Centre for Biological Signalling Studies

CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation

Keller CW, Kotur MB, Mundt S, Dokalis N, Ligeon LA, Shah AM, Prinz M, Becher B, Münz C, Lünemann JD.

Autophagy. 2020 May 13:1-15. online ahead of print

Autophagy.                       online article

Here, we report that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2, also known as CYBB/NOX2, in conventional DCs (cDCs) regulates endocytosed MOG (myelin oligodendrocyte protein) antigen processing and supports MOG-antigen presentation to CD4+ T cells through LC3-associated phagocytosis (LAP).