Cingulate overexpression of mitogen-activated protein kinase phosphatase-1 as a key factor for depression
Barthas F, Humo M, Gilsbach R, Waltisperger E, Karatas M, Leman S, Hein L, Belzung C, Boutillier AL, Barrot M, Yalcin I.
Depression is frequently associated with chronic pain or chronic stress. The current work shows, that
during chronic pain–induced depression, the mitogen-activated protein kinase phosphatase-1 (MKP-1) is overexpressed in the anterior cingulate cortex (ACC). MKP-1 overexpression is also observed with unpredictable chronic mild stress and repeated ACC optogenetic stimulation and is reversed by fluoxetine. A knockout, an antagonist, or a local silencing of MKP-1 attenuates depressive-like behaviors, pointing to an important role of this phosphatase in depression.