Cluster of Excellence –
University of Freiburg

Prof. Dr. Roland Schüle

Prof. Dr. Roland Schüle

Centre for Clinical Research, University Medical Center Freiburg

+49 761 270 63100

 

10 selected publications:

  • Lsd1 prevents ageprogramed loss of beige adipocytes.
    Duteil D, Tosic M, Willmann D, Georgiadi A, Kanouni T, Schüle R. (2017).
    Proc. Natl. Acad. Sci. USA 114, 5265-5270.
  • KDM4 inhibition targets breast cancer stem-like cells.
    Metzger E, Stepputtis SS, Strietz J, Preca BT, Urban S, Willmann D, Allen A, Zenk F, Iovino N, Bronsert P, Proske A, Follo M, Boerries M, Stickeler E, Xu J, Wallace MB, Stafford JA, Kanouni T, Maurer J, Schüle R. (2017).
    Cancer Res. 77, 5900-5912
  • Assembly of methylated KDM1 and CHD1 drives AR-dependent transcription and translocation.
    Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R. (2016).
    Nat. Struct. Mol. Biol. 23, 132-139.
  • Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue.
    Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R. (2016).
    Cell Rep. 17, 1008-1021. LSD1 promotes oxidative metabolism of white adipose tissue. Duteil D, Metzger E, Willmann D, Karagianni P, Friedrichs N, Greschik H, Günther T, Buettner R, Talianidis I, Metzger D, Schüle R. (2014).
    Nat. Commun. 5, 4093.
  • Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.
    Zhu D, Hölz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Günther T, Arnold SJ, Schüle R. (2014).
    Nat. Commun. 5, 3174-3184.
  • Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4. Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R. (2010).
    Nature 464, 792-796.
  • Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation.
    Metzger E, Yin N, Wissmann M, Kunowska N, Fischer K, Friedrichs N, Patnaik D, Higgins JM, Potier N, Scheidtmann KH, Buettner R, Schüle R. (2008).
    Nat. Cell Biol. 10, 53-60.
  • Co-operative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
    Wissmann M, Yin N, Müller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Günther T, Buettner R, Metzger E, Schüle R. (2007).
    Nat. Cell Biol. 9, 347-353.
  • LSD1 demethylates repressive histone marks to promote androgen receptor dependent transcription.
    Metzger E, Wissmann M, Yin N, Müller JM, Schneider R, Peters AH, Günther T, Buettner R, Schüle R. (2005).
    Nature 437, 436-439.