Funded by:

Prof. Dr. Jens Timmer

        

Institute of Physics, University of Freiburg

Tel:      +49 761 203 5829

Email: jeti@fdm.uni-freiburg.de

homepage

 

Dynamic processes are ubiquitous in the life sciences. They can be found from the regulation in cells up to oscillations in tremor. Malfunction of these dynamical processes can be a cause or a sign of diseases. In interdisciplinary projects, the group "Data Analysis and Modeling of Dynamic Processes in the Life Sciences"  of Prof. Timmer develops and applies mathematical methods to analyse and model these processes based on measured data.
The final aim is to help to turn the life sciences from a qualitative descriptive into a quantitative predictive science.

 

Short CV

 

10 selected publications:

  • Photoconversion and nuclear trafficking cycles determine phytochrome A's response profile to far-red light.
    Rausenberger J, Tscheuschler A, Nordmeier W, Wüst F, Timmer J, Schäfer E, Fleck C, Hiltbrunner A (2011).
    Cell. 146(5):813-25
  • Covering a broad dynamic range: Information processing at the erythropoietin receptor.
    Becker V, Schilling M, Bachmann J, Baumann U, Raue A, Maiwald T, Timmer J, Klingmüller U (2010).
    Science 328, 1404-1408.
  • Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development.
    Onichtchouk D, Geier F, Polok B, Messerschmidt D, Mössner R, Wendik B, Song S, Taylor V, Timmer J, Driever W (2010).
    Mol Syst Biol 6, 354.
  • Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions.
    Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann WD, Timmer J, Klingmüller U (2009).
    Mol Syst Biol 5, 334.
  • Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.
    Borisov N, Aksamitiene E, Kiyatkin A, Legewie S, Berkhout J, Maiwald T, Kaimachnikov NP, Timmer J, Hoek JB, Kholodenko BN (2009).
    Mol Syst Biol 2009;5:256.
  • Control of plant organ size by KLUH/CYP78A5-dependent intracellular signalling.
    Anastasiou E, Kenz S, Gerstung M, MacLean D, Timmer J, Fleck C, Lenhard M (2007).
    Dev Cell 13(6):843-56.
  • Genome-wide analysis of DNA copy number changes in CLL using high-density SNP arrays.
    Pfeifer D, Pantic M, Skatulla I, Rawluk J, Kreutz C, Martens UM, Fisch P, Timmer J, Veelken H (2006).
    Blood 109(3):1202-10.
  • WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism.
    Sick S, Reinker S, Timmer J, Schlake T (2006).
    Science 314, 1447-1450.
  • Design principles of a bacterial signalling network.
    Kollmann M, Bartholome K, Lovdok L, Timmer J, Sourjik V (2005).
    Nature 438, 504-507.
  • Identification of nucleocytoplasmic cycling as a remote sensor in cellular signalling by databased modeling.
    Swameye I, Muller TG, Timmer J, Sandra O, Klingmuller U (2003).
    Proc  Natl Acad Sci U S A 100, 1028-1033.