Synthetic Signalling Networks
Dr. Matias Zurbriggen
Tel: +49 761 203 97656
Synthetic biology applies basic engineering principles for the rational assembly of functionally well-characterised biological modules into higher order complex biological systems with desired properties. Central to the strategy is the rational design and development of new biological parts from natural existing components for the modular construction of these systems. In this way, synthetic biology facilitates the de novo engineering of genetic circuits, synthetic pathways, higher cellular structures or even organisms, and the analysis of signalling processes.
In particular, our research perspective is to apply synthetic biology in mammalian cell systems for the development of tools and techniques to control and understand eukaryotic cellular processes and regulatory networks in a quantitative and spatiotemporally resolved manner at every level of the signalling and regulatory pathways, and to design biological systems with novel properties. Specifically, we focus on:
i) Synthetic switches: Generation of novel chemically and light-triggered switches for the spatiotemporal regulation of gene expression and signalling.
ii) Synthetic regulatory networks: Interfacing synthetic switches with each other and with endogenous signalling processes to build (semi-) synthetic regulatory networks for controlling cell function.
ii) Synthetic Biological Sensors: Development of novel genetically encoded sensors for the quantitative and spatiotemporal analysis of cellular processes and regulatory networks.