Centre for Biological Signalling Studies

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

Hoermann B, Kokot T, Helm D, Heinzlmeir S, Chojnacki JE, Schubert T, Ludwig C, Berteotti A, Kurzawa N, Kuster B, Savitski MM, Köhn M.

Nat Commun. 2020;11(1):3583.

Nat Commun.              online article

The phosphatases PP1 and PP2A account for the majority of dephosphorylation on phosphoserine (pS) and phosphothreonine (pT). Scientists from the Köhn lab show that the specificity of PP1 and PP2A holoenzymes towards pT and of PP1 for basic motifs are intrinsic properties of the catalytic subunits.