Cluster of Excellence –
University of Freiburg

Prof. Dr. Roland Schüle

Prof. Dr. Roland Schüle

Centre for Clinical Research, University Medical Center Freiburg

+49 761 270 63100

 

10 selected publications:

 

  • Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.
    Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R.
    Nat Struct Mol Biol. 2016 Feb;23(2):132-9.
  • Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation.
    Ancelin K, Syx L, Borensztein M, Ranisavljevic N, Vassilev I, Briseno-Roa L, Liu T, Metzger E, Servant N, Barillot E, Chen CJ, Schüle R, Heard E.
    Elife. 2016 Feb 2;5. pii: e08851. doi: 10.7554/eLife.08851. [Epub ahead of print]
  • Lsd1 regulates differentiation onset and migration of trophoblast stem cells.
    Zhu D, Hölz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Günther T, Arnold SJ, Schüle R
    Nat. Commun. 2014; 5, 3174-3184.
  • Phosphorylation of LSD1 by PKCa Is Crucial for Circadian Rhythmicity and Phase Resetting.
    Nam HJ, Boo K, Kim DH, Choe HK, Kim CR, Sun W, Kim H, Kim K, Lee H, Schüle R, Yoo SH, Takahashi JS, Cho S, Son GH, Baek SH.
    Mol. Cell 2014; 3, 791-805.
  • LSD1 promotes oxidative metabolism of white adipose tissue.
    Duteil D, Metzger E, Willmann D, Karagianni P, Friedrichs N, Greschik H, Günther T, Buettner R, Talianidis I, Metzger D, Schüle R.
    Nat Commun. 2014 Jun 10;5:4093
  • Lysine Specific Demethylase 1 has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity.
    Cai C, He HH, Gao S, Chen S, Yu Z, Gao Y, Chen S, Chen MW, Zhang J, Ahmed M, Wang Y, Metzger E, Schüle R, Liu XS, Brown M, Balk SP.
    Cell Rep. 2014 Dec 11;9(5):1618-27.
  • PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells
    Jilg CA, Ketscher A, Metzger E, Hummel B, Willmann D, Rüsseler V, Drendel V, Imhof A, Jung M, Franz H, Hölz S, Krönig M, Müller JM, Schüle R.
    Oncotarget. 2014 Dec 30;5(24):12646-64.
  • CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells.
    Ray SK, Li HJ, Metzger E, Schüle R, Leiter AB.
    Mol Cell Biol. 2014 Jun;34(12):2308-17
  • 4-acyl pyrroles: Mimicking acetylated lysines in histone code reading.
    Lucas X, Wohlwend D, Hügle M, Schmidtkunz K, Gerhardt S, Schüle R, Jung M, Einsle O, Günther S.
    Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9.
  • Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.
    Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R.
    Nature. 2010 Apr 1;464(7289):792-6.