Cluster of Excellence –
University of Freiburg

Dr. Tilman Brummer

Dr. Tilman Brummer

Institute of Molecular Medicine and Cell Research, University of Freiburg

+49 761 203 9610

 

10 selected publications:

  • Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model.
    Halbach S, Köhler M, Uhl FM, Huber J, Zeiser R, Koschmieder S, Aumann K, Brummer T (2016).
    Leukemia. 30(9):1942-5
  • Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.
    Köhler M, Röring M, Schorch B, Heilmann K, Stickel N, Fiala GJ, Schmitt LC, Braun S, Ehrenfeld S, Uhl FM, Kaltenbacher T, Weinberg F, Herzog S, Zeiser R, Schamel WW, Jumaa H, Brummer T. (2016)
    EMBO J. 35(2):143-61.
  • Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling.
    Kordes M#, Röring M#, Heining C#, Braun S, Hutter B, Richter D, Geörg C, Scholl C, Gröschel S, Roth W, Rosenwald A, Geissinger E, von Kalle C, Jäger D, Brors B, Weichert W, Grüllich C, Glimm H*, Brummer T*, Fröhling S*. (2016)
    Leukemia. 30(4):937-46.
    #Co-first authors, *Co-senior authors.
  • B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells.
    Herr R, Köhler M, Andrlová H, Weinberg F, Möller Y, Halbach S, Lutz L, Mastroianni J, Klose M, Bittermann N, Kowar S, Zeiser R, Olayioye MA, Lassmann S, Busch H, Boerries M, Brummer T. (2015)
    Cancer Res. 75(1):216-29.
  • BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia.
    Yaktapour N, Meiss F, Mastroianni J, Zenz T, Andrlova H, Mathew NR, Claus R, Hutter B, Fröhling S, Brors B, Pfeifer D, Pantic M, Bartsch I, Spehl TS, Meyer PT, Duyster J, Zirlik K, Brummer T, Zeiser R. (2014)
    J Clin Invest. 124(11):5074-84
  • Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
    Wöhrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Lassmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T (2013).
    Leukemia 27: 118-129
  • Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.
    Röring M, Herr R, Fiala GJ, Heilmann K, Braun S, Eisenhardt AE, Halbach S, Capper D, von Deimling A, Schamel WW, Saunders DN, Brummer T (2012)
    EMBO J 31: 2629-2647
  • Phosphorylation dependent binding of 14-3-3 proteins terminates signalling by the Gab2 docking protein.
    Brummer T, Larance M, Herrera M, Timpson P, Emmerich C, Guilhaus M, James DE, Daly RJ (2008).
    EMBO J 27 (17), pp. 2305-2316.
  • Positive regulation of immune cell function and inflammatory responses by PAC-1 phosphatase.
    Jeffrey KL, Brummer T, Rolph MS, Liu S, Callejas NA, Grumont RJ, Gillieron C, Mackay F, Grey S, Camps M, Rommel C, Gerondakis S, Mackay CR (2006).
    Nat Immunol. 7, 274-283.
  • Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling.
    Brummer T, Shaw PE, Reth M, Misawa Y (2002).
    EMBO J 21, 5611-5622.