Dr. Uwe Schulte

 Research Interests

• biochemical and functional characterization of ion channels and GPCRs (focus on pain and CNS disorders).
• development of methods for biochemical characterization and mass spectrometric analysis of membrane proteins and protein-ligand interactions.
• protein quantification and bioinformatic evaluation techniques.
• antibody profiling, antibody technologies.
• analysis of protein interaction networks.

10 selected publications

• Neuroplastin and basigin are essential auxiliary subunits of plasma membrane Ca2+-ATPases and key regulators of Ca2+ clearance.
  Schmidt N, Kollewe A, Constantin CE, Henrich S, Ritzau-Jost A, Bildl W, Saalbach A, Hallermann S, Kulik A, Fakler B*, Schulte U* (2017).
  Neuron 96;827-838
• The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.
  Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N (2017).
  Sci Rep. 7:10038
• Cryo-slicing blue native-Mass Spectrometry (csBN-MS), a novel technology for high resolution complexome profiling.
  Müller CS, Bildl W, Haupt A, Ellenrieder L, Becker T, Hunte C, Fakler B, Schulte U (2016).
  Mol Cell Proteomics 15:669-681
• Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain.
  Schwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Roeper J, Fakler B*, Schulte U* (2014).
  Neuron. 84:41-54
• Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells.
  Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M (2013).
  J Neurosci. 33:9508-9519
• GlialCAM, a protein defective in a Leukodystrophy, serves as a ClC-2 Cl− channel auxiliary subunit.
  Jeworutzki E, López-Hernández T, Capdevila-Nortes X, Sirisi S, Bengtsson L, Montolio M, Zifarelli G, Arnedo T, Müller CS, Schulte U, Nunes V, Martínez A, Jentsch TJ, Gasull X, Pusch M, Estévez R (2012).
  Neuron. 73:951-961
• Extending the dynamic range of label-free Mass Spectrometric quantification of affinity purifications.
  Bildl W, Haupt A, Mueller CS, Biniossek ML, Thumfart JO, Hueber B, Fakler B, Schulte U (2012).
  Mol Cell Proteomics 11:M111.007955.
• High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.
  Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Muller CS, Bildl W, Baehrens D, Huber B, Kulik A, Klöcker N, Schulte U*, Fakler B* (2012).
  Neuron 74:621-633
• Feature Article: Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.
  Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner, M Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U (2011).
  Proc Natl Acad Sci USA 107:14950-14957
• Native GABAB receptors are heteromultimers with a family of auxiliary subunits.
  Schwenk J, Metz M, Zolles G, Turecek R, Bildl W, Tarusawa E, Kulik A, Unger A, Tiao JY, Ivankova K, Seddik R, Gassmann M, Schulte U, Fakler B, Bettler B (2010).
  Nature 465:231-235

*shared senior authorship