Cluster of Excellence –
University of Freiburg

Soeren Lienkamp

Soeren Lienkamp

Renal Division, University Hospital Freiburg

+49 761 270 63220

Our group focuses on renal development and disease modelling in Xenopus laevis. The rapid embryonic development and ease of manipulation make Xenopus an ideal model system to study nephrogenesis. In particular, we are interested in the molecular control of nephron formation, and how renal tubules adopt and maintain their shape by dynamic cell rearrangement. We have developed live cell imaging methods to directly visualize nephron formation in vivo.

Nephronophthisis is a hereditary condition that frequently leads to renal failure and the need for dialysis or transplantation in children and young adults. Our second area of focus in on the molecular pathogenesis of nephronophthisis. Disease related proteins form complexes and localize to the primary cilium of renal tubular cells. To understand the composition and function of the nephronophthisis proteins, we are modeling the disease in Xenopus.

 

 

10 selected publications:

  • Using Xenopus to study genetic kidney diseases.
    Lienkamp SS .
    Semin Cell Dev Biol. 2016 Mar;51:117-24.
  • The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.
    Yasunaga T, Hoff S, Schell C, Helmstädter M, Kretz O, Kuechlin S, Yakulov TA, Engel C, Müller B, Bensch R, Ronneberger O, Huber TB, Lienkamp SS, Walz G.
    J Cell Biol. 2015 Dec 7;211(5):963-73
  • Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development.
    Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Chen J, Shril S, Hwang DY, Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship TH, Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM, Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Jüppner H, Kispert A, Hildebrandt F.
    Am J Hum Genet. 2015 Aug 6;97(2):291-301.
  • Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.
    Funk MC, Bera AN, Menchen T, Kuales G, Thriene K, Lienkamp SS, Dengjel J, Omran H, Frank M, Arnold SJ.
    EMBO J. 2015 Apr 15;34(8):1078-89.
  • The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin.
    Epting D, Slanchev K, Boehlke C, Hoff S, Loges NT, Yasunaga T, Indorf L, Nestel S, Lienkamp SS, Omran H, Kuehn EW, Ronneberger O, Walz G, Kramer-Zucker A.
    Development. 2015 Jan 1;142(1):174-84.
  • ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.
    Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS.
    Nat Genet. 2013 Aug;45(8):951-6.
  • Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension.
    Lienkamp SS, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB, Walz G.
    Nat Genet. 2012 Dec;44(12):1382-7.
  • Inversin relays Frizzled-8 signals to promote proximal pronephros development.
    Lienkamp S, Ganner A, Boehlke C, Schmidt T, Arnold SJ, Schäfer T, Romaker D, Schuler J, Hoff S, Powelske C, Eifler A, Krönig C, Bullerkotte A, Nitschke R, Kuehn EW, Kim E, Burkhardt H, Brox T, Ronneberger O, Gloy J, Walz G.
    Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20388-93
  • Regulation of ciliary polarity by the APC/C.
    Ganner A, Lienkamp S, Schäfer T, Romaker D, Wegierski T, Park TJ, Spreitzer S, Simons M, Gloy J, Kim E, Wallingford JB, Walz G.
    Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17799-804.
  • Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia.
    Bergmann C, Fliegauf M, Brüchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kränzlin B, Nürnberg G, Becker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Senderek J, Neuhaus TJ, Stallmach T, Zentgraf H, Nürnberg P, Gretz N, Lo C, Lienkamp S, Schäfer T, Walz G, Benzing T, Zerres K, Omran H.
    Am J Hum Genet. 2008 Apr;82(4):959-70.