Centre for Biological Signalling Studies

Prof. Dr. Olaf Groß

Prof. Dr. Olaf Groß

Institute of Neuropathology, Neurozentrum, University Medical Center Freiburg

+49 761 270 63810

The Metabolism and Inflammation Research Group investigates the fundamental mechanisms of inflammatory processes mediated by the innate immune system. A special focus lies on inflammasome biology. This intracellular signalling complex controls the production of the cytokine IL-1beta, thereby playing a central role in inflammation. In current projects, we are studying the role of the inflammasome in auto-inflammatory diseases and the interactions between cellular metabolism and the immune system.


10 selected publications:

  • The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity.
    Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Cikovic T, Sodenkamp J, Médard G, Naumann R, Ruland J, Kuster B, Broz P, Groß O. (2017)
    Cell Reports. 21, 3846-3859.
  • K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.
    Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Cikovic T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. (2016)
    Immunity. 45(4):761-773.
  • RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells.
    Höckendorf U*, Yabal M*, Herold T, Munkhbaatar E, Rott S, Jilg S, Kauschinger J, Magnani G, Reisinger F, Heuser M, Kreipe H, Sotlar K, Engleitner T, Rad R, Weichert W, Peschel C, Ruland J, Heikenwalder M, Spiekermann K, Slotta-Huspenina J, Groß O, Jost PJ. (2016)
    Cancer Cell. 30(1):75-91.
  • Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
    Neumann K, Castiñeiras-Vilariño M, Höckendorf U, Hannesschläger N, Lemeer S, Kupka D, Meyermann S, Lech M, Anders HJ, Kuster B, Busch DH, Gewies A, Naumann R, Groß O, Ruland J. (2014)
    Immunity. 40(3):389-99.
  • Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity.
    Groß O*, Yazdi AS*, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, and Tschopp J (2012).
  • Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
    Poeck H*, Bscheider M*, Groß O*, Finger K, Roth S, Rebsamen M, Hannesschlager N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J (2010)
    Nat Immunol. 11(1): 63-69
  • Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.
    Werninghaus K*, Babiak A*, Groß O*, Holscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, Nimmerjahn F, Brown GD, Kirschning C, Heit A, Andersen P, Wagner H, Ruland J, Lang R (2009)
    J Exp Med. 206(1): 89-97
  • Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
    Groß O*, Poeck H*, Bscheider M, Dostert C, Hannesschlager N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J (2009)
    Nature 459(7245): 433-436
  • Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
    LeibundGut-Landmann S, Groß O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C (2007)
    Nat Immunol. 8(6): 630-638
  • Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.
    Groß O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J (2006)
    Nature 442(7103): 651-656