Funded by:

PD Dr. Nils Wiedemann

        

Institute for Biochemistry and Molecular Biology

University of Freiburg

Tel:      +49 761 203 5280

Email:  nils.wiedemann@biochemie.uni-freiburg.de

 

Biogenesis of mitochondrial membranes:

The mitochondrial membranes are crucial for oxidative phosphorylation and cell survival. Most of the mitochondrial membrane proteins and lipids are synthesized in the cytosol and the endoplasmic reticulum (ER) respectively. We analyze the ER-mitochondria encounter structure, which forms an inter-organellar connection, and the protein translocases in the inner and outer membrane required for the import of membrane proteins and lipids.

 

Short CV

 

10 selected publications

  • Biogenesis of mitochondrial b-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex.
    Stroud DA, Becker T, Qiu J, Stojanovski D, Pfannschmidt S, Wirth C, Hunte C, Guiard B, Meisinger C, Pfanner N and Wiedemann N (2011).
    Mol Biol Cell. 22, 2823-2833.
  • Assembling the outer membrane.
    Stroud DA, Meisinger C, Pfanner N and Wiedemann N (2010).
    Science 328, 831-832.
  • Import and sorting of mitochondrial proteins.
    Wiedemann N, van der Laan M, Pfanner N (2009).
    Cell 138, 808.
  • Dissecting membrane insertion of mitochondrial b-barrel proteins.
    Kutik S, Stojanovski D, Becker L, Becker T, Meinecke M, Krüger V, Prinz C, Meisinger C, Guiard B, Wagner R, Pfanner N and Wiedemann N (2008).
    Cell 132, 1011-1024.
  • The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis.
    Kutik S, Rissler M, Guan XL, Guiard B, Shui G, Gebert N, Heacock PN, Rehling P, Dowhan W, Wenk MR, Pfanner N and Wiedemann N (2008).
    J Cell Biol 183, 1213-1221.
  • Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase.
    Gebert N, Chacinska A, Wagner K, Guiard B, Koehler CM, Rehling P, Pfanner N and Wiedemann N (2008).
    EMBO Rep 9, 548-554.
  • Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors.
    Becker T, Pfannschmidt S, Guiard B, Stojanovski D, Milenkovic D, Kutik S, Pfanner N, Meisinger C and Wiedemann N (2008).
    J Biol Chem 283, 120-127.
  • Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain.
    Wiedemann N, van der Laan M, Hutu DP, Rehling P and Pfanner N (2007).
    J Cell Biol 179, 1115-1122.
  • Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins.
    Wiedemann N, Urzica E, Guiard B, Müller H, Lohaus C, Meyer HE, Ryan MT, Meisinger C, Mühlenhoff U, Lill R and Pfanner N (2006).
    EMBO J 25, 184-195.
  • Machinery for protein sorting and assembly in the mitochondrial outer membrane.  
    Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan MT, Pfanner N and Meisinger C (2003).
    Nature 424, 565-571.