Centre for Biological Signalling Studies

Dr. Stefan Schiller

Dr. Stefan Schiller

FRIAS Freiburg Institute for Advanced Studies,
Zentrum für Biosystemanalyse ZBSA
University of Freiburg

+49 761 203 97405

Research Interests

  • Chemical Systems Biology: Bioorthogonal protein functionalization; heterobisfunctional linker chemistry; lipid & carbohydrate conjugate libraries; novel unnatural amino acids for site specific in vivo translation - introducing defined posttranslational modification pattern; spatiotemporal signaling platforms
  • Synthetic Biology & Bionanotechnology: Development of new components for the in vivo translational machinery - tRNA synthetases for the site-specific incorporation of novel unnatural amino acids; novel systems to assemble genetic information to construct nano-defined block copolymer proteins, thermoresponsive protein switches, nano-compartments/artificial organelles in vivo, novel protein-rubbers, scaffolds with adjustable mechanical properties for reg. med.; barrel & donut-forming proteins for nanoparticle assembly (e.g. supermagnets), pseudoenzyme moieties; quantum dot based photonic wires and “bio-solar cells”
  • Bionic Material Science: Polymeric Nanomaterials - nanoparticle controlled enzymatic catalysts e.g.  for ring opening polymerization of renewable monomers, green catalysts, oriented nano-confined nano-particle biomineralization and methods of “non-classical” crystallization,  neuro-regeneration via inkjet printing of neuro-interfaces;  programmed 3D scaffolds & asymmetric nano-layer scaffolds for regenerative medicine & stem cell niches


10 selected publications

  • Designer amphiphilic proteins as building blocks for the intracellular formation of organelle-like compartments.
    Huber MC, Schreiber A, von Olshausen P, Varga BR, Kretz O, Joch B, Barnert S, Schubert R, Eimer S, Kele P, Schiller SM.
    Nat Mater. 2015 Jan;14(1):125-32
  • Reversible biomechano-responsive surface based on green fluorescent protein genetically modified with unnatural amino acids.
    Longo J, Yao C, Rios C, Chau NT, Boulmedais F, Hemmerlé J, Lavalle P, Schiller SM, Schaaf P, Jierry L.
    Chem Commun (Camb). 2015 Jan 4;51(1):232-5.
  • Protein Adaptor with Genetically Encoded Interaction-Sites Guiding the Hierarchical Assembly of Plasmonically Active Nanoarchitectures.
    Schreiber A, Huber MC, Cölfen H, Schiller, SM.
    Nat Commun. 2015 Mar 27;6:6705
  • Introducing a combinatorial DNA-toolbox platform constituting defined protein-based biohybrid-materials.
    Huber MC, Schreiber A, Wild W, Benz K, Schiller SM.
    Biomaterials. 2014 Oct;35(31):8767-79.
  • Non-toxic catalysts for ring-opening polymerizations of biodegradable polymers at room temperature for biohybrid materials.
    Hege C, Schiller SM.
    Green Chem. 2014;16 (3), 1410-1416
  • Protein Tectons in Synthetic Biology: The expansion of cellular functionality combining chemical biology of small organic molecules with protein tectons – unnatural amino acids, protein based biohybrid materials & de novo organelles.
    Schiller, SM.
    in Synthetic Biology, ed. Giese, B., von Gleich, A., Pade, C., Wigger, H. (Springer, 2014, ISBN 978-3-319-02782-1)
  • Nanobiotechnology of Protein Compartments: Steps towards Nanofactories.
    Schreiber A, Schiller SM.
    Bioinspired, Biomimetic and Nanobiomaterials (ICE Virtual Library) 2013, 4, 2, 157-164
  • From Bioconjugation to Selfassembly in Nanobiotechnology: Quantum Dots Trapped and Stabilised by Toroid Protein Yoctowells.
    Schreiber A, Yuan Y, Huber MC, Thomann R, Ziegler A, Cölfen H, Dengjel J, Krüger M, Schiller SM.
    Adv Eng Materials 2012;14,6,B344-B350
  • Protein Yoctowell Nanoarchitectures: Assembly of Donut Shaped Protein Containers and Nanofibres.
    Schreiber A, Zaitseva E, Thomann Y, Thomann R, Dengjel J, Hanselmann R, Schiller SM.
    Soft Matter 2011;7(6):2875-2878
  • Biomimetische Lipo-Glycopolymer-Membranen: photochemische Oberflächenanbindung supramolekularer Architekturen mit definierter Orientierung.
    Schiller SM, Reisinger-Friebis A, Goetz H, Hawker CJ, Frank CW, Naumann R, Knoll W.
    Angew. Chem. 2009, 121, 7028-7032
    („Biomimetic Lipoglycopolymer Membranes: Photochemical Surface Attachment of Supramolecular Architectures with Defined Orientation“ Angew. Chem. Int. Ed. 2009, 48, (37) 6896-6899)