Cluster of Excellence –
University of Freiburg

Prof. Dr. Lutz Hein

Prof. Dr. Lutz Hein

Institute of Experimental and Clinical Pharmacology
and Toxicology II, University of Freiburg

+49 761 203 5314

 

Research activities of the group of Lutz Hein are focussed on signaling mechanisms in the cardiovascular system. Previous studies have determined the physiological and pharmacological significance of angiotensin and adrenoceptor subtypes (e.g. AT2- and a2A,B,C-receptors) and signaling molecules (e.g. phosducin) which are important for neuroendocrine control in chronic heart failure. More recently, the group has identified epigenetic mechanisms (e.g. miR-143/145, MeCP2) of cardiovascular regulation. In order to better understand cell type-specific signaling mechanisms, we have developed methods to purify cardiomyocyte nuclei from intact cardiac tissue by fluorescence-assisted sorting and to generate whole genome DNA methylation and chromatin modification maps by methylC-seq and ChIP-seq. We will apply these methods to generate epigenomes of essential cardiac cell types during development, postnatal maturation and disease and integrate these maps with signaling mechanisms which are relevant during disease development.

 

10 selected publications:

  • Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo.
    Gilsbach R, Schwaderer M, Preissl S, Grüning BA, Kranzhöfer D, Schneider P, Nührenberg TG, Mulero-Navarro S, Weichenhan D, Braun C, Dreßen M, Jacobs AR, Lahm H, Doenst T, Backofen R, Krane M, Gelb BD, Hein L (2018).
    Nat Commun. 9, 391, 1-14
  • The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia.
    Rommel C, Rösner S, Lother A, Barg M, Schwaderer M, Gilsbach R, Bömicke T, Schnick T, Mayer S, Doll S, Hesse M, Kretz O, Stiller B, Neumann FJ, Mann M, Krane M, Fleischmann BK, Ravens U, Hein L (2018).
    Circ. Res. 123, 550-63
  • DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes.
    Nothjunge S, Nührenberg TG, Grüning BA, Doppler SA, Preissl S, Schwaderer M, Rommel C, Krane M, Hein L, Gilsbach R (2017).
    Nat Commun. 8, 1667, 1-9
  • MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
    Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A (2016).
    Cell 167, 722-38
  • Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.
    Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K (2015).
    Nat Med 21, 1298-306
  • Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease.
    Gilsbach R, Preissl S, Grüning BA, Schnick T, Burger L, Benes V, Würch A, Bönisch U, Günther S, Backofen R, Fleischmann BK, Schübeler D, Hein L (2014).
    Nat Commun. 5, 5288, 1-13
  • Placental a2-adrenoceptors control vascular development at the interface between mother and embryo.
    Philipp M, Brede M, Hadamek K, Gessler M, Lohse MJ, Hein L (2002).
    Nat Genetics 31, 311-315
  • Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission.
    Hein L, Altman JD, Kobilka BK (1999).
    Nature 402, 181-184
  • Central hypotensive effects of the α2A-adrenergic receptor subtype.
    MacMillan LB, Hein L, Smith MS, Piascik MT, Limbird LE (1996).
    Science 273, 801-803
  • Cardiovascular regulation in mice lacking α2-adrenergic receptor subtypes b and c.
    Link RE, Desai K, Hein L, Stevens ME, Chruscinski A, Bernstein D, Barsh GS, Kobilka BK (1996).
    Science 273, 803-805