Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1- T-bet+ intraepithelial lymphocyte precursors
Hummel JF, Zeis P, Ebert K, Fixemer J, Konrad P, Schachtrup C, Arnold SJ, Grün D, Tanriver Y.
Mucosal Immunol. 2020;13(2):257-270
Mucosal Immunol. online article
This report by Hummel and colleagues describes the developmental trajectory of intraepithelial lymphocytes (IELs), important contributors to intestinal immune homeostasis, from thymic IEL precursors, revealing regulatory roles of Id2 and Id3 proteins as well as c-myc.