Cluster of Excellence –
University of Freiburg

Prof. Dr. Cassian Sitaru

Prof. Dr. Cassian Sitaru

Department of Dermatology
University Medical Centre Freiburg

+49 761 270 67690

10 selected publications:

  • The flavonoid luteolin inhibits Fc?-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice.
    Oswald E, Sesarman A, Franzke CW, Wölfle U, Bruckner-Tuderman L, Jakob T, Martin SF, Sitaru C (2012).
    PLoS ONE, 7(2): e31066
  • T cells are required for the production of blister-inducing autoantibodies in experimental epidermolysis bullosa acquisita.
    Sitaru AG, Sesarman A, Mihai S, Chiriac MT, Zillikens D, Hultman P, Solbach W, Sitaru C (2010).
    J Immunol, 184:1596-603
  • Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita.
    Sesarman A, Sitaru AG, Olaru F, Zillikens D, Sitaru C (2008).
    J Mol Med, 86:951-9
  • NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage.
    Chiriac MT,  Roesler J, Sindrilaru A, Scharffetter-Kochanek K, Zillikens D, Sitaru C (2007).
    J Pathol, 212:56-65
  • The alternative pathway of complement activation is critical for the induction of experimental epidermolysis bullosa acquisita.
    Mihai S, Chiriac MT, Takahashi K, Thurman JM, Holers VM,  Zillikens D, Botto M, Sitaru C (2007).
    J Immunol, 178:6514-21
  • Non-complement fixing IgG4 autoantibodies activate leukocytes and induce dermal-epidermal separation.
    Mihai S, Chiriac MT, Herrero-Gonzalez JE, Goodall M, Jefferis R, Savage COS, Zillikens D, Sitaru C (2007).
    J Cell Mol Med, 11:1117-1129
  • Immunoadsorption against two distinct epitopes on human type XVII collagen abolishes dermal-epidermal separation induced in vitro by autoantibodies from pemphigoid gestationis patients.
    Herrero-Gonzalez JE, Brauns O, Egner R, Rönspeck W, Mascaro JM, Jonkman MF, Zillikens D, Sitaru C (2006).
    Eur J Immunol 36: 1039-1048.
  • Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal  blistering in mice.
    Sitaru C, Chiriac MT, Mihai S, Büning J, Gebert A, Ishiko A, Zillikens D (2006).
    J Immunol, 177:3461-8
  • Induction of dermal-epidermal separation in mice by passive transfer of antibodies to type VII collagen.
    Sitaru C, Mihai S, Otto C, Chiriac MT, Haußer I, Dotterweich B, Saito H, Rose C, Ishiko A, Zillikens D (2005).
    J Clin Invest, 115:870-878
  • Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid.
    Shimanovich I, Mihai S, Oostingh G J, Ilenchuk T, Bröcker E-B, Opdenakker G, Zillikens D, Sitaru C (2004).
    J Pathol 204: 519-527