In vivo imaging of antileukemic drug asparaginase reveals a rapid macrophage mediated clearance from the bone marrow
van der Meer LT, Terry SY, van Ingen Schenau D, Andree KC, Franssen GM, Roeleveld DM, Metselaar BM, Reinheckel T, Hoogerbrugge PM, Boerman OC, van Leeuwen FN.
The antileukemic drug asparaginase, a key component in the treatment of acute lymphoblastic leukemia, acts by depleting asparagine from the blood. However, little is known about its pharmacokinetics and mechanisms of therapy resistance are poorly understood. Here, we explored the in vivo biodistribution of radiolabeled asparaginase, using a combination of imaging and biochemical techniques, and provide evidence for tissue specific clearance mechanisms, which could reduce effectiveness of the drug at these specific sites.