BIOSS
Centre for Biological Signalling Studies

Dr. Julia Jellusova

Dr. Julia Jellusova

BIOSS Centre for Biological Signalling Studies and
Institute of Biology III
University of Freiburg

+49 761 203 97663

Nutrient acquisition and utilization are dynamically regulated in lymphocytes and recent studies suggest that cell metabolism not only supports growth and proliferation, but in many cases dictates cell fate and function. Our aim is to gain deeper insight into the metabolic profile of different B cell subsets and to elucidate how various signaling pathways regulate metabolic processes in B cells. Furthermore, our goal is to gain a better understanding of how normal and malignant B cells match nutrient availability with their metabolic and energetic demands and how these cells respond to metabolic stress.

 

10 selected publications:

  • Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes.
    Jumaa H, Caganova M, McAllister EJ, Hoenig L, He X, Saltukoglu D, Brenker K, Köhler M, Leben R, Hauser AE, Niesner R, Rajewsky K, Reth M, Jellusova J.
    Life Sci Alliance. 2020 Apr 27;3(6):e202000700.
  • The role of metabolic checkpoint regulators in B cell survival and transformation.
    Jellusova J.
    Immunol Rev. 2020 May;295(1):39-53.
  • Metabolic control of B cell immune responses.
    Jellusova J.
    Curr Opin Immunol. 2020 Apr;63:21-28.
  • Self-reactive B cells in the GALT are actively curtailed to prevent gut inflammation.
    Shukla A, Chen C, Jellusova J, Leung CR, Kao E, Bhat N, Lin WW, Apgar JR, Rickert RC.
    JCI Insight. 2019 Jul 23;5(16):e130621.
  • New methods to analyze B cell immune responses to thymus-dependent antigen sheep red blood cells.
    McAllister EJ, Apgar JR, Leung CR, Rickert RC, Jellusova J.
    J Immunol. 2017 Oct 15;199(8):2998-3003.
  • Gsk3 is a metabolic checkpoint regulator in B cells.
    Jellusova J, Cato MH, Apgar JR, Ramezani-Rad P, Leung CR, Chen C, Richardson AD, Conner EM, Benschop RJ, Woodgett JR, Rickert RC.
    Nat Immunol. 2017 Mar;18(3):303-312.
  • Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells.
    Miletic AV, Jellusova J, Cato MH, Lee CR, Baracho GV, Conway EM, Rickert RC.
    J Immunol. 2016 Mar 1;196(5):2195-204.
  • Context-specific BAFF-R signaling by the NF-κB and PI3K pathways.
    Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC.
    Cell Rep. 2013 Nov 27;5(4):1022-35.
  • Context-specific BAFF-R signaling by the NF-κB and PI3K pathways.
    Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC.
    Cell Rep. 2013 Nov 27;5(4):1022-35.
  • CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.
    Jellusova J, Wellmann U, Amann K, Winkler TH, Nitschke L.
    J Immunol. 2010 Apr 1;184(7):3618-27