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Publications supported by BIOSS

2012

MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation

Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P.

Cell. 2012;151(7):1528-41.

SILAC for the study of mammalian cell lines and yeast protein complexes

Piechura H, Oeljeklaus S, Warscheid B.

Methods Mol Biol. 2012;893:201-21.

Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex

Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J

Nat Commun. 2012;3:1252.

Resistance to hypoxia-induced, BNIP3-mediated cell death contributes to an increase in a CD133-positive cell population in human glioblastomas in vitro

Kahlert UD, Maciaczyk D, Dai F, Claus R, Firat E, Doostkam S, Bogiel T, Carro MS, Döbrössy M, Herold-Mende C, Niedermann G, Prinz M, Nikkhah G, Maciaczyk J.

J Neuropathol Exp Neurol. 2012;71(12):1086-1099.

γδ T-cell conference 2012: Close encounters for the fifth time

Silva-Santos B, Schamel WW, Fisch P, Eberl M.

Eur J Immunol. 2012;42(12):3101-5

Photoreductive uncaging of fluorophore in response to protein oligomers by templated reaction in vitro and in cellulo

Sadhu KK, Eierhoff T, Römer W, Winssinger N.

J Am Chem Soc. 2012;134(49):20013-6

Biosynthesis of allene oxides in Physcomitrella patens

Scholz J, Brodhun F, Hornung E, Herrfurth C, Stumpe M, Beike AK, Faltin B, Frank W, Reski R, Feussner I.

BMC Plant Biol. 2012;12(1):228

Increasing the dynamic control space of mammalian transcription devices by combinatorial assembly of homologous regulatory elements from different bacterial species

Bacchus W, Weber W, Fussenegger M.

Metab Eng. 2013;15;144–150

Differential distribution of glycine receptor subtypes at the rat calyx of held synapse

Hruskova B, Trojanova J, Kulik A, Kralikova M, Pysanenko K, Bures Z, Syka J, Trussell LO, Turecek R.

J Neurosci. 2012;32(47):17012-24.

Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension

Lienkamp SS, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB, Walz G.

Nat Genet. 2012;44(12):1382-7

A universally conserved ATPase regulates the oxidative stress response in Escherichia coli.

Wenk M, Ba Q, Erichsen V, Macinnes K, Wiese H, Warscheid B, Koch HG.

J Biol Chem. 2012;287(52):43585-98

Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish

Ernst S, Liu K, Agarwala S, Moratscheck N, Avci ME, Nogare DD, Chitnis AB, Ronneberger O, Lecaudey V.

Development. 2012;139(24):4571-81

Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs.

Curtis BA, Tanifuji G, Burki F, Gruber A, Irimia M, Maruyama S, Arias MC, Ball SG, Gile GH, Hirakawa Y, Hopkins JF, Kuo A, Rensing SA, Schmutz J, Symeonidi A, Elias M, Eveleigh RJ, Herman EK, Klute MJ, Nakayama T, Oborník M, Reyes-Prieto A, Armbrust EV, Aves SJ, Beiko RG, Coutinho P, Dacks JB, Durnford DG, Fast NM, Green BR, Grisdale CJ, Hempel F, Henrissat B, Höppner MP, Ishida K, Kim E, Kořený L, Kroth PG, Liu Y, Malik SB, Maier UG, McRose D, Mock T, Neilson JA, Onodera NT, Poole AM, Pritham EJ, Richards TA, Rocap G, Roy SW, Sarai C, Schaack S, Shirato S, Slamovits CH, Spencer DF, Suzuki S, Worden AZ, Zauner S, Barry K, Bell C, Bharti AK, Crow JA, Grimwood J, Kramer R, Lindquist E, Lucas S, Salamov A, McFadden GI, Lane CE, Keeling PJ, Gray MW, Grigoriev IV, Archibald JM.

Nature. 2012;492(7427):59-65.

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

Zhang L, Orban M, Lorenz M, Barocke V, Braun D, Urtz N, Schulz C, von Brühl ML, Tirniceriu A, Gaertner F, Proia RL, Graf T, Bolz SS, Montanez E, Prinz M, Müller A, von Baumgarten L, Billich A, Sixt M, Fässler R, von Andrian UH, Junt T, Massberg S.

J Exp Med. 2012;209(12):2165-81.

Mitofilin complexes: conserved organizers of mitochondrial membrane architecture

Zerbes RM, van der Klei IJ, Veenhuis M, Pfanner N, van der Laan M, Bohnert M.

Biol Chem. 2012;393(11):1247-61

Optical non-contact localization of liquid-gas interfaces on disk during rotation for measuring flow rates and viscosities

Hoffmann J, Riegger L, Bundgaard F, Mark D, Zengerle R, Ducrée J

Lab Chip. 2012; 12(24):5231-6

Centrifugo-dynamic inward pumping of liquids on a centrifugal microfluidic platform

Zehnle S, Schwemmer F, Roth G, von Stetten F, Zengerle R, Paust N

Lab Chip. 2012; 12(24):5142-5

RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans

Sasidharan N, Sumakovic M, Hannemann M, Hegermann J, Liewald JF, Olendrowitz C, Koenig S, Grant BD, Rizzoli SO, Gottschalk A, Eimer S.

Proc Natl Acad Sci U S A. 2012; 109(46):18944-9

Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering

Molnár E, Swamy M, Holzer M, Beck-García K, Worch R, Thiele C, Guigas G, Boye K, Luescher IF, Schwille P, Schubert R, Schamel WW.

J Biol Chem. 2012;287(51):42664-74

Protein quality control in the intermembrane space of mitochondria

Böttinger L, Becker T

J Mol Biol. 2012; 424(5):225-6

Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium

Lü W, Schwarzer NJ, Du J, Gerbig-Smentek E, Andrade SL, Einsle O

Proc Natl Acad Sci U S A. 2012; 109(45):18395-400

A hydrogel sensing pathological urate concentrations

Geraths C, Christen EH, Weber W.

Macromol Rapid Commun. 2012; 33 (24): 2103–2108

The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells

Hoyler T, Klose CS, Souabni A, Turqueti-Neves A, Pfeifer D, Rawlins EL, Voehringer D, Busslinger M, Diefenbach A.

Immunity. 2012;37(4):634-48

The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner

Reinhold R, Krüger V, Meinecke M, Schulz C, Schmidt B, Grunau SD, Guiard B, Wiedemann N, van der Laan M, Wagner R, Rehling P, Dudek J.

Mol Cell Biol. 2012;32(24):5009-21

Influence of cell-to-cell variability on spatial pattern formation

Greese B, Wester K, Bensch R, Ronneberger O, Timmer J, Hülskamp M, Fleck C

IET Syst Biol. 2012;6(4):143-153

Mechanisms of protein sorting in mitochondria

Stojanovski D, Bohnert M, Pfanner N, van der Laan M.

Cold Spring Harb Perspect Biol. 2012;4(10)

Navigating the unexplored seascape of pre-miRNA candidates in single-genome approaches

Mendes ND, Heyne S, Freitas AT, Sagot MF, Backofen R

Bioinformatics. 2012;28(23):3034-3041.

Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2

Schwer CI, Stoll P, Rospert S, Fitzke E, Schallner N, Bürkle H, Schmidt R, Humar M.

Int J Biochem Cell Biol. 2012; 45(2):201-212

Opposite effects of KCTD subunit domains on GABAB receptor-mediated desensitization

Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B

J Biol Chem. 2012;16;287(47):39869-77

Quantitative regional and ultrastructural Localization of the Cav2.3 subunit of R-type calcium channel in mouse brain.

Parajuli LK, Nakajima C, Kulik A, Matsui K, Schneider T, Shigemoto R, Fukazawa Y.

J Neurosci. 2012;32(39):13555-13567

RAC/Ssb is required for translational repression induced by polylysine segments within nascent chains

Chiabudini M, Conz C, Reckmann F, Rospert S.

Mol Cell Biol. 2012; 32(23):4769-79

Object-adapted optical trapping and shapetracking of energy-switching helical bacteria

Koch M, Rohrbach A

Nat Photonics 2012; 6, 680-686

Deep brain photoreceptors control light-seeking behavior in zebrafish larvae

Fernandes AM, Fero K, Arrenberg AB, Bergeron SA, Driever W, Burgess HA.

Curr Biol. 2012; 22(21):2042-7

Synthetic two-way communication between mammalian cells

Bacchus W, Lang M, El-Baba MD, Weber W, Stelling J, Fussenegger M

Nat Biotechnol. 2012; 30(10):991-6

Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1

Horvath SE, Böttinger L, Vöegtle FN, Wiedemann N, Meisinger C, Becker T, Daum G.

J Biol Chem. 2012; 287(44):36744-55

Prolongation of electrode lifetime in biofuel cells by periodic enzyme renewal

Rubenwolf S, Sané S, Hussein L, Kestel J, von Stetten F, Urban G, Krueger M, Zengerle R, Kerzenmacher S.

Appl Microbiol Biotechnol. 2012;96(3):841-9

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

Dühren-von Minden M, Übelhart R, Schneider D, Wossning T, Bach MP, Buchner M, Hofmann D, Surova E, Follo M, Köhler F, Wardemann H, Zirlik K, Veelken H, Jumaa H.

Nature. 2012;489(7415):309-12

Intermembrane space proteome of yeast mitochondria

Voegtle FN, Burkhart JM, Rao S, Gerbeth C, Hinrichs J, Martinou JC, Chacinska A, Sickmann A, Zahedi RP, Meisinger C.

Mol Cell Proteomics. 2012; 11(12):1840-52

Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes

Böttinger L, Horvath SE, Kleinschroth T, Hunte C, Daum G, Pfanner N, Becker T.

J Mol Biol. 2012;423(5):677-86.

Comprehensive estimation of input signals and dynamics in biochemical reaction networks

Schelker M, Raue A, Timmer J, Kreutz C.

Bioinformatics. 2012;28(18):i529-i534

Likelihood based observability analysis and confidence intervals for predictions of dynamic models

Kreutz C, Raue A, Timmer J.

BMC Syst Biol. 2012;6(1):120.

A variational approach to parameter estimation in ordinary differential equations

Kaschek D, Timmer J

BMC Systems Biology 2012;14;6:99

Porous platinum electrodes fabricated by cyclic electrodeposition of PtCu Alloy: Application to implantable glucose fuel cells

Kloke A, Köhler C, Zengerle R, Kerzenmacher S

J Phys Chem 2012, 116, 19689−19698

The origin of the plant body axis

Ueda M, Laux T.

Curr Opin Plant Biol. 2012;15(6):578-84.

Sensing mitochondrial homeostasis: the protein import machinery takes control

Vögtle FN, Meisinger C

Dev Cell. 2012;23(2):234-6.

Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans

Qi W, Huang X, Neumann-Haefelin E, Schulze E, Baumeister R.

PLoS Genet. 2012;8(8):e1002836

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane

Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Müller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N, van der Laan M

Mol Biol Cell. 2012;23(20):3948-3956.

Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells

Yogev N, Frommer F, Lukas D, Kautz-Neu K, Karram K, Ielo D, von Stebut E, Probst HC, van den Broek M, Riethmacher D, Birnberg T, Blank T, Reizis B, Korn T, Wiendl H, Jung S, Prinz M, Kurschus FC, Waisman A.

Immunity. 2012;37(2):264-75.

Find pairs: the module for protein quantification of the PeakQuant software suite

Eisenacher M, Kohl M, Wiese S, Hebeler R, Meyer HE, Warscheid B, Stephan C.

OMICS. 2012;16(9):457-67

Mussel-mimetic tissue adhesive for fetal membrane repair: An ex vivo evaluation

Haller CM, Buerzle W, Kivelio A, Perrini M, Brubaker CE, Gubeli RJ, Mallik AS, Weber W, Messersmith PB, Mazza E, Ochsenbein-Koelble N, Zimmermann R, Ehrbar M.

Acta Biomater. 2012; 8(12):4365-70

RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate

Shi A, Liu O, Koenig S, Banerjee R, Chen CC, Eimer S, Grant BD.

Proc Natl Acad Sci U S A. 2012;109(35): 2306-15.

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors

Wöhrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Laßmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T.

Leukemia. 2013; 27(1):118-29

Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/b-catenin target gene expression

Wallmen B, Schrempp M, Hecht A

Nucleic Acids Res. 2012; 40(19):9455-69

Building synthetic cell systems from the ground up

Alper H, Weber W

Curr Opin Biotechnol. 2012; 23(5):641-3

The formate channel FocA exports the products of mixed-acid fermentation

Lü W, Du J, Schwarzer NJ, Gerbig-Smentek E, Einsle O, Andrade SL.

Proc Natl Acad Sci U S A. 2012; 109(33):13254-9

A flat and cost effective actuator based on superabsorbent polymer driving a skin attachable drug delivery system

Vosseler M, Clemenz M, Zengerle R

Smart Mater Struct 2012; 21; 105002 (11pp)

Experimental design for parameter estimation of gene regulatory networks

Steiert B, Raue A, Timmer J, Kreutz C.

PLoS One. 2012;7(7):e40052

Thermodynamics of transport through the ammonium transporter Amt-1 investigated with free energy calculations

Ullmann RT, Andrade SL, Ullmann GM.

J Phys Chem B. 2012; 116(32):9690-703

The Versatile Role of Gab1 in the Circulatory System

Wöhrle FU, Halbach S, Brummer T.

Circ J. 2012; 76(8):1838-9

Combinatorial Use of Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC) and Strong Cation Exchange (SCX) Chromatography for In-Depth Phosphoproteome Analysis

Zarei M, Sprenger A, Gretzmeier C, Dengjel J.

J Proteome Res. 2012;11(8):4269-76

An essential novel component of the noncanonical mitochondrial outer membrane protein import system of trypanosomatids

Pusnik M, Mani J, Schmidt O, Niemann M, Oeljeklaus S, Schnarwiler F, Warscheid B, Lithgow T, Meisinger C, Schneider A

Mol Biol Cell. 2012;23(17):3420-8

Response to Comment on "A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation": Building a Model of the mTOR Signaling Network with a Potentially Faulty Tool

Dalle Pezze P, Sonntag AG, Shanley DP, Thedieck K.

Sci Signal. 2012;5(232):lc4.

FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair

Zhou W, Otto EA, Cluckey A, Airik R, Hurd TW, Chaki M, Diaz K, Lach FP, Bennett GR, Gee HY, Ghosh AK, Natarajan S, Thongthip S, Veturi U, Allen SJ, Janssen S, Ramaswami G, Dixon J, Burkhalter F, Spoendlin M, Moch H, Mihatsch MJ, Verine J, Reade R, Soliman H, Godin M, Kiss D, Monga G, Mazzucco G, Amann K, Artunc F, Newland RC, Wiech T, Zschiedrich S, Huber TB, Friedl A, Slaats GG, Joles JA, Goldschmeding R, Washburn J, Giles RH, Levy S, Smogorzewska A, Hildebrandt F.

Nat Genet. 2012;44(8):910-5

Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase: NEW PERSPECTIVES FROM COMPARATIVE SINGLE CHANNEL ELECTROPHYSIOLOGY

Harsman A, Niemann M, Pusnik M, Schmidt O, Burmann BM, Hiller S, Meisinger C, Schneider A, Wagner R.

J Biol Chem. 2012;287(37):31437-45

Functional Study of Mammalian Neph Proteins in Drosophila melanogaster.

Helmstädter M, Lüthy K, Gödel M, Simons M, Ashish, Nihalani D, Rensing SA, Fischbach KF, Huber TB.

PLoS One. 2012;7(7):e40300.

Pathogen and Toxin Entry - How Pathogens and Toxins Induce and Harness Endocytotic Mechanisms

Eierhoff T, Stechmann B, Römer W

Molecular Regulation of Endocytosis, ISBN: 978-953-51-0662-3

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M.

Cancer Cell. 2012;22(1):91-105.

New players in the pathogenesis of focal segmental glomerulosclerosis.

Schell C, Huber TB.

Nephrol Dial Transplant. 2012; 27(9):3406-12

Microfluidic sorting of arbitrary cells with dynamic optical tweezers

Landenberger B, Höfemann H, Wadle S, Rohrbach A

Lab Chip. 2012;12(17):3177-83

Evaluation of Bicinchoninic Acid as Ligand for Copper(I)-catalyzed Azide-Alkyne Bioconjugations

Christen EH, Gübeli RJ, Kaufmann B, Merkel L, Schoenemakers R, Budisa N, Fussenegger M, Weber W, Wiltschi B

Org Biomol Chem. 2012;10(33):6629-32

Functional characterization of cancer-associated Gab1 mutations

Ortiz-Padilla C, Gallego-Ortega D, Browne BC, Hochgräfe F, Caldon CE, Lyons RJ, Croucher DR, Rickwood D, Ormandy CJ, Brummer T, Daly RJ.

Oncogene. 2012 Jul 2. [Epub ahead of print]

Emerging role of autophagy in kidney function, diseases and aging

Huber TB, Edelstein CL, Hartleben B, Inoki K, Jiang M, Koya D, Kume S, Lieberthal W, Pallet N, Quiroga A, Ravichandran K, Susztak K, Yoshida S, Dong Z.

Autophagy 2012;8(7); 1009 - 1031

How many ways can a podocyte die?

Tharaux PL, Huber TB

Semin Nephrol. 2012 Jul;32(4):394-404.

NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum

Zhang Y, Berndt U, Gölz H, Tais A, Oellerer S, Wölfle T, Fitzke E, Rospert S.

Mol Biol Cell. 2012;23(16):3027-40

Cyclic Electrodeposition of PtCu Alloy: Facile Fabrication of Highly Porous Platinum Electrodes

Kloke A, Köhler C, Gerwig R, Zengerle R, Kerzenmacher S

Adv Mater. 2012;24(21):2916-21

Microglia as modulators of cognition and neuropsychiatric disorders

Blank T, Prinz M.

Glia. 2013; 61(1):62-70

Solid-phase PCR in a picowell array for immobilizing and arraying 100,000 PCR products to a microscope slide

Hoffmann J, Trotter M, von Stetten F, Zengerle R, Roth G

Lab Chip 2012; 12(17):3049-54

New insights into myosin phosphorylation during cyclic nucleotide-mediated smooth muscle relaxation

Puetz S, Schroeter MM, Piechura H, Reimann L, Hunger MS, Lubomirov LT, Metzler D, Warscheid B, Pfitzer G.

J Muscle Res Cell Motil. 2012;33(6):471-83

Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota

Ganal SC, Sanos SL, Kallfass C, Oberle K, Johner C, Kirschning C, Lienenklaus S, Weiss S, Staeheli P, Aichele P, Diefenbach A.

Immunity. 2012;37(1):171-86.

Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development

Filippi A, Jainok C, Driever W.

Dev Biol. 2012;369(1):133-49

ViBE-Z: a framework for 3D virtual colocalization analysis in zebrafish larval brains

Ronneberger O, Liu K, Rath M, Rueβ D, Mueller T, Skibbe H, Drayer B, Schmidt T, Filippi A, Nitschke R, Brox T, Burkhardt H, Driever W.

Nat Methods. 2012;9(7):735-42

Release probability of hippocampal glutamatergic terminals scales with the size of the active zone

Holderith N, Lorincz A, Katona G, Rózsa B, Kulik A, Watanabe M, Nusser Z.

Nat Neurosci. 2012;15(7):988-97

The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity

Holeiter G, Bischoff A, Braun AC, Huck B, Erlmann P, Schmid S, Herr R, Brummer T, Olayioye MA

Oncogenesis 2012; 1, e13; doi:10.1038/oncsis.2012.13

CARNA--alignment of RNA structure ensembles

Sorescu DA, Möhl M, Mann M, Backofen R, Will S.

Nucleic Acids Res. 2012 Jul;40(Web Server issue):W49-53

Mitochondrial protein import: Common principles and physiological networks

Dudek J, Rehling P, van der Laan M

Biochim Biophys Acta. 2013 Feb;1833(2):274-85

How type I interferons shape myeloid cell function in CNS autoimmunity

Brendecke SM, Prinz M.

J Leukoc Biol. 2012; 92(3):479-88

Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition

Kahlert UD, Maciaczyk D, Doostkam S, Orr BA, Simons B, Bogiel T, Reithmeier T, Prinz M, Schubert J, Niedermann G, Brabletz T, Eberhart CG, Nikkhah G, Maciaczyk J

Cancer Lett. 2012; 325(1):42-53

Synthesis and Characterization of PEG-Based Drug-Responsive Biohybrid Hydrogels

Gübeli RJ, Ehrbar M, Fussenegger M, Friedrich C, Weber W.

Macromol Rapid Commun. 2012; 33(15):1280-5

TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans

Hannemann M, Sasidharan N, Hegermann J, Kutscher LM, Koenig S, Eimer S.

PLoS Genet. 2012;8(5):e1002722.

An intra-cerebral drug delivery system for freely moving animals drug delivery in neural research

Spieth S, Schumacher A, Holtzman T, Rich PD, Theobald DE, Dalley JW, Nouna R, Messner S, Zengerle R

Biomed Microdevices. 2012; 14(5):799-809

High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes

Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller CS, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler B.

Neuron. 2012;74(4):621-33.

Moss-based production of asialo-erythropoietin devoid of Lewis A and other plant-typical carbohydrate determinants.

Parsons J, Altmann F, Arrenberg CK, Koprivova A, Beike AK, Stemmer C, Gorr G, Reski R, Decker EL

Plant Biotechnol J. 2012;10(7):851-61

Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes

Gebert M, Schrempp SG, Mehnert CS, Heißwolf AK, Oeljeklaus S, Ieva R, Bohnert M, von der Malsburg K, Wiese S, Kleinschroth T, Hunte C, Meyer HE, Haferkamp I, Guiard B, Warscheid B, Pfanner N, van der Laan M.

J Cell Biol. 2012;197(5):595-604

The NeuroMedicator—a micropump integrated with silicon microprobes for drug delivery in neural research

Spieth S, Schumacher A, Kallenbach C, Messner S, Zengerle R

J. Micromech. Microeng. 22 (2012) 065020 (11pp)

Microfluidic Apps for off-the-shelf instruments

Mark D, von Stetten F, Zengerle R

Lab Chip. 2012;12(14):2464-8

Completely Superhydrophobic PDMS Surfaces for Microfluidics

Tropmann A, Tanguy L, Koltay P, Zengerle R, Riegger L

Langmuir. 2012;28(22):8292-5

Role of MINOS in Mitochondrial Membrane Architecture: Cristae Morphology and Outer Membrane Interactions Differentially Depend on Mitofilin Domains

Zerbes RM, Bohnert M, Stroud DA, von der Malsburg K, Kram A, Oeljeklaus S, Warscheid B, Becker T, Wiedemann N, Veenhuis M, van der Klei IJ, Pfanner N, van der Laan M.

J Mol Biol. 2012; 422(2):183-91

Role of the polarity protein Scribble for podocyte differentiation and maintenance

Hartleben B, Widmeier E, Wanner N, Schmidts M, Kim ST, Schneider L, Mayer B, Kerjaschki D, Miner JH, Walz G, Huber TB.

PLoS One. 2012;7(5):e36705.

Design and construction of Synthetic Gene Networks in Mammalian Cells

Karlsson M, Weber W, Fussenegger M

Methods Mol Biol. 2012;813:359-76

Synthetic Gene Networks as Blueprint for Smart Hydrogels

Kämpf MM, Weber W

Methods Mol Biol. 2012;813:377-89

TSSi - An R package for transcription start site identification from 5' mRNA tag data

Kreutz C, Gehring JS, Lang D, Reski R, Timmer J, Rensing SA.

Bioinformatics. 2012, 28: 1641-1642

The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop

Haupt K, Jahreis G, Linnert M, Maestre-Martínez M, Malesevic M, Pechstein A, Edlich F, Lücke C.

J Biol Chem. 2012;287(23):19665-73

Enhanced identification of peptides lacking basic residues by LC-ESI-MS/MS analysis of singly charged peptides

Biniossek ML, Schilling O

Proteomics. 2012;12(9):1303-9

Rewiring and dosing of systems modules as a design approach for synthetic mammalian signaling networks

Kämpf MM, Engesser R, Busacker M, Hörner M, Karlsson M, Zurbriggen MD, Fussenegger M, Timmer J, Weber W.

Mol Biosyst. 2012;8(6):1824-32

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

Liu S, Hartleben B, Kretz O, Wiech T, Igarashi P, Mizushima N, Walz G, Huber TB

Autophagy. 2012; 8(5):826-37.

Meeting report signal transduction meets Systems Biology

Louis-Dit-Sully C, Kubatzky KF, Lindquist JA, Blattner C, Janssen O, Schamel WW.

Cell Commun Signal. 2012;10(1):11.

The relevance of compartmentation for cysteine synthesis in phototrophic organisms

Birke H, Müller SJ, Rother M, Zimmer AD, Hoernstein SNW, Wesenberg D, Wirtz M, Kraus GJ, Reski R, Hell R

Protoplasma 2012; 249 Suppl 2:S147-55

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

Röring M, Herr R, Fiala GJ, Heilmann K, Braun S, Eisenhardt AE, Halbach S, Capper D, von Deimling A, Schamel WW, Saunders DN, Brummer T.

EMBO J. 2012; 31(11):2629-47

Sorting and lysis of single cells by BubbleJet technology

Hoefemann H, Wadle S, Bakhtina N, Kondrashov V, Wangler N, Zengerle R

Sensors and Actuators B 2012, 168, 442-5

Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system.

Prinz M, Knobeloch KP

Front Immunol. 2012;3:67

Dynamics of TGF-β/Smad signaling

Zi Z, Chapnick DA, Liu X

FEBS Lett 2012; 586(14):1921-8

DICER-LIKE3 activity in Physcomitrella patens DICER-LIKE4 mutants causes severe developmental dysfunction and sterility

Arif MA, Fattash I, Ma Z, Cho SH, Beike AK, Reski R, Axtell MJ, Frank W.

Mol Plant. 2012;5(6):1281-94

Epigenetic Rejuvenation

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Genes Cells. 2012;17(5):337-43

Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases

Licarete E, Ganz S, Recknagel M, Di Zenzo G, Hashimoto T, Hertl M, Zambruno G, Hundorfean G, Mudter J, Neurath M, Bruckner-Tuderman L, Sitaru C.

BMC Immunol. 2012;13(1):16.

NSP4, an elastase-related protease in human neutrophils with arginine specificity

Perera NC, Schilling O, Kittel H, Back W, Kremmer E, Jenne DE.

Proc Natl Acad Sci U S A. 2012;109(16):6229-34

A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation

Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, Baumeister R, Shanley DP, Thedieck K.

Sci Signal. 2012 Mar 27;5(217):ra25

Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ

Hucke S, Floßdorf J, Grützke B, Dunay IR, Frenzel K, Jungverdorben J, Linnartz B, Mack M, Peitz M, Brüstle O, Kurts C, Klockgether T, Neumann H, Prinz M, Wiendl H, Knolle P, Klotz L

Brain. 2012 May;135(Pt 5):1586-605.

A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin

Sonntag AG, Dalle Pezze P, Shanley DP, Thedieck K

FEBS J. 2012; 279(18):3314-28

Aberrant B-raf signaling in human cancer - 10 years from bench to bedside

Roring M, Brummer T

Crit Rev Oncog. 2012;17(1):97-121.

Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis

Oeljeklaus S, Reinartz BS, Wolf J, Wiese S, Tonillo J, Podwojski K, Kuhlmann K, Stephan C, Meyer HE, Schliebs W, Brocard C, Erdmann R, Warscheid B.

J Proteome Res. 2012;11(4):2567-80.

A lineage of myeloid cells independent of Myb and hematopoietic stem cells

Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K, Prinz M, Wu B, Jacobsen SE, Pollard JW, Frampton J, Liu KJ, Geissmann F

Science. 2012;336(6077):86-90

Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans

Liu S, Schulze E, Baumeister R

PLoS One. 2012;7(3):e32360

Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS

Kalinke U, Prinz M.

Immunol Cell Biol. 2012;90(5):505-9

The path from β-carotene to carlactone, a strigolactone-like plant hormone.

Alder A, Jamil M, Marzorati M, Bruno M, Vermathen M, Bigler P, Ghisla S, Bouwmeester H, Beyer P, Al-Babili S.

Science. 2012;335(6074):1348-51.

Non-scarring skin blistering disease and mucosal lesions with IgA autoantibodies reactive with collagen VII and IgG reactivity with laminin γ2.

Florea F, Torio-Padron N, Hashimoto T, Sitaru C.

Br J Dermatol. 2012; 167(4):938-41.

Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import

Rao S, Schmidt O, Harbauer AB, Schönfisch B, Guiard B, Pfanner N, Meisinger C.

Mol Biol Cell. 2012;23(9):1618-27

Universal protocol for grafting PCR primers onto various Lab-ona-Chip substrates for solid-phase PCR

Hoffmann J, Hin S, von Stetten F, Zengerle R, Roth G

RSC Advances 2012, DOI: 10.1039/C2RA01250B

Molecular switches in animal cells

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FEBS Lett. 2012;586(15):2084-96

Role of MINOS in mitochondrial membrane architecture and biogenesis

van der Laan M, Bohnert M, Wiedemann N, Pfanner N.

Trends Cell Biol. 2012;22(4):185-92.

Specific lipids influence the import capacity of the chloroplast outer envelope precursor protein translocon

Elkehal R, Becker T, Sommer MS, Königer M, Schleiff E.

Biochim Biophys Acta. 2012;1823(5):1033-40

Mammalian target of rapamycin signaling in the podocyte

Inoki K, Huber TB

Curr Opin Nephrol Hypertens. 2012;21(3):251-7

Roles of the Middle Domain-Specific WUSCHEL-RELATED HOMEOBOX Genes in Early Development of Leaves in Arabidopsis

Nakata M, Matsumoto N, Tsugeki R, Rikirsch E, Laux T, Okada K.

Plant Cell. 2012;24(2):519-35

Global or local? Predicting secondary structure and accessibility in mRNAs

Lange SJ, Maticzka D, Möhl M, Gagnon JN, Brown CM, Backofen R.

Nucleic Acids Res. 2012;40(12):5215-26

Cyanophora paradoxa genome elucidates origin of photosynthesis in algae and plants

Price DC, Chan CX, Yoon HS, Yang EC, Qiu H, Weber AP, Schwacke R, Gross J, Blouin NA, Lane C, Reyes-Prieto A, Durnford DG, Neilson JA, Lang BF, Burger G, Steiner JM, Löffelhardt W, Meuser JE, Posewitz MC, Ball S, Arias MC, Henrissat B, Coutinho PM, Rensing SA, Symeonidi A, Doddapaneni H, Green BR, Rajah VD, Boore J, Bhattacharya D.

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In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems

Maiwald T, Blumberg J, Raue A, Hengl S, Schilling M, Sy SK, Becker V, Klingmüller U, Timmer J

BMC Syst Biol. 2012 Feb 27;6:13.

Synthetic Immune Signalling

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Curr Opin Biotechnol. 2012;23(5):780-4

Osmotic micropumps for drug delivery

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Adv Drug Deliv Rev. 2012;64(14):1617-27

Involvement of a Class III Peroxidase and the Mitochondrial Protein TSPO in Oxidative Burst Upon Treatment of Moss Plants with a Fungal Elicitor.

Lehtonen MT, Akita M, Frank W, Reski R, Valkonen JP.

Mol Plant Microbe Interact. 2012;25(3):363-71.

CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells

Poppensieker K, Otte DM, Schürmann B, Limmer A, Dresing P, Drews E, Schumak B, Klotz L, Raasch J, Mildner A, Waisman A, Scheu S, Knolle P, Förster I, Prinz M, Maier W, Zimmer A, Alferink J.

Proc Natl Acad Sci U S A. 2012;109(10):3897-902

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

Wilfling F, Weber A, Potthoff S, Vögtle FN, Meisinger C, Paschen SA, Häcker G.

Cell Death Differ. 2012;19(8):1328-36

Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex

Vukotic M, Oeljeklaus S, Wiese S, Vögtle FN, Meisinger C, Meyer HE, Zieseniss A, Katschinski DM, Jans DC, Jakobs S, Warscheid B, Rehling P, Deckers M.

Cell Metab. 2012;15(3):336-47

Plant Stem Cell Niches

Aichinger E, Kornet N, Friedrich T, Laux T.

Annu Rev Plant Biol. 2012;63:615-36

The Flavonoid Luteolin inhibits Fcc-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice

Oswald E, Sesarman A, Franzke CW, Wölfle U, Bruckner-Tuderman L, Jakob T, Martin SF, Sitaru C

PLoS One 2012, 7, 12 e31066

The Degradative Inventory of the Cell: Proteomic Insights

Engelke R, Becker AC, Dengjel J

Antioxid Redox Signal. 2012;17(5):803-12

Predictive mathematical models of cancer signalling pathways.

Bachmann J, Raue A, Schilling M, Becker V, Timmer J, Klingmüller U.

J Intern Med. 2012;271(2):155-65.

Therapeutic synthetic gene networks

Karlsson M, Weber W.

Curr Opin Biotechnol. 2012;23(5):703-11

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination.

Alkhatib A, Werner M, Hug E, Herzog S, Eschbach C, Faraidun H, Köhler F, Wossning T, Jumaa H.

J Exp Med. 2012;209(2):395-406.

Plant and bacterial systems biology as platform for plant synthetic bio(techno)logy

Zurbriggen MD, Moor A, Weber W

J Biotechnol. 2012 Jan 25. [Epub ahead of print]

Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?

Vogel S, Raulf N, Bregenhorn S, Biniossek ML, Maurer U, Czabotar P, Borner C.

J Biol Chem. 2012;287(12):9112-27

AMPA receptors commandeer an ancient cargo exporter for use as an auxiliary subunit for signaling

Harmel N, Cokic B, Zolles G, Berkefeld H, Mauric V, Fakler B, Stein V, Klöcker N

PLoS One. 2012;7(1):e30681

Why human pemphigoid autoantibodies do not trigger disease by the passive transfer into mice?

Sesarman A, Oswald E, Chiriac MT, Csorba K, Vuta V, Feldrihan V, Baican A, Bruckner-Tuderman L, Sitaru C.

Immunol Lett. 2012;143(1):92-100

Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes

Ferreira KS, Kreutz C, Macnelly S, Neubert K, Haber A, Bogyo M, Timmer J, Borner C.

Apoptosis. 2012;17(5):503-15.

Synthetic biology for mammalian cell technology and materials sciences

Gübeli RJ, Burger K, Weber W

Biotechnol Adv. 2012 Jan 21. [Epub ahead of print]

Transcriptional interpretation of the EGF receptor signaling gradient.

Fuchs A, Cheung LS, Charbonnier E, Shvartsman SY, Pyrowolakis G.

Proc Natl Acad Sci U S A. 2012;109(5):1572-7.

Propagation stability of self-reconstructing Bessel beams enables contrast-enhanced imaging in thick media

Fahrbach FO, Rohrbach A.

Nat Commun. 2012;3:632

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury.

Linkermann A, Bräsen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U, Krautwald S.

Kidney Int. 2012; 81(8):751-61

Mutated in colorectal cancer protein modulates the NFκB pathway.

Sigglekow ND, Pangon L, Brummer T, Molloy M, Hawkins NJ, Ward RL, Musgrove EA, Kohonen-Corish MR.

Anticancer Res. 2012 Jan;32(1):73-9.

Multiview Deblurring for 3-D Images from Light Sheet based Fluorescence Microscopy.

Temerinac-Ott M, Ronneberger O, Ochs P, Driever W, Brox T, Burkhardt H.

IEEE Trans Image Process 2012; 21(4): 1863-1873

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS

Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M.

Nat Neurosci. 2012; 15(1):98-106

Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency.

Fuchs S, Rensing-Ehl A, Speckmann C, Bengsch B, Schmitt-Graeff A, Bondzio I, Maul-Pavicic A, Bass T, Vraetz T, Strahm B, Ankermann T, Benson M, Caliebe A, Fölster-Holst R, Kaiser P, Thimme R, Schamel WW, Schwarz K, Feske S, Ehl S.

J Immunol. 2012;188(3):1523-33.