Cluster of Excellence –
University of Freiburg

Prof. Dr. Thomas Reinheckel

Prof. Dr. Thomas Reinheckel

Institute of Molecular Medicine, University of Freiburg

+49 761 203 9606

 

10 selected publications:

  • B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model.
    Köhler M, Ehrenfeld S, Halbach S, Lauinger M, Burk U, Reischmann N, Cheng S, Spohr C, Uhl FM, Köhler N, Ringwald K, Braun S, Peters C, Zeiser R, Reinheckel T*, Brummer T.* (2019)
    Oncogene. 38(8):1324-1339.
  • MMP14 empowers tumor-initiating breast cancer cells underhypoxic nutrient-depleted conditions.
    Hillebrand LE, Wickberg SM, Gomez-Auli A, Follo M, Maurer J, Busch H, Boerries M, Reinheckel T.
    FASEB J. 2018 Dec 6 [Epub ahead of print]
  • Mitophagy in intestinal epithelial dells triggers adaptive immunity during tumorigenesis.
    Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR. (2018)
    Cell. 174(1):88-101.
  • Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells.
    Kern U, Wischnewski V, Biniossek ML, Schilling O, Reinheckel T. (2015)
    Mol. Cancer 14:39 ff
  • Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo
    Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T. (2014)
    Nat Commun. 5:4931.
  • Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression.
    Bengsch F, Buck A, Günther SC, Seiz JR, Tacke M, Pfeifer D, von Elverfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T. (2014)
    Oncogene 33(36):4474-84.
  • Specialized roles for cysteine cathepsins in health and disease
    Reiser J, Adair B, and Reinheckel T. (2010)
    J Clin Invest 120(10):3421-31.
  • Synergistic anti-tumor effects of combined cathepsin B and cathepsin X/Z deficiencies on breast cancer progression and metastasis in mice.
    Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T (2010).
    Proc Natl Acad Sci U S A. 107(6):2497-502
  • Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
    Vasiljeva O, Papazoglou A, Krüger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, Peters C, Reinheckel T. (2006)
    Cancer Res. 66, 5242-5250.
  • Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.
    Stypmann J, Gläser K, Roth W, Tobin DJ, Petermann I, Matthias R, Mönnig G, Haverkamp W, Breithardt G, Schmahl W, Peters C, Reinheckel T. (2002)
    Proc. Natl. Acad. Sci. U S A. 99, 6234-6239