Centre for Biological Signalling Studies

Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches

Nelson BR, Hodge RD, Daza RA, Tripathi PP, Arnold SJ, Millen KJ, Hevner RF.

Elife. 2020;9:e53777.

Elife.                 online article

Nelson and colleagues demonstrate how intermediate progenitors (IPs) pioneer the migration during hippocampal dentate gyrus formation to guide and support later emigrating, Sox9+ neural progenitors (NPCs). The contacts of IPS with NPCs might be mediated through interactions via Delta-Notch signals.