Cluster of Excellence –
University of Freiburg

Dr. Uwe Schulte

Dr. Uwe Schulte

Institute of Physiology
University of Freiburg

+49 761 203 5163

 Research Interests

  • biochemical and functional characterization of ion channels and GPCRs (focus on pain and CNS disorders).
  • development of methods for biochemical characterization and mass spectrometric analysis of membrane proteins and protein-ligand interactions.
  • protein quantification and bioinformatic evaluation techniques.
  • antibody profiling, antibody technologies.
  • analysis of protein interaction networks.

 

10 selected publications

  • Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.
    López-Hernández T, Ridder MC, Montolio M, Capdevila-Nortes X, Polder E, Sirisi S, Duarri A, Schulte U, Fakler B, Nunes V, Scheper GC, Martínez A, Estévez R, van der Knaap MSU (2011).
    Am J Hum Genet. 88(4):422-32.
  • Ca2+-activated k+ channels: from protein complexes to function.
    Berkefeld H, Fakler B, Schulte U (2010).
    Physiol Rev. 90(4):1437-59.
  • Ion channels and their molecular environments - Glimpses and insights from functional proteomics.
    Schulte U, Müller C, Fakler B (2010).
    Semin Cell Dev Biol. 22(2):132-44
  • Feature Article: Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.
    Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U (2010).
    Proc Natl Acad Sci U S A. 107(34):14950-7.
  • Native GABAB receptors are heteromultimers with a family of auxiliary subunits.  
    Schwenk J, Metz M, Zolles G, Turecek R, Bildl W, Tarusawa E, Kulik A, Unger A, Tiao JY, Ivankova K, Seddik R, Gassmann M, Schulte U, Fakler B, Bettler B (2010).
    Nature 2010 465, 231-235.
  • Polycystin-1 and -2 dosage regulates pressure sensing.
    Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJ, Honoré E (2009).
    Cell 139(3):587-96.
  • Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation.
    Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller CS, Thumfart JO, Vlachos A, Deller T, Pfeifer A, Fleischmann BK, Roeper J, Fakler B, Klöcker N (2009).
    Neuron 62(6):814-25.
  • Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.
    Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker N (2009).
    Science 323(5919):1313-9.
  • Extracellular loop C of NPC1L1 is important for binding to ezetimibe.
    Weinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML (2008).
    Proc Natl Acad Sci U S A. 105(32):11140-5.
  • Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity.
    Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS (2008).
    Mol Cell Proteomics 7(11):2188-98.