Gefördert durch:

Prof. Dr. Ralf Baumeister

        

Institut für Biologie III/ Bioinformatik und Molekulargenetik, Universität Freiburg

Tel:      +49 761 203 2799

Email: baumeister@celegans.de

homepage

 

Short CV

 

10 ausgewählte Publikationen:

  • A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress.
    Springer W, Hoppe T, Schmidt E, Baumeister R (2005).
    Hum. Mol. Genet. 14, 3407-3423.
  • Regulation of the Myosin-Directed Chaperone UNC-45 by a Novel E3/E4-Multiubiquitylation Complex in C. elegans.
    Hoppe T, Cassata G, Barral JM, Springer W, Epstein HF, Baumeister R (2004). 
    Cell 118, 337-349.
  • A novel actin barbed end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
    Croce A, Cassata G, Disanza A, Gagliani MC, Tacchetti C, Malabarba MG, Carlier MF, Scita G, Baumeister R, Di Fiore PP (2004). 
    Nat. Cell Biol. 6, 1173-1179.
  • C. elegans sgk-1 is the critical component in the Akt/PKB kinase couples to control stress response and life span.
    Hertweck M, Göbel C, Baumeister R (2004). 
    Dev. Cell 6, 577-587.
  • Loss of spr-5 bypasses the requirement for the C. elegans presenilin sel-12 by derepressing hop-1.
    Eimer S, Lakowski B, Donhauser R, Baumeister R (2002). 
    EMBO J. 21, 5787-5796.
  • Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.
    Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim MG, Baumeister R, Fechteler K, Haass C (2000).
    Nat. Cell Biol. 2, 848-851.
  • Presenilin activity is required for proper neuron morphology and function in C. elegans.
    Wittenburg N, Eimer S, Lakowski B, Röhrig S, Rudolph C, Baumeister R (2000).
    Nature 406, 306-309
  • Presenilin1 differentially facilitates endoproteolysis of the ß-amyloid precursor protein and Notch.
    Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C (2000). 
    Nat. Cell Biol. 2, 205-211.
  • Thermal avoidance in Caenorhabditis elegans: An approach to the study of nociception.
    Wittenburg N, Baumeister R (1999).
    Proc. Natl. Acad. Sci. USA 96, 10477-1048.
  • Lineage-specific regulators couple cell lineage asymmetry to the transcription of the C.elegans POU gene unc-86 during neurogenesis.
    Baumeister R, Liu Y, Ruvkun G (1996).
    Genes & Dev. 10, 1395-1410.