Cluster of Excellence –
University of Freiburg

Retrograde BMP signaling activates neuronal gene expression through widespread deployment of a conserved BMP-responsive cis-regulatory activation element

Vuilleumier R, Lian T, Flibotte S, Khan ZN, Fuchs A, Pyrowolakis G, Allan DW.

Nucleic Acids Res. 2018 Nov 22. [Epub ahead of print]

Nucleic Acids Res.             online article

We have previously identified a DNA motif, the AE,  that mediates direct transcriptional activation to BMP signalling in Drosophila and vertebrates. We now show that the AE can be utilized for high-confidence, computational identification of BMP dependent enhancers during Drosophila neurogenesis. The battery of de-novo identified and verified BMP target genes and the finding that AE-dependent gene activation is evolutionarily conserved, will help addressing  BMP-dependent networks of neuronal subtype specification and synaptic function.