Centre for Biological Signalling Studies

Prof. Dr. Christoph Peters

Prof. Dr. Christoph Peters

Institute of Molecular Medicine and Cell Research, University of Freiburg

+49 761 203 9601


10 selected publications:

  • Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
    Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA.
    Genes & Development. 2014;28(19):2134–50.
  • Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment.
    Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I, Babes L, Reinheckel T, Peters C, Zeiser R, Bogyo M, Turk V, Psakhye SG, Turk B, Vasiljeva O. br /> Nat Nanotechnol. 2011;6(9):594–602.
  • Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
    Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Mueller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T.
    Proc Natl Acad Sci U S A. 2010;107(6):2497–502.
  • Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
    Vasiljeva O, Papazoglou A, Krueger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen B, Almholt K, Bogyo M, Peters C, Reinheckel T.
    Cancer Res. 2006;66(10):5242–50.
  • Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
    Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi M, Vajkoczy P, Hofmann W, Peters C, Pennacchio L, Abolmaali N, Chavakis E, Reinheckel T, Zeiher A, Dimmeler S.
    Nat Medicine. 2005;11(2):206–13.
  • The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.
    Reinheckel T, Hagemann S, Dollwet-Mack S, Martinez E, Lohmuller T, Zlatkovic G, Tobin D, Maas-Szabowski N, Peters C.
    J Cell Science. 2005;118(15):3387–95.
  • Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
    Halangk W, Lerch M, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussing J.
    J Clin Invest. 2000;106(6):773–81.
  • Cathepsin L: Critical role in Ii degradation and CD4 T cell selection in the thymus.
    Nakagawa T, Roth W, Wong P, Nelson A, Farr A, Deussing J, Villadangos J, Ploegh H, Peters C, Rudensky A.
    Science. 1998;280(5362):450–3.
  • Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
    Saftig P, Hetman M, Schmahl W, Weber K, Heine L, Mossmann H, Koster A, Hess B, Evers M, von Figura K, Peters C.
    EMBO J. 1995;14(15):3599–608.
  • The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a beta turn.
    Eberle W, Sander C, Klaus W, Schmidt B, von Figura K, Peters C.
    Cell 1991;67(6):1203–9.