Cluster of Excellence –
University of Freiburg

Dr. Asifa Akhtar

Dr. Asifa Akhtar

Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg

+49 761 5108 565

10 selected publications:

  • Rapid evolutionary turnover underlies conserved lncRNA-genome interactions.
    Quinn JJ, Zhang QC, Georgiev P, Ilik IA, Akhtar A, Chang HY (2016).
    Genes Dev. 30(2):191-207.
  • High-affinity sites form an interaction network to facilitate spreading of the MSL complex across the X chromosome in Drosophila.
    Ramirez F, Lingg T, Toscano S, Lam KC, Georgiev P, Chung HR, Lajoie BR, de Wit E, Zhan Y, de Laat W, Dekker J, Manke T, Akhtar A.
    Mol Cell. 60(1):146-62.
  • Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.
    Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J, Akhtar A (2014).
    Genes Dev. 28(9):929-42.
  • Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.
    Ilik IA, Quinn JJ, Georgiev P, Tavares-Cadete F, Maticzka D, Toscano S, Wan Y, Spitale RC, Luscombe N, Backofen R, Chang HY, Akhtar A (2013).
    Mol Cell. 51(2):156-73.
  • Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters.
    Conrad T, Cavalli FMG, Vaquerizas JM, Luscombe NM, Akhtar A (2012).
    Science 337(6095):742-6.
  • NSL complex regulates housekeeping genes in Drosophila.
    Lam KC, Muelfordt F, Vaquerizas JM, Raja S, Luscombe NM, Manke T, Akhtar A (2012).
    PloS Genet.8(6):e1002736
  • The MOF chromobarrel domain controls genomewide H4K16 acetylation and spreading of the MSL complex.
    Conrad T,  Cavalli F, Hallacli E, Holz H, Kind J, Iilk I, Vaquerizas JM, Luscombe NM, Akhtar A (2012).
    Dev. Cell 22: 610-624.
  • NSL complex is a novel transcription regulator in Drosophila.
    Raja SJ, Charapitsa I, Gebhardt P, Holz H, Conrad T, Fraterman S, Vaquerizas JM, Luscombe NM, Akhtar A (2010).
    Mol Cell 38: 827-841.
  • Nuclear pore components Nup153 and Megator define transcriptionally active regions in the fly genome.
    Vaquerizas JM, Suyama R, Kind J, Miura K, Luscombe NM, and Akhtar A (2010).
    PLoS Genet. 6(2): e1000846.
  • Genomewide analysis revealed MOF as key regulator of gene dosage compensation and gene expression in Drosophila.
    Kind J, Vaquerizas J, Gebhardt P, Gentzel M, Luscombe NM, Bertone   P, Akhtar A (2008).
    Cell 133(5): 813-828.