Cluster of Excellence –
University of Freiburg

Lab news

10.03.2017          Nada Al Samra receives her Master degree.

16.02.2017          Michael Damrat passes his Master thesis defence at the Faculty of Chemistry and Pharmacy.

10.02.2017          Gina Fiala is granted with a Post-doctoral Marie Curie Fellowship! Congratulations!

07.02.2017          The kick-off meeting of the our European Union consortium EN-ACT2ING takes place in Madrid. An open PhD position
                                is available.

17.01.2017          Frederike Hartl successfully defends her PhD with „magna cum laude“. Well done!

01.01.2017          Susana Minguet has been selected for inclusion in the Elite Programme of the Baden-Württemberg Foundation. Very

06.12.2016          Schachtrup´s group publication in Cell Reports is on-line. Congratulations!

01.11.2016          Our brief review is accepted in the J Immunol. It develops a new concept on the allosteric regulation of the TCR. Thank
                                 you Balbino and Thomas for your input.

01.10.2016          Niko Thorausch joins our department as a new PhD student. Welcome and good luck!

01.09.2016          Wolfgang Schamel joined the Advisory Board of TCR2 Therapeutics Inc., an immuno-oncology company located in
                                 Cambridge, Massachusetts, developing novel T cell therapies that unleash the full signaling power of complete
                                  T cell receptors (TCR).

22.07.2016          For her excellent PhD thesis Gina Fiala is awarded with the GEFI prize of the Faculty of Biology. Congrats!

22.07.2016          Sandra Hess is awarded with a prize to the best Master thesis of the year 2016 of the Faculty of Biology.

07.07.2016          Susana Minguet is accepted as member of the EIRA Mentoring program of the Faculty of Medicine, congratulations!

27.06.2016          To promote our paper on a LAT-deficiency in humans, Art Weiss publishes an “insights” note in J Exp Med.

19.06.2016          Gina Fiala, Anna Morath and Katrin Raute go to the γδ T cell conference in London.

01.05.2016          Our collaborative work on the identification and characterisation of the first human LAT deficiency is accepted in J Exp
. Thank you Klaus and Bärbel for the great cooperation.

31.04.2016          We are awarded with a grant of the European Union, to study T cell activation in a consortium lead by Hisse van
                                Santen. Thank you Hisse for all your great work.

08.04.2016          In a collaboration with Feng Wang and Mark Davis, our manuscript on the role of cholesterol-sulfate in TCR
                                 nanoclustering is accepted in Nat Immunol. Thank you Feng and Mark for the great cooperation.

11.04.2016          We are so happy that our story on the role of cholesterol in regulating the CD3 conformational change in the TCR is
                                  accepted in Immunity. It took so long to develop this story. Thank you Thomas Höfer and Balbino Alarcon for your
                                   valuable contributions. Time to party!!

23.03.2016          The Weber lab and our lab hold a big competition in three Lasertag fights. Luckily we win 2:1, due to our training a
                                 month before. Photos can be seen on the fun page.

20.02.2016          Katharina Rauch receives her PhD degree.

19.02.2016          Sandra Hess receives her Master degree.

03.02.2016          Iga Janowska receives her Master degree.

31.01.2016          Our collaborative work on role of Caveolin-1 regulating TCR signalling strength and T cell fate during GvHD is
                                 accepted in Blood. We thanks Robert Zeiser and his lab for the great cooperation.

15.01.2016          For her J Exp Med paper on the role of Kidins220 in B cells Gina Fiala is awarded with the publication prize of the CCI in

01.01.2016          Katrin Raute, Anna-Maria Schaffer and Laurenz Herr join our department as new PhD students. Welcome and good

12.12.2015          Erna Mindrup receives her Diploma degree.

12.11.2015          Our collaborative work on the role of Caveolin-1 deficiency on epithelial-mesenchymal transition and fibrosis during
                                peritoneal dialysis is accepted in EMBO Molecular Medicine, thanks to Raffaele and co-workers in Madrid.

07.11.2015          Many members of our department are invited to the big 30-years-Reth-group party. It was great fun. Thank you

28.10.2015          We helped Tilman Brummer’s lab to analyse a B-Raf mutated mouse. The manuscript is accepted in the EMBO J. Thank
                                 you Tilman for the nice cooperation.

23.10.2015          Our biochemical paper on binding mechanism of Nck to the TCR is accepted in the J Immunol. Thank you Pussadee
and Sutatip Pongcharoen for the great cooperation.

14.08.2015          Our paper on the role of the membrane protein Kidins220 in B cell development and activation is accepted in J Exp
. We thank all collaborators who have contributed so enthusiastically.

03.08.2015          Lea Flachsmann and Hauke Weiss receive their Bachelor degree.

24.07.2015          Katrin Raute and Jan Mentzel are awarded with the prices to the best Master thesis of the year 2014 of the Faculty of
                                 Biology. Congratulations!

06.07.2015          Katrin Raute is selected as SGBM student on Track-1. Congratulations Katrin!

01.07.2015          A paper on a ZAP-70 mutation in humans, where we have contributed some experiments, is accepted in Clin Immunol.
                                Thank you Fabian Hauck and Stephan Ehl for the cooperation.

21.06.2015          Our long term collaborator and friend Balbino Alarcon come to visit us for a few days.

15.06.2015          Alexandra Menner receives her PhD degree.

15.06.2015          A manuscript in accepted in Nat Immunol, in which we helped the Knobeloch lab to characterize a USP8 knock out
                                mouxe.Thank you Almut Dufner, Klaus-Peter Knobeloch and Marco Prinz for the good cooperation.

25.05.2015          The DFG decided to fund Susana Minguet´s research proposal for the next 3 years. Congratulations!

21.05.2015          The DFG decided to fund the Collaborative Research Center initiative: IMPATH. Thanks to all the members and
                                  specially to Prof. Ehl for his great leadership

30.04.2015          After having been with us for one year to terminate her PhD experiments, Pussadee Paensuwan leaves us. We will miss
                                  you and good luck in Thailand.

24.03.2015          A paper on light-regulated nuclear import by the Zurbriggen, Römer and Weber groups is accepted in ACS Synthet.
Thank you Wilfried and Matias for the nice collaboration.

02.02.2015          Together with the lab of Paul Fisch we have characterized the gamma delta T cell malignancies of thymoma patients.
                                 After long time, the story is accepted in J Immunol. Thank you Paul for this nice cooperation.

20.01.2015           A collaborative grant between S. Minguet and M. Zurbriggen will be funded by the “Innovationsfonds” program of
                                 the University of Freiburg. Looking forward for working together!

19.12.2014          Esmeralda Beck receives her PhD degree.

15.12.2014          We have analysed the membrane microdomain localisation of TCR nanoclusters. The manuscript is accepted in Biochem
                               Biophys Acta

25.11.2014          Alina Rudorf receives her Master degree.

12.11.2014          We helped the Alarcon lab to characterize a knock in mouse in which the TCR cannot undergo the CD3 conformational
                                 change. The paper is accepted in Sci Signaling. Thank you Balbino for the great cooperation.

07.11.2014          Katrin Raute receives her Master degree.

28.10.2014          Jan Mentzel receives her Master degree.

11.08.2014          Julia Anna Zimmermann receives her Bachelor degree.

30.07.2014          Liz Cerqueira and Nada Al-Samra receive their Bachelor degrees.

13.03.2014          Our collaborative study on the role of the two Nck isoforms Nck1 and Nck2 in human T cells is accepted in J Immunol
                                 together with Sutatip Pongcharoen.

01.04.2015          Our co-edited special issue in BBA - Molecular Cell Research on "Nanoscale Membrane Organisation" is lauched

11.02.2015          Together with Stepahn Ehl, Freiburg, we publish findings of anti-viral immune responses under attenuated TCR
                                 signalling in the J Immunol.

13.01.2015          Gina Fiala receives her doctoral degree with "summa cum laude".

19.12.2014          Esmeralda Beck receives her doctoral degree with "magna cuml laude".

02.12.2014          Our collaborative work with the group of Balbino Alarcon, Spain, on the role of the CD3 conformational change in T cell
                                 development is published in Science Signalling.

01.08.2014          Anna Morath obtains the Alumni prize of the Faculty of Biology for her Diploma work.

01.08.2014          Miriam Hils gets the Alumni prize of the Faculty of Biology for her Master work.

02.07.2014          Qusai Al-Kayyal receives his Master degree

06.06.2014          Our paper on the CD3 conformational change in the gd TCR is published in Cell Reports; including a picture by Pashu
                                on the cover page.

26.03.2014          Our paper on the role of Nck1 and Nck2 in T cell activation in published in Cell Commun Signal. This was a cooperation
                                 with S. Pongcharoen´s group from Thailand.

01.03.2014          Our collaboraive studiy with Balbino Alarcon´s group on the CD3e-Nck interaction is published in J Immunol.

07.01.2014          Our work with Hermann Eibel´s group on the nanoscale clusterin of the BAFFR is puglished in JACI

01.01.2014         We welcome Anna Morath as a new SGBM PhD student.

18.12.2013          Carina Zorzin receives her Master degree.

15.12.2013          The Zurbriggen and our group are awarded with a research grant from the University Freiburg.

06.12.2013          Our data-based simulation of BCR nanoclustering is published in Front. Immunol.

06.12.2013          The 29th BII Glögg party is held in parallel in Nice, France and in our lab.

29.11.2013          Kathrin Beck receives her docotral degree with “magna cum laude“.

25.11.2013          The SYBILLA Virtual T cell goes online.

24./25.10.2013  The BIOSS conference of nanoscale signalling that we co-organize is a big success.

18.09.2013          At the SYBILLA meeting in Oxford we decided that SYBILLA will continue.

30.09.2013          Our lab manager Thilo Bass leaves our lab after so many years, to work at the university clinics .

15.09.2013          Thomas Plum receives his Master degree.

01.08.2013          Our application to obtain a robotic station to generate signalling data is awarded by the German government.

15.05.2013          Our method to analyse lipid-protein interactions is published in Anal. Biochem.

01.03.2013          We publish the identification of Kidins220 as a novel T cell signalling protein in the J Immunol.

31.01.2013          Our big review on TCR nano-clustering is published in Immunol Rev.

15.01.2013          Jatuporn Ngoenkam from Thailand joins our lab for 3 month.

14.12.2012          We publish the lipid-based mechanism of TCR nanoclustering in J Biol Chem.

10.12.2012          For the first time our lab organizes a BII Glögg party.

23.10.2012          Our review on synthetic immunology is published in Curr Opin Biotechnol.

08.10.2012          Weng Fang from Stanford joins our lab for 2 weeks.

mid 2012              We move from the MPI to the Signalhaus at Freiburg University.