, Bierwagen J, Birngruber KA, Bosch M, Breitlow J, Cameron LA, Chalfoun J, Chambers JJ, Chen CL, Conde-Sousa E, Corbett AD, Cordelieres FP, Nery ED, Dietzel R, Eismann F, Fazeli E, Felscher A, Fried H, Gaudreault N, Goh WI, Guilbert T, Hadleigh R, Hemmerich P, Holst GA, Itano MS, Jaffe CB, Jambor HK, Jarvis SC, Keppler A, Kirchenbuechler D, Kirchner M, Kobayashi N, Krens G, Kunis S, Lacoste J, Marcello M, Martins GG, Metcalf DJ, Mitchell CA, Moore J, Mueller T, Nelson MS, Ogg S, Onami S, Palmer AL, Paul-Gilloteaux P, Pimentel JA, Plantard L, Podder S, Rexhepaj E, Royon A, Saari MA, Schapman D, Schoonderwoert V, Schroth-Diez B, Schwartz S, Shaw M, Spitaler M, Stoeckl MT, Sudar D, Teillon J, Terjung S, Thuenauer R, Wilms CD, Wright GD, Nitschke R.
J Microsc. 2021 Oct;284(1):56-73.
Deciphering the role of Minor histocompatibility antigens for acute graft-versus-host disease.
Giesler S, Zeiser R.
Transplant Cell Ther. 2021 Jul;27(7):523-524.
Synthetic biology as driver for the biologization of materials sciences.
Burgos-Morales O, Gueye M, Lacombe L, Nowak C, Schmachtenberg R, Hörner M, Jerez-Longres C, Mohsenin H, Wagner HJ, Weber W.
Mater Today Bio. 2021 May 26;11:100115.
Gene-rich UV sex chromosomes harbor conserved regulators of sexual development.
Carey SB, Jenkins J, Lovell JT, Maumus F, Sreedasyam A, Payton AC, Shu S, Tiley GP, Fernandez-Pozo N, Healey A, Barry K, Chen C, Wang M, Lipzen A, Daum C, Saski CA, McBreen JC, Conrad RE, Kollar LM, Olsson S, Huttunen S, Landis JB, Burleigh JG, Wickett NJ, Johnson MG, Rensing SA, Grimwood J, Schmutz J, McDaniel SF.
Sci Adv. 2021 Jun 30;7(27):eabh2488.
The Polycomb group protein MEDEA controls cell proliferation and embryonic patterning in Arabidopsis.
Simonini S, Bemer M, Bencivenga S, Gagliardini V, Pires ND, Desvoyes B, van der Graaff E, Gutierrez C, Grossniklaus U.
Dev Cell. 2021 Jul 12;56(13):1945-1960.e7.
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Schwabenland M, Salié H, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B.
Immunity. 2021 Jul 13;54(7):1594-1610.e11.
Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells.
Ngoenkam J, Paensuwan P, Wipa P, Schamel WWA, Pongcharoen S.
Cell Dev Biol. 2021 Jun 8;9:674572.
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis.
Shen JX, Couchet M, Dufau J, de Castro Barbosa T, Ulbrich MH, Helmstädter M, Kemas AM, Zandi Shafagh R, Marques MA, Hansen JB, Mejhert N, Langin D, Rydén M, Lauschke VM.
Adv Sci (Weinh). 2021 Aug;8(16):e2100106.
Hierarchical dynamics in allostery following ATP hydrolysis monitored by single molecule FRET measurements and MD simulations.
Wolf S, Sohmen B, Hellenkamp B, Thurn J, Stock G, Hugel T.
Chem Sci. 2021 Jan 15;12(9):3350-3359.
StoatyDive: Evaluation and classification of peak profiles for sequencing data.
Heyl F, Backofen R.
Gigascience. 2021 Jun 18;10(6):giab045.
Neutrophils self-limit swarming to contain bacterial growth in vivo.
Kienle K, Glaser KM, Eickhoff S, Mihlan M, Knöpper K, Reátegui E, Epple MW, Gunzer M, Baumeister R, Tarrant TK, Germain RN, Irimia D, Kastenmüller W, Lämmermann T.
Science. 2021 Jun 18;372(6548):eabe7729. d
Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors.
Hörner M, Jerez-Longres C, Hudek A, Hook S, Yousefi OS, Schamel WWA, Hörner C, Zurbriggen MD, Ye H, Wagner HJ, Weber W.
Sci Adv. 2021 Jun 16;7(25):eabf0797.
CRISPRloci: comprehensive and accurate annotation of CRISPR-Cas systems.
Alkhnbashi OS, Mitrofanov A, Bonidia R, Raden M, Tran VD, Eggenhofer F, Shah SA, Öztürk E, Padilha VA, Sanches DS, de Carvalho ACPLF, Backofen R.
Nucleic Acids Res. 2021 Jul 2;49(W1):W125-W130.
The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.
Rubio T, Weyershaeuser J, Montero MG, Hoffmann A, Lujan P, Jechlinger M, Sotillo R, Köhn M.
J Mol Med (Berl). 2021 Oct;99(10):1413-1426.
Expanding the SiMPl Plasmid Toolbox for Use with Spectinomycin/Streptomycin.
Palanisamy N, Ballestin JB, Di Ventura B.
ACS Omega. 2021 May 21;6(22):14148-14153.
Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions.
Hoermann B, Köhn M. Biochem Soc Trans. 2021 Jun 30;49(3):1065-1074.
Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.
Herati RS, Silva LV, Vella LA, Muselman A, Alanio C, Bengsch B, Kurupati RK, Kannan S, Manne S, Kossenkov AV, Canaday DH, Doyle SA, Ertl HCJ, Schmader KE, Wherry EJ.
Cell Rep Med. 2021 May 7;2(5):100262.
Immunomodulatory Therapies for the Treatment of Graft-versus-host Disease.
Braun LM, Zeiser R.
Hemasphere. 2021 Jun 1;5(6):e581.
A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Lines.
Fahrner M, Kook L, Fröhlich K, Biniossek ML, Schilling O.
Proteomes. 2021 May 25;9(2):26.
Optogenetic Approaches for the Spatiotemporal Control of Signal Transduction Pathways. Kramer MM, Lataster L, Weber W, Radziwill G.
Int J Mol Sci. 2021 May 18;22(10):5300.
Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation.
Friedrich SK, Schmitz R, Bergerhausen M, Lang J, Duhan V, Hardt C, Tenbusch M, Prinz M, Asano K, Bhat H, Hamdan TA, Lang PA, Lang KS.
Pathogens. 2021 May 19;10(5):622.
Mapping of Metabolic Heterogeneity of Glioma Using MR-Spectroscopy.
Franco P, Huebschle I, Simon-Gabriel CP, Dacca K, Schnell O, Beck J, Mast H, Urbach H, Wuertemberger U, Prinz M, Hosp JA, Delev D, Mader I, Heiland DH.
Cancers (Basel). 2021 May 17;13(10):2417.
Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding.
Yousefi OS, Ruggieri M, Idstein V, von Prillwitz KU, Herr LA, Chalupsky J, Köhn M, Weber W, Timmer J, Schamel WWA.
Int J Mol Sci. 2021 May 6;22(9):4920.
DIMA: Data-Driven Selection of an Imputation Algorithm.
Egert J, Brombacher E, Warscheid B, Kreutz C.
J Proteome Res. 2021 Jul 2;20(7):3489-3496.
GPCRomics of Homeostatic and Disease-Associated Human Microglia.
Hsiao CC, Sankowski R, Prinz M, Smolders J, Huitinga I, Hamann J.
Front Immunol. 2021 May 14;12:674189.
Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin.
Sponga A, Arolas JL, Schwarz TC, Jeffries CM, Rodriguez Chamorro A, Kostan J, Ghisleni A, Drepper F, Polyansky A, De Almeida Ribeiro E, Pedron M, Zawadzka-Kazimierczuk A, Mlynek G, Peterbauer T, Doto P, Schreiner C, Hollerl E, Mateos B, Geist L, Faulkner G, Kozminski W, Svergun DI, Warscheid B, Zagrovic B, Gautel M, Konrat R, Djinović-Carugo K.
Sci Adv. 2021 May 28;7(22):eabg7653.
Metabolic reprogramming of inner ear cell line HEI-OC1 after dexamethasone application.
Kather M, Koitzsch S, Breit B, Plontke S, Kammerer B, Liebau A.
Metabolomics. 2021 May 24;17(6):52.
The Rise of Molecular Optogenetics.
Di Ventura B, Weber W.
Adv Biol (Weinh). 2021 May;5(5):e2100776.
The Universally Conserved ATPase YchF Regulates Translation of Leaderless mRNA in Response to Stress Conditions.
Landwehr V, Milanov M, Angebauer L, Hong J, Jüngert G, Hiersemenzel A, Siebler A, Schmit F, Öztürk Y, Dannenmaier S, Drepper F, Warscheid B, Koch HG.
Front Mol Biosci. 2021 May 7;8:643696.
QUAREP-LiMi: a community endeavor to advance quality assessment and reproducibility in light microscopy.
Boehm U, Nelson G, Brown CM, Bagley S, Bajcsy P, Bischof J, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North AJ, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow JR, Nitschke R.
Nat Methods. 2021 Dec;18(12):1423-1426
Coregulation of gene expression by White collar 1 and phytochrome in Ustilago maydis.
Brych A, Haas FB, Parzefall K, Panzer S, Schermuly J, Altmüller J, Engelsdorf T, Terpitz U, Rensing SA, Kiontke S, Batschauer A.
Fungal Genet Biol. 2021 Jul;152:103570.
S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV).
Görög A, Antiga E, Caproni M, Cianchini G, De D, Dmochowski M, Dolinsek J, Drenovska K, Feliciani C, Hervonen K, Lakos Jukic I, Kinyó Á, Koltai T, Korponay-Szabó I, Marzano AV, Patsatsi A, Rose C, Salmi T, Schmidt E, Setterfield J, Shahid M, Sitaru C, Uzun S, Valitutti F, Vassileva S, Yayli S, Sárdy M.
J Eur Acad Dermatol Venereol. 2021 Jun;35(6):1251-1277.
Automated and semi-automated enhancement, segmentation and tracing of cytoskeletal networks in microscopic images: A review.
Özdemir B, Reski R.
Comput Struct Biotechnol J. 2021 Apr 15;19:2106-2120.
Synthetic Biology: Emerging Concepts to Design and Advance Adeno-Associated Viral Vectors for Gene Therapy.
Wagner HJ, Weber W, Fussenegger M.
Adv Sci (Weinh). 2021 Feb 26;8(9):2004018.
Extrusion-Based 3D Bioprinting of Gradients of Stiffness, Cell Density, and Immobilized Peptide Using Thermogelling Hydrogels.
Kuzucu M, Vera G, Beaumont M, Fischer S, Wei P, Shastri VP, Forget A.
ACS Biomater Sci Eng. 2021 Jun 14;7(6):2192-2197.
Eplerenone Improves Pulmonary Vascular Remodeling and Hypertension by Inhibition of the Mineralocorticoid Receptor in Endothelial Cells.
Kowalski J, Deng L, Suennen C, Koca D, Meral D, Bode C, Hein L, Lother A.
Hypertension. 2021 Aug;78(2):456-465.
Architecture of the membrane-bound cytochrome c heme lyase CcmF.
Brausemann A, Zhang L, Ilcu L, Einsle O.
Nat Chem Biol. 2021 Jul;17(7):800-805.
2nSILAC for Quantitative Proteomics of Prototrophic Baker’s Yeast.
Dannenmaier S, Oeljeklaus S, Warscheid B.
Methods Mol Biol. 2021;2228:253-270.
Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation.
Emmerich F, Zschiedrich S, Reichenbach-Braun C, Süsal C, Minguet S, Pauly MC, Seidl M.
Molecules. 2021 Apr 30;26(9):2648.
Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition.
Catalano A, Adlesic M, Kaltenbacher T, Klar RFU, Albers J, Seidel P, Brandt LP, Hejhal T, Busenhart P, Röhner N, Zodel K, Fritsch K, Wild PJ, Duyster J, Fritsch R, Brummer T, Frew IJ.
Cancers (Basel). 2021 Apr 13;13(8):1852.
Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups.
Rammensee HG, Gouttefangeas C, Heidu S, Klein R, Preuß B, Walz JS, Nelde A, Haen SP, Reth M, Yang J, Tabatabai G, Bösmüller H, Hoffmann H, Schindler M, Planz O, Wiesmüller KH, Löffler MW.
Vaccines (Basel). 2021 Apr 24;9(5):428.
Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.
Hartl FA, Ngoenkam J, Beck-Garcia E, Cerqueira L, Wipa P, Paensuwan P, Suriyaphol P, Mishra P, Schraven B, Günther S, Pongcharoen S, Schamel WWA, Minguet S.
Cells. 2021 Apr 7;10(4):834.
GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
Bhandari P, Vandael D, Fernández-Fernández D, Fritzius T, Kleindienst D, Önal C, Montanaro J, Gassmann M, Jonas P, Kulik A, Bettler B, Shigemoto R, Koppensteiner P.
Elife. 2021 Apr 29;10:e68274.
Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells.
Hatscher L, Lehmann CHK, Purbojo A, Onderka C, Liang C, Hartmann A, Cesnjevar R, Bruns H, Gross O, Nimmerjahn F, Ivanović-Burmazović I, Kunz M, Heger L, Dudziak D.
Sci Signal. 2021 Apr 27;14(680):eabe1757.
Engineering AraC to make it responsive to light instead of arabinose.
Romano E, Baumschlager A, Akmeriç EB, Palanisamy N, Houmani M, Schmidt G, Öztürk MA, Ernst L, Khammash M, Di Ventura B.
Nat Chem Biol. 2021 Jul;17(7):817-827.
CD4+ T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate.
Bernardi C, Maurer G, Ye T, Marchal P, Jost B, Wissler M, Maurer U, Kastner P, Chan S, Charvet C.
Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2023172118.
Barcoded viral tracing of single-cell interactions in central nervous system inflammation.
Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ.
Science. 2021 Apr 23;372(6540):eabf1230.
Molecular basis of F-actin regulation and sarcomere assembly via myotilin.
Kostan J, Pavšič M, Puž V, Schwarz TC, Drepper F, Molt S, Graewert MA, Schreiner C, Sajko S, van der Ven PFM, Onipe A, Svergun DI, Warscheid B, Konrat R, Fürst DO, Lenarčič B, Djinović-Carugo K.
PLoS Biol. 2021 Apr 12;19(4):e3001148.
The Leishmania donovani LDBPK_220120.1 Gene Encodes for an Atypical Dual Specificity Lipid-Like Phosphatase Expressed in Promastigotes and Amastigotes; Substrate Specificity, Intracellular Localizations, and Putative Role(s).
Papadaki A, Tziouvara O, Kotopouli A, Koumarianou P, Doukas A, Rios P, Tardieux I, Köhn M, Boleti H.
Front Cell Infect Microbiol. 2021 Mar 25;11:591868.
HAG1 and SWI3A/B control of male germ line development in P. patens suggests conservation of epigenetic reproductive control across land plants.
Genau AC, Li Z, Renzaglia KS, Fernandez Pozo N, Nogué F, Haas FB, Wilhelmsson PKI, Ullrich KK, Schreiber M, Meyberg R, Grosche C, Rensing SA.
Plant Reprod. 2021 Jun;34(2):149-173.
Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19.
Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT.
Brain. 2021 May 7;144(4):1263-1276.
Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing.
Emig R, Knodt W, Krussig MJ, Zgierski-Johnston CM, Gorka O, Groß O, Kohl P, Ravens U, Peyronnet R.
Cells. 2021 Mar 16;10(3):663.
Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis.
Hoefflin R, Lazarou A, Hess ME, Reiser M, Wehrle J, Metzger P, Frey AV, Becker H, Aumann K, Berner K, Boeker M, Buettner N, Dierks C, Duque-Afonso J, Eisenblaetter M, Erbes T, Fritsch R, Ge IX, Geißler AL, Grabbert M, Heeg S, Heiland DH, Hettmer S, Kayser G, Keller A, Kleiber A, Kutilina A, Mehmed L, Meiss F, Poxleitner P, Rawluk J, Ruf J, Schäfer H, Scherer F, Shoumariyeh K, Tzschach A, Peters C, Brummer T, Werner M, Duyster J, Lassmann S, Miething C, Boerries M, Illert AL, von Bubnoff N.
Cancers (Basel). 2021 Mar 8;13(5):1151.
Multiscale Molecular Dynamics Studies Reveal Different Modes of Receptor Clustering by Gb3-Binding Lectins.
Kociurzynski R, Makshakova ON, Knecht V, Römer W.
J Chem Theory Comput. 2021 Apr 13;17(4):2488-2501.
Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants.
Schwenk P, Sheerin DJ, Ponnu J, Staudt AM, Lesch KL, Lichtenberg E, Medzihradszky KF, Hoecker U, Klement E, Viczián A, Hiltbrunner A. Elife. 2021 Mar 30;10:e63697.
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices.
Lerner E, Barth A, Hendrix J, Ambrose B, Birkedal V, Blanchard SC, Börner R, Sung Chung H, Cordes T, Craggs TD, Deniz AA, Diao J, Fei J, Gonzalez RL, Gopich IV, Ha T, Hanke CA, Haran G, Hatzakis NS, Hohng S, Hong SC, Hugel T, Ingargiola A, Joo C, Kapanidis AN, Kim HD, Laurence T, Lee NK, Lee TH, Lemke EA, Margeat E, Michaelis J, Michalet X, Myong S, Nettels D, Peulen TO, Ploetz E, Razvag Y, Robb NC, Schuler B, Soleimaninejad H, Tang C, Vafabakhsh R, Lamb DC, Seidel CA, Weiss S.
Elife. 2021 Mar 29;10:e60416.
Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development.
Schoels M, Zhuang M, Fahrner A, Küchlin S, Sagar, Franz H, Schmitt A, Walz G, Yakulov TA.
Am J Physiol Renal Physiol. 2021 May 1;320(5):F826-F837.
Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice.
Vasiljeva O, Sevenich L, Reinheckel T.
Methods Mol Biol. 2021;2294:275-293.
CEDAR, an online resource for the reporting and exploration of complexome profiling data.
van Strien J, Haupt A, Schulte U, Braun HP, Cabrera-Orefice A, Choudhary JS, Evers F, Fernandez-Vizarra E, Guerrero-Castillo S, Kooij TWA, Páleníková P, Pardo M, Ugalde C, Wittig I, Wöhlbrand L, Brandt U, Arnold S, Huynen MA.
Biochim Biophys Acta Bioenerg. 2021 Jul 1;1862(7):148411.
Comprehensive Integration of Genome-Wide Association and Gene Expression Studies Reveals Novel Gene Signatures and Potential Therapeutic Targets for Helicobacter pylori-Induced Gastric Disease.
Badr MT, Omar M, Häcker G.
Front Immunol. 2021 Feb 24;12:624117.
A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction.
Siegel PM, Bojti I, Bassler N, Holien J, Flierl U, Wang X, Waggershauser P, Tonnar X, Vedecnik C, Lamprecht C, Stankova I, Li T, Helbing T, Wolf D, Anto-Michel N, Mitre LS, Ehrlich J, Orlean L, Bender I, Przewosnik A, Mauler M, Hollederer L, Moser M, Bode C, Parker MW, Peter K, Diehl P.
Basic Res Cardiol. 2021 Mar 15;116(1):17.
Involvement of N-glycans in binding of Photorhabdus luminescens Tc toxin.
Ng’ang’a PN, Siukstaite L, Lang AE, Bakker H, Römer W, Aktories K, Schmidt G.
Cell Microbiol. 2021 Aug;23(8):e13326.
Is the Pr form of phytochrome biologically active in the nucleus?
Li J, Hiltbrunner A.
Mol Plant. 2021 Apr 5;14(4):535-537.
Optimizing Protocols for Arabidopsis Shoot and Root Protoplast Cultivation.
Pasternak T, Paponov IA, Kondratenko S.
Plants (Basel). 2021 Feb 15;10(2):375.
Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells.
Kern U, Fröhlich K, Bedacht J, Schmidt N, Biniossek ML, Gensch N, Baerenfaller K, Schilling O.
Cells. 2021 Feb 16;10(2):404.
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A.
Immunity. 2021 Apr 13;54(4):648-659.e8.
The active repertoire of Escherichia coli peptidoglycan amidases varies with physiochemical environment.
Mueller EA, Iken AG, Ali Öztürk M, Winkle M, Schmitz M, Vollmer W, Di Ventura B, Levin PA.
Mol Microbiol. 2021 Jul;116(1):311-328.
Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides.
Frensch B, Lechtenberg T, Kather M, Yunt Z, Betschart M, Kammerer B, Lüdeke S, Müller M, Piel J, Teufel R.
Nat Commun. 2021 Mar 4;12(1):1431.
Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.
Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S.
Nat Commun. 2021 Feb 4;12(1):782.