Prof. Dr. Annegret Wilde
Cyanobacteria are photosynthetic bacteria that populate extremely diverse environments like soil crusts, open oceans, deserts, hot springs, permafrost and glacial regions, or have adopted a symbiotic lifestyle. They have produced the oxygenic atmosphere on Earth and are the ancestors of chloroplasts. We are investigating regulatory systems and adaptation strategies of cyanobacteria on a molecular level. We intend to focus our work on a model cyanobacterium with a well-annotated genome and simple genetic manipulation systems in order to characterize specific cyanobacterial functions that also might be relevant for future biotechnological applications. Main current projects include investigations on phototaxis using different photoreceptors, circadian clock and the role of regulatory RNA in cyanobacteria. In addition, we are working on several applied projects elucidating the potential of cyanobacteria as producers of amino acids, proteins as well as biofuels.
10 selected publications:
- The small regulatory RNA SyR1/PsrR1 controls photosynthetic functions in cyanobacteria.
Georg J, Dienst D, Schuergers N, Wallner T, Kopp D, Stazic D, Kuchmina K, Klähn S, Lokstein H, Hess WR, Wilde A (2014)
Plant Cell 26, 3661-79.
- Binding of the RNA chaperone Hfq to the type IV pilus base is crucial for its function in Synechocystis sp. PCC 6803.
Schuergers N, Ruppert U, Watanabe S, Nürnberg DJ, Lochnit G, Dienst D, Mullineaux CW, Wilde A (2014)
Mol Microbiol 92, 840-852.
- Light-induced alteration of c-di-GMP level controls motility of Synechocystis sp. PCC 6803.
Savakis P, De Causmaecker S, Angerer V, Ruppert U, Anders K, Essen LO, Wilde A (2012)
Mol Microbiol 85, 239-251.
- An experimentally anchored map of transcriptional start sites in the model cyanobacterium Synechocystis sp. PCC 6803.
Mitschke J, Georg J, Scholz I, Sharma CM, Dienst D, Bantscheff J, Voß B, Steglich C, Wilde A, Vogel J, Hess WR (2011)
Proc Natl Acad Sci 108, 2124-2129.
- Evidence for a major role of antisense RNAs in cyanobacterial gene regulation.
Georg J, Voss B, Scholz I, Mitschke J, Wilde A, Hess WR (2009)
Molecular Systems Biology 5, 305.
- Biochemical evidence for a timing mechanism in Prochlorococcus.
Axmann IM, Dühring U, Seeliger L, Arnold A, Vanselow JT, Kramer A, Wilde A (2009)
J Bacteriol 191, 5342-5347.
- Assembly of the cyanobacterial photosystem I.
Dühring U, Ossenbühl F, Wilde A (2007)
J Biol Chem 282, 10915-10921.
- A naturally occurring antisense RNA affecting expression of isiA and assembly of IsiA supercomplexes.
Dühring U, Axmann IM, Hess WR, Wilde A (2006)
Proc Nat Acad Sci 103, 7054-7058.
- The cyanobacterial phytochrome Cph2 inhibits phototaxis towards blue light.
Wilde A, Fiedler B, Börner T (2002)
Mol. Microbiol 44, 981-988.
- A prokaryotic phytochrome.
Hughes J, Lamparter T, Mittmann F, Hartmann E, Gärtner W, Wilde A, Börner T (1997)
Nature 386, 663.