Cluster of Excellence –
University of Freiburg

PD Dr. Akos Kulik

PD Dr. Akos Kulik

Institute of Physiology II
University of Freiburg

+49 761 203 67305

Functionally diverse metabotropic GABAB and glutamate receptors (mGluRs) control neuronal excitability and synaptic transmission by activating or inhibiting various types of ion channels, such as high voltage-activated Ca2+, as well as K+ channels. The impact of receptor activation on synaptic integration and regulation of transmitter release depends on the spatial relationship and coupling of receptors and their effectors in subcellular compartments of the target neurons. We have been, therefore, investigating the structural and functional basis of metabotropic receptor-effector ion channel complex-mediated signaling in cortical principal cells and GABAergic interneurons, as well as studying the activity-dependent regulation of the surface dynamics of protein complexes.

10 selected publications

  • Joint CP-AMPA and group I mGlu receptor activation is required for synaptic plasticity in dentate gyrus fast-spiking interneurons.
    Hainmüller T, Krieglstein K, Kulik A, Bartos M (2014).
    Proceedings of the National Academy of Sciences 111, 13211-13216 
  • Differential GABAB receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons.
    Booker SA, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing M, Wickman K, Watanabe M, Kulik A*, Vida I* (2013).
    The Journal of Neuroscience 33, 7961-7974   (*Corresponding authors).
  •  Quantitative regional and ultrastructural localization of the Cav2.3 subunit of R-type calcium channels in mouse brain.
    Parajuli LK, Nakajima C, Kulik A*, Matsui K, Schneider T, Shigemoto R, Fukazawa Y* (2012).
    The Journal of Neuroscience 32, 13555-13567.    (*Corresponding authors).
  • The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses.
    Guetg N, Seddik R, Vigot R, Turecek R, Gassmann M, Vogt KE, Bräuner-Osborne H, Shigemoto R, Kretz O, Frotscher M, Kulik A*, Bettler B* (2009).
    Journal of Neuroscience 29, 1414-1423.    (*Corresponding authors).
  • Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse.
    Bucurenciu I, Kulik A, Schwaller B, Frotscher M, Jonas P (2008).
    Neuron 57, 536-545.
  • Compartment-dependent co-localization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells.
    Kulik A, Vida I, Fukazawa Y, Guetg N, Kasugai Y, Marker C, Rigato F, Bettler B, Wickman K, Frotscher M, Shigemoto R (2006).
    Journal of Neuroscience 26, 4289-4297.
  • Immunocytochemical localization of the a1A subunit of the P/Q-type calcium channel in the rat cerebellum.
    Kulik A, Nakadate K, Hagiwara A, Fukazawa Y, Lujan R, Saito H, Suzuki N, Futatsugi A, Mikoshiba K, Frotscher M, Shigemoto R (2004).
    European Journal of Neuroscience 19, 2169-2178.
  • Subcellular localization of metabotropic GABAB receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus.
    Kulik A, Vida I, Lujan R, Haas CA, Lopez-Bendito G, Shigemoto R, Frotscher M (2003).
    Journal of Neuroscience 23, 11026-11035.
  • Distinct localization of GABAB receptors relative to synapses in the rat cerebellum and ventrobasal thalamus.
    Kulik A, Nakadate K, Nyiri G, Notomi T, Malitschek B, Bettler B, Shigemoto R (2002).
    European Journal of Neuroscience 15, 328-341.
  • Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone of hippocampal neurons.
    Shigemoto R, Kulik A, Roberts JDB, Ohishi H, Nusser Z, Kaneko T, Somogyi P (1996)
    Nature 381, 523-525.