Immunosuppressive activity of artemisia argyi extract and isolated compounds
Zimmermann-Klemd AM, Reinhardt JK, Morath A, Schamel WW, Steinberger P, Leitner J, Huber R, Hamburger M, Gründemann C.
In this publication we found that substances that are present in the plant Artemisia (Beifuss in German), can supress the activity of human T cells. A careful analysis of the intracellular signalling pathways in T cells indicated that the immunomodulatory effect was based on an inhibition of the T cell receptor-initiated Ca influx and a subsequent inhibition of the NFAT pathway. A potential use of the substances in the treatment of autoimmune diseases is discussed.