Cluster of Excellence –
University of Freiburg

Prof. Dr. Rudolf Grosschedl

Prof. Dr. Rudolf Grosschedl

Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg

+49 761 5108 711

10 selected publications:

  • Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin.
    Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET and Grosschedl R (2010).
    Immunity 32, 714-725.
  • Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.
    Savarese F, Dávila A, Nechanitzky R, de la Rosa-Velazquez IA, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, and Grosschedl R (2009).
    Genes & Dev. 22, 2625-2638.
  • Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
    Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM (2008).
    Cell 1, 103-115.
  • SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.
    Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, Grosschedl R (2006). 
    Cell 125, 971-986.


  • EBF2 regulates osteoblast-dependent differentiation of osteoclasts.
    Kieslinger M, Folberth S, Dobreva G, Dorn T, Croci L, Erben R, Consalez GG, Grosschedl R (2005). 
    Dev Cell 9, 757-767.
  • LEF1-mediated regulation of Delta-like1 links Wnt- and Notch signalling in somitogenesis.
    Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R (2004). 
    Genes & Dev. 18, 2708-2714.
  • SUMO modification of a novel MAR-binding protein, SATB2, regulates immunoglobulin ? gene expression.
    Dobreva G, Dambacher J, Grosschedl R (2003).
    Genes & Dev. 17, 3048-3061.
  • PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.
    Sachdev S, Bruhn L, Sieber H, Pichler A, Melchior F, Grosschedl R (2001). 
    Genes & Dev. 15, 3088-3103.
  • Wnt signalling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
    Reya T, O'Riordan M, Okamura R, Devaney E, Willert K, Nusse R, Grosschedl R (2000). 
    Immunity 13, 15-24.
  • Extension of chromatin accessibility by nuclear matrix attachment regions.
    Jenuwein T, Forrester WC, Fernandez-Herrero LA, Laible G, Dull M, Grosschedl R (1997).
    Nature 385, 269-272.