Cluster of Excellence –
University of Freiburg

Prof. Dr. Thomas Reinheckel

Prof. Dr. Thomas Reinheckel

Institute of Molecular Medicine, University of Freiburg

+49 761 203 9606

10 selected publications:

  • Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo
    Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T. (2014)
    Nat Commun. 5:4931.
  • Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression.
    Bengsch F, Buck A, Günther SC, Seiz JR, Tacke M, Pfeifer D, von Elverfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T. (2014)
    Oncogene 33(36):4474-84.
  • The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction.
    Müller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, Deshmukh SD, Dauth S, Brix K, Saftig P, Peters C, Henneke P, Reinheckel T. (2014)
    FASEB J. 28(1):162-75.
  • Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
    Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA.
    Genes Dev. 2014 Oct 1;28(19):2134-50.
  • Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.
    Dennemärker J, Lohmüller T, Mayerle J, Tacke M, Lerch MM, Coussens LM, Peters C, Reinheckel T. (2010)
    Oncogene. 18;29(11):1611-21.
  • Specialized roles for cysteine cathepsins in health and disease.
    Reiser J, Adair B, Reinheckel T (2010).
    J Clin Invest 120(10):3421-31.
  • Synergistic anti-tumor effects of combined cathepsin B and cathepsin X/Z deficiencies on breast cancer progression and metastasis in mice.
    Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T (2010).
    Proc Natl Acad Sci U S A. 107(6):2497-502
  • The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
    Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT (2008). 
    Nat Immunol. 9(8), 857-65. 
  • Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer
    Vasiljeva O, Papazoglou A, Krüger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, Peters C, Reinheckel T (2006).
    Cancer Res. 66, 5242-5250.
  • Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsinL.
    Stypmann J, Glaser K, Roth W, Tobin DJ, Petermann I, Matthias R, Mönnig G, Haverkamp W, Breithardt G, Schmahl W, Peters C, Reinheckel T (2002).
    Proc. Natl. Acad. Sci. U S A. 99, 6234-6239