Centre for Biological Signalling Studies


With great motivation and fun, we prepare the lectures and teach Immunology at the Department of Biology. From left to right: Wolfgang Schamel, Susana Minguet and Marco Cavallari - your congenial immunology team.


Bachelor and Master

The University of Freiburg is one of the few German universities, in which Immunobiology can be studied at the Faculty of Biology, thus focusing on the basic science aspects of this topic. However, courses and Bachelor-, Master- or PhD-thesis can also be taken at the Medical Faculty. Indeed, PIs working on the applied side of Immunology (diagnostics and treatment of patients) are actively participating in our teaching modules. This guarantees that the students get a very comprehensive training in immunology, including basic research, clinical studies, virology and medical microbiology.

We established the focus “Immunology” within the bachelor and master studies at the department of biology.
The teaching in the bachelor courses is in German whereas in the master studies it is in English. We are spending a lot of time on preparing the classes and actually enjoy teaching very much. 


Here is a link to the Master’s Major in Immunology:

Here is a link to the Module Guides of the Faculty of Biology:

ILIAS, the University´s E-Learning Platform:


Our teaching activities are as follows:

4. Sem. Bachelor Modul „Biochemistry, Microbiology, Immunology“, 8 ECTS, lecture, seminar, practical course, written exam

5. Sem. Bachelor Vertiefungsmodul „Antibodies“, 8 ECTS, lecture, seminar, practical course, written exam

5. Sem. Bachelor Profilmodul „Methods in Immunology“, 6 ECTS seminar, practical course

5. Sem. Bachelor Profilmodul „Signaltransduction in der Tumour- und Immunobiology“, 6 ECTS lecture, seminar

6. Sem. Bachelor Projektmodul, Bachelorthesis and Colloquium, 23 ECTS


1. Sem. Master Orientation Module „Immunology“, 9 ECTS, lecture, seminar, practical course, written exam

2. Sem Master Specialization Module „Immunology 1“, 12 ECTS, lecture, seminar, practical course, written exam

2. Sem Master Optional Module „Current topics in Immunology“, 9 ECTS, lecture, seminar, practical course

2. Sem Master Optional Module „Clinical Immunology“, 9 ECTS, lecture, seminar, practical course

2. Sem Master Optional Module „Virology“, 9 ECTS, lecture, seminar, practical course

2. Sem Master Optional Module „Synthetic Immunology“, 9 ECTS, lecture, seminar, practical course

3. Sem Master Specialization Module „Immunology II“, 21 ECTS, lecture, seminar, practical course

3. Sem Master Project Module „Immunology“, 9 ECTS, practical course

4. Sem Master Master thesis and colloquium, 30 ECTS

We also hold a class in the master studies „Systems Biology” and “Molecular Medicine”.

Here are two links to the teaching activities at the Faculty of Biology:


PhD theses:

  • Misol Velasco Cárdenas (2023) “Harnessing CD3 diversity to optimize CAR T cells"
  • Matias Ruggieri (2022) “Role of γδ T cells in human T-cell lymphotropic virus type 1 infection and analysis of γδ TCR activation”
  • Anna-Maria Schaffer (2022) “The role of the membrane proteins Kidins220 and Caveolin-1 in B cell development and activation”
  • Laurenz Herr (2022) “Kidins220 negatively regulates TCR signaling in iNKT and conventional αβ T cell development”
  • Niko Thorausch (2021) "HLA-independent engagement of the TCR complex using synthetic TRuC receptors: A novel approach to genetically reprogram T cells for potent cancer immunotherapy"
  • Katrin Raute (2020) "Using γδ T cell immunotherapy against breast cancer stem-like cells"
  • Anna Morath (2019) “RASEF enhances γδ T cell receptor signaling”
  • Sascha Yousefi (2018) “Optogenetic control of the T cell receptor demonstrates a kinetic proof-reading mechanism for ligand discrimination”
  • Frederike Hartl (2017) „Activation of Src kinase Lck by the TCR“, magna cum laude
  • Katharina Rauch (2016) “The role of the transcriptional regulator Id3 in peripheral regulatory T cell maintenance and differentiation”
  • Alexandra Menner (2015) “Regulation of CD8+ T cell differentiation by transcriptional regulator id3 following acute and chronic LCMV infection”
  • Gina Fiala (2015) „A systems biology analysis of antigen receptor clustering“, magna cum laude, GEFI Preis
  • Esmeralda Beck (2014) „Quantitative Analysis of the proximal kinase module at the TCR“, magna cum laude
  • Katharina Beck (2013) „The molecular mechanism of TCR triggering“, magna cum laude
  • Sumit Deswal (2012) „Quantitative Studies of Early Events in T Cell Activation“, summa cum laude
  • Elaine Pashupati Dopfer (2010) „Signal Initiation at the T-Cell Antigen Receptor“, magna cum laude
  • Mahima Swamy (2008) „The stoichiometry and activation oft he monovalent and multivalent T cell antigen receptor complexes“, summa cum laude
  • Gabrielle M. Siegers (2006) „Structure-Function Analysis of the B and T Cell Antigen Receptors“, magna cum laude


Master theses:

  • Caroline Schwenzel (2023) “Role of the CD3ε RK motif in gd TCR signaling”
  • Sara Hartmann (2023) “Novel compounds fine-tune TCR and CAR signaling”
  • Hanmu Guo (2022) “Analysis of the role of RASEF in TCR signaling”
  • Badeel Khalaf (2021) “The impact of CD3ε tyrosine phospho-mimicking variants on TCR and 19BBε CAR signaling”
  • Stephanie Doetsch (2021) “Investigating the molecular features of the CD3ε RK motif”
  • Kevin Echle (2021) “Role of Syndapin II on limiting the amounts of TCRs”
  • Ira Godbole (2021) “Development of eTRuCs against SARS-CoV-2”
  • Marissa Russ (2021) “Development of a membrane-bound phytochrome B protein for light-controllable cell-cell interaction to investigate T cell activation”
  • Anna Ehret (2020) "Analysis of the activity decay in the MAP kinase pathway after optogenetic ligand detachment from the T cell receptor"
  • Marina Zintchenko (2020) "Rational design of chimeric antigen receptors against chronic lymphocytic leukemia"
  • Annabelle Buschky (2020) "Characterization of CD3ε functional motifs in CAR T cells"
  • Simon Brandl (2020) "Improvement of CAR T cell-based immunotherapies by the rational design of novel chimeric antigen receptors against human cancer"
  • Max Wess (2020) “Investigation of the role of Lck and LAT in kinetic proofreading“
  • Paul Matusewicz (2020) "Characterization of two hLck mutants"
  • Gregor Conrad (2020) "Linking oncogenic signaling to γδ T cell activation"
  • Helena Brandt (2019) "The interaction between caveolin-1 and the cytoskeleton and its role in B cell receptor activation"
  • Vincent Idstein (2019) "Development of a GFP-free PIF-TCR for light inducible activation of Jurkat cells and primary T cell blasts"
  • Max Kistner (2019) „In vitro analysis of the influence of ADAMs on T cell migration“
  • Xueting Wang (2019) “Cancer Immunotherapy: The development of second-generation T cell receptor fusion constructs (TRuCs)”
  • Nadine Wössner (2019) “The role of Lck in early T cell receptor and chimeric antigen receptor signaling”
  • Nada Al-Samra (2018) “Kidins220 enhances TLR4 signaling in alveolar macrophages-like MPI-2 cells”
  • Michael Damrat (2017) “The role of Kidins220 in proximal T-cell signaling”
  • Mailin Ashoff (2017) “The role of Kidins220 in T cell signaling and development” Nora Janzer (2017): “Optogenetic T cell stimulation”
  • Julia Chalupsky (2017) "T cell activation depends on a defined duration of ligand-TCR interaction"
  • Liz Cerqueira (2017) “The role of Lck and Nck in early T cell activation”
  • Andreas Narr (2017) “Influence of matrix organization and metalloproteases on T cell migration“
  • Iga Janowska (2016) “Characterization of the role of Kidins220 in B and T cell signaling and development”
  • Sandra Hess (2016) „Role of the Transmembrane Protein Kidins220 in Macrophage Activation“·  
  • Iga Janowska (2015) “Characterization of the role of Kidins220 in B and T cell signaling and development”
  • Alina Rudorf (2014) “Analysis of signaling pathways in human B lymphocytes - Validation of the boolean BCR network”
  • Carina Zorzin (2014) “Reconstitution of the T Cell Antigen Receptor and the Kinase LCK into Liposomes”
  • Qusai Al-Kayyal (2014) “The CD3δ ITAM has an inhibitory role in T cell antigen receptor signaling”
  • Miriam Hils (2014) “Specific functions of the E2A splice variants E12 and E47 in B cell differentiation”
  • Katrin Raute (2014) „In vitro analysis of the influence of the extracellular matrix on T-cell migration“
  • Jan Mentzel (2014) „PLA to investigate early Signaling Events upon TCR activation“
  • Carina Zorzin (2013) “Reconstitution of the T cell antigen receptor and the kinase LCK into liposomes"
  • Thomas Plum (2013) “The role of Kidins220 in B cell receptor signaling”


Bachelor theses:

  • Lisa Entringer (2023) “Investigating the performance of a BBζ CAR in optogenetically expanded primary human T cells”
  • Zidain Bratzler (2022) “The use of optogenetics in the immune system”
  • Marcella Mandel (2022) "Novel strategies to improve CAR-T cell migration in solid tumors"
  • Alex Bofi Cuadros (2022) “The role of oncogenic mutations in ECM stiffening in colorectal cancer”
  • Evelyn Teuber (2022) “Targeting SARS-CoV-2 with anti-Spike CAR gd T cells”
  • Vincent Hammes (2021) “Analysis of cholesterol binding deficient mutants of TCR”
  • Sonia Maria Krißmer (2021) “Primary human γδ T cells lentivirally transduced with TCR fusion constructs (TRuCs) show anti-tumor activity”
  • Celia Makoviec (2020) "The effects of sterol lipids on TCR activation"
  • Hanmu Guo (2019) “Biochemical characterization of RASEF:Lck interaction”
  • Paula Alarcon (2018) “Characterization of a new mutation in Lck protein”
  • Sophie Pfeiffer (2017) “Analysis of the subcellular localization of Kidins220 in immune cells”
  • Lara Althaus (2016) “The role of Kidnis220 in lipopolysaccharide signaling in murine macrophages”
  • Hauke Weiß (2015) “The biology of Kidins220 and its CRISPR/Cas9 mediated deletion in T cells”
  • Lea Flachsmann (2015) “Nanoscale organization of Lck and the TCr during t cell activation”
  • Liz Cerqueira (2014) “Light-induced T-cell activation: kinetic studies of early T-cell receptor activation”
  • Sebastian Gulde (2014) „Impacts of ligand and T cell receptor binding durations on T cell activation“
  • Nada Al-Samra (2014) “Kidins 220 enhances TLR4 signaling in alveolar macrophage-like MPI-2 cells”
  • Lisa Hauswald (2014) “Role of the Rho-associated kinase in B cell receptor signaling”
  • Julia Anna Zimmermann (2014) “ A TCR reporter model for Lck activity and its free accessibility at the cytosolic interface of the TCR”
  • Oliver Alka (2013) “ In vitro reconstitution of CD3 phosphorylation”
  • Christoph Bauer (2013) “Establishing the TALEN technology for mutating the CD3δ chain in a murine T cell line”
  • Ognjen Deronja (2013) “Interaction of Coronin 1a with Syk in Drosophila S2 cells”
  • Iga Janowska (2013) “Analysis of a first mouse with a B cell-specific Kidins220 knockout and characterization of the Kidins220-BCR interaction”
  • Nina Koralegedara (2013) “Construction of an inducible receptor to investigate TCR-mediated Lck regulation”
  • Melanie Schächtle (2013) “Comparison of different P6A-TCRβ expressing constructs in 31-13 cells and analysis of their TCr surface expression”
  • Daria Alfano (2012) “Analysis of the Coronin 1A-ZAP-70 interaction in Jurkat cells”
  • Fabiloa Prutek (2012) “Kidins220 positively regulates Erk signaling in K46 B cells”
  • Simon Zenke (2012) “SHIP-1 interacts with the TCR upon anti-TCR stimulation in situ”
  • Markus Mukenhirn (2012) “Reconstitution of the Interaction of Coronin 1a with ZAP70 in Drosophula S2 cells”
  • Sheila Bohler (2011) “Mutating L19 to A in the ƪ TM region reduces TCR phosphorylation but does neither influence assembly nor oligomerization”
  • Miriam Hils (2011) "Analyse der molekularen Mechanismen des E2A Spleißens während der B-Zell-Entwicklung"


Diploma theses

  • Erna Mindrup (2014) “Vergleichende Analyse der Signalübertragung des αβ und ϒδ TCRs“
  • Anna Morath (2013) „Analysis of the B Cell Receptor Organisation“
  • Frederike Deibel (2012) „Construction of a reporter for Src kinase activity at the T cell receptor“
  • Anja Meyer (2011) „Functional Characterisation of Kidins220 as a New Interaction Partner fort he T Cell Antigen Receptor“
  • Stanislav Karnatsevych (2011) „Validierung des Boolschen Netzwerks für die Signalleitung in B-Zellen“
  • Esmeralda Beck (2010) „Analysis of specific hydrophobic interactions between lipids and proteins“
  • Kathrin Jakobus (2009) „Characterization of MST4 and Fer as novel interaction partners of the TCR“
  • Gina Fiala (2008) „Structure-Function Analysis of the pre-TCR and gdTCR“
  • Ester Heupel (2008) „Analysis of the signaling properties of mutant ZAP70 that causes autoimmune arthritis“
  • Oliver Eberhardt (2007)„Role of the tyrosines in the signaltransduction of the T cell antigen receptor complex“
  • Thomas Bock (2006) „High Throughput Identification of Multiprotein Complexes“
  • Eva-Maria Weiß (2005) „Signaltransduction of the CD3g-deficient T cell antigen receptor complex in mice and men“
  • Elaine Pashupati Dopfer (2005) „The Ig-a/Ig-b disulfide-bond: Role in B cell antigen receptor signaling and structure”
  • Barbara Schöpf (2005) „Phosphorylation of the TCR z chain by Src and Syk family kinases in a Drosophila reconstitution system“
  • Claudia Dürr (2005) „Analysis of the signaling properties of mutant ZAP70 that causes autoimmune arthritis“
  • Careen Pollmer (2004) „Studying B cell activation events induced by lipopolysaccharide”
  • Kerstin Höhne (2003) „Reconstitution of the T cell antigen receptor in drosophila cells and analysis of the proximal signalling molecules”