Prof. Dr. Thomas Reinheckel

10 selected publications:

• Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
  Ketterer S, Mitschke J, Ketscher A, Schlimpert M, Reichardt W, Baeuerle N, Hess M, Metzger P, Boerries M, Peters C, Kammerer B, Brummer T, Steinberg F, Reinheckel T (2020).
  Nat. Commun. 11: 5133
• MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions.
  Hillebrand LE, Wickber SM, Gomez-Auli A, Follo M, Maurer J, Busch H, Boerries M, Reinheckel T (2019).
  FASEB J. 33, 4124-4140.
• B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model.
  Köhler M, Ehrenfeld S, Halbach S, Lauinger M, Burk U, Reischmann N, Cheng S, Spohr C, Uhl FM, Köhler N, Ringwald K, Braun S, Peters C, Zeiser R, Reinheckel T*, Brummer T.* (2019)
  Oncogene. 38(8):1324-1339.
• Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis.
  Martínez-Fábregas J, Prescott A, van Kasteren S, Pedrioli DL, McLean I, Moles A, Reinheckel T, Poli V, Watts C (2018).
  Nat Commun 17;9(1):5343.
• Mitophagy in intestinal epithelial dells triggers adaptive immunity during tumorigenesis.
  Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR. (2018)
  Cell. 174(1):88-101.
• Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo
  Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T. (2014)
  Nat Commun. 5:4931.
• Specialized roles for cysteine cathepsins in health and disease
  Reiser J, Adair B, and Reinheckel T. (2010)
  J Clin Invest 120(10):3421-31.
• Synergistic anti-tumor effects of combined cathepsin B and cathepsin X/Z deficiencies on breast cancer progression and metastasis in mice.
  Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T (2010).
  Proc Natl Acad Sci U S A. 107(6):2497-502
• Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
  Vasiljeva O, Papazoglou A, Krüger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, Peters C, Reinheckel T. (2006)
  Cancer Res. 66, 5242-5250.
• Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.
  Stypmann J, Gläser K, Roth W, Tobin DJ, Petermann I, Matthias R, Mönnig G, Haverkamp W, Breithardt G, Schmahl W, Peters C, Reinheckel T. (2002)
  Proc. Natl. Acad. Sci. U S A. 99, 6234-6239