Cluster of Excellence –
University of Freiburg

Dr. Julia Jellusova

Dr. Julia Jellusova

BIOSS Centre for Biological Signalling Studies and
Institute of Biology III
University of Freiburg

+49 761 203 97663

Nutrient acquisition and utilization are dynamically regulated in lymphocytes and recent studies suggest that cell metabolism not only supports growth and proliferation, but in many cases dictates cell fate and function. Our aim is to gain deeper insight into the metabolic profile of different B cell subsets and to elucidate how various signaling pathways regulate metabolic processes in B cells. Furthermore, our goal is to gain a better understanding of how normal and malignant B cells match nutrient availability with their metabolic and energetic demands and how these cells respond to metabolic stress.

 

10 selected publications:

  • Gsk3 is a metabolic checkpoint regulator in B cells.
    Jellusova J, Cato MH, Apgar JR, Ramezani-Rad P, Leung CR, Chen C, Richardson AD, Conner EM, Benschop RJ, Woodgett JR, Rickert RC.
    Nat Immunol. 2017 Mar;18(3):303-312.
  • The PI3K pathway in B cell metabolism.
    Jellusova J, Rickert RC.
    Crit Rev Biochem Mol Biol. 2016 Sep;51(5):359-378
  • Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells.
    Miletic AV, Jellusova J, Cato MH, Lee CR, Baracho GV, Conway EM, Rickert RC.
    J Immunol. 2016 Mar 1;196(5):2195-204.
  • Context-specific BAFF-R signaling by the NF-κB and PI3K pathways.
    Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC.
    Cell Rep. 2013 Nov 27;5(4):1022-35.
  • Requirement for Rictor in homeostasis and function of mature B lymphoid cells.
    Lee K, Heffington L, Jellusova J, Nam KT, Raybuck A, Cho SH, Thomas JW, Rickert RC, Boothby M.
    Blood. 2013 Oct 3;122(14):2369-79.
  • Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen.
    Yau IW, Cato MH, Jellusova J, Hurtado de Mendoza T, Brink R, Rickert RC.
    J Immunol. 2013 Aug 1;191(3):1082-90.
  • JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression.
    Sitte S, Gläsner J, Jellusova J, Weisel F, Panattoni M, Pardi R, Gessner A.
    J Immunol. 2012 Mar 15;188(6):2677-86.
  • NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.
    Bhattacharyya S, Deb J, Patra AK, Thuy Pham DA, Chen W, Vaeth M, Berberich-Siebelt F, Klein-Hessling S, Lamperti ED, Reifenberg K, Jellusova J, Schweizer A, Nitschke L, Leich E, Rosenwald A, Brunner C, Engelmann S, Bommhardt U, Avots A, Müller MR, Kondo E, Serfling E.
    J Exp Med. 2011 Apr 11;208(4):823-39
  • Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22.
    Jellusova J, Nitschke L.
    Front Immunol. 2012 Jan 11;2:96.
  • CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.
    Jellusova J, Wellmann U, Amann K, Winkler TH, Nitschke L.
    J Immunol. 2010 Apr 1;184(7):3618-27