Publications supported by BIOSS
2011
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Xiang D, Yang H, Venglat P, Cao Y, Wen R, Ren M, Stone S, Wang E, Wang H, Xiao W, Weijers D, Berleth T, Laux T, Selvaraj G, Datla R. Plant Cell 2011, 23(12):4348-67. |
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Embryonic development in Arabidopsis thaliana: from the zygote division to the shoot meristem Bosca S, Knauer S, Laux T Frontiers in Plant Science 2011, 2, 93 |
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Old friends form alliance against podocytes Simons M, Huber TB. Kidney Int. 2011;80(11):1117-9. |
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Mitochondrialer Komplex 1 - Analyser einer komplexen Maschine Zickermann V, Hunte C, Brandt U Biospektrum 3/2011, 278-280 |
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Sensitivity analysis approaches applied to systems biology models Zi Z IET Syst Biol. 2011;5(6):336 |
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Emerging biomedical applications of synthetic biology Weber W, Fussenegger M. Nat Rev Genet. 2011; 13(1):21-35 |
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Evidence for interstitial carbon in nitrogenase FeMo cofactor Spatzal T, Aksoyoglu M, Zhang L, Andrade SL, Schleicher E, Weber S, Rees DC, Einsle O Science. 2011;334(6058):940 |
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Drosophila CENH3 is sufficient for centromere formation Mendiburo MJ, Padeken J, Fülöp S, Schepers A, Heun P. Science. 2011;334(6056):686-90 |
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De novo design and construction of an inducible gene expression system in mammalian cells. Karlsson M, Weber W, Fussenegger M. Methods Enzymol. 2011;497:239-53. |
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Dempwolff F, Reimold C, Reth M, Graumann PL PLoS One. 2011;6(11):e27035. |
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Tholen S, Biniossek ML, Geßler AL, Müller S, Weißer J, Kizhakkedathu JN, Reinheckel T, Schilling O Biol Chem. 2011;392(11):961-971 |
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Prorenin Receptor is essential for Podocyte Autophagy and Survival Riediger F, Quack I, Qadri F, Hartleben B, Park JK, Potthoff SA, Sohn D, Sihn G, Rousselle A, Fokuhl V, Maschke U, Purfürst B, Schneider W, Rump LC, Luft FC, Dechend R, Bader M, Huber TB, Nguyen G, Muller DN. J Am Soc Nephrol. 2011 Dec;22(12):2193-202. |
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Biniossek ML, Nägler DK, Becker-Pauly C, Schilling O J Proteome Res. 2011; 10(12):5363-73 |
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Hamaratoglu F, de Lachapelle AM, Pyrowolakis G, Bergmann S, Affolter M. PLoS Biol. 2011;9(10):e1001182 |
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Mitochondrial preprotein translocase of trypanosomatids has a bacterial origin. Pusnik M, Schmidt O, Perry AJ, Oeljeklaus S, Niemann M, Warscheid B, Lithgow T, Meisinger C, Schneider A. Curr Biol. 2011;21(20):1738-43. |
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Gene targeting of the cysteine peptidase cathepsin h impairs lung surfactant in mice. Bühling F, Kouadio M, Chwieralski CE, Kern U, Hohlfeld JM, Klemm N, Friedrichs N, Roth W, Deussing JM, Peters C, Reinheckel T PLoS One. 2011;6(10):e26247 |
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Active-site remodelling in the bifunctional fructose-1,6-bisphosphate aldolase/phosphatase. Du J, Say RF, Lü W, Fuchs G, Einsle O Nature. 2011;478(7370):534-7 |
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Strategies for the Fabrication of Porous Platinum Electrodes Kloke A, von Stetten F, Zengerle R, Kerzenmacher S Adv Mat 2011; 23 (43); 4976-5008 |
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Focke M, Kosse D, Al-Bamerni D, Lutz S, Müller C, Reinecke H, Zengerle R, von Stetten F J. Micromech. Microeng. 21 (2011) 115002 (11pp) |
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Kleinschroth T, Castellani M, Trinh CH, Morgner N, Brutschy B, Ludwig B, Hunte C. Biochim Biophys Acta. 2011; 1807(12):1606-15 |
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Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jézégou A, Reinheckel T, Hasilik A, Saftig P, Schröder B Biochem J. 2011;439(1):113-28 |
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Molecular convergence of bacterial and eukaryotic surface order. Kaiser HJ, Surma MA, Mayer F, Levental I, Grzybek M, Klemm RW, Da Cruz S, Meisinger C, Muller V, Simons K, Lingwood D. J Biol Chem. 2011;286(47):40631-7 |
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Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. von der Malsburg K, Müller JM, Bohnert M, Oeljeklaus S, et al Dev Cell. 2011;21(4):694-707 |
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Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, Schamel WW, Alarcon B, van Santen HM. Immunity. 2011;35(3):375-87. |
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Composition and topology of the endoplasmic reticulum-mitochondria encounter structure Stroud DA, Oeljeklaus S, Wiese S, Bohnert M, Lewandrowski U, Sickmann A, Guiard B, van der Laan M, Warscheid B, Wiedemann N J Mol Biol. 2011;413(4):743-50. |
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Keller T, Egenberger B, Gorboulev V, Bernhard F, Uzelac Z, Gorbunov D, Wirth C, Koppatz S, Dötsch V, Hunte C, Sitte HH, Koepsell H. J Biol Chem. 2011;286(43):37874-86. |
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Rausenberger J, Tscheuschler A, Nordmeier W, Wüst F, Timmer J, Schäfer E, Fleck C, Hiltbrunner A Cell. 2011;146(5):813-25. |
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A new vampire saga: the molecular mechanism of T cell trogocytosis Dopfer EP, Minguet S, Schamel WW. Immunity. 2011;35(2):151-3. |
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Wanner N, Noutsou F, Baumeister R, Walz G, Huber TB, Neumann-Haefelin E. PLoS One 2011;6(8):e23598 |
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N2O binding at a [4Cu:2S] copper–sulphur cluster in nitrous oxide reductase Pomowski A, Zumft WG, Kroneck PMH, Einsle O Nature 2011; 477(7363):234-7 |
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Ben-Zvi D, Pyrowolakis G, Barkai N, Shilo BZ. Curr Biol. 2011; 21(16):1391-6. |
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The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. Becker T, Wenz LS, Krüger V, Lehmann W, Müller JM, Goroncy L, Zufall N, Lithgow T, Guiard B, Chacinska A, Wagner R, Meisinger C, Pfanner N. J Cell Biol. 2011;194(3):387-95 |
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Castellani M, Havens J, Kleinschroth T, Millett F, Durham B, Malatesta F, Ludwig B. Biochim Biophys Acta. 2011;1807(11):1383-9 |
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Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I, Babes L, Reinheckel T, Peters C, Zeiser R, Bogyo M, Turk V, Psakhye SG, Turk B, Vasiljeva O. Nat Nanotechnol. 2011;6(9):594-602. |
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Deswal S, Schulze AK, Höfer T, Schamel WW PLoS One. 2011;6(7):e22928 |
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Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range Bachmann J, Raue A, Schilling M, Boehm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U Mol Syst Biol. 2011; 7:516 |
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A novel MCF-10A line allowing conditional oncogene expression in 3D culture Herr R, Wöhrle FU, Danke C, Berens C, Brummer T Cell Commun Signal. 2011;9:17. |
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Comparison of ERLIC-TiO(2), HILIC-TiO(2), and SCX-TiO(2) for Global Phosphoproteomics Approaches. Zarei M, Sprenger A, Metzger F, Gretzmeier C, Dengjel J. J Proteome Res. 2011; 10(8):3474-83 |
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Efficient generation of B lymphocytes by recognition of self-antigens. Eschbach C, Bach MP, Fidler I, Pelanda R, Köhler F, Rajewsky K, Jumaa H. Eur J Immunol. 2011;41(8):2397-403 |
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Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver D EMBO J. 2011;30(14):2793-804 |
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Schad A, Timmer J, Roth M The Astrophysical Journal 734:97 (8pp) |
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Heterochromatin boundaries are hotspots for de novo kinetochore formation Olszak A, van Essen D, Pereira AJ, Diehl S, Manke T, Maiato H, Saccani S, Heun P Nat Cell Biol 2011;13(7):799-808 |
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Pentagone: patrolling BMP morphogen signaling. Vuilleumier R, Affolter M, Pyrowolakis G. Fly (Austin). 2011;5(3):210-4. |
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Signaling at the gate: Phosphorylation of the mitochondrial protein import machinery Rao S, Gerbeth C, Harbauer A, Mikropoulou D, Meisinger C, Schmidt O. Cell Cycle. 2011; 10(13):2083-90. |
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Stroud DA, Becker T, Qiu J, Stojanovski D, Pfannschmidt S, Wirth C, Hunte C, Guiard B, Meisinger C, Pfanner N, Wiedemann N. Mol Biol Cell. 2011; 22(16):2823-33 |
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Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase. Qian X, Gebert M, Höpker J, Yan M, Li J, Wiedemann N, van der Laan M, Pfanner N, Sha B. J Mol Biol. 2011; 411(3):513-9 |
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A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis Büttner S, Ruli D, Vögtle FN, Galluzzi L, Moitzi B, Eisenberg T, Kepp O, Habernig L, Carmona-Gutierrez D, Rockenfeller P, Laun P, Breitenbach M, Khoury C, Fröhlich KU, Rechberger G, Meisinger C, Kroemer G, Madeo F. EMBO J. 2011; 30(14):2779-92 |
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ErbB2-associated changes in the lysosomal proteome Nylandsted J, Becker AC, Bunkenborg J, Andersen JS, Dengjel J, Jäättelä M. Proteomics. 2011 Jul;11(14):2830-8 |
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Ubp15p, an ubiquitin hydrolase associated with the peroxisomal export machinery. Debelyy MO, Platta HW, Saffian D, Hensel A, Thoms S, Meyer HE, Warscheid B, Girzalsky W, Erdmann R. J Biol Chem. 2011, 286(32):28223-34 |
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Arabidopsis WIH1 and WIH2 genes act in the transition from somatic to reproductive cell fate Lieber D, Lora J, Schrempp S, Lenhard M, Laux T Curr Biol. 2011; 21(12):1009-17 |
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Tp53 deletion in B lineage cells predisposes mice to lymphomas with oncogenic translocations Rowh MA, Demicco A, Horowitz JE, Yin B, Yang-Iott KS, Fusello AM, Hobeika E, Reth M, Bassing CH Oncogene. 2011; 30(47):4757-64 |
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Csorba K, Schmidt S, Florea F, Ishii N, Hashimoto T, Hertl M, Karpati S, Bruckner-Tuderman L, Nishie W, Sitaru C. Orphanet J Rare Dis. 2011;6(1):31 |
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Computational discovery of human coding and non-coding transcripts with conserved splice sites. Rose D, Hiller M, Schutt K, Hackermüller J, Backofen R, Stadler PF. Bioinformatics. 2011;27(14):1894-1900. |
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Conditional DNA-protein interactions confer stimulus-sensing properties to biohybrid materials. Christen E, Karlsson M, Kämpf MM, Schoenmakers R, Gübeli RJ, Wischhusen HM, Friedrich C, Fussenegger M, Weber W Adv Func Mat 2011, 21 (15), 2861–2867 |
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Strong negative feedback from Erk to Raf confers robustness to MAPK signalling Fritsche-Guenther R, Witzel F, Sieber A, Herr R, Schmidt N, Braun S, Brummer T, Sers C, Blüthgen N Mol Sys Biol 2011; 7:489 |
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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice Gödel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S et al J Clin Invest. 2011;121(6):2197-209 |
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Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U. Mol Cell. 2011;42(5):584-96. |
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Belting HG, Wendik B, Lunde K, Leichsenring M, Mössner M, Driever W, Onichtchouk D Dev Biol 2011; 356; 323–336 |
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BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M. Nature. 2011;473(7347):384-8. |
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Alikhani N, Berglund AK, Engmann T, Spånning E, Vögtle FN, Pavlov P, Meisinger C, Langer T, Glaser E J Mol Biol. 2011;410(3):400-10 |
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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL. J Clin Invest. 2011;121(6):2181-96 |
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Kaller M, Liffers ST, Oeljeklaus S, Kuhlmann K, Röh S, Hoffmann R, Warscheid B, Hermeking H. Mol Cell Proteomics. 2011;10(8):M111.010462 |
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Quantitative analysis of transient and sustained transforming growth factor-β signaling dynamics Zi Z, Feng Z, Chapnick DA, Dahl M, Deng D, Klipp E, Moustakas A, Liu X Mol Sys Biol 2011; 7:492 |
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Peptide signaling in plant development. Katsir L, Davies KA, Bergmann DC, Laux T. Curr Biol. 2011;21(9):R356-64. |
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The Selaginella Genome Identifies Genetic Changes Associated with the Evolution of Vascular Plants. Banks JA, Nishiyama T, Hasebe M, Bowman JL, Gribskov M et al Science. 2011; 332(6032):960-3. |
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A comparison of different automated methods for the detection of white matter lesions in MRI data. Klöppel S, Abdulkadir A, Hadjidemetriou S, Issleib S, Frings L, Thanh TN, Mader I, Teipel SJ, Hüll M, Ronneberger O (2011). Neuroimage 15;57(2):416-22 |
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Insecticidal toxin complex proteins from Xenorhabdus nematophilus: Structure and pore formation. Sheets JJ, Hey TD, Fencil KJ, Burton SL, Ni W, Lang AE, Benz R, Aktories K. J Biol Chem. 2011;286(26):22742-9. |
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Vögtle FN, Prinz C, Kellermann J, Lottspeich F, Pfanner N, Meisinger C. Mol Biol Cell. 2011; 22(13):2135-43. |
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PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, Herrmann C, Meyer HE, Wiese S, Warscheid B, Theiss C, Erdmann R. J Cell Sci. 2011;124(Pt 10):1759-68 |
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Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain. Metz M, Gassmann M, Fakler B, Schaeren-Wiemers N, Bettler B. J Comp Neurol. 2011;519(8):1435-54 |
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pH-dependent gating in a FocA formate channel. Lü W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O. Science. 2011;332(6027):352-4. |
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PI3Kβ plays a critical role in neutrophil activation by immune complexes. LKulkarni S, Sitaru C, Jakus Z, Anderson KE, Damoulakis G, Davidson K et al Sci Signal. 2011;4(168):ra23 |
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Actin as target for modification by bacterial protein toxins. Aktories K, Lang AE, Schwan C, Mannherz HG.. FEBS J. 2011;278(23):4526-43 |
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Rüdinger M, Szövényi P, Rensing SA, Knoop V. Plant J. 2011;67(2):370-80. |
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Ephrin/ephrin receptor expression during early stages of mouse inner ear development. Saeger BM, Suhm M, Neubüser A. Dev Dyn. 2011 Jun;240(6):1578-85 |
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Molecular diversity – the toolbox for synthetic gene switches and networks Weber W, Fussenegger M. Curr Opin Chem Biol. 2011;15(3):414-20. |
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Cin H, Meyer C, Herr R, Janzarik WG, Lambert S et al Acta Neuropathol. 2011;121(6):763-74 |
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Dufner A, Schamel WW. Cell Commun Signal. 2011;9(1):6 |
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Schneider J, Lother A, Hein L, Gilsbach R. Basic Res Cardiol. 2011;106(4):591-602 |
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Timmerhaus G, Hanke ST, Buchta K, Rensing SA Mol Plant 2011, 4(4):713-29 |
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Ma L, Reisert M, Burkhardt H. IEEE/ACM Trans Comput Biol Bioinform. [Epub ahead of print] |
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Broeckel U, Stoll M, Hein L. Curr Opin Nephrol Hypertens. 2011;20(2):118-24. |
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Kuhn P, Weiche B, Sturm L, Sommer E, Drepper F, Warscheid B, Sourjik V, Koch HG. Traffic. 2011;12(5):563-78. |
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A single layer glucose fuel cell intended as power supplying coating for medical implants loke A, Biller B, Kräling U, Kerzenmacher S, Zengerle R, von Stetten F Fuel Cells 11, 2, 316–326 |
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Fiala GJ, Schamel WW, Blumenthal B. J Vis Exp. 2011;(48) |
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Schmich K, Schlatter R, Corazza N, Sá Ferreira K, Ederer M, Brunner T, Borner C, Merfort I. Hepatology. 2011;53(1):282-92 |
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Ueda M, Zhang Z, Laux T. Dev Cell. 2011;20(2):264-70 |
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Lother A, Berger S, Gilsbach R, Rösner S, Ecke A, Barreto F, Bauersachs J, Schütz G, Hein L. Hypertension. 2011;57(4):746-54 |
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CNK1 and other scaffolds for Akt/FoxO signaling. Fritz RD, Radziwill G. Biochim Biophys Acta. 2011;1813(11):1971-7 |
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SBML-PET-MPI: a parallel parameter estimation tool for Systems Biology Markup Language based models Zi, Z Bioinformatics. 2011;27(7):1028-9. |
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Aumann K, Lassmann S, Schöpflin A, May AM, Wöhrle FU, Zeiser R, Waller CF, Hauschke D, Werner M, Brummer T. Hum Pathol. 2011;42(5):719-26 |
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Christopoulos P, Pfeifer D, Bartholomé K, Follo M, Timmer J, Fisch P, Veelken H. Blood. 2011;117(14):3836-46. |
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Tay TL, Ronneberger O, Ryu S, Nitschke R, Driever W Nat Comm 2011;2:171 |
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The chaperone network connected to human ribosome-associated complex. Jaiswal H, Conz C, Otto H, Wölfle T, Fitzke E, Mayer MP, Rospert S. Mol Cell Biol. 2011;31(6):1160-73. |
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Saleh O, Issman N, Seumel GI, Stav R, Samach A, Reski R, Frank W, Arazi T. Plant J. 2011;65(4):661-74 |
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Hartmann B, Castelo R, Miñana B, Peden E, Blanchette M, Rio DC, Singh R, Valcárcel J. RNA 2011, 17(3):453-68. |
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Microfluidics in silicon/polymer technology as a cost-efficient alternative to silicon/glass Kalkandjiev K, Riegger L , Kosse D, Welsche M, Gutzweiler L, Zengerle R, Koltay P. J. Micromech. Microeng. 21 (2011) 025008 (8pp) |
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Aliquoting on the centrifugal microfluidic platform based on centrifugo-pneumatic valves Mark D, Weber P, Lutz S, Focke M, Zengerle R, von Stetten F Microfluid Nanofluid (2011) 10:1279–1288 |
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Lankisch TO, Metzger J, Negm AA, Voβkuhl K, Schiffer E, Siwy J, Weismüller TJ, Schneider AS, Thedieck K, Baumeister R, Zürbig P, Weissinger EM, Manns MP, Mischak H, Wedemeyer J. Hepatology 2011, 53, 3, 875-884 |
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Regulation of mitochondrial protein import by cytosolic kinases. Schmidt O, Harbauer AB, Rao S, Eyrich B, Zahedi RP, Stojanovski D, Schönfisch B, Guiard B, Sickmann A, Pfanner N, Meisinger C. Cell. 2011;144(2):227-39. |
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Yu Q, Ghisla S, Hirschberg J, Mann V, Beyer P J Biol Chem. 2011;286(10):8666-76. |
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Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma Eisenhardt AE, Olbrich H, Röring M, Janzarik W, Van Anh TN, Cin H, Remke M, Witt H, Korshunov A, Pfister SM, Omran H, Brummer T. Int J Cancer. 2011, 129(9):2297-2303 |
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B cell homeostasis and plasma cell homing controlled by Kruppel-like factor 2 Winkelmann R, Sandrock L, Porstner M, Roth E, Mathews M, Hobeika E, Reth M, Kahn ML, Schuh W, Jäck HM. Proc Natl Acad Sci U S A. 2011;108(2):710-5 |
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Raia V, Schilling M, Böhm M, Hahn B, Kowarsch A, Raue A, Sticht C, Bohl S, Saile M, Möller P, Gretz N, Timmer J, Theis F, Lehmann WD, Lichter P, Klingmüller U. Cancer Res 2011; 71(3); 693–704 |
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Seemann SE, Richter AS, Gesell T, Backofen R, Gorodkin J. Bioinformatics. 2011;27(2):211-9 |
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mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression. Huber TB, Walz G, Kuehn EW. Kidney Int. 2011 Mar;79(5):502-11 |
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Controlled counter-flow motion of magnetic bead chains rolling along microchannels Karle M, Wöhrle J, Miwa J, Paust N, Roth G, Zengerle R, von Stetten F Microfluid Nanofluid (2011) 10:935–939 |
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Becker T, Wenz LS, Thornton N, Stroud D, Meisinger C, Wiedemann N, Pfanner N. Mol Biol. 2011;405(1):113-24. |
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The physiological roles of phosducin: from retinal function to stress-dependent hypertension Beetz N, Hein L. Cell Mol Life Sci. 2011;68(4):599-612 |
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Lipase Congeners Designed by Genetic Code Engineering Hoesl MG, Acevedo-Rocha CG, Nehring S, Royter M, Wolschner C, Wiltschi B, Budisa N, Antranikian G ChemCatChem 2011;3;213-221 |
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Ion channels and their molecular environments--glimpses and insights from functional proteomics Schulte U, Müller CS, Fakler B. Semin Cell Dev Biol. 2011;22(2):132-44 |
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Generation-biased gene expression in a bryophyte model system Szövényi P, Rensing SA, Lang D, Wray GA, Shaw AJ. Mol Biol Evol. 2011 Jan;28(1):803-12 |
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Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Müller S, Follo M, Peters C, Reinheckel T. Oncogene. 2011, 6;30(1):54-64. |
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Production of biologically active recombinant human factor H in Physcomitrella patens. Büttner-Mainik A, Parsons J, Jérôme H, Hartmann A, Lamer S, Schaaf A, Schlosser A, Zipfel PF, Reski R, Decker EL. Plant Biotechnol J. 2011;9(3):373-83 |
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Mitochondrial protein import machineries and lipids: a functional connection. Gebert N, Ryan MT, Pfanner N, Wiedemann N, Stojanovski D. Biochim Biophys Acta. 2011 Mar;1808(3):1002-11. |
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Kerzenmacher S, Kräling U, Metz T, Zengerle R, von Stetten F Journal of Power Sources 196 (2011) 1264–1272 |
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Normally-closed peristaltic micropump with re-usable actuator and disposable fluidic chip Trenkle F, Häberle S, Zengerle R Sensors and Actuators B 154 (2011) 137–141 |
















































































































