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- Research Programme
- Synthetic Biology
- Signalhaus Freiburg
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Cellular signalling is the key to any form of life. Research in BIOSS-1 raised the concept that cellular signalling is mediated through protein assemblies of different complexity that operate as integrated circuits. Comprehensive understanding of these assemblies and their finely orchestrated operation represents the key to physiology, pathophysiology and manipulation of cells and organs.
BIOSS-A1 focusses on signalling at and across the plasma membrane studying organization of protein complexes and networks. The rules of their assembly as well as the structural and mechanistic details of their operation are studied by an integrative approach of high-end proteomic, biochemical, structural and functional analyses of a variety of distinct classes of membrane proteins. Investigations of how extracellular signals are translated into changes in gene expression and how epigenetic modifications of chromatin modulate proliferation, cell fate decisions and differentiation are pursued in BIOSS-A2.
BIOSS-A3 focusses on key signalling mechanisms that regulate biogenesis and function of mitochondria as well as inter-organellar communication with endoplasmic reticulum and peroxisomes. Comprehensive analysis of composition and dynamics of the signalling complexes with respect to the metabolic state of the cell and a complete suborganellar map of post-translational modifications of an entire cell organelle will unravel the crosstalk of organelles and the rest of the cell. In line with the BIOSS focus on nanoscale membrane signalling and BiNEP, the molecular, structural and mechanistic characterizations of nanoscale protein complexes and circuits will be combined with synthetic approaches including inducible switches and the rebuilding of protein complexes in natural and synthetic membranes.
Funded projects within Area A
- Nano-scale analysis of the X chromosome using super-resolution microscopy (Dr. Asifa Akhtar)
- Role of TPC1 channels and associated proteins in NAADP-mediated Ca2+ release and vesicle exocytosis (Molecular physiology of renal TPC1 channels) (Dr. Uwe Schulte, Prof. Gerd Walz)
- Dynamics and Regulation of Respiratory Chain Biogenesis in Mitochondria (Prof. Bettina Warscheid, PD Dr. Martin van der Laan)
- Characterizing a multi-protein sensor of mitochondrial damage regulating membrane dynamics, mitochondrial integrity and auto/mitophagy (Prof. Ralf Baumeister)
- Regulatory role of signal sequence modification in mitochondrial biogenesis and protein quality control (Dr. Thomas Becker, Prof. Chris Meisinger)
- Significance of the protein constituents of native AMPA receptors for operation and dynamics of excitatory synaptic transmission in the mammalian brain (Functional proteomics of AMPA receptors) (Prof. Bernd Fakler, Dr. Jochen Schwenk)
- Structure and mechanism of membrane signaling complexes (Prof. Carola Hunte)
- Quantitative analysis of axonal Ca2+ channels in cortical GABAergic neurons (PD Dr. Akos Kulik)
- Epigenetics of zebrafish Midblastula Transition: connection with Pou5f1 and SoxB1 transcriptional regulators (Dr. Daria Onichtchouk)
- Link between mitochondrial biogenesis, cellular metabolism and cell cycle regulation (PD Dr. Nils Wiedemann, Prof. Klaus Pfanner)
- What determines the sorting of closely related membrane proteins to either the ER or mitochondria? (Prof. Sabine Rospert)
Dr. Asifa Akhtar, Prof. Klaus Aktories, Dr. Marta Artal-Sanz, Prof. Susana Andrade, Prof. Ralf Baumeister, Dr. Thomas Becker, Dr. Tilman Borggrefe, Prof. Christoph Borner, Prof. Thomas Brabletz, Dr. Tilman Brummer, Dr. Jörn Dengjel, Dr. Frank Edlich, Prof. Oliver Einsle, Prof. Rudolf Grosschedl, Prof. Georg Häcker, Prof. Lutz Hein, Dr. Patrick Heun, Prof. Tobias Huber, Prof. Thomas Jenuwein, Prof. Hassan Jumaa, PD Dr. Akos Kulik, Prof. Chris Meisinger, Dr. Gerhard Mittler, Dr. Peter Nielsen, Prof. Klaus Pfanner, Prof. Ralf Reski, Prof. Michael Reth, Jun. Prof. Winfried Römer, Prof. Alexander Rohrbach, Jun. Prof. Dr. Olaf Ronneberger, Prof. Sabine Rospert, Prof. Wolfgang Schamel, Dr. Robert Schneider, Prof. Roland Schüle, Dr. Uwe Schulte, Dr. Jochen Schwenk, Dr. Kathrin Thedieck, Jun. Prof. Max Ulbrich, PD Dr. Martin van der Laan, Prof. Gerd Walz, Prof. Bettina Warscheid, Prof. Wilfried Weber, PD Dr. Nils Wiedemann