Cluster of Excellence –
University of Freiburg

Prof. Marco Prinz

Prof. Marco Prinz

Institute of Neuropathologie
University Medical Centre Freiburg

+49 761 270 51050

Mr. Marco Prinz serves as the Director of the Institute of Neuropathology at the University Hospital Freiburg, Germany. He graduated as a M.D. from the Medical School Charité of Humboldt University, Berlin. Subsequently, he joined the Molecular Neuroscience Laboratory of H.Kettenmann at the Max Delbrück Center (MDC) for Molecular Medicine in Berlin-Buch and started first work on microglia. After this period he was a postdoctoral fellow at the Institute of Neuropathology led by A.Aguzzi at the University Hospital Zurich, Medical School, Switzerland. Shortly after, he moved to Göttingen, Germany to continue his research on the brains immune system and became a lecturer and consultant in neuropathology. In 2008 he was appointed as Director of the Institute of Neuropathology at the University Hospital Freiburg, Germany.

His current research focuses on the brain specific immune functions during health and disease (autoimmune and neurodegenerative CNS disorders) and the fate of microglia in the brain. His group investigates the role of type I interferons such as IFN-alpha/beta for autoimmune inflammation (Prinz et al. Immunity 2008; Dann et al. Nat Neurosci 2011). Furthermore, the origin and function if microglia are of special interest for his research team (Goldmann et al. Nat Neurosci, 2013, Kierdorf et al. Nat Neurosci, 2013, Mildner et al. Nat Neurosci 2007, Prinz et al. Nat Neurosci 2011).

References:

Goldmann T, Wieghofer P, Müller PF, Wolf Y, Varol D, Yona S, Brendecke SM, Kierdorf K, Staszweski O, Datta M, Luedde T, Heikenwalder M, Jung S, Prinz M: A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci, 2013, 16(11):1618-1626. including cover 

Dann A, Poeck H, Croxford A, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth S, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M: Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation of the CNS. Nat Neurosc, 2012, 15:98-106.

Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Müller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M: Microglia emerge from erythromyeloid precursors via Pu.1 and IRF-8 dependent pathways. Nat Neurosci, 2013, 16(3):273-280. news & views

Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwälder M, Brück W, Priller J, Prinz M (2007): Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosc, 10(12):1544-53. incl. news & views                  

Prinz M, Priller J, Sisodia SS, Ransohoff RM (2011): Microglia in the CNS: Heterogeneity of central nervous system myeloid cells and their roles in neurodegeneration. Nat Neurosc 2011, 13(10):1227-35.           

Prinz M*, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Brück W, Kalinke U (2008): Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity, 28(5):675-86. *corresp. author, including cover + news & views

10 selected publications

  • Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease.
    Prinz M, Priller J (2014).
    Nat Rev Neurosci, 15(5):300-12.   
  • A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.  
    Goldmann T. Wieghofer P, Müller PF ….Jung S*, Prinz M*(2013). (*contributed equally).
    Nat Neurosci, 16(11):1618-1626. including cover
  • Microglia emerge from erythromyeloid precursors via Pu.1 and IRF-8 dependent pathways.
    Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C …. Prinz M (2013).
    Nat Neurosci, 16(3):273-280. news & views
  • Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation of the CNS.  
    Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M (2012).
    Nat Neurosci, 15:98-106.
  • Heterogeneity of central nervous system myeloid cells and their roles in neurodegeneration.
    Prinz M, Priller J, Sisodia SS, Ransohoff RM (2011).
    Nat Neurosci, 13(10):1227-35.
  • I kappa B kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappa B in the CNS.
    Raasch J, Zeller N, Van Loo G, Merkler D, Mildner A, Erny D, Knobeloch KP, Bethea JR, Waisman A, Knust M, DelTurco D, Deller T, Blank T, Priller J, Brück W, Pasparakis M, Prinz M (2011).
    Brain 134(4):1184-98.
  • Microglial pilgrimage to the brain.
    McLaren A, Ransohoff R, Prinz M (2010).
    Nat Medicine, 16 (12):1380-1381.
  • CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system.
    Mildner A, Mack M, Schmidt H, Brück W, Djukic M, Zabel MD, Hille A, Priller J, Prinz M (2009).
    Brain 132(9):2487-500.
  • Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system.
    Prinz M*, H.Schmidt, A.Mildner, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Brück W, Kalinke U (2008).
    Immunity 28(5):675-86. *corresp. author, including cover + news & views
  • Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.
    Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwälder M, Brück W, Priller J, Prinz M (2007).
    Nat Neurosc 10(12):1544-53. incl. news & views