Centre for Biological Signalling Studies

Prof. Dr. Heike Walles

Prof. Dr. Heike Walles

Department Tissue Engineering & Regenerative Medicine (TERM, University Hospital Würzburg)
Translational Center Würzburg, Regenerative Therapies in Oncology and Musculoskeletal Disease Würzburg, branch of the Fraunhofer Institut Interfacial Engineering and Biotechnology (IGB)
Würzburg, Germany

Translational Centre Würzburg and Department Tissue Engineering and Regenerative Medicine (TERM) University Hospital Würzburg

The Translational Center "Regenerative Therapies" (TLZ) is the Wuerzburg branch of the Fraunhofer IGB (FhG) Stuttgart and is headed by Prof. Heike Walles. The TLZ was founded in 2009, has been evaluated by an international experts in February 2014 as an "excellent interdisciplinary team, focusing on applied research."

The interdisciplinary team benefits from the synergy of leveraging the research of Fraunhofer and the TERM, a department of the Medical Faculty of Würzburg. The teams are composed of a variety of disciplines as biologists, pharmacists, engineers, and clinical staff, and is funded by internal and external grants, acquired on a competitive basis. The core competence of the teams are based on human cell biology and the cultivation of these cells on a vascularized scaffold (BioVaSc-TERM) in specific bioreactors. The main focus are in the field of Tissue Engineering, particularly on cancer diseases and novel oncologic therapies and diseases of musculoskeletal system as well as infectious diseases. Based on this expertise are the teams developing special solutions for cell-based tissue models, cell based processes, applications and biologically vascularized implants. In the EU-projects we and the partners are developing stem cell based new innovative ATMPs (Advanced Therapy Medicinal Products) for musculoskeletal therapies. The cultivation of our vascularized matrix (BioVaSc-TERM ) in specific bioreactors, with which we can produce complex vascular implants, was now also established under GMP conditions in cooperation with the University Hospital Würzburg.

Within this frame, the TLZ and TERM lays their focus on contract research for biotechnologic, pharmaceutic and medical-technical companies and clinics, diagnostic laboratories as well as research facilities.