BIOSS
Centre for Biological Signalling Studies

Lab news

2022

05.-06.05.2022            Susana Minguet and Wolfgang Schamel join the 3rd Interantional Symposium of the collaborative Research Centra 854 in Magdeburg where Susana presents our newest research.

27.04.2022                   We are thrilled to announce that Susana Minguet is awarded with the prestigeous Heisenberg professorship. Many congratulations on this outstanding recognition of the amazing work you are doing every day. We are so proud of you!

20.04.2022                    Susana Minguet publishes a review about inborn errors of immunity and immunodeficiencies. Congratulations on this great review! https://doi.org/10.1002/eji.202149529

06.04.2022                     We have received the 2nd funding period for the CIBSS excellence cluster! We are looking forward to many more amazing research projects and collaborations! #GoCIBSS

05.04.2022                     Alejandra Parigiani has been accepted into two great mentoring programs supporting early stage researchers in pursuing an academic career. Many congratulations and all the best for the #CIBSSLauchnpad and #AdvanceMent!

04.04.2022                     Araya Rattanasri joins our group as visiting PhD student for 1 year. She comes from the Naresuan University in Phitsanulok, Thailand and is supported by the National Research Council of Thailand. We are happy to have you and wish you a great time!

31.03.2022                    Anna-Maria Schaffer defends her amazing PhD project “The role of the membrane proteins Kidins220 and Caveolin-1 in B cell development and activation”. Many, many congratulations from all of us dear Anna! You did an amazing job Dr. Schaffer and we are really happy for you!!

24.03.2022                    Anna Ehret is accepted into the SGBM graduate school. Congratulations dear Anna, we hope you enjoy and benefit from becoming a part of this interdisziplinary research community!

24.02.2022                    Hamu Guo presents  his Master Thesis "Analysis of the role of RASEF in TCR signaling" in a great defense. Congratulations from all of us Hanmu!!

18.02.2022                    Laurenz Herr successfully defends his PhD Thesis "Kidins220 negatively regulates TCR signaling in iNKT and conventional αβ T cell development". Many congratulations from all of us on your great work and your fantastic presentation. Herr Doktor Herr, we are very proud of you!

15.01.2022                     We warmly welcome Trang Nguyen as new PhD student. She is part of the international, interdisciplinary and cross-sectoral PhD programme URIdoc, supported by the European Commission. It is really great having you!! https://www.urigroup.eu/euridoc/

 

2021

15.12.2021                    Badeel Khalaf defens his Maste Thesis "The impact of CD3ε tyrosine phospho-mimicking variants on TCR and 19BBε CAR signaling". Very nice work and great presentation Badeel! Congratulations!!

08.12.2021                    Stephanie Doetsch successfully defends her Master Thesis "Investigating the molecular features of the CD3ε RK motif". Great job and great presentation Steffi, congratulations from all of us!

12.11.2021                    Kevin Echle defends his Maste Thesis: Role of Syndapin II on limiting the amounts of TCRs. Congratulations on your nice presentation Kevin!

22.10.2021                   Salma Pathan and Wolfgang publish a paper together with our collaborators from China: "Cholesterol binds in a reversed orientation to TCRβ-TM in which its OH group is localized to the center of the lipid bilayer". Congratulations to all authors!!

22.10.2021                   We joined the Science Days 2021 at the Europa Park in Rust. Our group members answered question after question and aroused the curiosity of the many children with exciting experiments and interactive games!

15.10.2021                  All of us joined the 5th Upper Rhine Immunologie Meeting. Great poster presentation by Claudia Juraske, Vincent Idstein and Misol Velasco, who won the URI Poster Pize!

13.-14.10.2021          We very much enjoyed the gd Confernce in Würzburg with a great talk by Claudia Juraske and Maria Krißmer.

06.-07.10.2021          We were really happy to join the CIBSS retreat finally again in person. Sascha Yousefi, Anna Ehret, Nadine Wössner and Ira Godbole prepared great posters to share their project progress and we all very much enjoyed the vibrant discussions!

01.10.2021                 We warmly welcome María Alejandra Parigiani as new Postdoc! It's great having you and we wish you much success!

21.09.2021                 Susana Minguet is the first every winner of the "Novartis-Preis für therapierelevante immunologische Forschung". The DGfI honors her outstanding work about the molecular control of T cell responses leading to improved CAR T cell  therapies. We are super proud of you!! https://dgfi.org/ausgezeichnet-deutsche-gesellschaft-fuer-immunologie-dgfi-ehrt-herausragende-nachwuchswissenschaftler-4/

14.09.2021                 Niko Thorausch successfully defends his PhD Thesis titeled: "HLA-independent engagement of the TCR complex using synthetic TRuC receptors: A novel approach to genetically reprogram T cells for potent cancer immunotherapy"

08.09.2021                 Many congratulations to Susana Minguet for being selected as Internal Senior Fellows by FRIAS!

01.09.2021                 Vincent Hammes defends his Bachelor Thesis “Analysis of cholesterol binding deficient mutants of TCR”. Many congratulations on your nice presentation!

01.09.2021                 Marina Zintchenko officially starts her PhD. We are really happy to have you and wish you much success!

01.09.2021                 Maria Krißmer successfully defends her Bachelor Thesis “Primary human γδ T cells lentivirally transduced with TCR fusion constructs (TRuCs) show anti-tumor activity”. Many congratulations! Great job Maria!

28.08.2021                 Sergio Suárez Arcos presents his Bachelor Thesis "Timing of αβ- and γδ-TCR activation by ontogenetic system". Great job Sergio! We hope you enjoyed your Erasmus and we wish you a save trip home to Spain!

07.07.2021                We are very happy that we received the second funding period for the FOR 2799 "Receiving and Translating Signals via the gd TCR". Gamma Delta T cells rocking Germany!

02.07.2021                10 years ago Susana Minguet came back from Madrid to start her own group in Freiburg. Today we are all celebarting  together with cake and champagne!

21.05.2021                 The DFG has granted a new CRC in Freiburg "Oncoescape" for researching new types of cancer treatments. Susana Minguet is participating with an exciting research proposal! We are looking forward to it! https://www.pr.uni-freiburg.de/pm-en/press-releases-2021/eleven-million-euros-for-researching-new-types-of-cancer-treatment

13.05.2021                Ira Godbole successfully defends her Master Thesis: "Development of eTRuCs against SARS-CoV-2". Congratulations from all of us!

07.05.2021                Marissa Russ defends her Master Thesis: "Development of a membrane-bound phytochrome B protein for light-controllable cell-cell interaction to investigate T cell activation". Many congratulations on you great defens Marissa!

06.05.2021                Sascha Yousefi and Matias Ruggieri publish their paper "Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding". Many congratulations to all authors!! https://doi.org/10.3390/ijms22094920

26.-29.04.2021         Susana Minguet was invited as speaker to the IGBMC-FMI Graduate Student Symposium and presented our work on rational Chimeric antigen design!

22.04.2021                 We are proud that Susana Minguet is part of the "Gegen den Hass" project. https://www.pr.uni-freiburg.de/pm/2021/erfolgreich-mit-gegen-den-hass  https://carolin-emcke.de/gegen-den-hass/

07.04.2021                 Frederike Hartl publishes her paper "Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling". Many congratulations to all authors on this nice publication! https://doi.org/10.3390/cells10040834

25.02.2021                  Salma Pathan-Chhatbar publishes her second review "The role of cholesterol in TCR signalling in autoimmune diseases". Congratulations to all authors on this very nice article!! https://doi.org/10.18103/mra.v9i2.2284

01.03.2021                 Today Anna Ehret starts her PhD in our lab! Welcome back and we all wish you much success for your Thesis!

21.02.2021                  Susana Minguet got interviewed by Howard Wollinsky for EMBO reports about teaching in times of COVID. The article reflects on her personal experiences, difficulties and joys of teaching Immunology at the University of Freiburg during the first COVID lock down.  https://www.embopress.org/doi/full/10.15252/embr.202152513

08.01.2021                 Congratulations to Salma Pathan-Chhatbar for publishing her review about "Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol". We congratulate all authors on this very nice work! Great job!! https://doi.org/10.3389/fcell.2020.615996

02.01.2021                Since one party was not enough we decided to meet again to play some online-scribbel all together and celebrate Salmas birthday. Thanks to all of you for so much fun and laughter and happy brithday to you Salma!

30.12.2021                Anna Ehret finishes her Master Thesis "Analysis of the activity decay in the MAP kinase pathway after optogenetic ligand detachment from the T cell receptor". Great job Anna and congratulation to you! We are looking forward to welcome you back as PhD student!

22.12.2021               Today we celebrated our very first online christmas party. Thank you to all of you how made it such a magical and cheerful night!

07.12.2021               Juliane Striez, Simon Brandl, Gregor Conradt and Susana Minguet are part of the study "NLRC5 promotes transcription of BTN3A1-3 genes and Vγ9Vδ2 T cell-mediated killing". Many congratulations to all of you! https://doi.org/10.1016/j.isci.2020.101900

 

2020

26.11.2020                We are really happy that our latest review in now online. "Caveolin-1, tetraspanin CD81 and flotillins in lymphocyte cell membrane organization, signaling and immunopathology". We are proud of the great article by Anna-Maria Schaffer and Susana Minguet and thank the SFB-1160 for the support.  doi.org/10.1042/BST20190387

23.-25.11.2020        We attended the CIBSS Symposium "Signalling across Scales" and Nadine Wössner presented a poster and a Flash Talk about her current research. Thank you CIBBS for the organization and the opportunity for some very nice discussions! We all really enjoyed the meeting!

23.11.2020               Our dear collaborators from the group of Burkhart Schraven publish their paper about the Tyrosine 192 in Lck. Congratulations to you and we are happy that Nadine Wössner contributed to support the results using our recently published Proximity Ligation Assay. doi.org/10.1186/s12964-020-00673-z

12.11.2020               To foster the transition from postdoc to group leader, the SFB 1381 awarded Sascha Yousefi the Young Investigator Grant for his project “Analysis of dynamic signalosome assembly upon optogenetically controlled T cell signal input”. Congratulations Sascha this is amazing and well deserved!

12.11.2020               Marina Zintchenko defends her Master thesis about "Rational Design of Chimeric Antigen Receptors against Chronic Lymphocytic Leukemia". Congratulations, you did an amazing job and a great presentation! We are happy that you will stay some more months with us to continue your studies.

2.-3.11.2020            Anna-Maria Schaffer and Susana Minguet participate in the first online retreat of the SFB-1160. Great talk by Anna-Maria!

01.11.2020              After spending three year as a PostDoc in Lisboa, Portugal, we welcome back Gina Fiala! Gina got support from the Universtiy Freiburgs COME and STAY programm.

30.10.2020              Misol Velasco is awarded with a two-year scholarship from the FAZIT foundation to finish her doctoral degree. Congratulations Misol and much success finishing your PhD!

26.10.2020              Celia Makowiec finished her Bachelor thesis with a great defense about "The effects of sterol lipids on TCR activation". Congratulations from all of us and we are happy you are staying a few more months with us before starting your Masters in Basel.

16.10.2020              We joined the 4th Upper Rhine Immunology meeting  and contributed with a great talk from Nadine Wössner and two amazing posters from Salma Pathan-Chhatbar and Matias Ruggieri.

12.10.2020              Annabelle Buschky very successfully defends her Master Thesis: "Characterisation of CD3ε functional motifs in CAR T cells". Congratulation and all the best for your and your new job at Roche!

01.10.2020              Great filming day in BIOSS! Thanks to all the group for your perfect “acting”! twitter.com/LabMinguet/status/1311778380791021576

01.10.2020              Simon Brandl starts his PhD. It's great having you and we wish you much success!

25.09.2020              Niko Thorausch and Wolfgang Schamel supported a study about "PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model". Very nice work and congratulations to all authors! doi.org/10.1016/j.omto.2020.06.014

17.09.2020              Susana Minguet is invited by the SFB-854, Magdeburg, to share our latest research.

13.09.2020              Anna-Maria Schaffer is awarded with an EMBO Short-Term-Fellowship and is off to Madrid for three month to perform exciting experiments studying immune synapse formation in B cells in the lab of Yolanda R. Carrasco. We wish you much success and a great time!

11.09.2020              Simon Brandl defends his Master Thesis: "Improvement of CAR T Cell-based Immunotherapies by the Rational Design of Novel Chimeric Antigen Receptors against Human Cancer". Simon we are very proud of you! You did a great job and a great presentation.

31.07.2020              Max Wess and Paul Matusewicz successfully denfend their Master Theses on “Investigation of the role of Lck and LAT in kinetic proofreading“ and "Characterization of two hLck mutants". Well done and congratulations to both of you!

20.07.2020              We are really happy that our latest manuscript is online (Hartl et al., 2020 Nature Immunology). Great collaborative effort of many, many people along the years, travelling from basic knowledge of T cell receptor function to  rational design of a novel Chimeric Antigen Receptor (CAR) for cancer immunotherapy. Congratulation to all collaborators and authors, especially Frederike Hartl. And thank you to the whole Schamel and Minguet group for your support and inspiration. #Teamwork https://www.pr.uni-freiburg.de/pm-en/press-releases-2020/how-immune-cells-activate-the-killer-mode?set_language=en https://www.nature.com/articles/s41590-020-0732-3

01.07.2020             Together with Kerstin Fehrenbach we celebrate her 25. anniversary of working for the University of Freiburg with a get-together in the botanical garden. Dear Kerstin we are more than grateful to have you in our group for 10 years now. You are doing an outstanding job: keeping the overview, managing the lab and taking care of everyone in the lab. Thank you so much for all you efforts, you are much appreciated!

June 2020              First fully online Flow Cytometry course for Master students of Uni Freiburg, Basel and Straßburg. Organised by Susana Minguet with the support of Uni Straßburg and Uni Basel and the incredible tutoring by our PhD students. Thank you for your help! https://twitter.com/03Sp1/status/1273555638912716801

May 2020               First ever fully online practical course for the students of the SP-1 module using Twitter: Immunobiology in 280 characters or less! Read the nice article that Pascal Lienhard wrote about our innovative teaching approach during the COVI-19 lock down  https://www.pr.uni-freiburg.de/pm-en/online-magazine/teaching-and-learning/immunobiology-in-280-characters-or-less?set_language=en

20.05.2020            Claudia Juraske and Vincent Idstein have been officially admitted to be members of the Spemann Graduate School f Biology and Medicine (SGBM). We are really proud of you and hope you will enjoy to be part of this community!

20.05.2020            Katrin Raute defends her innovative PhD Thesis "Using γδ T cell immunotherapy against breast cancer stem-like cells", which is awarded with a highly deserved summa cum laude!  Many congratulations Dr. Raute, you did an outstanding job!

29.04.2020            Celebrating the Day of Immunology with CIBSS! See all videos

08.04.2020            Anna Morath and Wolfgang Schamel are happy to be part of the study "Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds". Well done :) doi: 10.3389/fphar.2020.00402

05.03.2020            We published two bio-protocol papers in order for other groups around the world to use our optogenetic T cell stimulation system. Herein, we describe our methods in great detail.  Hörner M, Yousefi OS, Schamel W & Weber W. Production, Purification and Characterization of Recombinant Biotinylated Phytochrome B for Extracellular Optogenetics. BIO-PROTOCOL 10, (2020). bio-protocol.org/e3541; Yousefi et al. Optogenetic Tuning of Ligand Binding to The Human T cell Receptor Using The opto-ligand-TCR System. BIO-PROTOCOL 10, (2020). https://bio-protocol.org/e3540. Congratulation to all authors and thank you for this great team work @BIOSS and @CIBSS.

18.02.2020            Gregor Conradt defends his Master Thesis on "Linking oncogenic signaling to γδ T cell activation". You did a great job and we wish you all the best for your internship at Novartis!

31.01.2020            Niko Thorausch and Wolfgang Schamel are part of a study investigating the "Molecular mechanism of SHP2 activation by PD-1 stimulation". Congratulations to all authors on this great paper! doi: 10.1126/sciadv.aay4458

29.01.2020            "αβ and γδ T cell receptors: Similar but different" is the titel of the great review Anna Morath and Wolfgang wrote together. Very nice work you two, we love it :)  doi.org/10.1002/JLB.2MR1219-233R

08.01.2020            We congratulate Juliane Striez on her great work supporting the paper "Chemotherapeutic Stress Influences Epithelial–Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer" published by the group of Jochen Maurer. doi.org/10.3390/ijms21020404

01.01.2020            Claudia Juraske and Vincent Idstein start their PhDs. We are happy that you will stay with us and we wish you both much success for the next years!

 

2019

29.11.2019            Vincent Idstein successfully defends his Master Thesis: "Development of a GFP-free PIF-TCR for light inducible activation of Jurkat cells and primary T cell blasts". Congratulations Vincent, you really did a great job and prepared a great presentation!

29.11.2019            Helena Brandt defends her Master Thesis titled: "The Interaction between Caveolin-1 and the Cytoskeleton and its role in B Cell Receptor Activation". Many congratulations to you Lena and all the best for your PhD in Heidelberg!

12.11.2019            We contributed to a study by Marcela Maus and colleagues designing a a new CAR. This work is published today and Misol-Ha did the biochemical work. We a happy to be part of it.
 https://www.ncbi.nlm.nih.gov/pubmed/31698455

01.11.2019            We joined forces with our collaborators and friends in Thailand and publish today a paper on the role of the actin cytoskeleton in regulating conformational changes at the TCR. https://www.ncbi.nlm.nih.gov/pubmed/31674657

31.10.2019            Anna Morath, Claudia Juraske and Wolfgang Schamel supported the group of Barbara Di Ventura with their paper "Split intein-mediated selection of cells containing two plasmids using a single antibiotic". Congratulations to all! doi.org/10.1038/s41467-019-12911-1

19.10.2019            We joined the 3rd Annual Meeting of the Upper Rhine Immunology (URI) Group in Basel. It was a great opportunity for networking, discussing and establishing new collaborations with scientists working in the fields of adaptive and innate immunity, signaling and the immune response, hematopoiesis, immunodeficiency, inflammation and disease, and immunotherapy from Freiburg, Strasbourg and Basel. Sascha Yousefi presented his work on the optogenetical TCR and Niko Thorausch on the TRuCs. Thank you everyone for such an exciting day!
http://www.ubaselimmunology.org/uri2019.html

17.-18.10.2019      We participated in the scientific symposium “Celebrate 40 years Cancer Research Center Freiburg” in the “Historisches Kaufhaus Freiburg”. Susana Minguet shared our data on the rational design of novel Chimeric Antigen Receptors in Immunotherapy. We all enjoyed the interesting talks and the great discussions!
 https://www.uniklinik-freiburg.de/celebrate40yearscancercenterfreiburg.html

29.09.2019             Together with our long-standing collaborator Balbino Alarcón from Madrid (Spain), we have published a critical review of how the T cell receptor functions as a macromolecular machinery. We hope you enjoy learning more about the TCR! Original publication: The TCR is an allosterically regulated macromolecular machinery changing its conformation while working. Schamel WW, Alarcon B, Minguet S. Immunol Rev. 2019 Sep;291(1):8-25. doi: 10.1111/imr.12788. Review.

27.–30.09.2019     Salma Pathan went to the EMBO workshop “Lipid function in health and disease” in Dresden, to learn about lipids and get new scientific friends. Well done Salma.

27.09.2019              Nadine Wössner is elected CIBBS doctoral representative at the CIBSS junior scientist kick-off event.

17.-22.09.2019      Carina Drechsler and Wolfgang Schamel visit our collaborators in Shanghai in China. It was an interesting experience fostering our cooperations.

12.09.2019             Max Kistner defended his master thesis. Congratulations Max, you did a great job and a great presentation! We are really happy for you!

11.09.2019             Xuting Wang defended her master thesis entitled “Cancer Immunotherapy: The Development of Second-generation T cell Receptor Fusion Constructs (TRuCs)”. Congrats for a great job, a great presentation and a great defence!

10.09.2019             Hanmu Guo defends his Bachelor Thesis "Biochemical characterization of RASEF:Lck interaction". Congratulations Hanmu, we are happy you will stay with us for your Masters!

22.07.2019             Our collaborator and friend Immo Prinz from Hannover visited us and gave a talk invited by the SFB-1160. We really enjoyed great and insightful discussions with you! Thanks Immo!

15.07.2019             We congratulate Dr. Gina Fiala for her most recent publication demonstrating that the functioning of Lck-promoter Cre is ineffective in adult gamma delta T cells. This work inspires the re-interpretation of many studies applying this commonly used delete mouse line to investigate the function of multiple genes in the development of gamma delta T cells. Great work! Original publication: Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult γδ T Cell Development. Fiala GJ, Schaffer AM, Merches K, Morath A, Swann J, Herr LA, Hils M, Esser C, Minguet S, Schamel WWA. J Immunol. 2019 Jul 15;203(2):569-579. doi: 10.4049/jimmunol.1701521.

05.07.2019             Our collaborator and friend Emmanuel Donnadieu from Paris visited us invited by the SFB-850. Thanks Emmanuel for the nice talk, the insightful discussion and the collaborations to come. Emmanuel joined us to visit the Wine festival here in Freiburg that we really enjoyed!

01.07.2019             Nadine Wössner starts her PhD in our group. We are super happy you decided to stay with us!

01.07.2019             We are happy to be part of the local consortium to study the assembly process of the TCR. This consortium is the CRC1381 “Dynamic Organisation of Cellular Protein Machineries: From Biogenesis and Modular Assembly to Function” to be funded by the German Research Council DFG. Claudia Juraske will work on the prohect and starts today. Welcome and good luck, Claudia. https://www.sfb1381.uni-freiburg.de/

03.06.2019             Our findings about the use of a kinetic proofreading mechanism in T cells using our opto-ligand-TCR system have been highlighted in the Quanta magazine.
 https://www.quantamagazine.org/immune-cells-measure-time-to-identify-foreign-proteins-20190603/

23.05.2019             Our SFB-1160 is renewed for another 4-years period! We are really happy that the DFG recognizes the great cooperative value of this collaborative research center! https://www.sfb1160.uni-freiburg.de/

17.05.2019             Nadine Wössner defended her Master Thesis entitled “The role of Lck in early T cell receptor and chimeric antigen receptor signaling”. Great job, great defense; Congratulations Nadine!

13-16.05.2019       Anna Maria Schaffer and Susana Minguet participated in the first EMBO workshop on Caveolae and nanodomains: Translating structural principles and dynamics into function. Susana shared our work identifying Caveolin-1 as the unnoticed player in lymphocyte activation. Anna Maria presented her poster regarding the role of Caveolin-1 in B cell activation. We thank SFB-1160´s support to attend to this fantastic workshop.

07.05.2019             In a joint effort with TCR2 therapeutics, we have developed TRuC (TCR Fusion Construct) T cells, which harness the natural T cell receptor complex to recognize and kill cancer cells using the full power of T cell signaling pathways independent of HLA. This is novel T cell-based immunotherapy might be a major breakthrough in the treatment of solid cancer in the future. Congratulation to all the authors, and especially to Niko Thorausch and Wolfgang  Schamel. We are really excited to see the performance of this new technology in the clinical trials started by TCR2 therapeutics! Original publication: Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response. Baeuerle PA, Ding J, Patel E, Thorausch N, Horton H, Gierut J, Scarfo I, Choudhary R, Kiner O, Krishnamurthy J, Le B, Morath A, Baldeviano GC, Quinn J, Tavares P, Wei Q, Weiler S, Maus MV, Getts D, Schamel WW, Hofmeister R. Nat Commun. 2019 May 7;10(1):2087. doi: 10.1038/s41467-019-10097-0.
 http://investors.tcr2.com/news-releases/news-release-details/tcr2-therapeutics-publishes-first-peer-reviewed-data

08.04.2019             We really enjoyed today doing some out-of-the-lab activities together. We took an introductory course in Bouldering  and enjoyed a whole afternoon climbing up in Blockhaus. Thanks to everybody for the great time!

05.04.2019             After last year’s preprint in bioRxiv, we now published our novel engineered optogenetic T cell stimulation system (opto-ligand-TCR system) in eLife showing that T cells use a kinetic proofreading mechanism to distinguish between stimulatory and non-stimulatory ligands. Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD, Höfer T, Weber W, Schamel WW. Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor. Elife 8, 301 (2019).
 https://elifesciences.org/articles/42475
 https://www.bioss.uni-freiburg.de/newsroom-and-media/2019/weber-elife-paper-2019/
 http://www.pr.uni-freiburg.de/pm-en/press-releases-2019/a-question-of-time

31.03.2019             We are happy of the success of an exciting collaboration with Prof. Weber and Dr. Maximilian Hörner. We have developed a hydrogel whose stiffness and permeability to cells can be controlled with light, and demonstrated that primary T cell lymphocytes preferentially migrate in soft hydrogels. Original publication: Phytochrome-based extracellular matrix with reversibly tunable mechanical properties. Hörner M, Raute K, Hummel B, Madl J, Creusen G, Thomas OS, Christen EH, Hotz N, Gübeli RJ, Engesser R, Rebmann B, Lauer J, Rolauffs B, Timmer J, Schamel WWA, Pruszak J, Römer W, Zurbriggen MD, Friedrich C, Walther A, Minguet S, Sawarkar R, Weber W. Adv Mater. 2019 Mar;31(12):e1806727.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201806727
https://www.bioss.uni-freiburg.de/newsroom-and-media/2019/weber-hydrogel-2019/
http://www.pr.uni-freiburg.de/pm-en/press-releases-2019/traffic-control-of-cells

27.02.2019             Anna Morath defended her PhD thesis entitled: “RASEF enhances γδ T cell receptor signaling”. The Faculty of Biology recognizes her outstanding work with a magna cum laude. Congratulations Dr. Morath!
https://www.instagram.com/p/BubFEQLHMrr/?utm_source=ig_twitter_share&igshid=1hd5xwd6arshn

26.02.2019             Together with the Weber and Warscheid groups, we published our collaborative work on light-controlled protein purification for highly pure protein complex analysis by subsequent mass spectrometry. Hörner, M*, Eble J*, Yousefi OS*, Schwarz J*, Warscheid B, Weber W, Schamel WWA. Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome. Front Immunol 10, 637 (2019). *Authors contributed equally.
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00226/full

20.-22.02.2019     We participated in the 4th International Symposium Control of Cell Motility in Development and Cancer organized by the SFB-850 in Freiburg. Susana Minguet shared our unpublished data on development of novel Chimeric Antigen Receptors (CARs) for immunotherapy.

08.01.2019             Our intense collaborations with the group of Prof. Weber resulted in another joint publication entitled “Optogenetic control of integrin-matrix interaction”. Baaske J, Mühlhäuser WWD, Yousefi OS, Zanner S, Radziwill G, Hörner M, Schamel WWA, Weber W. Commun Biol. 2019 Jan 8;2:15. doi: 10.1038/s42003-018-0264-7. Congratulation to all the authors!

 

2018

13.12.2018             Our traditional Christmas dinner was huge fun! Wolfgang and Susana thanked everybody in our group for this great
                                   year and for being such a good team! Merry Christmas and happy 2019 for everyone!

06.12.2018             We got the nice news that our project “Lipid regulation of TCR transmembrane signaling” which is a joint project with
                                   China will be funded by the German Research Council, DFG. This is a good X-mas present for us.

28.11.2018             We participated in the 13th Freiburg Immunology Meeting. Susana Minguet, Katrin Raute and Laurenz Herr shared
                                   their work on TCR signaling initiation, anti-tumor therapies using gamma delta T cells and the role of Kidins220 in
                                   lymphocyte development. We all enjoyed the meeting and the discussions. Anna Morath won one of the prices for the
                                   best poster; congratulation Anna! Wolfgang Schamel and Stephan Ehl shared the deep sadness of Paul Fisch leaving
                                   this life. He was remembered as one of the true pioneers of the gamma delta T cell field, as an inspiring colleague,
                                   collaborator and a true friend. A minute of silence was kept in his memory.

30.10.2018            The university of Freiburg made a huge effort in assembling a large grant in the frame of the Excellence Initiative
                                  by the German government. Today, we got the fantastic news, that our new grant “Centre for Integrative Biological
                                 Signalling Studies, CIBSS”
will be funded – and we are part of this centre twice: with a project by Susana and another
                                  one by Wolfgang. For the university and for us this is great.

19.10.2018            We participated in the 2nd Annual meeting of the Upper Rhine Immunology (URI) group in Freiburg. Anna-Maria
                                 Schaffer
shared her work on the role of Kidins220 in the development of B cells. We all enjoy the meeting and the
                                  discussions. Sascha Yousefi presented a poster.

24.10.2018            Sascha Yousefi defended his PhD thesis entitled: “Optogenetic Control of the T Cell Receptor Demonstrates a Kinetic
                                  Proof-Reading Mechanism for Ligand Discrimination”. The Faculty of Biology recognizes his outstanding work with
                                  a summa cum laude. Congratulations Dr. Yousefi!

09.10.2018            In a joint collaboration with Prof. Zurbriggen and Prof. Weber, we have developed a new optogenetic tool to readily
                                  and rapidly control protein levels. Thanks to all for this fantastic joint piece of work in Science Reports!
                                  Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells.
                                  Baaske J, Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA,
                                  Minguet S, Davies JA, Timmer J, Weber W, Zurbriggen MD. https://www.ncbi.nlm.nih.gov/pubmed/30301909

01.10.2018           We published our first preprint on bioRxiv on the upcoming story of how we engineered a novel optogenetic T cell
                                 stimulation system to show that T cells use a kinetic proofreading mechanism to distinguish between stimulatory
                                 and non-stimulatory ligands.
                                 Original publication: Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor.
                                 Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD,
                                 Höfer T, Weber W, Schamel WWA
                                 https://www.biorxiv.org/content/early/2018/10/01/432740

02.08.2018           Susana Minguet defended her Habilitation. Title: CAR T Cells: Engineering Immune Cells to Treat Cancer.
                                 Fantastic, a next step in her career. Congrats Susana.

26.07.2018           Paula Alarcon defended her Bachelor thesis entitled “Characterization of a new mutation in Lck protein”.
                                 Congratulations Paula.

09.07.2018           Our work centered in boosting anti-tumor activity of gd T cells is published in Frontiers in Immunology. Congratulation
                                 to all and thanks to our collaborators! Original publication: Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ
                                 T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor. Juraske C, Wipa P, Morath A, Hidalgo JV,
                                 Hartl FA, Raute K, Oberg HH, Wesch D, Fisch P, Minguet S, Pongcharoen S, Schamel WW.
                                 https://www.ncbi.nlm.nih.gov/pubmed/30038626

05.07.2018          We got the nice news that our project “Understanding the mechanism of γδ TCR activation, in order to enhance tumour
                                killing” will be funded by the German Research Council, DFG. It is part of the research unit FOR2799 “Receiving and
                                Translating Signals via the γδ TCR” headed by Prof. Immo Prinz. Our project deals with the signaling mechanisms
                                of the γδ TCR. https://for2799.de/

05.07.2018          Together with the group of Balbino Alarcón, our long-term collaborators in Spain, we have published in Nature
                               communication:
“A window of opportunity for cooperativity in the T Cell Receptor”. Martin-Blanco N, Blanco R,
                                Alda-Catalinas C, Bovolenta ER, Oeste CL, Palmer E, Schamel WW, Lythe G, Molina-París C, Castro M, Alarcon B.
                                https://www.ncbi.nlm.nih.gov/pubmed/29976994

16.06.2018          Sascha Yousefi took part in the Young Scientist Critical Thinking Chalk Talks at the Friedrich Miescher Institute in
                                Basel, presenting the big ideas driving his research at a joint event of the Spemann Graduate School of Biology and
                                Medicine (SGBM) and the FMI. https://twitter.com/FMIscience/status/1009083872418648064

01.01.2018          Misol-Ha Velasco Cardenas joins our department as a new PhD student working in the EN-ACT2ING consortium of the
                                 EU. Welcome to Freiburg!!

 

2017

31.12.2017          After having contributed to the success of our department for many years, Gina Fiala leaves us for a postdoc to
                                 Portugal. Good luck Gina!

07.12.2017          Susana Minguet receives the CCI-Prize for the best publication of 2017 for the study published in Nature Immunology
                                on the role of Caveolin in the functioning of the BCR 2017
                                (http://www.bioss.uni-freiburg.de/newsroom-and-media/2017/minguet-nat-immunol-paper-2017/)

06.12.2017          Wolfgang Schamel is co-PI with Burkhart Schraven and Luca Simeoni in a project within the third funding period of the
                                 SFB854. The project will start in January 2018.

05.12.2017          Wolfgang Schamel receives a Guy Newton fellowship to do his sabbatical at the Dunn school of Pathology in Oxford,
                                UK. Congratulations.

01.12.2017          We participated in the 1st Annual Meeting of the Upper Rhine Immunology Group in Illkirch. Nice science, nice time
                                together! https://uri-2017.sciencesconf.org/

24.11.2017          The third funding period of the SFB-850 is awarded! Susana Minguet is newly integrated is this funding period as PI.
                                 Congratulations! http://www.sfb850.uni-freiburg.de/en

25.10.2017          Together with Bodo Grimbacher we organized the 12th Freiburg Immunology Meeting.

27.10.2017          Susana Minguet and Miriam Hils collaborated with Kristina Schachtrup in the last publication of her group, regarding
                                 the role of regulatory T cells in chronic infections. Thanks for such a nice working together!
                                 https://www.ncbi.nlm.nih.gov/pubmed/29262527

18-20.10.2017     We all participated in the Signals From the Invisible Symposium in Freiburg organized by SGBM-BIOSS. Great
                                 meeting, great science and great organization, thanks! http://www.sfti2017.de/

15.10.2017          Together with the labs of Michael Reth (Freiburg) and Balbino Alarcon (Madrid) we spent 2 days in the black forest
                                for a combined lab retreat, including visit to the silver mines in Schauinsland.

12.10.2017          Signalhaus symposium with BBQ, really nice time together and great science sharing!

28.09.2017          Sophie Pfeiffer receives her Bachelor degree.

27.09.2017          International impact of our investigations. The leading portal dedicated to innovation, innovaspain, has recently
                                interviewed Susana Minguet, regarding the her most recently published results in Nature Immunology. 
                                https://www.innovaspain.com/susana-minguet-alemania-mucho-mas-respeto-la-ciencia/

12-14.09.2017    We participated in the 47th Annual Meeting of the German Society for Immunology in Erlangen. Wolfgang and Susana
                                 hold talks. It was a really exciting meeting!
                                 http://www.immunology-conference.de/

05.09.2017          Our review with our Thailand friends on TCR interactions partners is published in Immunology. Thank you Sutatip
                                Pongcharoen and Jatuporn Ngoenkam.
                                https://www.ncbi.nlm.nih.gov/pubmed/28771705

01.08.2017          Marina Freudenberg and Wolfgang Schamel publish their story on the identification of the adenovirus receptor on
                                macrophages in mBio. We thank all the people that were involved.
                                https://www.ncbi.nlm.nih.gov/pubmed/28765216

31.07.2017          We had our annual time-together, we enjoyed a really nice boat-trip, walking and lunch together. It was great fun,
                                thanks!

28.07.2017          Nada El Samra received the Alummi Prize 2017 for the best Master Thesis of the Faculty of Biology, congratulations
                                Nada!

20.07.2017          Andreas Narr receives his Master degree.

27.06.2017          Susana Minguet and Andreas Narr published together with the group of Prof. Zeiser about the role of Byglycan in
                                organizing the tumor stroma and tumor cell invasiveness. Thanks Robert Zeiser for such a pleasant collaboration!
                                 https://www.ncbi.nlm.nih.gov/pubmed/28476030

23.06.2017          Susana Minguet and Gina Fiala participated in the publication of the group of Prof. Reth investigating how the
                                proliferation to differentiation switch in B lymphocytes works. This work was published in Nature Immunolgy and it
                                was a great teamwork, thanks!
                                www.bioss.uni-freiburg.de/newsroom-and-media/2017/reth-nat-immunol-paper-2017/

10.03.2017          Nada Al Samra receives her Master degree.

16.02.2017          Michael Damrat passes his Master thesis defence at the Faculty of Chemistry and Pharmacy.

10.02.2017          Gina Fiala is granted with a Post-doctoral Marie Curie Fellowship! Congratulations!

07.02.2017          The kick-off meeting of the our European Union consortium EN-ACT2ING takes place in Madrid. An open PhD
                               position
is available.

17.01.2017          Frederike Hartl successfully defends her PhD with „magna cum laude“. Well done!

01.01.2017          Susana Minguet has been selected for inclusion in the Elite Programme of the Baden-Württemberg Foundation. Very
                                good!

2017:                     Marina Freudenberg was elected as a foreign fellow of The Learned Society, which is an association of distinguished
                                scholars of the Czech Republic.

 

2016

14.12.2016          Together with Bodo Grimbacher we organized the 11th Freiburg Immunology Meeting.

06.12.2016          Schachtrup´s group publication in Cell Reports is on-line. Congratulations!

01.11.2016          Our brief review is accepted in the J Immunol. It develops a new concept on the allosteric regulation of the TCR.
                                 Thank you Balbino and Thomas for your input.

01.10.2016          Niko Thorausch joins our department as a new PhD student. Welcome and good luck!

01.09.2016          Wolfgang Schamel joined the Advisory Board of TCR2 Therapeutics Inc., an immuno-oncology company located in
                                Cambridge, Massachusetts, developing novel T cell therapies that unleash the full signaling power of complete
                                T cell receptors (TCR).

22.07.2016          For her excellent PhD thesis Gina Fiala is awarded with the GEFI prize of the Faculty of Biology. Congrats!

22.07.2016          Sandra Hess is awarded with a prize to the best Master thesis of the year 2016 of the Faculty of Biology.
                                Congratulations!

07.07.2016          Susana Minguet is accepted as member of the EIRA Mentoring program of the Faculty of Medicine, congratulations!

27.06.2016          To promote our paper on a LAT-deficiency in humans, Art Weiss publishes an “insights” note in J Exp Med.

19.06.2016          Gina Fiala, Anna Morath and Katrin Raute go to the γδ T cell conference in London.

01.05.2016          Our collaborative work on the identification and characterisation of the first human LAT deficiency is accepted in J
                               Exp Med
. Thank you Klaus and Bärbel for the great cooperation.

31.04.2016          We are awarded with a grant of the European Union, to study T cell activation in a consortium lead by Hisse van
                                Santen. Thank you Hisse for all your great work.

08.04.2016          In a collaboration with Feng Wang and Mark Davis, our manuscript on the role of cholesterol-sulfate in TCR
                                nanoclustering is accepted in Nat Immunol. Thank you Feng and Mark for the great cooperation.

11.04.2016          We are so happy that our story on the role of cholesterol in regulating the CD3 conformational change in the TCR is
                                 accepted in Immunity. It took so long to develop this story. Thank you Thomas Höfer and Balbino Alarcon for your
                                 valuable contributions. Time to party!!

23.03.2016          The Weber lab and our lab hold a big competition in three Lasertag fights. Luckily we win 2:1, due to our training a
                                 month before. Photos can be seen on the fun page.

20.02.2016          Katharina Rauch receives her PhD degree.

19.02.2016          Sandra Hess receives her Master degree.

03.02.2016          Iga Janowska receives her Master degree.

31.01.2016          Our collaborative work on role of Caveolin-1 regulating TCR signalling strength and T cell fate during GvHD is
                                 accepted in Blood. We thanks Robert Zeiser and his lab for the great cooperation.

15.01.2016          For her J Exp Med paper on the role of Kidins220 in B cells Gina Fiala is awarded with the publication prize of the CCI
                                 in Freiburg.

01.01.2016          Katrin Raute, Anna-Maria Schaffer and Laurenz Herr join our department as new PhD students. Welcome and good
                                 luck.

2016:                      Marina Freudenberg got Honoree of the Sheldon E. Greisman award. The award is given by the International Endotoxin
                                 and Innate Immunity Society to an investigator (MD or PhD) in the clinical or basic sciences who has made substantial
                                 and original contributions which have led to an increased understanding of the interactions between microorganisms
                                and innate immunity.

 

2015

12.12.2015          Erna Mindrup receives her Diploma degree.

25.11.2015          Together with Bodo Grimbacher we organized the 10th Freiburg Immunology Meeting

12.11.2015          Our collaborative work on the role of Caveolin-1 deficiency on epithelial-mesenchymal transition and fibrosis during
                                peritoneal dialysis is accepted in EMBO Molecular Medicine, thanks to Raffaele and co-workers in Madrid.

07.11.2015          Many members of our department are invited to the big 30-years-Reth-group party. It was great fun. Thank you
                                Michael.

28.10.2015          We helped Tilman Brummer’s lab to analyse a B-Raf mutated mouse. The manuscript is accepted in the EMBO J.
                                 Thank you Tilman for the nice cooperation.

23.10.2015          Our biochemical paper on binding mechanism of Nck to the TCR is accepted in the J Immunol. Thank you Pussadee
                                Paensuwan
and Sutatip Pongcharoen for the great cooperation.

14.08.2015          Our paper on the role of the membrane protein Kidins220 in B cell development and activation is accepted in J Exp
                               Med
. We thank all collaborators who have contributed so enthusiastically.

03.08.2015          Lea Flachsmann and Hauke Weiss receive their Bachelor degree.

24.07.2015          Katrin Raute and Jan Mentzel are awarded with the prices to the best Master thesis of the year 2014 of the Faculty
                                of Biology. Congratulations!

06.07.2015          Katrin Raute is selected as SGBM student on Track-1. Congratulations Katrin!

01.07.2015          A paper on a ZAP-70 mutation in humans, where we have contributed some experiments, is accepted in Clin Immunol.
                                Thank you Fabian Hauck and Stephan Ehl for the cooperation.

21.06.2015          Our long term collaborator and friend Balbino Alarcon come to visit us for a few days.

15.06.2015          Alexandra Menner receives her PhD degree.

15.06.2015          A manuscript in accepted in Nat Immunol, in which we helped the Knobeloch lab to characterize a USP8 knock out
                                mouse.Thank you Almut Dufner, Klaus-Peter Knobeloch and Marco Prinz for the good cooperation.

25.05.2015          The DFG decided to fund Susana Minguet´s research proposal for the next 3 years. Congratulations!

21.05.2015          The DFG decided to fund the Collaborative Research Center initiative: IMPATH. Thanks to all the members and
                                  specially to Prof. Ehl for his great leadership

30.04.2015          After having been with us for one year to terminate her PhD experiments, Pussadee Paensuwan leaves us. We will
                                  miss you and good luck in Thailand.

24.03.2015           A paper on light-regulated nuclear import by the Zurbriggen, Römer and Weber groups is accepted in ACS Synthet
                                Biol
. Thank you Wilfried and Matias for the nice collaboration.

02.02.2015          Together with the lab of Paul Fisch we have characterized the gamma delta T cell malignancies of thymoma patients.
                                 After long time, the story is accepted in J Immunol. Thank you Paul for this nice cooperation.

20.01.2015           A collaborative grant between S. Minguet and M. Zurbriggen will be funded by the “Innovationsfonds” program of
                                 the University of Freiburg. Looking forward for working together!

 

2014

19.12.2014          Esmeralda Beck receives her PhD degree.

15.12.2014          We have analysed the membrane microdomain localisation of TCR nanoclusters. The manuscript is accepted in Biochem
                               Biophys Acta
.

25.11.2014          Alina Rudorf receives her Master degree.

12.11.2014          We helped the Alarcon lab to characterize a knock in mouse in which the TCR cannot undergo the CD3 conformational
                                 change. The paper is accepted in Sci Signaling. Thank you Balbino for the great cooperation.

07.11.2014          Katrin Raute receives her Master degree.

05.11.2014         Together with Bodo Grimbacher we organized the 9th Freiburg Immunology Meeting.

28.10.2014          Jan Mentzel receives her Master degree.

11.08.2014          Julia Anna Zimmermann receives her Bachelor degree.

30.07.2014          Liz Cerqueira and Nada Al-Samra receive their Bachelor degrees.

13.03.2014          Our collaborative study on the role of the two Nck isoforms Nck1 and Nck2 in human T cells is accepted in J Immunol
                                 together with Sutatip Pongcharoen.

01.04.2015          Our co-edited special issue in BBA - Molecular Cell Research on "Nanoscale Membrane Organisation" is lauched

11.02.2015          Together with Stepahn Ehl, Freiburg, we publish findings of anti-viral immune responses under attenuated TCR
                                 signalling in the J Immunol.

13.01.2015          Gina Fiala receives her doctoral degree with "summa cum laude".

19.12.2014          Esmeralda Beck receives her doctoral degree with "magna cuml laude".

02.12.2014          Our collaborative work with the group of Balbino Alarcon, Spain, on the role of the CD3 conformational change in T
                                 cell development is published in Science Signalling.

01.08.2014          Anna Morath obtains the Alumni prize of the Faculty of Biology for her Diploma work.

01.08.2014          Miriam Hils gets the Alumni prize of the Faculty of Biology for her Master work.

02.07.2014          Qusai Al-Kayyal receives his Master degree

06.06.2014          Our paper on the CD3 conformational change in the gd TCR is published in Cell Reports; including a picture by Pashu
                                on the cover page.

26.03.2014          Our paper on the role of Nck1 and Nck2 in T cell activation in published in Cell Commun Signal. This was a
                                 cooperation with S. Pongcharoen´s group from Thailand.

01.03.2014          Our collaboraive studiy with Balbino Alarcon´s group on the CD3e-Nck interaction is published in J Immunol.

07.01.2014          Our work with Hermann Eibel´s group on the nanoscale clusterin of the BAFFR is puglished in JACI

01.01.2014          We welcome Anna Morath as a new SGBM PhD student.

 

2013

18.12.2013          Carina Zorzin receives her Master degree.

15.12.2013          The Zurbriggen and our group are awarded with a research grant from the University Freiburg.

06.12.2013          Our data-based simulation of BCR nanoclustering is published in Front. Immunol.

06.12.2013          The 29th BII Glögg party is held in parallel in Nice, France and in our lab.

29.11.2013          Kathrin Beck receives her docotral degree with “magna cum laude“.

25.11.2013          The SYBILLA Virtual T cell goes online.

24./25.10.2013  The BIOSS conference of nanoscale signalling that we co-organize is a big success.

18.09.2013          At the SYBILLA meeting in Oxford we decided that SYBILLA will continue.

30.09.2013          Our lab manager Thilo Bass leaves our lab after so many years, to work at the university clinics .

15.09.2013          Thomas Plum receives his Master degree.

01.08.2013          Our application to obtain a robotic station to generate signalling data is awarded by the German government.

15.05.2013          Our method to analyse lipid-protein interactions is published in Anal. Biochem.

01.03.2013          We publish the identification of Kidins220 as a novel T cell signalling protein in the J Immunol.

31.01.2013          Our big review on TCR nano-clustering is published in Immunol Rev.

15.01.2013          Jatuporn Ngoenkam from Thailand joins our lab for 3 month.

 

2012

14.12.2012          We publish the lipid-based mechanism of TCR nanoclustering in J Biol Chem.

10.12.2012          For the first time our lab organizes a BII Glögg party.

23.10.2012          Our review on synthetic immunology is published in Curr Opin Biotechnol.

08.10.2012          Weng Fang from Stanford joins our lab for 2 weeks.

mid 2012              We move from the MPI to the Signalhaus at Freiburg University.